MOUSE:CXCL2

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Cxcl2 (synonyms: Mip-2, Mip2, Scyb2)
Protein Name(s)	C-X-C motif chemokine 2 Macrophage inflammatory protein 2 MIP2
External Links
UniProt	P10889
EMBL	X53798
CCDS	CCDS39144.1
PIR	JH0200
RefSeq	NP_033166.1
UniGene	Mm.4979
PDB	1MI2 3N52
PDBsum	1MI2 3N52
ProteinModelPortal	P10889
SMR	P10889
BioGrid	203135
PRIDE	P10889
Ensembl	ENSMUST00000075433
GeneID	20310
KEGG	mmu:20310
UCSC	uc008ybm.1
CTD	2920
MGI	MGI:1340094
eggNOG	NOG327267
HOGENOM	HOG000220915
HOVERGEN	HBG107789
InParanoid	P10889
KO	K05505
OMA	HPRVIQS
OrthoDB	EOG7NSB57
PhylomeDB	P10889
TreeFam	TF333433
Reactome	REACT_230248 REACT_250376
EvolutionaryTrace	P10889
NextBio	298079
PMAP-CutDB	P10889
PRO	PR:P10889
Proteomes	UP000000589
Bgee	P10889
CleanEx	MM_CXCL2
ExpressionAtlas	P10889
Genevestigator	P10889
GO	GO:0005615 GO:0071347 GO:0071222 GO:0006955 GO:0006954 GO:0070997 GO:0030593 GO:0007204 GO:0001975 GO:0032355 GO:0010332 GO:0051384 GO:0009408 GO:0002237 GO:0042060
InterPro	IPR001089 IPR018048 IPR001811
PANTHER	PTHR10179
Pfam	PF00048
PRINTS	PR00437
SMART	SM00199
SUPFAM	SSF54117
PROSITE	PS00471

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0002237	response to molecule of bacterial origin	PMID:19912257^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071222	cellular response to lipopolysaccharide	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000021269 RGD:621812 RGD:70069 RGD:708540 UniProtKB:P02778 UniProtKB:P10145 UniProtKB:P80162 UniProtKB:P80221	P		Seeded From UniProt	complete
involved_in	GO:0070098	chemokine-mediated signaling pathway	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000021269 UniProtKB:O14625 UniProtKB:P02778	P		Seeded From UniProt	complete
involved_in	GO:0061844	antimicrobial humoral immune response mediated by antimicrobial peptide	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1888711 PANTHER:PTN000021269 UniProtKB:P02776 UniProtKB:P80162 UniProtKB:P80221	P		Seeded From UniProt	complete
involved_in	GO:0030595	leukocyte chemotaxis	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000021269 RGD:70069 UniProtKB:P02776	P		Seeded From UniProt	complete
involved_in	GO:0030593	neutrophil chemotaxis	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1339941 MGI:MGI:3037818 PANTHER:PTN000021269 RGD:619869 RGD:621812 RGD:70069 UniProtKB:P10145 UniProtKB:P79255 UniProtKB:P80162 UniProtKB:P80221	P		Seeded From UniProt	complete
enables	GO:0008009	chemokine activity	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1339941 MGI:MGI:1888499 MGI:MGI:1888712 MGI:MGI:3037818 PANTHER:PTN000021269 RGD:619869 RGD:620209 RGD:621812 RGD:70069 RGD:708540 RGD:727827 UniProtKB:O14625 UniProtKB:O43927 UniProtKB:P02778 UniProtKB:P10145 UniProtKB:P80162 UniProtKB:P80221 UniProtKB:Q07325	F		Seeded From UniProt	complete
involved_in	GO:0006955	immune response	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000021269 RGD:3305 RGD:620209 RGD:727827	P		Seeded From UniProt	complete
involved_in	GO:0006954	inflammatory response	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1339941 PANTHER:PTN000021269 RGD:621812 RGD:708540	P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:108068 MGI:MGI:1340094 MGI:MGI:1352449 MGI:MGI:1352450 MGI:MGI:1888499 PANTHER:PTN000021269 RGD:619869 RGD:620209 RGD:621812 RGD:70069 RGD:708540 UniProtKB:P19876	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070997	neuron death	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70069	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030595	leukocyte chemotaxis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70069	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030593	neutrophil chemotaxis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70069	P		Seeded From UniProt	complete
enables	GO:0008009	chemokine activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70069	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007204	positive regulation of cytosolic calcium ion concentration	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70069	P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:25084278^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:21148126^[4]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000312)	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:16618742^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:16239543^[6]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:16894)	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:12055258^[7]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:35683)	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P19876	C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70069	C		Seeded From UniProt	complete
part_of	GO:0005623	cell	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0007204	C		Seeded From UniProt	complete
part_of	GO:0005623	cell	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0007204	C		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0005125	P		Seeded From UniProt	complete
involved_in	GO:0071347	cellular response to interleukin-1	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P30348 ensembl:ENSRNOP00000003745	P		Seeded From UniProt	complete
involved_in	GO:0071222	cellular response to lipopolysaccharide	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P30348 ensembl:ENSRNOP00000003745	P		Seeded From UniProt	complete
involved_in	GO:0070997	neuron death	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P30348 ensembl:ENSRNOP00000003745	P		Seeded From UniProt	complete
involved_in	GO:0051384	response to glucocorticoid	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P30348 ensembl:ENSRNOP00000003745	P		Seeded From UniProt	complete
involved_in	GO:0042060	wound healing	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P30348 ensembl:ENSRNOP00000003745	P		Seeded From UniProt	complete
involved_in	GO:0032355	response to estradiol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P30348 ensembl:ENSRNOP00000003745	P		Seeded From UniProt	complete
involved_in	GO:0030595	leukocyte chemotaxis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P30348 ensembl:ENSRNOP00000003745	P		Seeded From UniProt	complete
involved_in	GO:0030593	neutrophil chemotaxis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P30348 ensembl:ENSRNOP00000003745	P		Seeded From UniProt	complete
involved_in	GO:0010332	response to gamma radiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P30348 ensembl:ENSRNOP00000003745	P		Seeded From UniProt	complete
involved_in	GO:0009408	response to heat	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P30348 ensembl:ENSRNOP00000003745	P		Seeded From UniProt	complete
enables	GO:0008009	chemokine activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P30348 ensembl:ENSRNOP00000003745	F		Seeded From UniProt	complete
involved_in	GO:0007204	positive regulation of cytosolic calcium ion concentration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P30348 ensembl:ENSRNOP00000003745	P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P30348 ensembl:ENSRNOP00000003745	C		Seeded From UniProt	complete
involved_in	GO:0001975	response to amphetamine	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P30348 ensembl:ENSRNOP00000003745	P		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001089 InterPro:IPR001811 InterPro:IPR018048 InterPro:IPR036048	C		Seeded From UniProt	complete
involved_in	GO:0006935	chemotaxis	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR033899	P		Seeded From UniProt	complete
involved_in	GO:0006952	defense response	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR033899	P		Seeded From UniProt	complete
involved_in	GO:0006955	immune response	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001089 InterPro:IPR001811 InterPro:IPR018048 InterPro:IPR036048	P		Seeded From UniProt	complete
enables	GO:0008009	chemokine activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001089 InterPro:IPR001811 InterPro:IPR018048 InterPro:IPR033899 InterPro:IPR036048	F		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0202	C		Seeded From UniProt	complete
enables	GO:0005125	cytokine activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0202	F		Seeded From UniProt	complete
involved_in	GO:0006954	inflammatory response	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0395	P		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C		Seeded From UniProt	complete
involved_in	GO:0006935	chemotaxis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0145	P		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Oshima, N et al. (2010) A20 is an early responding negative regulator of Toll-like receptor 5 signalling in intestinal epithelial cells during inflammation. Clin. Exp. Immunol. 159 185-98 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 ^2.8 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Sônego, F et al. (2014) MyD88-, but not Nod1- and/or Nod2-deficient mice, show increased susceptibility to polymicrobial sepsis due to impaired local inflammatory response. PLoS ONE 9 e103734 PubMed GONUTS page
↑ Wolf, R et al. (2010) Gene from a psoriasis susceptibility locus primes the skin for inflammation. Sci Transl Med 2 61ra90 PubMed GONUTS page
↑ Wislez, M et al. (2006) High expression of ligands for chemokine receptor CXCR2 in alveolar epithelial neoplasia induced by oncogenic kras. Cancer Res. 66 4198-207 PubMed GONUTS page
↑ Kielian, T et al. (2005) Toll-like receptor 2 modulates the proinflammatory milieu in Staphylococcus aureus-induced brain abscess. Infect. Immun. 73 7428-35 PubMed GONUTS page
↑ Fierer, J et al. (2002) The role of lipopolysaccharide binding protein in resistance to Salmonella infections in mice. J. Immunol. 168 6396-403 PubMed GONUTS page

[PMID:19912257-1] Oshima, N et al. (2010) A20 is an early responding negative regulator of Toll-like receptor 5 signalling in intestinal epithelial cells during inflammation. Clin. Exp. Immunol. 159 185-98 PubMed GONUTS page

[PMID:21873635-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 ^2.8 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:25084278-3] Sônego, F et al. (2014) MyD88-, but not Nod1- and/or Nod2-deficient mice, show increased susceptibility to polymicrobial sepsis due to impaired local inflammatory response. PLoS ONE 9 e103734 PubMed GONUTS page

[PMID:21148126-4] Wolf, R et al. (2010) Gene from a psoriasis susceptibility locus primes the skin for inflammation. Sci Transl Med 2 61ra90 PubMed GONUTS page

[PMID:16618742-5] Wislez, M et al. (2006) High expression of ligands for chemokine receptor CXCR2 in alveolar epithelial neoplasia induced by oncogenic kras. Cancer Res. 66 4198-207 PubMed GONUTS page

[PMID:16239543-6] Kielian, T et al. (2005) Toll-like receptor 2 modulates the proinflammatory milieu in Staphylococcus aureus-induced brain abscess. Infect. Immun. 73 7428-35 PubMed GONUTS page

[PMID:12055258-7] Fierer, J et al. (2002) The role of lipopolysaccharide binding protein in resistance to Salmonella infections in mice. J. Immunol. 168 6396-403 PubMed GONUTS page

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MOUSE:CXCL2

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Annotations

Notes

References

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