MOUSE:COF1

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Cfl1
Protein Name(s)	Cofilin-1 Cofilin, non-muscle isoform
External Links
UniProt	P18760
EMBL	D00472 BC046225 BC058726
PIR	S12584
RefSeq	NP_031713.1
UniGene	Mm.329655
ProteinModelPortal	P18760
SMR	P18760
BioGrid	198684
DIP	DIP-38073N
IntAct	P18760
MINT	MINT-1862314
PhosphoSite	P18760
REPRODUCTION-2DPAGE	P18760
SWISS-2DPAGE	P18760
MaxQB	P18760
PaxDb	P18760
PRIDE	P18760
GeneID	12631
KEGG	mmu:12631
UCSC	uc008gdq.2
CTD	1072
MGI	MGI:101757
eggNOG	NOG286948
HOGENOM	HOG000039697
HOVERGEN	HBG000381
InParanoid	P18760
KO	K05765
PhylomeDB	P18760
Reactome	REACT_198374 REACT_254306 REACT_257656
NextBio	281816
PRO	PR:P18760
Proteomes	UP000000589
Bgee	P18760
CleanEx	MM_CFL1
ExpressionAtlas	P18760
Genevestigator	P18760
GO	GO:0005911 GO:0030864 GO:0005737 GO:0005829 GO:0005576 GO:0005615 GO:0070062 GO:0031258 GO:0016363 GO:0032587 GO:0030042 GO:0007015 GO:0030030 GO:0006928 GO:0007010 GO:0030010 GO:0000281 GO:0045792 GO:0001755 GO:0001842 GO:0030836 GO:0006468 GO:0022604 GO:0061001 GO:0043200 GO:0009615
Gene3D	3.40.20.10
InterPro	IPR002108 IPR029006 IPR017904 IPR027234
PANTHER	PTHR11913 PTHR11913:SF17
Pfam	PF00241
PRINTS	PR00006
SMART	SM00102
PROSITE	PS51263

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0030836	positive regulation of actin filament depolymerization	PMID:23921380^[1]	ECO:0000314			P		Figure 7 B-C show that when exposed to cofilin, the rate of actin filament depolymerization increases.	complete CACAO 8816
part_of	GO:0005615	extracellular space	PMID:24006456^[2]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	produced_by:(CL:0002548)	Seeded From UniProt	complete
enables	GO:0051015	actin filament binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P10668	F		Seeded From UniProt	complete
enables	GO:0051015	actin filament binding	PMID:11809832^[3]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0030042	actin filament depolymerization	PMID:11809832^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030043	actin filament fragmentation	PMID:11809832^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030836	positive regulation of actin filament depolymerization	PMID:23921380^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0061001	regulation of dendritic spine morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P23528	P	occurs_in:(CL:0002608)	Seeded From UniProt	complete
part_of	GO:0030027	lamellipodium	PMID:25107909^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	PMID:24052308^[5]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P97484	F	occurs_in:(UBERON:0001890)	Seeded From UniProt	complete
involved_in	GO:0022604	regulation of cell morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P23528	P		Seeded From UniProt	complete
involved_in	GO:0007010	cytoskeleton organization	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P23528	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000814	positive regulation of barbed-end actin filament capping	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:69285	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000784	positive regulation of establishment of cell polarity regulating cell shape	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:69285	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000147	positive regulation of cell motility	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:69285	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000146	negative regulation of cell motility	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:69285	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1990314	cellular response to insulin-like growth factor stimulus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:69285	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1905875	negative regulation of postsynaptic density organization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:69285	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1905873	positive regulation of protein localization to cell leading edge	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:69285	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1904783	positive regulation of NMDA glutamate receptor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:69285	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1902951	negative regulation of dendritic spine maintenance	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:69285	P		Seeded From UniProt	complete
enables	GO:1902936	phosphatidylinositol bisphosphate binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:69285	F		Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:69285	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0098885	modification of postsynaptic actin cytoskeleton	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:69285	P		Seeded From UniProt	complete
part_of	GO:0097060	synaptic membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:69285	C		Seeded From UniProt	complete
part_of	GO:0090732	cofilin-actin rod	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:69285	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071364	cellular response to epidermal growth factor stimulus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:69285	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071356	cellular response to tumor necrosis factor	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:69285	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071354	cellular response to interleukin-6	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:69285	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071347	cellular response to interleukin-1	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:69285	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070301	cellular response to hydrogen peroxide	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:69285	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0061001	regulation of dendritic spine morphogenesis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P23528	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060999	positive regulation of dendritic spine development	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:69285	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051894	positive regulation of focal adhesion assembly	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:69285	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051511	negative regulation of unidimensional cell growth	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:69285	P		Seeded From UniProt	complete
enables	GO:0051015	actin filament binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P23528	F		Seeded From UniProt	complete
enables	GO:0051015	actin filament binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:69285	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045862	positive regulation of proteolysis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:69285	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045792	negative regulation of cell size	PMID:16286931^[6]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P45592	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0044794	positive regulation by host of viral process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P23528	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043200	response to amino acid	PMID:17018287^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0043197	dendritic spine	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:69285	C		Seeded From UniProt	complete
part_of	GO:0043025	neuronal cell body	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:69285	C		Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:69285	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032232	negative regulation of actin filament bundle assembly	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:69285	P		Seeded From UniProt	complete
part_of	GO:0031966	mitochondrial membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:69285	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031915	positive regulation of synaptic plasticity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:69285	P		Seeded From UniProt	complete
part_of	GO:0031252	cell leading edge	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:69285	C		Seeded From UniProt	complete
part_of	GO:0030864	cortical actin cytoskeleton	PMID:15548599^[8]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0030864	cortical actin cytoskeleton	PMID:15004221^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030836	positive regulation of actin filament depolymerization	PMID:15548599^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030835	negative regulation of actin filament depolymerization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:69285	P		Seeded From UniProt	complete
part_of	GO:0030426	growth cone	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:69285	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030307	positive regulation of cell growth	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:69285	P		Seeded From UniProt	complete
part_of	GO:0030175	filopodium	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:69285	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030042	actin filament depolymerization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P23528	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030030	cell projection organization	PMID:16286931^[6]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P45592	P		Seeded From UniProt	complete
part_of	GO:0030027	lamellipodium	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:69285	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030010	establishment of cell polarity	PMID:15606898^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3574399	P	occurs_in:(CL:0000333)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0022604	regulation of cell morphogenesis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P23528	P		Seeded From UniProt	complete
enables	GO:0019903	protein phosphatase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:69285	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010593	negative regulation of lamellipodium assembly	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:69285	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010592	positive regulation of lamellipodium assembly	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:69285	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007162	negative regulation of cell adhesion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:69285	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007015	actin filament organization	PMID:15606898^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3574399	P	occurs_in:(CL:0000333)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007010	cytoskeleton organization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P23528	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006606	protein import into nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:69285	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006468	protein phosphorylation	PMID:17018287^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005925	focal adhesion	PMID:29162887^[11]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P23528	C		Seeded From UniProt	complete
part_of	GO:0005911	cell-cell junction	PMID:23793062^[12]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:15548599^[8]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P23528	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:69285	C		Seeded From UniProt	complete
enables	GO:0003779	actin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:69285	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001842	neural fold formation	PMID:15649475^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3574399	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001755	neural crest cell migration	PMID:15649475^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3574399	P	occurs_in:(EMAPA:16039) results_in_movement_of:(CL:0000333)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000281	mitotic cytokinesis	PMID:15548599^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0061001	regulation of dendritic spine morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23528 ensembl:ENSP00000432660	P		Seeded From UniProt	complete
enables	GO:0051015	actin filament binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23528 ensembl:ENSP00000432660	F		Seeded From UniProt	complete
involved_in	GO:0044794	positive regulation by host of viral process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23528 ensembl:ENSP00000432660	P		Seeded From UniProt	complete
involved_in	GO:0030042	actin filament depolymerization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23528 ensembl:ENSP00000432660	P		Seeded From UniProt	complete
involved_in	GO:0022604	regulation of cell morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23528 ensembl:ENSP00000432660	P		Seeded From UniProt	complete
involved_in	GO:0009615	response to virus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23528 ensembl:ENSP00000432660	P		Seeded From UniProt	complete
involved_in	GO:0007010	cytoskeleton organization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23528 ensembl:ENSP00000432660	P		Seeded From UniProt	complete
part_of	GO:0005925	focal adhesion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23528 ensembl:ENSP00000432660	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23528 ensembl:ENSP00000432660	C		Seeded From UniProt	complete
involved_in	GO:2000814	positive regulation of barbed-end actin filament capping	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P45592 ensembl:ENSRNOP00000059624	P		Seeded From UniProt	complete
involved_in	GO:2000784	positive regulation of establishment of cell polarity regulating cell shape	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P45592 ensembl:ENSRNOP00000059624	P		Seeded From UniProt	complete
involved_in	GO:2000147	positive regulation of cell motility	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P45592 ensembl:ENSRNOP00000059624	P		Seeded From UniProt	complete
involved_in	GO:2000146	negative regulation of cell motility	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P45592 ensembl:ENSRNOP00000059624	P		Seeded From UniProt	complete
involved_in	GO:1990314	cellular response to insulin-like growth factor stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P45592 ensembl:ENSRNOP00000059624	P		Seeded From UniProt	complete
involved_in	GO:1905875	negative regulation of postsynaptic density organization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P45592 ensembl:ENSRNOP00000059624	P		Seeded From UniProt	complete
involved_in	GO:1905873	positive regulation of protein localization to cell leading edge	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P45592 ensembl:ENSRNOP00000059624	P		Seeded From UniProt	complete
involved_in	GO:1904783	positive regulation of NMDA glutamate receptor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P45592 ensembl:ENSRNOP00000059624	P		Seeded From UniProt	complete
involved_in	GO:1902951	negative regulation of dendritic spine maintenance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P45592 ensembl:ENSRNOP00000059624	P		Seeded From UniProt	complete
enables	GO:1902936	phosphatidylinositol bisphosphate binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P45592 ensembl:ENSRNOP00000059624	F		Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P45592 ensembl:ENSRNOP00000059624	C		Seeded From UniProt	complete
involved_in	GO:0098885	modification of postsynaptic actin cytoskeleton	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P45592 ensembl:ENSRNOP00000059624	P		Seeded From UniProt	complete
part_of	GO:0097060	synaptic membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P45592 ensembl:ENSRNOP00000059624	C		Seeded From UniProt	complete
part_of	GO:0090732	cofilin-actin rod	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P45592 ensembl:ENSRNOP00000059624	C		Seeded From UniProt	complete
involved_in	GO:0071364	cellular response to epidermal growth factor stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P45592 ensembl:ENSRNOP00000059624	P		Seeded From UniProt	complete
involved_in	GO:0071362	cellular response to ether	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P45592 ensembl:ENSRNOP00000059624	P		Seeded From UniProt	complete
involved_in	GO:0071356	cellular response to tumor necrosis factor	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P45592 ensembl:ENSRNOP00000059624	P		Seeded From UniProt	complete
involved_in	GO:0071354	cellular response to interleukin-6	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P45592 ensembl:ENSRNOP00000059624	P		Seeded From UniProt	complete
involved_in	GO:0071347	cellular response to interleukin-1	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P45592 ensembl:ENSRNOP00000059624	P		Seeded From UniProt	complete
involved_in	GO:0070301	cellular response to hydrogen peroxide	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P45592 ensembl:ENSRNOP00000059624	P		Seeded From UniProt	complete
involved_in	GO:0060999	positive regulation of dendritic spine development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P45592 ensembl:ENSRNOP00000059624	P		Seeded From UniProt	complete
involved_in	GO:0051894	positive regulation of focal adhesion assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P45592 ensembl:ENSRNOP00000059624	P		Seeded From UniProt	complete
involved_in	GO:0051511	negative regulation of unidimensional cell growth	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P45592 ensembl:ENSRNOP00000059624	P		Seeded From UniProt	complete
enables	GO:0051015	actin filament binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P45592 ensembl:ENSRNOP00000059624	F		Seeded From UniProt	complete
involved_in	GO:0045862	positive regulation of proteolysis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P45592 ensembl:ENSRNOP00000059624	P		Seeded From UniProt	complete
involved_in	GO:0045792	negative regulation of cell size	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P45592 ensembl:ENSRNOP00000059624	P		Seeded From UniProt	complete
part_of	GO:0043197	dendritic spine	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P45592 ensembl:ENSRNOP00000059624	C		Seeded From UniProt	complete
part_of	GO:0043025	neuronal cell body	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P45592 ensembl:ENSRNOP00000059624	C		Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P45592 ensembl:ENSRNOP00000059624	C		Seeded From UniProt	complete
involved_in	GO:0032232	negative regulation of actin filament bundle assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P45592 ensembl:ENSRNOP00000059624	P		Seeded From UniProt	complete
part_of	GO:0031966	mitochondrial membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P45592 ensembl:ENSRNOP00000059624	C		Seeded From UniProt	complete
involved_in	GO:0031915	positive regulation of synaptic plasticity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P45592 ensembl:ENSRNOP00000059624	P		Seeded From UniProt	complete
part_of	GO:0031252	cell leading edge	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P45592 ensembl:ENSRNOP00000059624	C		Seeded From UniProt	complete
involved_in	GO:0030835	negative regulation of actin filament depolymerization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P45592 ensembl:ENSRNOP00000059624	P		Seeded From UniProt	complete
part_of	GO:0030426	growth cone	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P45592 ensembl:ENSRNOP00000059624	C		Seeded From UniProt	complete
involved_in	GO:0030307	positive regulation of cell growth	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P45592 ensembl:ENSRNOP00000059624	P		Seeded From UniProt	complete
part_of	GO:0030175	filopodium	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P45592 ensembl:ENSRNOP00000059624	C		Seeded From UniProt	complete
involved_in	GO:0030030	cell projection organization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P45592 ensembl:ENSRNOP00000059624	P		Seeded From UniProt	complete
part_of	GO:0030027	lamellipodium	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P45592 ensembl:ENSRNOP00000059624	C		Seeded From UniProt	complete
involved_in	GO:0021766	hippocampus development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P45592 ensembl:ENSRNOP00000059624	P		Seeded From UniProt	complete
enables	GO:0019903	protein phosphatase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P45592 ensembl:ENSRNOP00000059624	F		Seeded From UniProt	complete
involved_in	GO:0014823	response to activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P45592 ensembl:ENSRNOP00000059624	P		Seeded From UniProt	complete
involved_in	GO:0014070	response to organic cyclic compound	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P45592 ensembl:ENSRNOP00000059624	P		Seeded From UniProt	complete
involved_in	GO:0010593	negative regulation of lamellipodium assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P45592 ensembl:ENSRNOP00000059624	P		Seeded From UniProt	complete
involved_in	GO:0010592	positive regulation of lamellipodium assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P45592 ensembl:ENSRNOP00000059624	P		Seeded From UniProt	complete
involved_in	GO:0007162	negative regulation of cell adhesion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P45592 ensembl:ENSRNOP00000059624	P		Seeded From UniProt	complete
involved_in	GO:0006606	protein import into nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P45592 ensembl:ENSRNOP00000059624	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P45592 ensembl:ENSRNOP00000059624	C		Seeded From UniProt	complete
enables	GO:0003779	actin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P45592 ensembl:ENSRNOP00000059624	F		Seeded From UniProt	complete
enables	GO:0003779	actin binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002108	F		Seeded From UniProt	complete
part_of	GO:0015629	actin cytoskeleton	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR017904 InterPro:IPR027234	C		Seeded From UniProt	complete
involved_in	GO:0030042	actin filament depolymerization	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR017904 InterPro:IPR027234	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-NUL-421139 Reactome:R-MMU-482767	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	Reactome:R-MMU-482767	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003	C		Seeded From UniProt	complete
part_of	GO:0005856	cytoskeleton	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0206 UniProtKB-SubCell:SL-0090	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539	C		Seeded From UniProt	complete
part_of	GO:0042995	cell projection	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0966	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963	C		Seeded From UniProt	complete
enables	GO:0003779	actin binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0009	F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
part_of	GO:0031258	lamellipodium membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0292	C		Seeded From UniProt	complete
part_of	GO:0032587	ruffle membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0301	C		Seeded From UniProt	complete
part_of	GO:0030027	lamellipodium	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0291	C		Seeded From UniProt	complete
part_of	GO:0016363	nuclear matrix	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0181	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Chacón-Martínez, CA et al. (2013) The switch-associated protein 70 (SWAP-70) bundles actin filaments and contributes to the regulation of F-actin dynamics. J. Biol. Chem. 288 28687-703 PubMed GONUTS page
↑ Abonnenc, M et al. (2013) Extracellular matrix secretion by cardiac fibroblasts: role of microRNA-29b and microRNA-30c. Circ. Res. 113 1138-47 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Vartiainen, MK et al. (2002) The three mouse actin-depolymerizing factor/cofilins evolved to fulfill cell-type-specific requirements for actin dynamics. Mol. Biol. Cell 13 183-94 PubMed GONUTS page
↑ Lee, IC et al. (2014) Adaptor protein LRAP25 mediates myotonic dystrophy kinase-related Cdc42-binding kinase (MRCK) regulation of LIMK1 protein in lamellipodial F-actin dynamics. J. Biol. Chem. 289 26989-7003 PubMed GONUTS page
↑ Kim, T et al. (2013) Human LilrB2 is a β-amyloid receptor and its murine homolog PirB regulates synaptic plasticity in an Alzheimer's model. Science 341 1399-404 PubMed GONUTS page
↑ ^6.0 ^6.1 Tavazoie, SF et al. (2005) Regulation of neuronal morphology and function by the tumor suppressors Tsc1 and Tsc2. Nat. Neurosci. 8 1727-34 PubMed GONUTS page
↑ ^7.0 ^7.1 Offenhäuser, N et al. (2006) Increased ethanol resistance and consumption in Eps8 knockout mice correlates with altered actin dynamics. Cell 127 213-26 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 Hotulainen, P et al. (2005) Actin-depolymerizing factor and cofilin-1 play overlapping roles in promoting rapid F-actin depolymerization in mammalian nonmuscle cells. Mol. Biol. Cell 16 649-64 PubMed GONUTS page
↑ Bertling, E et al. (2004) Cyclase-associated protein 1 (CAP1) promotes cofilin-induced actin dynamics in mammalian nonmuscle cells. Mol. Biol. Cell 15 2324-34 PubMed GONUTS page
↑ ^10.0 ^10.1 Bailey, CD & Johnson, GV (2005) Tissue transglutaminase contributes to disease progression in the R6/2 Huntington's disease mouse model via aggregate-independent mechanisms. J. Neurochem. 92 83-92 PubMed GONUTS page
↑ Rogg, M et al. (2017) The WD40-domain containing protein CORO2B is specifically enriched in glomerular podocytes and regulates the ventral actin cytoskeleton. Sci Rep 7 15910 PubMed GONUTS page
↑ Liang, Y et al. (2013) The lymphoid lineage-specific actin-uncapping protein Rltpr is essential for costimulation via CD28 and the development of regulatory T cells. Nat. Immunol. 14 858-66 PubMed GONUTS page
↑ ^13.0 ^13.1 Gurniak, CB et al. (2005) The actin depolymerizing factor n-cofilin is essential for neural tube morphogenesis and neural crest cell migration. Dev. Biol. 278 231-41 PubMed GONUTS page

[PMID:23921380-1] 1.0 ^1.1 Chacón-Martínez, CA et al. (2013) The switch-associated protein 70 (SWAP-70) bundles actin filaments and contributes to the regulation of F-actin dynamics. J. Biol. Chem. 288 28687-703 PubMed GONUTS page

[PMID:24006456-2] Abonnenc, M et al. (2013) Extracellular matrix secretion by cardiac fibroblasts: role of microRNA-29b and microRNA-30c. Circ. Res. 113 1138-47 PubMed GONUTS page

[PMID:11809832-3] 3.0 ^3.1 ^3.2 Vartiainen, MK et al. (2002) The three mouse actin-depolymerizing factor/cofilins evolved to fulfill cell-type-specific requirements for actin dynamics. Mol. Biol. Cell 13 183-94 PubMed GONUTS page

[PMID:25107909-4] Lee, IC et al. (2014) Adaptor protein LRAP25 mediates myotonic dystrophy kinase-related Cdc42-binding kinase (MRCK) regulation of LIMK1 protein in lamellipodial F-actin dynamics. J. Biol. Chem. 289 26989-7003 PubMed GONUTS page

[PMID:24052308-5] Kim, T et al. (2013) Human LilrB2 is a β-amyloid receptor and its murine homolog PirB regulates synaptic plasticity in an Alzheimer's model. Science 341 1399-404 PubMed GONUTS page

[PMID:16286931-6] 6.0 ^6.1 Tavazoie, SF et al. (2005) Regulation of neuronal morphology and function by the tumor suppressors Tsc1 and Tsc2. Nat. Neurosci. 8 1727-34 PubMed GONUTS page

[PMID:17018287-7] 7.0 ^7.1 Offenhäuser, N et al. (2006) Increased ethanol resistance and consumption in Eps8 knockout mice correlates with altered actin dynamics. Cell 127 213-26 PubMed GONUTS page

[PMID:15548599-8] 8.0 ^8.1 ^8.2 ^8.3 Hotulainen, P et al. (2005) Actin-depolymerizing factor and cofilin-1 play overlapping roles in promoting rapid F-actin depolymerization in mammalian nonmuscle cells. Mol. Biol. Cell 16 649-64 PubMed GONUTS page

[PMID:15004221-9] Bertling, E et al. (2004) Cyclase-associated protein 1 (CAP1) promotes cofilin-induced actin dynamics in mammalian nonmuscle cells. Mol. Biol. Cell 15 2324-34 PubMed GONUTS page

[PMID:15606898-10] 10.0 ^10.1 Bailey, CD & Johnson, GV (2005) Tissue transglutaminase contributes to disease progression in the R6/2 Huntington's disease mouse model via aggregate-independent mechanisms. J. Neurochem. 92 83-92 PubMed GONUTS page

[PMID:29162887-11] Rogg, M et al. (2017) The WD40-domain containing protein CORO2B is specifically enriched in glomerular podocytes and regulates the ventral actin cytoskeleton. Sci Rep 7 15910 PubMed GONUTS page

[PMID:23793062-12] Liang, Y et al. (2013) The lymphoid lineage-specific actin-uncapping protein Rltpr is essential for costimulation via CD28 and the development of regulatory T cells. Nat. Immunol. 14 858-66 PubMed GONUTS page

[PMID:15649475-13] 13.0 ^13.1 Gurniak, CB et al. (2005) The actin depolymerizing factor n-cofilin is essential for neural tube morphogenesis and neural crest cell migration. Dev. Biol. 278 231-41 PubMed GONUTS page

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