MOUSE:CALR

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Calr
Protein Name(s)	Calreticulin CRP55 Calregulin Endoplasmic reticulum resident protein 60 ERp60 HACBP
External Links
UniProt	P14211
EMBL	X14926 M92988 AK075605 AK160197 BC003453
CCDS	CCDS22479.1
PIR	S06763
RefSeq	NP_031617.1
UniGene	Mm.1971 Mm.467043
PDB	3O0V 3O0W 3O0X 3RG0
PDBsum	3O0V 3O0W 3O0X 3RG0
ProteinModelPortal	P14211
SMR	P14211
BioGrid	198458
IntAct	P14211
MINT	MINT-1679870
STRING	10090.ENSMUSP00000003912
PhosphoSite	P14211
COMPLUYEAST-2DPAGE	P14211
REPRODUCTION-2DPAGE	IPI00123639 P14211
SWISS-2DPAGE	P14211
MaxQB	P14211
PaxDb	P14211
PRIDE	P14211
Ensembl	ENSMUST00000003912
GeneID	12317
KEGG	mmu:12317
UCSC	uc009mnp.1
CTD	811
MGI	MGI:88252
eggNOG	NOG305105
GeneTree	ENSGT00430000030841
HOGENOM	HOG000192435
HOVERGEN	HBG005407
InParanoid	P14211
KO	K08057
OMA	IANPEYV
OrthoDB	EOG77126Z
PhylomeDB	P14211
TreeFam	TF338438
Reactome	REACT_280759 REACT_285184 REACT_308964 REACT_339401 REACT_341075 REACT_346699
ChiTaRS	Calr
NextBio	280884
PRO	PR:P14211
Proteomes	UP000000589
Bgee	P14211
CleanEx	MM_CALR
ExpressionAtlas	P14211
Genevisible	P14211
GO	GO:0001669 GO:0005737 GO:0005829 GO:0005783 GO:0005788 GO:0009897 GO:0070062 GO:0031012 GO:0005576 GO:0005615 GO:0005925 GO:0005794 GO:0016020 GO:0042824 GO:0005634 GO:0048471 GO:0045335 GO:0005844 GO:0033018 GO:0005790 GO:0050681 GO:0005509 GO:0030246 GO:0001948 GO:0042562 GO:0005178 GO:0005506 GO:0003729 GO:0042277 GO:0044822 GO:0031625 GO:0055007 GO:0007050 GO:0071285 GO:0071310 GO:0090398 GO:0061077 GO:0030866 GO:0033144 GO:0045665 GO:0048387 GO:0000122 GO:0045892 GO:0017148 GO:0002502 GO:0045787 GO:0008284 GO:2000510 GO:0045740 GO:0010628 GO:0050766 GO:1900026 GO:0006611 GO:0034504 GO:0050821 GO:0040020 GO:0042493 GO:0032355 GO:0033574 GO:0007283
Gene3D	2.60.120.200
InterPro	IPR001580 IPR018124 IPR009169 IPR009033 IPR013320
PANTHER	PTHR11073
Pfam	PF00262
PIRSF	PIRSF002356
PRINTS	PR00626
SUPFAM	SSF49899 SSF63887
PROSITE	PS00803 PS00804 PS00805 PS00014

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
part_of	GO:0044322	endoplasmic reticulum quality control compartment	PMID:11408579^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	exists_during:(GO:1903070)	Seeded From UniProt	complete
involved_in	GO:0090398	cellular senescence	PMID:14726956^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050766	positive regulation of phagocytosis	PMID:17187072^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045787	positive regulation of cell cycle	PMID:14726956^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0042824	MHC class I peptide loading complex	PMID:11825569^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0003729	mRNA binding	PMID:14726956^[2]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0002502	peptide antigen assembly with MHC class I protein complex	PMID:11825569^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050821	protein stabilization	PMID:21652723^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0034504	protein localization to nucleus	PMID:15998798^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0030246	carbohydrate binding	PMID:20880849^[7]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	PMID:15998798^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0005509	calcium ion binding	PMID:21652723^[5]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000510	positive regulation of dendritic cell chemotaxis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P27797	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1901224	positive regulation of NIK/NF-kappaB signaling	PMID:24998604^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1901164	negative regulation of trophoblast cell migration	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P27797	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1900026	positive regulation of substrate adhesion-dependent cell spreading	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P27797	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090398	cellular senescence	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P27797	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071157	negative regulation of cell cycle arrest	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P27797	P		Seeded From UniProt	complete
part_of	GO:0062023	collagen-containing extracellular matrix	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620288	C		Seeded From UniProt	complete
enables	GO:0050681	androgen receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P27797	F		Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P27797	C		Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620288	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048387	negative regulation of retinoic acid receptor signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P27797	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045892	negative regulation of transcription, DNA-templated	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P27797	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045787	positive regulation of cell cycle	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P27797	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045665	negative regulation of neuron differentiation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P27797	P		Seeded From UniProt	complete
part_of	GO:0043231	intracellular membrane-bounded organelle	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620288	C		Seeded From UniProt	complete
part_of	GO:0042824	MHC class I peptide loading complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P27797	C		Seeded From UniProt	complete
enables	GO:0042562	hormone binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620288	F		Seeded From UniProt	complete
enables	GO:0042277	peptide binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620288	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0040020	regulation of meiotic nuclear division	PMID:15136153^[9]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_o_occurs_in:(CL:0000025)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0034504	protein localization to nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P27797	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0033144	negative regulation of intracellular steroid hormone receptor signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P27797	P		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620288	C		Seeded From UniProt	complete
enables	GO:0031625	ubiquitin protein ligase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P27797	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030866	cortical actin cytoskeleton organization	PMID:15136153^[9]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0000025)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0017148	negative regulation of translation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P27797	P		Seeded From UniProt	complete
part_of	GO:0016529	sarcoplasmic reticulum	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620288	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:22572157^[10]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P27797	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010595	positive regulation of endothelial cell migration	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P27797	P		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620288	C		Seeded From UniProt	complete
part_of	GO:0009897	external side of plasma membrane	PMID:15136153^[9]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000025)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P27797	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006611	protein export from nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P27797	P		Seeded From UniProt	complete
part_of	GO:0005844	polysome	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P27797	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P27797	C		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620288	C		Seeded From UniProt	complete
part_of	GO:0005790	smooth endoplasmic reticulum	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620288	C		Seeded From UniProt	complete
part_of	GO:0005788	endoplasmic reticulum lumen	PMID:21187406^[11]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005788	endoplasmic reticulum lumen	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P27797	C		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	PMID:27435297^[12]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	PMID:23530063^[13]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:16105)	Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	PMID:21892174^[14]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	PMID:21532570^[15]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	PMID:17923681^[16]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	PMID:15977177^[17]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	PMID:15131110^[18]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	PMID:14517290^[19]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	PMID:12676993^[20]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	PMID:23395171^[21]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P27797	C		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620288	C		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P27797	C		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	PMID:18385140^[22]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P18418	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P27797	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620288	C		Seeded From UniProt	complete
part_of	GO:0005635	nuclear envelope	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P27797	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P27797	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620288	C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:15136153^[9]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000025)	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P27797	C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620288	C		Seeded From UniProt	complete
enables	GO:0005509	calcium ion binding	PMID:3513762^[23]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0005509	calcium ion binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P27797	F		Seeded From UniProt	complete
enables	GO:0005509	calcium ion binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620288	F		Seeded From UniProt	complete
enables	GO:0005506	iron ion binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620288	F		Seeded From UniProt	complete
enables	GO:0005178	integrin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P27797	F		Seeded From UniProt	complete
enables	GO:0003729	mRNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P27797	F		Seeded From UniProt	complete
enables	GO:0003729	mRNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620288	F		Seeded From UniProt	complete
part_of	GO:0001669	acrosomal vesicle	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620288	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P27797	P		Seeded From UniProt	complete
involved_in	GO:0071310	cellular response to organic substance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18418 ensembl:ENSRNOP00000004091	P		Seeded From UniProt	complete
involved_in	GO:0071285	cellular response to lithium ion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18418 ensembl:ENSRNOP00000004091	P		Seeded From UniProt	complete
part_of	GO:0062023	collagen-containing extracellular matrix	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18418 ensembl:ENSRNOP00000004091	C		Seeded From UniProt	complete
involved_in	GO:0055007	cardiac muscle cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18418 ensembl:ENSRNOP00000004091	P		Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18418 ensembl:ENSRNOP00000004091	C		Seeded From UniProt	complete
part_of	GO:0043231	intracellular membrane-bounded organelle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18418 ensembl:ENSRNOP00000004091	C		Seeded From UniProt	complete
enables	GO:0042562	hormone binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18418 ensembl:ENSRNOP00000004091	F		Seeded From UniProt	complete
involved_in	GO:0042493	response to drug	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18418 ensembl:ENSRNOP00000004091	P		Seeded From UniProt	complete
enables	GO:0042277	peptide binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18418 ensembl:ENSRNOP00000004091	F		Seeded From UniProt	complete
involved_in	GO:0033574	response to testosterone	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18418 ensembl:ENSRNOP00000004091	P		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18418 ensembl:ENSRNOP00000004091	C		Seeded From UniProt	complete
involved_in	GO:0032355	response to estradiol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18418 ensembl:ENSRNOP00000004091	P		Seeded From UniProt	complete
part_of	GO:0016529	sarcoplasmic reticulum	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18418 ensembl:ENSRNOP00000004091	C		Seeded From UniProt	complete
involved_in	GO:0010033	response to organic substance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18418 ensembl:ENSRNOP00000004091	P		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18418 ensembl:ENSRNOP00000004091	C		Seeded From UniProt	complete
involved_in	GO:0007283	spermatogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18418 ensembl:ENSRNOP00000004091	P		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18418 ensembl:ENSRNOP00000004091	C		Seeded From UniProt	complete
part_of	GO:0005790	smooth endoplasmic reticulum	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18418 ensembl:ENSRNOP00000004091	C		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18418 ensembl:ENSRNOP00000004091	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18418 ensembl:ENSRNOP00000004091	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18418 ensembl:ENSRNOP00000004091	C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18418 ensembl:ENSRNOP00000004091	C		Seeded From UniProt	complete
enables	GO:0005509	calcium ion binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18418 ensembl:ENSRNOP00000004091	F		Seeded From UniProt	complete
enables	GO:0005506	iron ion binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18418 ensembl:ENSRNOP00000004091	F		Seeded From UniProt	complete
enables	GO:0003729	mRNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18418 ensembl:ENSRNOP00000004091	F		Seeded From UniProt	complete
part_of	GO:0001669	acrosomal vesicle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18418 ensembl:ENSRNOP00000004091	C		Seeded From UniProt	complete
involved_in	GO:2000510	positive regulation of dendritic cell chemotaxis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P27797 ensembl:ENSP00000320866	P		Seeded From UniProt	complete
involved_in	GO:1901164	negative regulation of trophoblast cell migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P27797 ensembl:ENSP00000320866	P		Seeded From UniProt	complete
involved_in	GO:1900026	positive regulation of substrate adhesion-dependent cell spreading	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P27797 ensembl:ENSP00000320866	P		Seeded From UniProt	complete
involved_in	GO:0090398	cellular senescence	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P27797 ensembl:ENSP00000320866	P		Seeded From UniProt	complete
involved_in	GO:0071157	negative regulation of cell cycle arrest	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P27797 ensembl:ENSP00000320866	P		Seeded From UniProt	complete
enables	GO:0050681	androgen receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P27797 ensembl:ENSP00000320866	F		Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P27797 ensembl:ENSP00000320866	C		Seeded From UniProt	complete
involved_in	GO:0048387	negative regulation of retinoic acid receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P27797 ensembl:ENSP00000320866	P		Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P27797 ensembl:ENSP00000320866	P		Seeded From UniProt	complete
involved_in	GO:0045787	positive regulation of cell cycle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P27797 ensembl:ENSP00000320866	P		Seeded From UniProt	complete
involved_in	GO:0045665	negative regulation of neuron differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P27797 ensembl:ENSP00000320866	P		Seeded From UniProt	complete
part_of	GO:0042824	MHC class I peptide loading complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P27797 ensembl:ENSP00000320866	C		Seeded From UniProt	complete
involved_in	GO:0034504	protein localization to nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P27797 ensembl:ENSP00000320866	P		Seeded From UniProt	complete
involved_in	GO:0033144	negative regulation of intracellular steroid hormone receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P27797 ensembl:ENSP00000320866	P		Seeded From UniProt	complete
enables	GO:0031625	ubiquitin protein ligase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P27797 ensembl:ENSP00000320866	F		Seeded From UniProt	complete
involved_in	GO:0017148	negative regulation of translation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P27797 ensembl:ENSP00000320866	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P27797 ensembl:ENSP00000320866	C		Seeded From UniProt	complete
involved_in	GO:0010595	positive regulation of endothelial cell migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P27797 ensembl:ENSP00000320866	P		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P27797 ensembl:ENSP00000320866	P		Seeded From UniProt	complete
involved_in	GO:0006611	protein export from nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P27797 ensembl:ENSP00000320866	P		Seeded From UniProt	complete
part_of	GO:0005844	polysome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P27797 ensembl:ENSP00000320866	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P27797 ensembl:ENSP00000320866	C		Seeded From UniProt	complete
part_of	GO:0005788	endoplasmic reticulum lumen	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P27797 ensembl:ENSP00000320866	C		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P27797 ensembl:ENSP00000320866	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P27797 ensembl:ENSP00000320866	C		Seeded From UniProt	complete
part_of	GO:0005635	nuclear envelope	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P27797 ensembl:ENSP00000320866	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P27797 ensembl:ENSP00000320866	C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P27797 ensembl:ENSP00000320866	C		Seeded From UniProt	complete
enables	GO:0005509	calcium ion binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P27797 ensembl:ENSP00000320866	F		Seeded From UniProt	complete
enables	GO:0005178	integrin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P27797 ensembl:ENSP00000320866	F		Seeded From UniProt	complete
enables	GO:0003729	mRNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P27797 ensembl:ENSP00000320866	F		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P27797 ensembl:ENSP00000320866	P		Seeded From UniProt	complete
enables	GO:0005509	calcium ion binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001580 InterPro:IPR009033 InterPro:IPR009169 InterPro:IPR018124	F		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001580 InterPro:IPR009169	C		Seeded From UniProt	complete
involved_in	GO:0006457	protein folding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001580 InterPro:IPR009169	P		Seeded From UniProt	complete
enables	GO:0051082	unfolded protein binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001580 InterPro:IPR009169	F		Seeded From UniProt	complete
part_of	GO:0045335	phagocytic vesicle	Reactome:R-NUL-1236962	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	Reactome:R-MMU-3221864 Reactome:R-MMU-2173779	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0256	C		Seeded From UniProt	complete
part_of	GO:0016529	sarcoplasmic reticulum	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0703	C		Seeded From UniProt	complete
enables	GO:0030246	carbohydrate binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0430	F		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
part_of	GO:0005788	endoplasmic reticulum lumen	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0096	C		Seeded From UniProt	complete
part_of	GO:0033018	sarcoplasmic reticulum lumen	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0240	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Kamhi-Nesher, S et al. (2001) A novel quality control compartment derived from the endoplasmic reticulum. Mol. Biol. Cell 12 1711-23 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Iakova, P et al. (2004) Competition of CUGBP1 and calreticulin for the regulation of p21 translation determines cell fate. EMBO J. 23 406-17 PubMed GONUTS page
↑ Obeid, M et al. (2007) Calreticulin exposure dictates the immunogenicity of cancer cell death. Nat. Med. 13 54-61 PubMed GONUTS page
↑ ^4.0 ^4.1 Gao, B et al. (2002) Assembly and antigen-presenting function of MHC class I molecules in cells lacking the ER chaperone calreticulin. Immunity 16 99-109 PubMed GONUTS page
↑ ^5.0 ^5.1 Pocanschi, CL et al. (2011) Structural and functional relationships between the lectin and arm domains of calreticulin. J. Biol. Chem. 286 27266-77 PubMed GONUTS page
↑ ^6.0 ^6.1 Lynch, J et al. (2005) Calreticulin signals upstream of calcineurin and MEF2C in a critical Ca(2+)-dependent signaling cascade. J. Cell Biol. 170 37-47 PubMed GONUTS page
↑ Kozlov, G et al. (2010) Structural basis of carbohydrate recognition by calreticulin. J. Biol. Chem. 285 38612-20 PubMed GONUTS page
↑ Massaeli, H et al. (2014) Loss of calreticulin function decreases NFκB activity by stabilizing IκB protein. Biochim. Biophys. Acta 1843 2385-93 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 Tutuncu, L et al. (2004) Calreticulin on the mouse egg surface mediates transmembrane signaling linked to cell cycle resumption. Dev. Biol. 270 246-60 PubMed GONUTS page
↑ Quiel, A et al. () Sensitive detection of idiotypic platelet-reactive alloantibodies by an electrical protein chip. Biosens Bioelectron 36 207-11 PubMed GONUTS page
↑ Valkova, C et al. (2011) Sorting receptor Rer1 controls surface expression of muscle acetylcholine receptors by ER retention of unassembled alpha-subunits. Proc. Natl. Acad. Sci. U.S.A. 108 621-5 PubMed GONUTS page
↑ Banushi, B et al. (2016) Regulation of post-Golgi LH3 trafficking is essential for collagen homeostasis. Nat Commun 7 12111 PubMed GONUTS page
↑ Hatle, KM et al. (2013) MCJ/DnaJC15, an endogenous mitochondrial repressor of the respiratory chain that controls metabolic alterations. Mol. Cell. Biol. 33 2302-14 PubMed GONUTS page
↑ Zhang, Z et al. (2011) The helicase DDX41 senses intracellular DNA mediated by the adaptor STING in dendritic cells. Nat. Immunol. 12 959-65 PubMed GONUTS page
↑ Nair, KS et al. (2011) Alteration of the serine protease PRSS56 causes angle-closure glaucoma in mice and posterior microphthalmia in humans and mice. Nat. Genet. 43 579-84 PubMed GONUTS page
↑ Lombard, DB et al. (2007) Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation. Mol. Cell. Biol. 27 8807-14 PubMed GONUTS page
↑ Barrow, KM et al. (2005) Embryonic expression of murine 5T4 oncofoetal antigen is associated with morphogenetic events at implantation and in developing epithelia. Dev. Dyn. 233 1535-45 PubMed GONUTS page
↑ Zhu, H et al. (2004) NCB5OR is a novel soluble NAD(P)H reductase localized in the endoplasmic reticulum. J. Biol. Chem. 279 30316-25 PubMed GONUTS page
↑ Cullinan, SB et al. (2003) Nrf2 is a direct PERK substrate and effector of PERK-dependent cell survival. Mol. Cell. Biol. 23 7198-209 PubMed GONUTS page
↑ Fukaya, M et al. (2003) Retention of NMDA receptor NR2 subunits in the lumen of endoplasmic reticulum in targeted NR1 knockout mice. Proc. Natl. Acad. Sci. U.S.A. 100 4855-60 PubMed GONUTS page
↑ Kim, H et al. (2013) Tmem64 modulates calcium signaling during RANKL-mediated osteoclast differentiation. Cell Metab. 17 249-60 PubMed GONUTS page
↑ Rardin, MJ et al. (2008) Dual specificity phosphatases 18 and 21 target to opposing sides of the mitochondrial inner membrane. J. Biol. Chem. 283 15440-50 PubMed GONUTS page
↑ Tuan, RS & Cavanaugh, ST (1986) Identification and characterization of a calcium-binding protein in the mouse chorioallantoic placenta. Biochem. J. 233 41-9 PubMed GONUTS page

[PMID:11408579-1] Kamhi-Nesher, S et al. (2001) A novel quality control compartment derived from the endoplasmic reticulum. Mol. Biol. Cell 12 1711-23 PubMed GONUTS page

[PMID:14726956-2] 2.0 ^2.1 ^2.2 Iakova, P et al. (2004) Competition of CUGBP1 and calreticulin for the regulation of p21 translation determines cell fate. EMBO J. 23 406-17 PubMed GONUTS page

[PMID:17187072-3] Obeid, M et al. (2007) Calreticulin exposure dictates the immunogenicity of cancer cell death. Nat. Med. 13 54-61 PubMed GONUTS page

[PMID:11825569-4] 4.0 ^4.1 Gao, B et al. (2002) Assembly and antigen-presenting function of MHC class I molecules in cells lacking the ER chaperone calreticulin. Immunity 16 99-109 PubMed GONUTS page

[PMID:21652723-5] 5.0 ^5.1 Pocanschi, CL et al. (2011) Structural and functional relationships between the lectin and arm domains of calreticulin. J. Biol. Chem. 286 27266-77 PubMed GONUTS page

[PMID:15998798-6] 6.0 ^6.1 Lynch, J et al. (2005) Calreticulin signals upstream of calcineurin and MEF2C in a critical Ca(2+)-dependent signaling cascade. J. Cell Biol. 170 37-47 PubMed GONUTS page

[PMID:20880849-7] Kozlov, G et al. (2010) Structural basis of carbohydrate recognition by calreticulin. J. Biol. Chem. 285 38612-20 PubMed GONUTS page

[PMID:24998604-8] Massaeli, H et al. (2014) Loss of calreticulin function decreases NFκB activity by stabilizing IκB protein. Biochim. Biophys. Acta 1843 2385-93 PubMed GONUTS page

[PMID:15136153-9] 9.0 ^9.1 ^9.2 ^9.3 Tutuncu, L et al. (2004) Calreticulin on the mouse egg surface mediates transmembrane signaling linked to cell cycle resumption. Dev. Biol. 270 246-60 PubMed GONUTS page

[PMID:22572157-10] Quiel, A et al. () Sensitive detection of idiotypic platelet-reactive alloantibodies by an electrical protein chip. Biosens Bioelectron 36 207-11 PubMed GONUTS page

[PMID:21187406-11] Valkova, C et al. (2011) Sorting receptor Rer1 controls surface expression of muscle acetylcholine receptors by ER retention of unassembled alpha-subunits. Proc. Natl. Acad. Sci. U.S.A. 108 621-5 PubMed GONUTS page

[PMID:27435297-12] Banushi, B et al. (2016) Regulation of post-Golgi LH3 trafficking is essential for collagen homeostasis. Nat Commun 7 12111 PubMed GONUTS page

[PMID:23530063-13] Hatle, KM et al. (2013) MCJ/DnaJC15, an endogenous mitochondrial repressor of the respiratory chain that controls metabolic alterations. Mol. Cell. Biol. 33 2302-14 PubMed GONUTS page

[PMID:21892174-14] Zhang, Z et al. (2011) The helicase DDX41 senses intracellular DNA mediated by the adaptor STING in dendritic cells. Nat. Immunol. 12 959-65 PubMed GONUTS page

[PMID:21532570-15] Nair, KS et al. (2011) Alteration of the serine protease PRSS56 causes angle-closure glaucoma in mice and posterior microphthalmia in humans and mice. Nat. Genet. 43 579-84 PubMed GONUTS page

[PMID:17923681-16] Lombard, DB et al. (2007) Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation. Mol. Cell. Biol. 27 8807-14 PubMed GONUTS page

[PMID:15977177-17] Barrow, KM et al. (2005) Embryonic expression of murine 5T4 oncofoetal antigen is associated with morphogenetic events at implantation and in developing epithelia. Dev. Dyn. 233 1535-45 PubMed GONUTS page

[PMID:15131110-18] Zhu, H et al. (2004) NCB5OR is a novel soluble NAD(P)H reductase localized in the endoplasmic reticulum. J. Biol. Chem. 279 30316-25 PubMed GONUTS page

[PMID:14517290-19] Cullinan, SB et al. (2003) Nrf2 is a direct PERK substrate and effector of PERK-dependent cell survival. Mol. Cell. Biol. 23 7198-209 PubMed GONUTS page

[PMID:12676993-20] Fukaya, M et al. (2003) Retention of NMDA receptor NR2 subunits in the lumen of endoplasmic reticulum in targeted NR1 knockout mice. Proc. Natl. Acad. Sci. U.S.A. 100 4855-60 PubMed GONUTS page

[PMID:23395171-21] Kim, H et al. (2013) Tmem64 modulates calcium signaling during RANKL-mediated osteoclast differentiation. Cell Metab. 17 249-60 PubMed GONUTS page

[PMID:18385140-22] Rardin, MJ et al. (2008) Dual specificity phosphatases 18 and 21 target to opposing sides of the mitochondrial inner membrane. J. Biol. Chem. 283 15440-50 PubMed GONUTS page

[PMID:3513762-23] Tuan, RS & Cavanaugh, ST (1986) Identification and characterization of a calcium-binding protein in the mouse chorioallantoic placenta. Biochem. J. 233 41-9 PubMed GONUTS page

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