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MOUSE:BIR1E
Contents
| Species (Taxon ID) | Mus musculus (Mouse). (10090) | |
| Gene Name(s) | Naip5 (synonyms: Birc1e, Naip-rs3) | |
| Protein Name(s) | Baculoviral IAP repeat-containing protein 1e
Neuronal apoptosis inhibitory protein 5 | |
| External Links | ||
| UniProt | Q9R016 | |
| EMBL | AF135492 AF131205 U66326 | |
| CCDS | CCDS26727.1 | |
| RefSeq | NP_035000.2 | |
| UniGene | Mm.290476 | |
| ProteinModelPortal | Q9R016 | |
| SMR | Q9R016 | |
| DIP | DIP-59148N | |
| STRING | 10090.ENSMUSP00000058611 | |
| iPTMnet | Q9R016 | |
| PhosphoSite | Q9R016 | |
| MaxQB | Q9R016 | |
| PaxDb | Q9R016 | |
| PRIDE | Q9R016 | |
| GeneID | 17951 | |
| KEGG | mmu:17951 | |
| CTD | 17951 | |
| MGI | MGI:1298220 | |
| eggNOG | KOG1101 ENOG410YPNM | |
| HOGENOM | HOG000236326 | |
| HOVERGEN | HBG050689 | |
| InParanoid | Q9R016 | |
| KO | K12807 | |
| PhylomeDB | Q9R016 | |
| NextBio | 292863 | |
| PRO | PR:Q9R016 | |
| Proteomes | UP000000589 | |
| CleanEx | MM_NAIP5 | |
| GO | GO:0005737 GO:0072557 GO:0005634 GO:0005524 GO:0043027 GO:0046872 GO:0004842 GO:0042742 GO:0050829 GO:0016045 GO:0006954 GO:1990001 GO:0045087 GO:0043066 GO:0016567 GO:0070269 GO:0009966 | |
| Gene3D | 1.10.1170.10 3.80.10.10 | |
| InterPro | IPR001370 IPR032675 IPR007111 IPR027417 | |
| Pfam | PF00653 | |
| SMART | SM00238 | |
| SUPFAM | SSF52540 | |
| PROSITE | PS01282 PS50143 PS50837 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
enables |
GO:0005524 |
ATP binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0050829 |
defense response to Gram-negative bacterium |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0032731 |
positive regulation of interleukin-1 beta production |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0072557 |
IPAF inflammasome complex |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0072557 |
IPAF inflammasome complex |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0070269 |
pyroptosis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0042742 |
defense response to bacterium |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0016045 |
detection of bacterium |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006954 |
inflammatory response |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005524 |
ATP binding |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0043204 |
perikaryon |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:621281 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0043025 |
neuronal cell body |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:621281 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0043005 |
neuron projection |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:621281 |
C |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0035635 |
entry of bacterium into host cell |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:3769036 |
P |
occurs_in:(CL:0000235) |
Seeded From UniProt |
complete | |
|
acts_upstream_of_or_within |
GO:0035635 |
entry of bacterium into host cell |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
occurs_in:(CL:0000235) |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:621281 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0043154 |
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0043027 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0043027 |
cysteine-type endopeptidase inhibitor activity involved in apoptotic process |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0043066 |
negative regulation of apoptotic process |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0050829 |
defense response to Gram-negative bacterium |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006915 |
apoptotic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0002376 |
immune system process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0000166 |
nucleotide binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006954 |
inflammatory response |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005524 |
ATP binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0046872 |
metal ion binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0045087 |
innate immune response |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 Yang, X et al. (2018) Structural basis for specific flagellin recognition by the NLR protein NAIP5. Cell Res. 28 35-47 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 2.4 Kofoed, EM & Vance, RE (2011) Innate immune recognition of bacterial ligands by NAIPs determines inflammasome specificity. Nature 477 592-5 PubMed GONUTS page
- ↑ 3.0 3.1 Wright, EK et al. (2003) Naip5 affects host susceptibility to the intracellular pathogen Legionella pneumophila. Curr. Biol. 13 27-36 PubMed GONUTS page
- ↑ Dubrez-Daloz, L et al. (2008) IAPs: more than just inhibitors of apoptosis proteins. Cell Cycle 7 1036-46 PubMed GONUTS page
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