MOUSE:ARRB2

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Arrb2
Protein Name(s)	Beta-arrestin-2 Arrestin beta-2
External Links
UniProt	Q91YI4
EMBL	AK154874 AK159317 AK170647 AK170889 AL596096 AL596096 BC016642
CCDS	CCDS24946.1 CCDS70226.1
RefSeq	NP_001258287.1 NP_001258288.1 NP_001258289.1 NP_663404.1
UniGene	Mm.203747
ProteinModelPortal	Q91YI4
SMR	Q91YI4
BioGrid	229812
DIP	DIP-36064N
IntAct	Q91YI4
STRING	10090.ENSMUSP00000078065
PhosphoSite	Q91YI4
MaxQB	Q91YI4
PaxDb	Q91YI4
PRIDE	Q91YI4
Ensembl	ENSMUST00000079056 ENSMUST00000102563 ENSMUST00000102564 ENSMUST00000108568
GeneID	216869
KEGG	mmu:216869
UCSC	uc007jur.1 uc007jus.1
CTD	409
MGI	MGI:99474
eggNOG	NOG302111
GeneTree	ENSGT00390000013152
HOGENOM	HOG000231319
HOVERGEN	HBG002399
InParanoid	Q91YI4
KO	K04439
OMA	KPHDHIT
PhylomeDB	Q91YI4
TreeFam	TF314260
Reactome	REACT_199384 REACT_220322 REACT_222404
ChiTaRS	Arrb2
NextBio	375424
PRO	PR:Q91YI4
Proteomes	UP000000589
Bgee	Q91YI4
CleanEx	MM_ARRB2
ExpressionAtlas	Q91YI4
Genevestigator	Q91YI4
GO	GO:0016323 GO:0005905 GO:0005737 GO:0043197 GO:0030139 GO:0005622 GO:0005634 GO:0014069 GO:0045211 GO:0043422 GO:0007628 GO:0007420 GO:0060326 GO:0002032 GO:0050965 GO:0042699 GO:0002031 GO:0043154 GO:0034260 GO:0032691 GO:0032695 GO:0032715 GO:0045953 GO:0032088 GO:0031397 GO:0090201 GO:0034392 GO:0034122 GO:0032720 GO:0051928 GO:2000573 GO:0070374 GO:0033138 GO:0050731 GO:0051897 GO:0031398 GO:0002092 GO:0032226 GO:0043161 GO:0015031 GO:0016567 GO:0060765 GO:0008277 GO:0001932 GO:0006366 GO:0007179
Gene3D	2.60.40.640 2.60.40.840
InterPro	IPR000698 IPR011021 IPR014752 IPR011022 IPR017864 IPR014753 IPR014756
PANTHER	PTHR11792
Pfam	PF02752 PF00339
PRINTS	PR00309
SMART	SM01017
SUPFAM	SSF81296
PROSITE	PS00295

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0010628	positive regulation of gene expression	PMID:24974728^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0002249) regulates_expression_of:(ENSEMBL:ENSMUSG00000040752) part_of:(GO:0055007)\|occurs_in(CL:0002249) regulates_expression_of:(ENSEMBL:ENSMUSG00000026414) part_of:(GO:0055007)\|occurs_in(CL:0002249) regulates_expression_of:(ENSEMBL:ENSMUSG00000021944) part_of:(GO:0055007)	Seeded From UniProt	complete
involved_in	GO:0001934	positive regulation of protein phosphorylation	PMID:24974728^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(PR:000029189) occurs_in:(CL:0002249) part_of:(GO:0055007)	Seeded From UniProt	complete
involved_in	GO:0001933	negative regulation of protein phosphorylation	PMID:24974728^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:Q9WV60) occurs_in:(CL:0002249) part_of:(GO:0055007)	Seeded From UniProt	complete
involved_in	GO:0045860	positive regulation of protein kinase activity	PMID:24974728^[1]	ECO:0000305	curator inference used in manual assertion	GO:0001933	P	has_regulation_target:(UniProtKB:Q9WV60) occurs_in:(CL:0002249) part_of:(GO:0055007)	Seeded From UniProt	complete
involved_in	GO:2000727	positive regulation of cardiac muscle cell differentiation	PMID:24974728^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051897	positive regulation of protein kinase B signaling	PMID:16051150^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0043422	protein kinase B binding	PMID:16051150^[2]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P31750	F		Seeded From UniProt	complete
involved_in	GO:0034122	negative regulation of toll-like receptor signaling pathway	PMID:16378096^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032720	negative regulation of tumor necrosis factor production	PMID:16378096^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032715	negative regulation of interleukin-6 production	PMID:16378096^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032695	negative regulation of interleukin-12 production	PMID:16378096^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032691	negative regulation of interleukin-1 beta production	PMID:16378096^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032226	positive regulation of synaptic transmission, dopaminergic	PMID:16051150^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0030139	endocytic vesicle	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P32121	C		Seeded From UniProt	complete
involved_in	GO:0007628	adult walking behavior	PMID:16051150^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P32121	C		Seeded From UniProt	complete
involved_in	GO:0002092	positive regulation of receptor internalization	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P32121	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000573	positive regulation of DNA biosynthetic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2157	P		Seeded From UniProt	complete
enables	GO:1990763	arrestin family protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2157	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1904037	positive regulation of epithelial cell apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2157	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090201	negative regulation of release of cytochrome c from mitochondria	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2157	P		Seeded From UniProt	complete
enables	GO:0071889	14-3-3 protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2157	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070374	positive regulation of ERK1 and ERK2 cascade	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P32121	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070374	positive regulation of ERK1 and ERK2 cascade	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2157	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060765	regulation of androgen receptor signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P32121	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060326	cell chemotaxis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P32121	P		Seeded From UniProt	complete
enables	GO:0060090	molecular adaptor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P32121	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051928	positive regulation of calcium ion transport	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2157	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051897	positive regulation of protein kinase B signaling	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2157	P		Seeded From UniProt	complete
enables	GO:0051019	mitogen-activated protein kinase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2157	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050965	detection of temperature stimulus involved in sensory perception of pain	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2157	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2157	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045953	negative regulation of natural killer cell mediated cytotoxicity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P32121	P		Seeded From UniProt	complete
part_of	GO:0045211	postsynaptic membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2157	C		Seeded From UniProt	complete
enables	GO:0044877	protein-containing complex binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2157	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043524	negative regulation of neuron apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2157	P		Seeded From UniProt	complete
part_of	GO:0043231	intracellular membrane-bounded organelle	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P32121	C		Seeded From UniProt	complete
part_of	GO:0043197	dendritic spine	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2157	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P32121	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2157	P		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2157	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042699	follicle-stimulating hormone signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2157	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0034392	negative regulation of smooth muscle cell apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2157	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0034260	negative regulation of GTPase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2157	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0033138	positive regulation of peptidyl-serine phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2157	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032967	positive regulation of collagen biosynthetic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2157	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032088	negative regulation of NF-kappaB transcription factor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P32121	P		Seeded From UniProt	complete
enables	GO:0031859	platelet activating factor receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2157	F		Seeded From UniProt	complete
enables	GO:0031826	type 2A serotonin receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2157	F		Seeded From UniProt	complete
enables	GO:0031762	follicle-stimulating hormone receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2157	F		Seeded From UniProt	complete
enables	GO:0031748	D1 dopamine receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2157	F		Seeded From UniProt	complete
enables	GO:0031702	type 1 angiotensin receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2157	F		Seeded From UniProt	complete
enables	GO:0031701	angiotensin receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P32121	F		Seeded From UniProt	complete
enables	GO:0031692	alpha-1B adrenergic receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2157	F		Seeded From UniProt	complete
enables	GO:0031691	alpha-1A adrenergic receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2157	F		Seeded From UniProt	complete
enables	GO:0031625	ubiquitin protein ligase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P32121	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031623	receptor internalization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P32121	P		Seeded From UniProt	complete
part_of	GO:0031410	cytoplasmic vesicle	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P32121	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031398	positive regulation of protein ubiquitination	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P32121	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031397	negative regulation of protein ubiquitination	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P32121	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031397	negative regulation of protein ubiquitination	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2157	P		Seeded From UniProt	complete
part_of	GO:0030139	endocytic vesicle	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P32121	C		Seeded From UniProt	complete
enables	GO:0019904	protein domain specific binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2157	F		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P32121	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016567	protein ubiquitination	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P32121	P		Seeded From UniProt	complete
part_of	GO:0016323	basolateral plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2157	C		Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2157	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008277	regulation of G protein-coupled receptor signaling pathway	PMID:11171997^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2157960	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008277	regulation of G protein-coupled receptor signaling pathway	PMID:11130073^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2157960	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008277	regulation of G protein-coupled receptor signaling pathway	PMID:10617462^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2157960	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008277	regulation of G protein-coupled receptor signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2157	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007186	G protein-coupled receptor signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2157	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007179	transforming growth factor beta receptor signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P32121	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006897	endocytosis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2157	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006366	transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P32121	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P32121	C		Seeded From UniProt	complete
part_of	GO:0005768	endosome	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2157	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P32121	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2157	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P32121	C		Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P32121	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002092	positive regulation of receptor internalization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P32121	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002092	positive regulation of receptor internalization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2157	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002032	desensitization of G protein-coupled receptor signaling pathway by arrestin	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P32121	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002032	desensitization of G protein-coupled receptor signaling pathway by arrestin	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2157	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002031	G protein-coupled receptor internalization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P32121	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001934	positive regulation of protein phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2157	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001932	regulation of protein phosphorylation	PMID:15218143^[7]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:2159617	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001932	regulation of protein phosphorylation	PMID:15218143^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0001664	G protein-coupled receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P32121	F		Seeded From UniProt	complete
involved_in	GO:2000573	positive regulation of DNA biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29067 ensembl:ENSRNOP00000026207	P		Seeded From UniProt	complete
enables	GO:1990763	arrestin family protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29067 ensembl:ENSRNOP00000026207	F		Seeded From UniProt	complete
involved_in	GO:1904037	positive regulation of epithelial cell apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29067 ensembl:ENSRNOP00000026207	P		Seeded From UniProt	complete
involved_in	GO:0090201	negative regulation of release of cytochrome c from mitochondria	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29067 ensembl:ENSRNOP00000026207	P		Seeded From UniProt	complete
enables	GO:0071889	14-3-3 protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29067 ensembl:ENSRNOP00000026207	F		Seeded From UniProt	complete
involved_in	GO:0070374	positive regulation of ERK1 and ERK2 cascade	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29067 ensembl:ENSRNOP00000026207	P		Seeded From UniProt	complete
involved_in	GO:0051928	positive regulation of calcium ion transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29067 ensembl:ENSRNOP00000026207	P		Seeded From UniProt	complete
involved_in	GO:0051897	positive regulation of protein kinase B signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29067 ensembl:ENSRNOP00000026207	P		Seeded From UniProt	complete
enables	GO:0051019	mitogen-activated protein kinase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29067 ensembl:ENSRNOP00000026207	F		Seeded From UniProt	complete
involved_in	GO:0050965	detection of temperature stimulus involved in sensory perception of pain	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29067 ensembl:ENSRNOP00000026207	P		Seeded From UniProt	complete
involved_in	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29067 ensembl:ENSRNOP00000026207	P		Seeded From UniProt	complete
part_of	GO:0045211	postsynaptic membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29067 ensembl:ENSRNOP00000026207	C		Seeded From UniProt	complete
enables	GO:0044877	protein-containing complex binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29067 ensembl:ENSRNOP00000026207	F		Seeded From UniProt	complete
involved_in	GO:0043524	negative regulation of neuron apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29067 ensembl:ENSRNOP00000026207	P		Seeded From UniProt	complete
part_of	GO:0043197	dendritic spine	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29067 ensembl:ENSRNOP00000026207	C		Seeded From UniProt	complete
involved_in	GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29067 ensembl:ENSRNOP00000026207	P		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29067 ensembl:ENSRNOP00000026207	F		Seeded From UniProt	complete
involved_in	GO:0042699	follicle-stimulating hormone signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29067 ensembl:ENSRNOP00000026207	P		Seeded From UniProt	complete
involved_in	GO:0034392	negative regulation of smooth muscle cell apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29067 ensembl:ENSRNOP00000026207	P		Seeded From UniProt	complete
involved_in	GO:0034260	negative regulation of GTPase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29067 ensembl:ENSRNOP00000026207	P		Seeded From UniProt	complete
involved_in	GO:0033138	positive regulation of peptidyl-serine phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29067 ensembl:ENSRNOP00000026207	P		Seeded From UniProt	complete
involved_in	GO:0032967	positive regulation of collagen biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29067 ensembl:ENSRNOP00000026207	P		Seeded From UniProt	complete
enables	GO:0031859	platelet activating factor receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29067 ensembl:ENSRNOP00000026207	F		Seeded From UniProt	complete
enables	GO:0031826	type 2A serotonin receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29067 ensembl:ENSRNOP00000026207	F		Seeded From UniProt	complete
enables	GO:0031762	follicle-stimulating hormone receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29067 ensembl:ENSRNOP00000026207	F		Seeded From UniProt	complete
enables	GO:0031748	D1 dopamine receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29067 ensembl:ENSRNOP00000026207	F		Seeded From UniProt	complete
enables	GO:0031702	type 1 angiotensin receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29067 ensembl:ENSRNOP00000026207	F		Seeded From UniProt	complete
enables	GO:0031692	alpha-1B adrenergic receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29067 ensembl:ENSRNOP00000026207	F		Seeded From UniProt	complete
enables	GO:0031691	alpha-1A adrenergic receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29067 ensembl:ENSRNOP00000026207	F		Seeded From UniProt	complete
involved_in	GO:0031397	negative regulation of protein ubiquitination	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29067 ensembl:ENSRNOP00000026207	P		Seeded From UniProt	complete
enables	GO:0019904	protein domain specific binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29067 ensembl:ENSRNOP00000026207	F		Seeded From UniProt	complete
part_of	GO:0016323	basolateral plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29067 ensembl:ENSRNOP00000026207	C		Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29067 ensembl:ENSRNOP00000026207	C		Seeded From UniProt	complete
involved_in	GO:0008277	regulation of G protein-coupled receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29067 ensembl:ENSRNOP00000026207	P		Seeded From UniProt	complete
involved_in	GO:0007420	brain development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29067 ensembl:ENSRNOP00000026207	P		Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29067 ensembl:ENSRNOP00000026207	P		Seeded From UniProt	complete
involved_in	GO:0006897	endocytosis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29067 ensembl:ENSRNOP00000026207	P		Seeded From UniProt	complete
part_of	GO:0005768	endosome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29067 ensembl:ENSRNOP00000026207	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29067 ensembl:ENSRNOP00000026207	C		Seeded From UniProt	complete
involved_in	GO:0002092	positive regulation of receptor internalization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29067 ensembl:ENSRNOP00000026207	P		Seeded From UniProt	complete
involved_in	GO:0002032	desensitization of G protein-coupled receptor signaling pathway by arrestin	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29067 ensembl:ENSRNOP00000026207	P		Seeded From UniProt	complete
involved_in	GO:0001934	positive regulation of protein phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29067 ensembl:ENSRNOP00000026207	P		Seeded From UniProt	complete
involved_in	GO:0070374	positive regulation of ERK1 and ERK2 cascade	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P32121 ensembl:ENSP00000403701	P		Seeded From UniProt	complete
involved_in	GO:0060765	regulation of androgen receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P32121 ensembl:ENSP00000403701	P		Seeded From UniProt	complete
involved_in	GO:0060326	cell chemotaxis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P32121 ensembl:ENSP00000403701	P		Seeded From UniProt	complete
enables	GO:0060090	molecular adaptor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P32121 ensembl:ENSP00000403701	F		Seeded From UniProt	complete
involved_in	GO:0045953	negative regulation of natural killer cell mediated cytotoxicity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P32121 ensembl:ENSP00000403701	P		Seeded From UniProt	complete
part_of	GO:0043231	intracellular membrane-bounded organelle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P32121 ensembl:ENSP00000403701	C		Seeded From UniProt	complete
involved_in	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P32121 ensembl:ENSP00000403701	P		Seeded From UniProt	complete
involved_in	GO:0032088	negative regulation of NF-kappaB transcription factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P32121 ensembl:ENSP00000403701	P		Seeded From UniProt	complete
enables	GO:0031701	angiotensin receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P32121 ensembl:ENSP00000403701	F		Seeded From UniProt	complete
enables	GO:0031625	ubiquitin protein ligase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P32121 ensembl:ENSP00000403701	F		Seeded From UniProt	complete
involved_in	GO:0031623	receptor internalization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P32121 ensembl:ENSP00000403701	P		Seeded From UniProt	complete
part_of	GO:0031410	cytoplasmic vesicle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P32121 ensembl:ENSP00000403701	C		Seeded From UniProt	complete
involved_in	GO:0031398	positive regulation of protein ubiquitination	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P32121 ensembl:ENSP00000403701	P		Seeded From UniProt	complete
involved_in	GO:0031397	negative regulation of protein ubiquitination	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P32121 ensembl:ENSP00000403701	P		Seeded From UniProt	complete
part_of	GO:0030139	endocytic vesicle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P32121 ensembl:ENSP00000403701	C		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P32121 ensembl:ENSP00000403701	F		Seeded From UniProt	complete
involved_in	GO:0016567	protein ubiquitination	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P32121 ensembl:ENSP00000403701	P		Seeded From UniProt	complete
involved_in	GO:0007179	transforming growth factor beta receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P32121 ensembl:ENSP00000403701	P		Seeded From UniProt	complete
involved_in	GO:0006366	transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P32121 ensembl:ENSP00000403701	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P32121 ensembl:ENSP00000403701	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P32121 ensembl:ENSP00000403701	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P32121 ensembl:ENSP00000403701	C		Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P32121 ensembl:ENSP00000403701	F		Seeded From UniProt	complete
involved_in	GO:0002092	positive regulation of receptor internalization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P32121 ensembl:ENSP00000403701	P		Seeded From UniProt	complete
involved_in	GO:0002032	desensitization of G protein-coupled receptor signaling pathway by arrestin	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P32121 ensembl:ENSP00000403701	P		Seeded From UniProt	complete
involved_in	GO:0002031	G protein-coupled receptor internalization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P32121 ensembl:ENSP00000403701	P		Seeded From UniProt	complete
enables	GO:0001664	G protein-coupled receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P32121 ensembl:ENSP00000403701	F		Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000698 InterPro:IPR014753	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-MMU-5632657	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0009968	negative regulation of signal transduction	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0734	P		Seeded From UniProt	complete
involved_in	GO:0015031	protein transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0653	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
part_of	GO:0005905	clathrin-coated pit	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0168 UniProtKB-SubCell:SL-0069	C		Seeded From UniProt	complete
part_of	GO:0031410	cytoplasmic vesicle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0968	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 Zhao, J et al. (2014) β-arrestin2/miR-155/GSK3β regulates transition of 5'-azacytizine-induced Sca-1-positive cells to cardiomyocytes. J. Cell. Mol. Med. 18 1562-70 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 Beaulieu, JM et al. (2005) An Akt/beta-arrestin 2/PP2A signaling complex mediates dopaminergic neurotransmission and behavior. Cell 122 261-73 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 Wang, Y et al. (2006) Association of beta-arrestin and TRAF6 negatively regulates Toll-like receptor-interleukin 1 receptor signaling. Nat. Immunol. 7 139-47 PubMed GONUTS page
↑ Kohout, TA et al. (2001) beta-Arrestin 1 and 2 differentially regulate heptahelical receptor signaling and trafficking. Proc. Natl. Acad. Sci. U.S.A. 98 1601-6 PubMed GONUTS page
↑ Bohn, LM et al. (2000) Mu-opioid receptor desensitization by beta-arrestin-2 determines morphine tolerance but not dependence. Nature 408 720-3 PubMed GONUTS page
↑ Bohn, LM et al. (1999) Enhanced morphine analgesia in mice lacking beta-arrestin 2. Science 286 2495-8 PubMed GONUTS page
↑ ^7.0 ^7.1 Wang, Q et al. (2004) Spinophilin blocks arrestin actions in vitro and in vivo at G protein-coupled receptors. Science 304 1940-4 PubMed GONUTS page

[PMID:24974728-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 Zhao, J et al. (2014) β-arrestin2/miR-155/GSK3β regulates transition of 5'-azacytizine-induced Sca-1-positive cells to cardiomyocytes. J. Cell. Mol. Med. 18 1562-70 PubMed GONUTS page

[PMID:16051150-2] 2.0 ^2.1 ^2.2 ^2.3 Beaulieu, JM et al. (2005) An Akt/beta-arrestin 2/PP2A signaling complex mediates dopaminergic neurotransmission and behavior. Cell 122 261-73 PubMed GONUTS page

[PMID:16378096-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 Wang, Y et al. (2006) Association of beta-arrestin and TRAF6 negatively regulates Toll-like receptor-interleukin 1 receptor signaling. Nat. Immunol. 7 139-47 PubMed GONUTS page

[PMID:11171997-4] Kohout, TA et al. (2001) beta-Arrestin 1 and 2 differentially regulate heptahelical receptor signaling and trafficking. Proc. Natl. Acad. Sci. U.S.A. 98 1601-6 PubMed GONUTS page

[PMID:11130073-5] Bohn, LM et al. (2000) Mu-opioid receptor desensitization by beta-arrestin-2 determines morphine tolerance but not dependence. Nature 408 720-3 PubMed GONUTS page

[PMID:10617462-6] Bohn, LM et al. (1999) Enhanced morphine analgesia in mice lacking beta-arrestin 2. Science 286 2495-8 PubMed GONUTS page

[PMID:15218143-7] 7.0 ^7.1 Wang, Q et al. (2004) Spinophilin blocks arrestin actions in vitro and in vivo at G protein-coupled receptors. Science 304 1940-4 PubMed GONUTS page

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MOUSE:ARRB2

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