MOUSE:ARC

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Arc (ECO:0000312 with EMBL:AAD43586.1, ECO:0000312 with MGI:MGI:88067)
Protein Name(s)	Activity-regulated cytoskeleton-associated protein ARC/ARG3.1 mArc Activity-regulated gene 3.1 protein homolog Arg3.1
External Links
UniProt	Q9WV31
EMBL	AF177701 AF162777 AK157822 AK170446 BC023127 AF254662
CCDS	CCDS37102.1
RefSeq	NP_001263613.1 NP_061260.1
UniGene	Mm.491310
ProteinModelPortal	Q9WV31
BioGrid	198182
DIP	DIP-31565N
IntAct	Q9WV31
PhosphoSite	Q9WV31
PaxDb	Q9WV31
PRIDE	Q9WV31
Ensembl	ENSMUST00000023268 ENSMUST00000110009
GeneID	11838
KEGG	mmu:11838
UCSC	uc007wfn.1
CTD	23237
MGI	MGI:88067
eggNOG	NOG81608
GeneTree	ENSGT00390000003914
HOGENOM	HOG000034037
HOVERGEN	HBG080862
InParanoid	Q9WV31
KO	K15867
OMA	RCQETIA
OrthoDB	EOG75B855
PhylomeDB	Q9WV31
TreeFam	TF335604
NextBio	279775
PRO	PR:Q9WV31
Proteomes	UP000000589
Bgee	Q9WV31
Genevestigator	Q9WV31
GO	GO:0001669 GO:0015629 GO:0030054 GO:0005856 GO:0043197 GO:0005768 GO:0014069 GO:0045211 GO:0003779 GO:0009952 GO:0016477 GO:0007010 GO:0006897 GO:0007492 GO:0007612 GO:0022604 GO:0048168
InterPro	IPR023263
PANTHER	PTHR15962
PRINTS	PR02027

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:1900452	regulation of long-term synaptic depression	PMID:29264923^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0045121	membrane raft	PMID:29264923^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:1903561	extracellular vesicle	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q63053	C		Seeded From UniProt	complete
enables	GO:0003729	mRNA binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q63053	F		Seeded From UniProt	complete
involved_in	GO:1900271	regulation of long-term synaptic potentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q63053	P		Seeded From UniProt	complete
involved_in	GO:0110077	vesicle-mediated intercellular transport	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q63053	P		Seeded From UniProt	complete
involved_in	GO:0051260	protein homooligomerization	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q63053	P		Seeded From UniProt	complete
involved_in	GO:0051028	mRNA transport	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q63053	P		Seeded From UniProt	complete
involved_in	GO:0007616	long-term memory	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q63053	P		Seeded From UniProt	complete
involved_in	GO:0022604	regulation of cell morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q7LC44	P		Seeded From UniProt	complete
involved_in	GO:0016477	cell migration	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q7LC44	P		Seeded From UniProt	complete
involved_in	GO:0007010	cytoskeleton organization	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q7LC44	P		Seeded From UniProt	complete
involved_in	GO:0099149	regulation of postsynaptic neurotransmitter receptor internalization	PMID:17088211^[2]	ECO:0006063	over expression analysis evidence used in manual assertion		P	occurs_in:(GO:0098978) occurs_in:(UBERON:0000061) occurs_in:(UBERON:0002421)	Seeded From UniProt	complete
involved_in	GO:0099149	regulation of postsynaptic neurotransmitter receptor internalization	PMID:17088211^[2]	ECO:0005589	confocal microscopy evidence used in manual assertion		P	occurs_in:(GO:0098978) occurs_in:(UBERON:0000061) occurs_in:(UBERON:0002421)	Seeded From UniProt	complete
involved_in	GO:0099149	regulation of postsynaptic neurotransmitter receptor internalization	PMID:17088211^[2]	ECO:0001225	knockout evidence used in manual assertion		P	occurs_in:(GO:0098978) occurs_in:(UBERON:0000061) occurs_in:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	PMID:17088211^[2]	ECO:0006063	over expression analysis evidence used in manual assertion		C	part_of:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	PMID:17088211^[2]	ECO:0005589	confocal microscopy evidence used in manual assertion		C	part_of:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	PMID:17088211^[2]	ECO:0001225	knockout evidence used in manual assertion		C	part_of:(UBERON:0002421)	Seeded From UniProt	complete
involved_in	GO:2000969	positive regulation of AMPA receptor activity	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000409796 RGD:62037	P		Seeded From UniProt	complete
involved_in	GO:1900271	regulation of long-term synaptic potentiation	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000409796 RGD:62037	P		Seeded From UniProt	complete
involved_in	GO:0048168	regulation of neuronal synaptic plasticity	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000409796 RGD:62037	P		Seeded From UniProt	complete
part_of	GO:0015629	actin cytoskeleton	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000409796 RGD:62037	C		Seeded From UniProt	complete
involved_in	GO:0007010	cytoskeleton organization	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000409796 UniProtKB:Q7LC44	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000409796 UniProtKB:Q7LC44	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000409796 UniProtKB:Q7LC44	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000969	positive regulation of AMPA receptor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:62037	P		Seeded From UniProt	complete
part_of	GO:1903561	extracellular vesicle	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:62037	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1900271	regulation of long-term synaptic potentiation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:62037	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0110077	vesicle-mediated intercellular transport	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:62037	P		Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:62037	C		Seeded From UniProt	complete
part_of	GO:0098845	postsynaptic endosome	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:62037	C		Seeded From UniProt	complete
part_of	GO:0098839	postsynaptic density membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:62037	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0061001	regulation of dendritic spine morphogenesis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:62037	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051260	protein homooligomerization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:62037	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051028	mRNA transport	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:62037	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050804	modulation of chemical synaptic transmission	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:62037	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0022604	regulation of cell morphogenesis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q7LC44	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016477	cell migration	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q7LC44	P		Seeded From UniProt	complete
part_of	GO:0015629	actin cytoskeleton	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:62037	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009952	anterior/posterior pattern specification	PMID:10727859^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2386454	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007616	long-term memory	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:62037	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007492	endoderm development	PMID:10727859^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2386454	P	results_in_development_of:(EMAPA:16051)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007010	cytoskeleton organization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q7LC44	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q7LC44	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q7LC44	C		Seeded From UniProt	complete
enables	GO:0003729	mRNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:62037	F		Seeded From UniProt	complete
involved_in	GO:2000969	positive regulation of AMPA receptor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q63053 ensembl:ENSRNOP00000063719	P		Seeded From UniProt	complete
part_of	GO:1903561	extracellular vesicle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q63053 ensembl:ENSRNOP00000063719	C		Seeded From UniProt	complete
involved_in	GO:1900271	regulation of long-term synaptic potentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q63053 ensembl:ENSRNOP00000063719	P		Seeded From UniProt	complete
involved_in	GO:0110077	vesicle-mediated intercellular transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q63053 ensembl:ENSRNOP00000063719	P		Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q63053 ensembl:ENSRNOP00000063719	C		Seeded From UniProt	complete
part_of	GO:0098845	postsynaptic endosome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q63053 ensembl:ENSRNOP00000063719	C		Seeded From UniProt	complete
part_of	GO:0098839	postsynaptic density membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q63053 ensembl:ENSRNOP00000063719	C		Seeded From UniProt	complete
involved_in	GO:0061001	regulation of dendritic spine morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q63053 ensembl:ENSRNOP00000063719	P		Seeded From UniProt	complete
involved_in	GO:0051260	protein homooligomerization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q63053 ensembl:ENSRNOP00000063719	P		Seeded From UniProt	complete
involved_in	GO:0051028	mRNA transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q63053 ensembl:ENSRNOP00000063719	P		Seeded From UniProt	complete
involved_in	GO:0050804	modulation of chemical synaptic transmission	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q63053 ensembl:ENSRNOP00000063719	P		Seeded From UniProt	complete
involved_in	GO:0048168	regulation of neuronal synaptic plasticity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q63053 ensembl:ENSRNOP00000063719	P		Seeded From UniProt	complete
part_of	GO:0015629	actin cytoskeleton	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q63053 ensembl:ENSRNOP00000063719	C		Seeded From UniProt	complete
involved_in	GO:0007616	long-term memory	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q63053 ensembl:ENSRNOP00000063719	P		Seeded From UniProt	complete
involved_in	GO:0007612	learning	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q63053 ensembl:ENSRNOP00000063719	P		Seeded From UniProt	complete
enables	GO:0003729	mRNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q63053 ensembl:ENSRNOP00000063719	F		Seeded From UniProt	complete
involved_in	GO:0022604	regulation of cell morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q7LC44 ensembl:ENSP00000349022	P		Seeded From UniProt	complete
involved_in	GO:0016477	cell migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q7LC44 ensembl:ENSP00000349022	P		Seeded From UniProt	complete
involved_in	GO:0007010	cytoskeleton organization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q7LC44 ensembl:ENSP00000349022	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q7LC44 ensembl:ENSP00000349022	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q7LC44 ensembl:ENSP00000349022	C		Seeded From UniProt	complete
part_of	GO:0005856	cytoskeleton	PMID:10727859^[4]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0003779	actin binding	PMID:10727859^[4]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0030054	cell junction	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0965	C		Seeded From UniProt	complete
part_of	GO:0005768	endosome	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0967	C		Seeded From UniProt	complete
enables	GO:0003723	RNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0694	F		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003	C		Seeded From UniProt	complete
part_of	GO:0042995	cell projection	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0966	C		Seeded From UniProt	complete
part_of	GO:0031410	cytoplasmic vesicle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0968	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963	C		Seeded From UniProt	complete
part_of	GO:0045211	postsynaptic membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0628 UniProtKB-SubCell:SL-0219	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
part_of	GO:0005856	cytoskeleton	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0206 UniProtKB-SubCell:SL-0090	C		Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0217	P		Seeded From UniProt	complete
involved_in	GO:0006897	endocytosis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0254	P		Seeded From UniProt	complete
part_of	GO:0045202	synapse	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0770 UniProtKB-SubCell:SL-0258	C		Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0297	C		Seeded From UniProt	complete
part_of	GO:0030425	dendrite	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0283	C		Seeded From UniProt	complete
part_of	GO:0005938	cell cortex	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0138	C		Seeded From UniProt	complete
part_of	GO:0031901	early endosome membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0093	C		Seeded From UniProt	complete
part_of	GO:0043197	dendritic spine	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0284	C		Seeded From UniProt	complete
part_of	GO:0001669	acrosomal vesicle	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0007	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Barylko, B et al. (2018) Palmitoylation and Membrane Binding of Arc/Arg3.1: A Potential Role in Synaptic Depression. Biochemistry 57 520-524 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 Chowdhury, S et al. (2006) Arc/Arg3.1 interacts with the endocytic machinery to regulate AMPA receptor trafficking. Neuron 52 445-59 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 Liu, D et al. (2000) Activity-regulated, cytoskeleton-associated protein (Arc) is essential for visceral endoderm organization during early embryogenesis. Mech. Dev. 92 207-15 PubMed GONUTS page

[PMID:29264923-1] 1.0 ^1.1 Barylko, B et al. (2018) Palmitoylation and Membrane Binding of Arc/Arg3.1: A Potential Role in Synaptic Depression. Biochemistry 57 520-524 PubMed GONUTS page

[PMID:17088211-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 Chowdhury, S et al. (2006) Arc/Arg3.1 interacts with the endocytic machinery to regulate AMPA receptor trafficking. Neuron 52 445-59 PubMed GONUTS page

[PMID:21873635-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:10727859-4] 4.0 ^4.1 ^4.2 ^4.3 Liu, D et al. (2000) Activity-regulated, cytoskeleton-associated protein (Arc) is essential for visceral endoderm organization during early embryogenesis. Mech. Dev. 92 207-15 PubMed GONUTS page

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MOUSE:ARC

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Annotations

Notes

References

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