MOUSE:ANXA1

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Anxa1 (synonyms: Anx1, Lpc-1, Lpc1)
Protein Name(s)	Annexin A1 Annexin I Annexin-1 Calpactin II Calpactin-2 Chromobindin-9 Lipocortin I Phospholipase A2 inhibitory protein p35
External Links
UniProt	P10107
EMBL	X07486 M69260 M69250 M69251 M69252 M69253 M69254 M69255 M69256 M69257 M69258 M69259 BC002289 BC004594 M24554
CCDS	CCDS29692.1
PIR	S02181
RefSeq	NP_034860.2
UniGene	Mm.248360
ProteinModelPortal	P10107
SMR	P10107
BioGrid	201194
IntAct	P10107
MINT	MINT-274958
PhosphoSite	P10107
COMPLUYEAST-2DPAGE	P10107
MaxQB	P10107
PaxDb	P10107
PRIDE	P10107
Ensembl	ENSMUST00000025561
GeneID	16952
KEGG	mmu:16952
UCSC	uc008gyi.1
CTD	301
MGI	MGI:96819
eggNOG	NOG282829
HOGENOM	HOG000158803
HOVERGEN	HBG061815
InParanoid	P10107
KO	K17091
OMA	MNDIKAC
OrthoDB	EOG74XS72
PhylomeDB	P10107
TreeFam	TF105452
Reactome	REACT_207651 REACT_229705 REACT_250376
ChiTaRS	Anxa1
NextBio	291004
PRO	PR:P10107
Proteomes	UP000000589
Bgee	P10107
CleanEx	MM_ANXA1
ExpressionAtlas	P10107
Genevestigator	P10107
GO	GO:0016323 GO:0009986 GO:0005929 GO:0001533 GO:0005615 GO:0070062 GO:0042629 GO:0031966 GO:0005634 GO:0043234 GO:0042383 GO:0036310 GO:0005509 GO:0005544 GO:0033676 GO:0004386 GO:0019834 GO:0003697 GO:0003727 GO:0005198 GO:0046632 GO:0050482 GO:0007166 GO:0071385 GO:0070301 GO:0032508 GO:0036292 GO:0031018 GO:0042063 GO:0070365 GO:0030073 GO:0030216 GO:2000483 GO:1900138 GO:0097350 GO:0001780 GO:0018149 GO:1900087 GO:0033031 GO:0031394 GO:0031340 GO:0070459 GO:0030850 GO:0042127 GO:0042493 GO:0032355 GO:0070555 GO:0043434 GO:0010165 GO:0007165
Gene3D	1.10.220.10
InterPro	IPR001464 IPR018502 IPR018252 IPR002388
PANTHER	PTHR10502:SF17
Pfam	PF00191
PRINTS	PR00196 PR00197
SMART	SM00335
PROSITE	PS00223

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0014839	myoblast migration involved in skeletal muscle regeneration	PMID:23144744^[1]	ECO:0000314			P		Fig. 3 shows ANXA1-derived Peptide Ac2-26 Induces C2C12 Cell Migration	complete CACAO 5887
	GO:0005886	plasma membrane	PMID:19095957^[2]	ECO:0000315			C		Fig. 4 A through D	complete CACAO 6734
part_of	GO:0062023	collagen-containing extracellular matrix	PMID:28071719^[3]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0000006)	Seeded From UniProt	complete
part_of	GO:0062023	collagen-containing extracellular matrix	PMID:22159717^[4]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0002048)	Seeded From UniProt	complete
part_of	GO:0062023	collagen-containing extracellular matrix	PMID:22159717^[4]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0001155)	Seeded From UniProt	complete
involved_in	GO:0006909	phagocytosis	PMID:12475898^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032652	regulation of interleukin-1 production	PMID:12475898^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0002685	regulation of leukocyte migration	PMID:12475898^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050727	regulation of inflammatory response	PMID:12475898^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071385	cellular response to glucocorticoid stimulus	PMID:12475898^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032743	positive regulation of interleukin-2 production	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P04083	P		Seeded From UniProt	complete
involved_in	GO:0031532	actin cytoskeleton reorganization	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P04083	P		Seeded From UniProt	complete
involved_in	GO:0008360	regulation of cell shape	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P04083	P		Seeded From UniProt	complete
involved_in	GO:0007187	G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P04083	P		Seeded From UniProt	complete
involved_in	GO:0002548	monocyte chemotaxis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P04083	P		Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P04083	C		Seeded From UniProt	complete
part_of	GO:0031232	extrinsic component of external side of plasma membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P04083	C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P04083	C		Seeded From UniProt	complete
involved_in	GO:0090303	positive regulation of wound healing	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P04083	P		Seeded From UniProt	complete
involved_in	GO:0071621	granulocyte chemotaxis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P04083	P		Seeded From UniProt	complete
involved_in	GO:0046883	regulation of hormone secretion	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P04083	P		Seeded From UniProt	complete
involved_in	GO:0045920	negative regulation of exocytosis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P04083	P		Seeded From UniProt	complete
involved_in	GO:0045629	negative regulation of T-helper 2 cell differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P04083	P		Seeded From UniProt	complete
involved_in	GO:0045627	positive regulation of T-helper 1 cell differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P04083	P		Seeded From UniProt	complete
involved_in	GO:0042102	positive regulation of T cell proliferation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P04083	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:18802107^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0016328	lateral plasma membrane	PMID:18802107^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0016324	apical plasma membrane	PMID:18802107^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0016324	apical plasma membrane	PMID:17384087^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0031514	motile cilium	PMID:17384087^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0031901	early endosome membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P19619	C		Seeded From UniProt	complete
part_of	GO:0031313	extrinsic component of endosome membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P19619	C		Seeded From UniProt	complete
enables	GO:0005544	calcium-dependent phospholipid binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P19619	F		Seeded From UniProt	complete
enables	GO:0005509	calcium ion binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P19619	F		Seeded From UniProt	complete
involved_in	GO:0006954	inflammatory response	PMID:18802107^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0014839	myoblast migration involved in skeletal muscle regeneration	PMID:23144744^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:19095957^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0046632	alpha-beta T cell differentiation	PMID:20139728^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0033031	positive regulation of neutrophil apoptotic process	PMID:21957127^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0002476)	Seeded From UniProt	complete
involved_in	GO:0001780	neutrophil homeostasis	PMID:21957127^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0002092)	Seeded From UniProt	complete
involved_in	GO:2000483	negative regulation of interleukin-8 secretion	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002574794 UniProtKB:P04083	P		Seeded From UniProt	complete
enables	GO:1990814	DNA/DNA annealing activity	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002574794 RGD:2118	F		Seeded From UniProt	complete
involved_in	GO:1900138	negative regulation of phospholipase A2 activity	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002574794 RGD:2118	P		Seeded From UniProt	complete
involved_in	GO:1900087	positive regulation of G1/S transition of mitotic cell cycle	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96819 PANTHER:PTN002574794	P		Seeded From UniProt	complete
involved_in	GO:0097350	neutrophil clearance	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002574794 UniProtKB:P04083	P		Seeded From UniProt	complete
involved_in	GO:0090303	positive regulation of wound healing	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002574794 UniProtKB:P04083	P		Seeded From UniProt	complete
involved_in	GO:0090050	positive regulation of cell migration involved in sprouting angiogenesis	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002574794 UniProtKB:P04083	P		Seeded From UniProt	complete
involved_in	GO:0071621	granulocyte chemotaxis	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002574794 UniProtKB:P04083	P		Seeded From UniProt	complete
involved_in	GO:0071385	cellular response to glucocorticoid stimulus	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96819 PANTHER:PTN002574794 RGD:2118 UniProtKB:P04083	P		Seeded From UniProt	complete
involved_in	GO:0070555	response to interleukin-1	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002574794 RGD:2118	P		Seeded From UniProt	complete
involved_in	GO:0070459	prolactin secretion	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000052711 RGD:2118	P		Seeded From UniProt	complete
involved_in	GO:0070365	hepatocyte differentiation	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002574794 RGD:2118	P		Seeded From UniProt	complete
involved_in	GO:0070301	cellular response to hydrogen peroxide	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002574794 RGD:2118	P		Seeded From UniProt	complete
involved_in	GO:0050727	regulation of inflammatory response	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96819 PANTHER:PTN002574794	P		Seeded From UniProt	complete
involved_in	GO:0050482	arachidonic acid secretion	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96819 PANTHER:PTN002574794	P		Seeded From UniProt	complete
enables	GO:0048306	calcium-dependent protein binding	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002574794 UniProtKB:P04083	F		Seeded From UniProt	complete
involved_in	GO:0046883	regulation of hormone secretion	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002574794 UniProtKB:P04083	P		Seeded From UniProt	complete
involved_in	GO:0046632	alpha-beta T cell differentiation	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96819 PANTHER:PTN002574794	P		Seeded From UniProt	complete
involved_in	GO:0045920	negative regulation of exocytosis	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002574794 UniProtKB:P04083	P		Seeded From UniProt	complete
involved_in	GO:0045629	negative regulation of T-helper 2 cell differentiation	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002574794 UniProtKB:P04083	P		Seeded From UniProt	complete
involved_in	GO:0045627	positive regulation of T-helper 1 cell differentiation	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002574794 UniProtKB:P04083	P		Seeded From UniProt	complete
involved_in	GO:0044849	estrous cycle	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000052711 RGD:2118	P		Seeded From UniProt	complete
involved_in	GO:0043434	response to peptide hormone	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002574794 RGD:2118	P		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002574794 RGD:2118	F		Seeded From UniProt	complete
involved_in	GO:0042493	response to drug	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002574794 RGD:2118	P		Seeded From UniProt	complete
involved_in	GO:0042127	regulation of cell population proliferation	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96819 PANTHER:PTN002574794	P		Seeded From UniProt	complete
involved_in	GO:0042102	positive regulation of T cell proliferation	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002574794 UniProtKB:P04083	P		Seeded From UniProt	complete
involved_in	GO:0042063	gliogenesis	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002574794 RGD:2118	P		Seeded From UniProt	complete
involved_in	GO:0035924	cellular response to vascular endothelial growth factor stimulus	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002574794 UniProtKB:P04083	P		Seeded From UniProt	complete
enables	GO:0033676	double-stranded DNA-dependent ATPase activity	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002574794 RGD:2118	F		Seeded From UniProt	complete
involved_in	GO:0033031	positive regulation of neutrophil apoptotic process	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96819 PANTHER:PTN002574794	P		Seeded From UniProt	complete
involved_in	GO:0032743	positive regulation of interleukin-2 production	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002574794 UniProtKB:P04083	P		Seeded From UniProt	complete
involved_in	GO:0032652	regulation of interleukin-1 production	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96819 PANTHER:PTN002574794	P		Seeded From UniProt	complete
involved_in	GO:0032508	DNA duplex unwinding	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002574794 RGD:2118	P		Seeded From UniProt	complete
involved_in	GO:0032355	response to estradiol	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002574794 RGD:2118	P		Seeded From UniProt	complete
involved_in	GO:0031532	actin cytoskeleton reorganization	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002574794 UniProtKB:P04083	P		Seeded From UniProt	complete
involved_in	GO:0031394	positive regulation of prostaglandin biosynthetic process	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002574794 RGD:2118	P		Seeded From UniProt	complete
involved_in	GO:0031340	positive regulation of vesicle fusion	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002574794 UniProtKB:P04083	P		Seeded From UniProt	complete
involved_in	GO:0031018	endocrine pancreas development	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002574794 RGD:2118	P		Seeded From UniProt	complete
involved_in	GO:0030850	prostate gland development	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002574794 RGD:2118	P		Seeded From UniProt	complete
enables	GO:0030674	protein binding, bridging	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002574794 UniProtKB:P04083	F		Seeded From UniProt	complete
involved_in	GO:0030216	keratinocyte differentiation	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002574794 UniProtKB:P04083	P		Seeded From UniProt	complete
involved_in	GO:0030073	insulin secretion	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002574794 RGD:2118	P		Seeded From UniProt	complete
enables	GO:0019834	phospholipase A2 inhibitor activity	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002574794 RGD:2118 UniProtKB:P04083	F		Seeded From UniProt	complete
involved_in	GO:0014839	myoblast migration involved in skeletal muscle regeneration	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96819 PANTHER:PTN002574794	P		Seeded From UniProt	complete
involved_in	GO:0010165	response to X-ray	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002574794 RGD:2118	P		Seeded From UniProt	complete
involved_in	GO:0008360	regulation of cell shape	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002574794 UniProtKB:P04083	P		Seeded From UniProt	complete
involved_in	GO:0007187	G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002574794 UniProtKB:P04083	P		Seeded From UniProt	complete
involved_in	GO:0007166	cell surface receptor signaling pathway	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002574794 RGD:2118	P		Seeded From UniProt	complete
involved_in	GO:0006954	inflammatory response	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96819 PANTHER:PTN002574794	P		Seeded From UniProt	complete
involved_in	GO:0006909	phagocytosis	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96819 PANTHER:PTN002574794	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96819 PANTHER:PTN002574794 RGD:2118 UniProtKB:P04083	C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002574794 RGD:2118 UniProtKB:P04083	C		Seeded From UniProt	complete
enables	GO:0005544	calcium-dependent phospholipid binding	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002574794 UniProtKB:P04083 UniProtKB:P19619	F		Seeded From UniProt	complete
enables	GO:0005198	structural molecule activity	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002574794 UniProtKB:P04083	F		Seeded From UniProt	complete
contributes_to	GO:0003727	single-stranded RNA binding	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002574794 RGD:2118	F		Seeded From UniProt	complete
contributes_to	GO:0003697	single-stranded DNA binding	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002574794 RGD:2118	F		Seeded From UniProt	complete
involved_in	GO:0002685	regulation of leukocyte migration	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96819 PANTHER:PTN002574794	P		Seeded From UniProt	complete
involved_in	GO:0002548	monocyte chemotaxis	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002574794 UniProtKB:P04083	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000483	negative regulation of interleukin-8 secretion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04083	P		Seeded From UniProt	complete
enables	GO:1990814	DNA/DNA annealing activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2118	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1900138	negative regulation of phospholipase A2 activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2118	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1900087	positive regulation of G1/S transition of mitotic cell cycle	PMID:12553880^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2449710	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0097350	neutrophil clearance	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04083	P		Seeded From UniProt	complete
part_of	GO:0097060	synaptic membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2118	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090303	positive regulation of wound healing	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04083	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090050	positive regulation of cell migration involved in sprouting angiogenesis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04083	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071621	granulocyte chemotaxis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04083	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071385	cellular response to glucocorticoid stimulus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04083	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071385	cellular response to glucocorticoid stimulus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2118	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070459	prolactin secretion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2118	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070301	cellular response to hydrogen peroxide	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2118	P		Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04083	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050709	negative regulation of protein secretion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2118	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050482	arachidonic acid secretion	PMID:12553880^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2449710	P		Seeded From UniProt	complete
enables	GO:0048306	calcium-dependent protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04083	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046883	regulation of hormone secretion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04083	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045920	negative regulation of exocytosis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04083	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045629	negative regulation of T-helper 2 cell differentiation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04083	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045627	positive regulation of T-helper 1 cell differentiation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04083	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043065	positive regulation of apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2118	P		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2118	F		Seeded From UniProt	complete
part_of	GO:0042629	mast cell granule	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2118	C		Seeded From UniProt	complete
part_of	GO:0042383	sarcolemma	PMID:14506282^[12]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042127	regulation of cell population proliferation	PMID:12553880^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2449710	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042102	positive regulation of T cell proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04083	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035924	cellular response to vascular endothelial growth factor stimulus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04083	P		Seeded From UniProt	complete
enables	GO:0033676	double-stranded DNA-dependent ATPase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2118	F		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2118	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032743	positive regulation of interleukin-2 production	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04083	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032508	DNA duplex unwinding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2118	P		Seeded From UniProt	complete
part_of	GO:0031966	mitochondrial membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2118	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031532	actin cytoskeleton reorganization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04083	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031394	positive regulation of prostaglandin biosynthetic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2118	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031340	positive regulation of vesicle fusion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04083	P		Seeded From UniProt	complete
part_of	GO:0031232	extrinsic component of external side of plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04083	C		Seeded From UniProt	complete
enables	GO:0030674	protein binding, bridging	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04083	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030216	keratinocyte differentiation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04083	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030073	insulin secretion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2118	P		Seeded From UniProt	complete
part_of	GO:0019898	extrinsic component of membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04083	C		Seeded From UniProt	complete
enables	GO:0019834	phospholipase A2 inhibitor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04083	F		Seeded From UniProt	complete
enables	GO:0019834	phospholipase A2 inhibitor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2118	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0018149	peptide cross-linking	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04083	P		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04083	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008360	regulation of cell shape	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04083	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007187	G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04083	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007166	cell surface receptor signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2118	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007165	signal transduction	PMID:12553880^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2449710	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04083	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2118	C		Seeded From UniProt	complete
colocalizes_with	GO:0005884	actin filament	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04083	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04083	C		Seeded From UniProt	complete
part_of	GO:0005768	endosome	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04083	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04083	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2118	C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04083	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04083	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2118	C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04083	C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2118	C		Seeded From UniProt	complete
enables	GO:0005544	calcium-dependent phospholipid binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04083	F		Seeded From UniProt	complete
enables	GO:0005543	phospholipid binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2118	F		Seeded From UniProt	complete
enables	GO:0005198	structural molecule activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04083	F		Seeded From UniProt	complete
contributes_to	GO:0003727	single-stranded RNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2118	F		Seeded From UniProt	complete
enables	GO:0003697	single-stranded DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2118	F		Seeded From UniProt	complete
contributes_to	GO:0003697	single-stranded DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2118	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002548	monocyte chemotaxis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04083	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001780	neutrophil homeostasis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04083	P		Seeded From UniProt	complete
part_of	GO:0001533	cornified envelope	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04083	C		Seeded From UniProt	complete
involved_in	GO:2000483	negative regulation of interleukin-8 secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04083 ensembl:ENSP00000366109	P		Seeded From UniProt	complete
involved_in	GO:0097350	neutrophil clearance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04083 ensembl:ENSP00000366109	P		Seeded From UniProt	complete
involved_in	GO:0090303	positive regulation of wound healing	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04083 ensembl:ENSP00000366109	P		Seeded From UniProt	complete
involved_in	GO:0090050	positive regulation of cell migration involved in sprouting angiogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04083 ensembl:ENSP00000366109	P		Seeded From UniProt	complete
involved_in	GO:0071621	granulocyte chemotaxis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04083 ensembl:ENSP00000366109	P		Seeded From UniProt	complete
involved_in	GO:0071385	cellular response to glucocorticoid stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04083 ensembl:ENSP00000366109	P		Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04083 ensembl:ENSP00000366109	C		Seeded From UniProt	complete
enables	GO:0048306	calcium-dependent protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04083 ensembl:ENSP00000366109	F		Seeded From UniProt	complete
involved_in	GO:0046883	regulation of hormone secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04083 ensembl:ENSP00000366109	P		Seeded From UniProt	complete
involved_in	GO:0045920	negative regulation of exocytosis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04083 ensembl:ENSP00000366109	P		Seeded From UniProt	complete
involved_in	GO:0045629	negative regulation of T-helper 2 cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04083 ensembl:ENSP00000366109	P		Seeded From UniProt	complete
involved_in	GO:0045627	positive regulation of T-helper 1 cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04083 ensembl:ENSP00000366109	P		Seeded From UniProt	complete
involved_in	GO:0042102	positive regulation of T cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04083 ensembl:ENSP00000366109	P		Seeded From UniProt	complete
involved_in	GO:0035924	cellular response to vascular endothelial growth factor stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04083 ensembl:ENSP00000366109	P		Seeded From UniProt	complete
involved_in	GO:0032743	positive regulation of interleukin-2 production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04083 ensembl:ENSP00000366109	P		Seeded From UniProt	complete
involved_in	GO:0031532	actin cytoskeleton reorganization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04083 ensembl:ENSP00000366109	P		Seeded From UniProt	complete
involved_in	GO:0031340	positive regulation of vesicle fusion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04083 ensembl:ENSP00000366109	P		Seeded From UniProt	complete
part_of	GO:0031232	extrinsic component of external side of plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04083 ensembl:ENSP00000366109	C		Seeded From UniProt	complete
involved_in	GO:0030216	keratinocyte differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04083 ensembl:ENSP00000366109	P		Seeded From UniProt	complete
part_of	GO:0019898	extrinsic component of membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04083 ensembl:ENSP00000366109	C		Seeded From UniProt	complete
enables	GO:0019834	phospholipase A2 inhibitor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04083 ensembl:ENSP00000366109	F		Seeded From UniProt	complete
involved_in	GO:0018149	peptide cross-linking	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04083 ensembl:ENSP00000366109	P		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04083 ensembl:ENSP00000366109	C		Seeded From UniProt	complete
involved_in	GO:0008360	regulation of cell shape	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04083 ensembl:ENSP00000366109	P		Seeded From UniProt	complete
involved_in	GO:0007187	G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04083 ensembl:ENSP00000366109	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04083 ensembl:ENSP00000366109	C		Seeded From UniProt	complete
part_of	GO:0005884	actin filament	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04083 ensembl:ENSP00000366109	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04083 ensembl:ENSP00000366109	C		Seeded From UniProt	complete
part_of	GO:0005768	endosome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04083 ensembl:ENSP00000366109	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04083 ensembl:ENSP00000366109	C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04083 ensembl:ENSP00000366109	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04083 ensembl:ENSP00000366109	C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04083 ensembl:ENSP00000366109	C		Seeded From UniProt	complete
enables	GO:0005544	calcium-dependent phospholipid binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04083 ensembl:ENSP00000366109	F		Seeded From UniProt	complete
involved_in	GO:0002548	monocyte chemotaxis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04083 ensembl:ENSP00000366109	P		Seeded From UniProt	complete
involved_in	GO:0001780	neutrophil homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04083 ensembl:ENSP00000366109	P		Seeded From UniProt	complete
part_of	GO:0001533	cornified envelope	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04083 ensembl:ENSP00000366109	C		Seeded From UniProt	complete
enables	GO:1990814	DNA/DNA annealing activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07150 ensembl:ENSRNOP00000023664	F		Seeded From UniProt	complete
involved_in	GO:1900138	negative regulation of phospholipase A2 activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07150 ensembl:ENSRNOP00000023664	P		Seeded From UniProt	complete
part_of	GO:0097060	synaptic membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07150 ensembl:ENSRNOP00000023664	C		Seeded From UniProt	complete
involved_in	GO:0071385	cellular response to glucocorticoid stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07150 ensembl:ENSRNOP00000023664	P		Seeded From UniProt	complete
involved_in	GO:0070555	response to interleukin-1	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07150 ensembl:ENSRNOP00000023664	P		Seeded From UniProt	complete
involved_in	GO:0070459	prolactin secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07150 ensembl:ENSRNOP00000023664	P		Seeded From UniProt	complete
involved_in	GO:0070365	hepatocyte differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07150 ensembl:ENSRNOP00000023664	P		Seeded From UniProt	complete
involved_in	GO:0070301	cellular response to hydrogen peroxide	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07150 ensembl:ENSRNOP00000023664	P		Seeded From UniProt	complete
involved_in	GO:0051384	response to glucocorticoid	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07150 ensembl:ENSRNOP00000023664	P		Seeded From UniProt	complete
involved_in	GO:0050709	negative regulation of protein secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07150 ensembl:ENSRNOP00000023664	P		Seeded From UniProt	complete
involved_in	GO:0044849	estrous cycle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07150 ensembl:ENSRNOP00000023664	P		Seeded From UniProt	complete
involved_in	GO:0043434	response to peptide hormone	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07150 ensembl:ENSRNOP00000023664	P		Seeded From UniProt	complete
involved_in	GO:0043065	positive regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07150 ensembl:ENSRNOP00000023664	P		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07150 ensembl:ENSRNOP00000023664	F		Seeded From UniProt	complete
part_of	GO:0042629	mast cell granule	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07150 ensembl:ENSRNOP00000023664	C		Seeded From UniProt	complete
involved_in	GO:0042493	response to drug	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07150 ensembl:ENSRNOP00000023664	P		Seeded From UniProt	complete
involved_in	GO:0042063	gliogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07150 ensembl:ENSRNOP00000023664	P		Seeded From UniProt	complete
enables	GO:0033676	double-stranded DNA-dependent ATPase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07150 ensembl:ENSRNOP00000023664	F		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07150 ensembl:ENSRNOP00000023664	C		Seeded From UniProt	complete
involved_in	GO:0032508	DNA duplex unwinding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07150 ensembl:ENSRNOP00000023664	P		Seeded From UniProt	complete
involved_in	GO:0032355	response to estradiol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07150 ensembl:ENSRNOP00000023664	P		Seeded From UniProt	complete
part_of	GO:0031966	mitochondrial membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07150 ensembl:ENSRNOP00000023664	C		Seeded From UniProt	complete
involved_in	GO:0031960	response to corticosteroid	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07150 ensembl:ENSRNOP00000023664	P		Seeded From UniProt	complete
involved_in	GO:0031394	positive regulation of prostaglandin biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07150 ensembl:ENSRNOP00000023664	P		Seeded From UniProt	complete
involved_in	GO:0031018	endocrine pancreas development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07150 ensembl:ENSRNOP00000023664	P		Seeded From UniProt	complete
involved_in	GO:0030850	prostate gland development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07150 ensembl:ENSRNOP00000023664	P		Seeded From UniProt	complete
involved_in	GO:0030073	insulin secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07150 ensembl:ENSRNOP00000023664	P		Seeded From UniProt	complete
enables	GO:0019834	phospholipase A2 inhibitor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07150 ensembl:ENSRNOP00000023664	F		Seeded From UniProt	complete
involved_in	GO:0014070	response to organic cyclic compound	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07150 ensembl:ENSRNOP00000023664	P		Seeded From UniProt	complete
involved_in	GO:0010165	response to X-ray	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07150 ensembl:ENSRNOP00000023664	P		Seeded From UniProt	complete
involved_in	GO:0009725	response to hormone	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07150 ensembl:ENSRNOP00000023664	P		Seeded From UniProt	complete
involved_in	GO:0007166	cell surface receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07150 ensembl:ENSRNOP00000023664	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07150 ensembl:ENSRNOP00000023664	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07150 ensembl:ENSRNOP00000023664	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07150 ensembl:ENSRNOP00000023664	C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07150 ensembl:ENSRNOP00000023664	C		Seeded From UniProt	complete
enables	GO:0005543	phospholipid binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07150 ensembl:ENSRNOP00000023664	F		Seeded From UniProt	complete
enables	GO:0003727	single-stranded RNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07150 ensembl:ENSRNOP00000023664	F		Seeded From UniProt	complete
enables	GO:0003697	single-stranded DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07150 ensembl:ENSRNOP00000023664	F		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q5TZZ9 ensembl:ENSP00000366109	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q5TZZ9 ensembl:ENSP00000366109	C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q5TZZ9 ensembl:ENSP00000366109	C		Seeded From UniProt	complete
enables	GO:0004859	phospholipase inhibitor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002388	F		Seeded From UniProt	complete
enables	GO:0005509	calcium ion binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001464 InterPro:IPR002388 InterPro:IPR018252 InterPro:IPR018502 InterPro:IPR037104	F		Seeded From UniProt	complete
enables	GO:0005544	calcium-dependent phospholipid binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001464 InterPro:IPR002388 InterPro:IPR018252 InterPro:IPR018502 InterPro:IPR037104	F		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-MMU-5332993	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0006954	inflammatory response	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0395	P		Seeded From UniProt	complete
involved_in	GO:0045087	innate immune response	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0399	P		Seeded From UniProt	complete
part_of	GO:0031410	cytoplasmic vesicle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0968	C		Seeded From UniProt	complete
enables	GO:0005544	calcium-dependent phospholipid binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0111	F		Seeded From UniProt	complete
involved_in	GO:0002376	immune system process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0391	P		Seeded From UniProt	complete
part_of	GO:0005929	cilium	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0969 UniProtKB-SubCell:SL-0066	C		Seeded From UniProt	complete
part_of	GO:0005768	endosome	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0967	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472 UniProtKB-SubCell:SL-0162	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
enables	GO:0019834	phospholipase A2 inhibitor activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0593	F		Seeded From UniProt	complete
involved_in	GO:0002250	adaptive immune response	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1064	P		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C		Seeded From UniProt	complete
part_of	GO:0042995	cell projection	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0966	C		Seeded From UniProt	complete
part_of	GO:0005769	early endosome	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0094	C		Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0466	C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0112	C		Seeded From UniProt	complete
part_of	GO:0030659	cytoplasmic vesicle membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0089	C		Seeded From UniProt	complete
part_of	GO:0016323	basolateral plasma membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0026	C		Seeded From UniProt	complete
part_of	GO:0016324	apical plasma membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0015	C		Seeded From UniProt	complete
part_of	GO:0001891	phagocytic cup	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0473	C		Seeded From UniProt	complete
part_of	GO:0016328	lateral plasma membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0153	C		Seeded From UniProt	complete
part_of	GO:0010008	endosome membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0100	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Bizzarro, V et al. (2012) Annexin A1 induces skeletal muscle cell migration acting through formyl peptide receptors. PLoS ONE 7 e48246 PubMed GONUTS page
↑ ^2.0 ^2.1 Gastardelo, TS et al. (2009) Functional and ultrastructural analysis of annexin A1 and its receptor in extravasating neutrophils during acute inflammation. Am. J. Pathol. 174 177-83 PubMed GONUTS page
↑ Naba, A et al. (2017) Quantitative proteomic profiling of the extracellular matrix of pancreatic islets during the angiogenic switch and insulinoma progression. Sci Rep 7 40495 PubMed GONUTS page
↑ ^4.0 ^4.1 Naba, A et al. (2012) The matrisome: in silico definition and in vivo characterization by proteomics of normal and tumor extracellular matrices. Mol. Cell Proteomics 11 M111.014647 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 Hannon, R et al. (2003) Aberrant inflammation and resistance to glucocorticoids in annexin 1-/- mouse. FASEB J. 17 253-5 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 Babbin, BA et al. (2008) Annexin A1 regulates intestinal mucosal injury, inflammation, and repair. J. Immunol. 181 5035-44 PubMed GONUTS page
↑ ^7.0 ^7.1 Reynolds, SD et al. (2007) CCSP regulates cross talk between secretory cells and both ciliated cells and macrophages of the conducting airway. Am. J. Physiol. Lung Cell Mol. Physiol. 293 L114-23 PubMed GONUTS page
↑ Paschalidis, N et al. (2010) Role of endogenous annexin-A1 in the regulation of thymocyte positive and negative selection. Cell Cycle 9 784-93 PubMed GONUTS page
↑ ^9.0 ^9.1 Dalli, J et al. (2012) Annexin A1 regulates neutrophil clearance by macrophages in the mouse bone marrow. FASEB J. 26 387-96 PubMed GONUTS page
↑ ^10.00 ^10.01 ^10.02 ^10.03 ^10.04 ^10.05 ^10.06 ^10.07 ^10.08 ^10.09 ^10.10 ^10.11 ^10.12 ^10.13 ^10.14 ^10.15 ^10.16 ^10.17 ^10.18 ^10.19 ^10.20 ^10.21 ^10.22 ^10.23 ^10.24 ^10.25 ^10.26 ^10.27 ^10.28 ^10.29 ^10.30 ^10.31 ^10.32 ^10.33 ^10.34 ^10.35 ^10.36 ^10.37 ^10.38 ^10.39 ^10.40 ^10.41 ^10.42 ^10.43 ^10.44 ^10.45 ^10.46 ^10.47 ^10.48 ^10.49 ^10.50 ^10.51 ^10.52 ^10.53 ^10.54 ^10.55 ^10.56 ^10.57 ^10.58 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 ^11.3 Croxtall, JD et al. (2003) Attenuation of glucocorticoid functions in an Anx-A1-/- cell line. Biochem. J. 371 927-35 PubMed GONUTS page
↑ Lennon, NJ et al. (2003) Dysferlin interacts with annexins A1 and A2 and mediates sarcolemmal wound-healing. J. Biol. Chem. 278 50466-73 PubMed GONUTS page

[PMID:23144744-1] 1.0 ^1.1 Bizzarro, V et al. (2012) Annexin A1 induces skeletal muscle cell migration acting through formyl peptide receptors. PLoS ONE 7 e48246 PubMed GONUTS page

[PMID:19095957-2] 2.0 ^2.1 Gastardelo, TS et al. (2009) Functional and ultrastructural analysis of annexin A1 and its receptor in extravasating neutrophils during acute inflammation. Am. J. Pathol. 174 177-83 PubMed GONUTS page

[PMID:28071719-3] Naba, A et al. (2017) Quantitative proteomic profiling of the extracellular matrix of pancreatic islets during the angiogenic switch and insulinoma progression. Sci Rep 7 40495 PubMed GONUTS page

[PMID:22159717-4] 4.0 ^4.1 Naba, A et al. (2012) The matrisome: in silico definition and in vivo characterization by proteomics of normal and tumor extracellular matrices. Mol. Cell Proteomics 11 M111.014647 PubMed GONUTS page

[PMID:12475898-5] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 Hannon, R et al. (2003) Aberrant inflammation and resistance to glucocorticoids in annexin 1-/- mouse. FASEB J. 17 253-5 PubMed GONUTS page

[PMID:18802107-6] 6.0 ^6.1 ^6.2 ^6.3 Babbin, BA et al. (2008) Annexin A1 regulates intestinal mucosal injury, inflammation, and repair. J. Immunol. 181 5035-44 PubMed GONUTS page

[PMID:17384087-7] 7.0 ^7.1 Reynolds, SD et al. (2007) CCSP regulates cross talk between secretory cells and both ciliated cells and macrophages of the conducting airway. Am. J. Physiol. Lung Cell Mol. Physiol. 293 L114-23 PubMed GONUTS page

[PMID:20139728-8] Paschalidis, N et al. (2010) Role of endogenous annexin-A1 in the regulation of thymocyte positive and negative selection. Cell Cycle 9 784-93 PubMed GONUTS page

[PMID:21957127-9] 9.0 ^9.1 Dalli, J et al. (2012) Annexin A1 regulates neutrophil clearance by macrophages in the mouse bone marrow. FASEB J. 26 387-96 PubMed GONUTS page

[PMID:21873635-10] 10.00 ^10.01 ^10.02 ^10.03 ^10.04 ^10.05 ^10.06 ^10.07 ^10.08 ^10.09 ^10.10 ^10.11 ^10.12 ^10.13 ^10.14 ^10.15 ^10.16 ^10.17 ^10.18 ^10.19 ^10.20 ^10.21 ^10.22 ^10.23 ^10.24 ^10.25 ^10.26 ^10.27 ^10.28 ^10.29 ^10.30 ^10.31 ^10.32 ^10.33 ^10.34 ^10.35 ^10.36 ^10.37 ^10.38 ^10.39 ^10.40 ^10.41 ^10.42 ^10.43 ^10.44 ^10.45 ^10.46 ^10.47 ^10.48 ^10.49 ^10.50 ^10.51 ^10.52 ^10.53 ^10.54 ^10.55 ^10.56 ^10.57 ^10.58 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:12553880-11] 11.0 ^11.1 ^11.2 ^11.3 Croxtall, JD et al. (2003) Attenuation of glucocorticoid functions in an Anx-A1-/- cell line. Biochem. J. 371 927-35 PubMed GONUTS page

[PMID:14506282-12] Lennon, NJ et al. (2003) Dysferlin interacts with annexins A1 and A2 and mediates sarcolemmal wound-healing. J. Biol. Chem. 278 50466-73 PubMed GONUTS page

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