MOUSE:5HT2C

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Htr2c (synonyms: 5ht1c, Htr1c)
Protein Name(s)	5-hydroxytryptamine receptor 2C 5-HT-2C 5-HT2C 5-HTR2C 5-hydroxytryptamine receptor 1C 5-HT-1C 5-HT1C Serotonin receptor 2C
External Links
UniProt	P34968
EMBL	X72230 S44559 S44556 S44557 S44558 AL808014 AL662932 AL662932 AL808014
CCDS	CCDS30459.1
PIR	A43951
RefSeq	NP_032338.3
UniGene	Mm.439670
ProteinModelPortal	P34968
SMR	P34968
STRING	10090.ENSMUSP00000043936
BindingDB	P34968
ChEMBL	CHEMBL3006
iPTMnet	P34968
PhosphoSitePlus	P34968
PaxDb	P34968
PRIDE	P34968
Ensembl	ENSMUST00000036303 ENSMUST00000096299
GeneID	15560
KEGG	mmu:15560
UCSC	uc009und.2
CTD	3358
MGI	MGI:96281
eggNOG	KOG3656 ENOG410XRW9
GeneTree	ENSGT00870000136395
HOGENOM	HOG000240378
HOVERGEN	HBG107487
InParanoid	P34968
KO	K04157
OMA	LCGKACN
OrthoDB	EOG091G06VI
TreeFam	TF316350
Reactome	[www.reactome.org/content/detail/R-MMU-390666 R-MMU-390666] [www.reactome.org/content/detail/R-MMU-416476 R-MMU-416476]
ChiTaRS	Htr2c
PRO	PR:P34968
Proteomes	UP000000589
Bgee	ENSMUSG00000041380
CleanEx	MM_HTR2C
ExpressionAtlas	P34968
Genevisible	P34968
GO	GO:0009897 GO:0005887 GO:0005622 GO:0005886 GO:0071886 GO:0008144 GO:0004993 GO:0001587 GO:0030594 GO:0051378 GO:0001662 GO:0006874 GO:0006182 GO:0007631 GO:0048016 GO:0007626 GO:0007200 GO:0007208 GO:0051482 GO:0070374 GO:0045600 GO:0010513 GO:0032098 GO:0043397 GO:0031644 GO:0051209 GO:0042493 GO:0007210
InterPro	IPR000377 IPR002231 IPR000276 IPR017452
PANTHER	PTHR24247:SF169
Pfam	PF00001
PRINTS	PR00517 PR01101 PR00237
SMART	SM01381
PROSITE	PS00237 PS50262

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0006874	cellular calcium ion homeostasis	PMID:27931246^[1]	ECO:0000314			P	Provides regulation of calcium ion uptake activity.	complete CACAO 12851
involved_in	GO:0051482	positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway	PMID:21835345^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0043397	regulation of corticotropin-releasing hormone secretion	PMID:17596444^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0043397	regulation of corticotropin-releasing hormone secretion	PMID:17451451^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0032098	regulation of appetite	PMID:21048120^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0031644	regulation of neurological system process	PMID:17596444^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0031644	regulation of neurological system process	PMID:21048120^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007631	feeding behavior	PMID:7700379^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007208	phospholipase C-activating serotonin receptor signaling pathway	PMID:21835345^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P28335	C	Seeded From UniProt	complete
enables	GO:0004993	G protein-coupled serotonin receptor activity	PMID:21835345^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0001662	behavioral fear response	PMID:17451451^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0001587	Gq/11-coupled serotonin receptor activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P28335	F	Seeded From UniProt	complete
involved_in	GO:0051209	release of sequestered calcium ion into cytosol	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000664115 UniProtKB:O46635 UniProtKB:P28223 UniProtKB:P28335	P	Seeded From UniProt	complete
involved_in	GO:0042493	response to drug	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000664115 RGD:2848 RGD:61800 UniProtKB:O46635 UniProtKB:P28223 UniProtKB:P28335	P	Seeded From UniProt	complete
enables	GO:0030594	neurotransmitter receptor activity	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000664111 RGD:71034	F	Seeded From UniProt	complete
part_of	GO:0030425	dendrite	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000664111 RGD:2342 RGD:2343 RGD:2518 RGD:2522 RGD:2851 RGD:61800 RGD:61801 RGD:620023 RGD:62044 RGD:71034	C	Seeded From UniProt	complete
involved_in	GO:0007268	chemical synaptic transmission	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000664111 RGD:2830 RGD:2846	P	Seeded From UniProt	complete
involved_in	GO:0007200	phospholipase C-activating G protein-coupled receptor signaling pathway	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000664115 UniProtKB:P28335	P	Seeded From UniProt	complete
involved_in	GO:0007187	G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000664111 RGD:2851 RGD:62044	P	Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000037 PANTHER:PTN000664111 RGD:2343 UniProtKB:P08172 UniProtKB:P08908 UniProtKB:P21917 UniProtKB:P28221 UniProtKB:P28222 UniProtKB:P28335 UniProtKB:P28566 UniProtKB:P30546 UniProtKB:P30939 WB:WBGene00001519	C	Seeded From UniProt	complete
enables	GO:0004993	G protein-coupled serotonin receptor activity	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0004168 FB:FBgn0004573 FB:FBgn0087012 FB:FBgn0263116 MGI:MGI:109323 MGI:MGI:96273 MGI:MGI:96274 MGI:MGI:96276 MGI:MGI:96281 MGI:MGI:96284 PANTHER:PTN000664111 RGD:2845 RGD:2846 RGD:2848 RGD:2850 RGD:2851 RGD:61800 RGD:62044 RGD:62388 RGD:71034 UniProtKB:A0A0B4KFU6 UniProtKB:P08908 UniProtKB:P28221 UniProtKB:P28222 UniProtKB:P28223 UniProtKB:P28335 UniProtKB:P28566 UniProtKB:P30939 UniProtKB:P41595 UniProtKB:P47898 UniProtKB:Q13639 WB:WBGene00004776 WB:WBGene00004779	F	Seeded From UniProt	complete
enables	GO:0004930	G protein-coupled receptor activity	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000664111 RGD:2518	F	Seeded From UniProt	complete
enables	GO:0071886	1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P28335	F	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070374	positive regulation of ERK1 and ERK2 cascade	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P28335	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051930	regulation of sensory perception of pain	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2848	P	Seeded From UniProt	complete
enables	GO:0051378	serotonin binding	PMID:7582481^[8]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P28335	F	Seeded From UniProt	complete
enables	GO:0051378	serotonin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P28335	F	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051209	release of sequestered calcium ion into cytosol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P28335	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048016	inositol phosphate-mediated signaling	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P08909	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045963	negative regulation of dopamine metabolic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2848	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045907	positive regulation of vasoconstriction	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2848	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045600	positive regulation of fat cell differentiation	PMID:20719859^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042493	response to drug	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P28335	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042493	response to drug	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2848	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0040013	negative regulation of locomotion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2848	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035095	behavioral response to nicotine	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2848	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031583	phospholipase D-activating G protein-coupled receptor signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2848	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0019934	cGMP-mediated signaling	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P28335	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0014057	positive regulation of acetylcholine secretion, neurotransmission	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2848	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0014054	positive regulation of gamma-aminobutyric acid secretion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2848	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010513	positive regulation of phosphatidylinositol biosynthetic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P28335	P	Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2848	C	Seeded From UniProt	complete
part_of	GO:0009897	external side of plasma membrane	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P08909	C	Seeded From UniProt	complete
enables	GO:0008144	drug binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P28335	F	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007631	feeding behavior	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2848	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007210	serotonin receptor signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P28335	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007208	phospholipase C-activating serotonin receptor signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2848	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007200	phospholipase C-activating G protein-coupled receptor signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P28335	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006874	cellular calcium ion homeostasis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P28335	P	Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P28335	C	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P28335	C	Seeded From UniProt	complete
enables	GO:0004993	G protein-coupled serotonin receptor activity	PMID:7582481^[8]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P28335	F	Seeded From UniProt	complete
enables	GO:0004993	G protein-coupled serotonin receptor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2848	F	Seeded From UniProt	complete
enables	GO:0004993	G protein-coupled serotonin receptor activity	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P08909	F	Seeded From UniProt	complete
enables	GO:0001587	Gq/11-coupled serotonin receptor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P28335	F	Seeded From UniProt	complete
enables	GO:0071886	1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P28335 ensembl:ENSP00000276198	F	Seeded From UniProt	complete
involved_in	GO:0070374	positive regulation of ERK1 and ERK2 cascade	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P28335 ensembl:ENSP00000276198	P	Seeded From UniProt	complete
enables	GO:0051378	serotonin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P28335 ensembl:ENSP00000276198	F	Seeded From UniProt	complete
involved_in	GO:0051209	release of sequestered calcium ion into cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P28335 ensembl:ENSP00000276198	P	Seeded From UniProt	complete
involved_in	GO:0042493	response to drug	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P28335 ensembl:ENSP00000276198	P	Seeded From UniProt	complete
involved_in	GO:0019934	cGMP-mediated signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P28335 ensembl:ENSP00000276198	P	Seeded From UniProt	complete
involved_in	GO:0010513	positive regulation of phosphatidylinositol biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P28335 ensembl:ENSP00000276198	P	Seeded From UniProt	complete
enables	GO:0008144	drug binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P28335 ensembl:ENSP00000276198	F	Seeded From UniProt	complete
involved_in	GO:0007210	serotonin receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P28335 ensembl:ENSP00000276198	P	Seeded From UniProt	complete
involved_in	GO:0007200	phospholipase C-activating G protein-coupled receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P28335 ensembl:ENSP00000276198	P	Seeded From UniProt	complete
involved_in	GO:0006874	cellular calcium ion homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P28335 ensembl:ENSP00000276198	P	Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P28335 ensembl:ENSP00000276198	C	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P28335 ensembl:ENSP00000276198	C	Seeded From UniProt	complete
enables	GO:0004993	G protein-coupled serotonin receptor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P28335 ensembl:ENSP00000276198	F	Seeded From UniProt	complete
enables	GO:0001587	Gq/11-coupled serotonin receptor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P28335 ensembl:ENSP00000276198	F	Seeded From UniProt	complete
enables	GO:0004930	G protein-coupled receptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000276	F	Seeded From UniProt	complete
enables	GO:0004993	G protein-coupled serotonin receptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000377 InterPro:IPR002231	F	Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000377 InterPro:IPR002231	C	Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000276 InterPro:IPR000377 InterPro:IPR002231	P	Seeded From UniProt	complete
involved_in	GO:0007626	locomotory behavior	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000377	P	Seeded From UniProt	complete
involved_in	GO:0007631	feeding behavior	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000377	P	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000276 InterPro:IPR017452	C	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C	Seeded From UniProt	complete
involved_in	GO:0007610	behavior	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0085	P	Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0297	P	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C	Seeded From UniProt	complete
enables	GO:0004930	G protein-coupled receptor activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0297	F	Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0807	P	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Garfield, AS et al. (2016) Increased alternate splicing of Htr2c in a mouse model for Prader-Willi syndrome leads disruption of 5HT2C receptor mediated appetite. Mol Brain 9 95 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Sohn, JW et al. (2011) Serotonin 2C receptor activates a distinct population of arcuate pro-opiomelanocortin neurons via TRPC channels. Neuron 71 488-97 PubMed GONUTS page
↑ ^3.0 ^3.1 Heisler, LK et al. (2007) Serotonin activates the hypothalamic-pituitary-adrenal axis via serotonin 2C receptor stimulation. J. Neurosci. 27 6956-64 PubMed GONUTS page
↑ ^4.0 ^4.1 Heisler, LK et al. (2007) Serotonin 5-HT(2C) receptors regulate anxiety-like behavior. Genes Brain Behav. 6 491-6 PubMed GONUTS page
↑ ^5.0 ^5.1 Xu, Y et al. (2010) A serotonin and melanocortin circuit mediates D-fenfluramine anorexia. J. Neurosci. 30 14630-4 PubMed GONUTS page
↑ Tecott, LH et al. (1995) Eating disorder and epilepsy in mice lacking 5-HT2c serotonin receptors. Nature 374 542-6 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 ^7.6 ^7.7 ^7.8 ^7.9 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^8.0 ^8.1 Bonhaus, DW et al. (1995) The pharmacology and distribution of human 5-hydroxytryptamine2B (5-HT2B) receptor gene products: comparison with 5-HT2A and 5-HT2C receptors. Br. J. Pharmacol. 115 622-8 PubMed GONUTS page
↑ Kinoshita, M et al. (2010) Regulation of adipocyte differentiation by activation of serotonin (5-HT) receptors 5-HT2AR and 5-HT2CR and involvement of microRNA-448-mediated repression of KLF5. Mol. Endocrinol. 24 1978-87 PubMed GONUTS page

[PMID:27931246-1] Garfield, AS et al. (2016) Increased alternate splicing of Htr2c in a mouse model for Prader-Willi syndrome leads disruption of 5HT2C receptor mediated appetite. Mol Brain 9 95 PubMed GONUTS page

[PMID:21835345-2] 2.0 ^2.1 ^2.2 Sohn, JW et al. (2011) Serotonin 2C receptor activates a distinct population of arcuate pro-opiomelanocortin neurons via TRPC channels. Neuron 71 488-97 PubMed GONUTS page

[PMID:17596444-3] 3.0 ^3.1 Heisler, LK et al. (2007) Serotonin activates the hypothalamic-pituitary-adrenal axis via serotonin 2C receptor stimulation. J. Neurosci. 27 6956-64 PubMed GONUTS page

[PMID:17451451-4] 4.0 ^4.1 Heisler, LK et al. (2007) Serotonin 5-HT(2C) receptors regulate anxiety-like behavior. Genes Brain Behav. 6 491-6 PubMed GONUTS page

[PMID:21048120-5] 5.0 ^5.1 Xu, Y et al. (2010) A serotonin and melanocortin circuit mediates D-fenfluramine anorexia. J. Neurosci. 30 14630-4 PubMed GONUTS page

[PMID:7700379-6] Tecott, LH et al. (1995) Eating disorder and epilepsy in mice lacking 5-HT2c serotonin receptors. Nature 374 542-6 PubMed GONUTS page

[PMID:21873635-7] 7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 ^7.6 ^7.7 ^7.8 ^7.9 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:7582481-8] 8.0 ^8.1 Bonhaus, DW et al. (1995) The pharmacology and distribution of human 5-hydroxytryptamine2B (5-HT2B) receptor gene products: comparison with 5-HT2A and 5-HT2C receptors. Br. J. Pharmacol. 115 622-8 PubMed GONUTS page

[PMID:20719859-9] Kinoshita, M et al. (2010) Regulation of adipocyte differentiation by activation of serotonin (5-HT) receptors 5-HT2AR and 5-HT2CR and involvement of microRNA-448-mediated repression of KLF5. Mol. Endocrinol. 24 1978-87 PubMed GONUTS page

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MOUSE:5HT2C

Contents

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