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MCV1:CFLA

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Species (Taxon ID) Molluscum contagiosum virus subtype 1 (MOCV) (MCVI). (10280)
Gene Name(s) No Information Provided.
Protein Name(s) Viral CASP8 and FADD-like apoptosis regulator

v-CFLAR Viral FLICE-inhibitory protein v-FLIP

External Links
UniProt Q98325
EMBL U60315
U86888
PIR T30761
RefSeq NP_044110.1
PDB 2BBR
2BBZ
2F1S
PDBsum 2BBR
2BBZ
2F1S
ProteinModelPortal Q98325
SMR Q98325
GeneID 1487017
Reactome REACT_1503
EvolutionaryTrace Q98325
Proteomes UP000000869
GO GO:0006915
GO:0060545
GO:0019050
Gene3D 1.10.533.10
InterPro IPR011029
IPR001875
Pfam PF01335
SMART SM00031
SUPFAM SSF47986
PROSITE PS50168

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0060545

positive regulation of necroptotic process

PMID:22274400[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

GO:0039504

suppression by virus of host adaptive immune response

PMID:22301546[2]

ECO:0000314

P

As seen in figure 8, the MC159 protein interacts with IKKγ during poxvirus infection. The IKK complex plays a crucial role in NF-κB activation, making it an appealing target for poxviruses as a means to block NF-κB-mediated activation of the pro-inflammatory response.

complete
CACAO 6885

enables

GO:0004197

cysteine-type endopeptidase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002398

F

Seeded From UniProt

complete

involved_in

GO:0006508

proteolysis

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002398

P

Seeded From UniProt

complete

involved_in

GO:0042981

regulation of apoptotic process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001875

P

Seeded From UniProt

complete

involved_in

GO:0016032

viral process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0945

P

Seeded From UniProt

complete

involved_in

GO:0039526

modulation by virus of host apoptotic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1119

P

Seeded From UniProt

complete

involved_in

GO:0019050

suppression by virus of host apoptotic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1082

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. Feoktistova, M et al. (2012) Pick your poison: the Ripoptosome, a cell death platform regulating apoptosis and necroptosis. Cell Cycle 11 460-7 PubMed GONUTS page
  2. Randall, CM et al. (2012) The MC159 protein from the molluscum contagiosum poxvirus inhibits NF-κB activation by interacting with the IκB kinase complex. J. Immunol. 188 2371-9 PubMed GONUTS page