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LEIDO:C8CCV9

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Species (Taxon ID) Leishmania donovani. (5661)
Gene Name(s) No Information Provided.
Protein Name(s) Arabino-1,4-lactone oxidase (ECO:0000313 with EMBL:ACV04074.1)
External Links
UniProt C8CCV9
EMBL GQ389776
GO GO:0016020
GO:0003885
GO:0050660
GO:0008762
Gene3D 3.30.43.10
3.30.465.10
InterPro IPR007173
IPR016169
IPR016166
IPR016167
IPR023595
IPR006094
Pfam PF04030
PF01565
PIRSF PIRSF000136
SUPFAM SSF56176
PROSITE PS51387

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0019853

L-ascorbic acid biosynthetic process

PMID:24456202[1]

ECO:0000314

P

Figure 1, panel B shows a decreased level of ascorbic acid in the lysate of the ALO knockout grown in standard media. Panel C shows that there is no ascorbic acid in the lysate of ALO knockouts grown in ascorbate depleted media

complete
CACAO 10887

GO:0020015

glycosome

PMID:21907739[2]

ECO:0000314

C

Figure 4 panel A shows that LdALO localizes to the same cellular location as GADPH, a known glycosomal marker.

complete
CACAO 10888

part_of

GO:0020015

glycosome

PMID:21907739[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0003885

D-arabinono-1,4-lactone oxidase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR007173

F

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR007173

C

Seeded From UniProt

complete

enables

GO:0016491

oxidoreductase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR006094

F

Seeded From UniProt

complete

enables

GO:0016899

oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR010031

F

Seeded From UniProt

complete

enables

GO:0050660

flavin adenine dinucleotide binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR006094
InterPro:IPR036318

F

Seeded From UniProt

complete

involved_in

GO:0055114

oxidation-reduction process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR006094
InterPro:IPR007173
InterPro:IPR010031

P

Seeded From UniProt

complete

enables

GO:0071949

FAD binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR016166

F

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. Manhas, R et al. (2014) Deletion of Vitamin C biosynthesis enzyme, Arabino-1, 4-lactone oxidase in Leishmania donovani results in increased pro-inflammatory responses from host immune cells. Mol. Microbiol. 91 1227-39 PubMed GONUTS page
  2. 2.0 2.1 Biyani, N & Madhubala, R (2011) Leishmania donovani encodes a functional enzyme involved in vitamin C biosynthesis: arabino-1,4-lactone oxidase. Mol. Biochem. Parasitol. 180 76-85 PubMed GONUTS page