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LEIDO:C8CCV9
Contents
Species (Taxon ID) | Leishmania donovani. (5661) | |
Gene Name(s) | No Information Provided. | |
Protein Name(s) | Arabino-1,4-lactone oxidase (ECO:0000313 with EMBL:ACV04074.1) | |
External Links | ||
UniProt | C8CCV9 | |
EMBL | GQ389776 | |
GO | GO:0016020 GO:0003885 GO:0050660 GO:0008762 | |
Gene3D | 3.30.43.10 3.30.465.10 | |
InterPro | IPR007173 IPR016169 IPR016166 IPR016167 IPR023595 IPR006094 | |
Pfam | PF04030 PF01565 | |
PIRSF | PIRSF000136 | |
SUPFAM | SSF56176 | |
PROSITE | PS51387 |
Annotations
Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
---|---|---|---|---|---|---|---|---|---|---|
GO:0019853 |
L-ascorbic acid biosynthetic process |
ECO:0000314 |
P |
Figure 1, panel B shows a decreased level of ascorbic acid in the lysate of the ALO knockout grown in standard media. Panel C shows that there is no ascorbic acid in the lysate of ALO knockouts grown in ascorbate depleted media |
complete | |||||
GO:0020015 |
glycosome |
ECO:0000314 |
C |
Figure 4 panel A shows that LdALO localizes to the same cellular location as GADPH, a known glycosomal marker. |
complete | |||||
part_of |
GO:0020015 |
glycosome |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0003885 |
D-arabinono-1,4-lactone oxidase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0016020 |
membrane |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0016491 |
oxidoreductase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0016899 |
oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0050660 |
flavin adenine dinucleotide binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0055114 |
oxidation-reduction process |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0071949 |
FAD binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Manhas, R et al. (2014) Deletion of Vitamin C biosynthesis enzyme, Arabino-1, 4-lactone oxidase in Leishmania donovani results in increased pro-inflammatory responses from host immune cells. Mol. Microbiol. 91 1227-39 PubMed GONUTS page
- ↑ 2.0 2.1 Biyani, N & Madhubala, R (2011) Leishmania donovani encodes a functional enzyme involved in vitamin C biosynthesis: arabino-1,4-lactone oxidase. Mol. Biochem. Parasitol. 180 76-85 PubMed GONUTS page