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LEGPH:ACON

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Species (Taxon ID) Legionella pneumophila subsp. pneumophila (strain Philadelphia 1 /ATCC 33152 / DSM 7513). (272624)
Gene Name(s) acn
Protein Name(s) Aconitate hydratase A (ECO:0000303 with PMID:8366052[1])

ACN (ECO:0000303 with PMID:8366052[1]) Aconitase (ECO:0000303 with PMID:8366052[1]) (2R,3S)-2-methylisocitrate dehydratase (ECO:0000250 with UniProtKB:Q8ZP52) (2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate dehydratase (ECO:0000250 with UniProtKB:Q8ZP52) IP210 (ECO:0000303 with PMID:8366052[1]) Iron-responsive protein-like (ECO:0000305 with PMID:8366052[1]) IRP-like (ECO:0000305 with PMID:8366052[1]) Major iron-containing protein (ECO:0000303 with PMID:8366052[1]) MICP (ECO:0000303 with PMID:8366052[1]) Probable 2-methyl-cis-aconitate hydratase (ECO:0000250 with UniProtKB:Q8ZP52) RNA-binding protein (ECO:0000305 with PMID:8366052[1])

External Links
UniProt P37032
EMBL L22081
AE017354
PIR B48642
RefSeq WP_010947417.1
YP_095717.1
ProteinModelPortal P37032
SMR P37032
STRING 272624.lpg1690
PaxDb P37032
PRIDE P37032
EnsemblBacteria AAU27770
GeneID 19833255
KEGG lpn:lpg1690
PATRIC 22330500
eggNOG ENOG4108I0Z
COG1048
HOGENOM HOG000025704
KO K01681
OMA ENLAKWG
OrthoDB EOG67DPHM
BioCyc LPNE272624:GHDI-1689-MONOMER
RETL1328306-WGS:GSTH-4032-MONOMER
UniPathway UPA00223
UPA00946
Proteomes UP000000609
GO GO:0047456
GO:0051539
GO:0003994
GO:0046872
GO:0003730
GO:0003729
GO:0019679
GO:0006099
Gene3D 3.20.19.10
3.30.499.10
3.40.1060.10
InterPro IPR015931
IPR015937
IPR001030
IPR015928
IPR015932
IPR006249
IPR018136
IPR000573
PANTHER PTHR11670
Pfam PF00330
PF00694
PRINTS PR00415
SUPFAM SSF52016
SSF53732
TIGRFAMs TIGR01341
PROSITE PS00450
PS01244

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0003729

mRNA binding

PMID:8366052[1]

ECO:0000314

F

Fig. 1. Major IPs of L. pneumophila. A crude extract of L. pneumophila grown on agar medium containing 59Fe was subjected to ND-PAGE, and the radiolabeled proteins were visualized by autoradiography (right). A crude extract of E. coli obtained under the same conditions was included as a control (left).

complete
CACAO 11471

enables

GO:0003730

mRNA 3'-UTR binding

PMID:8366052[1]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0003729

mRNA binding

PMID:8366052[1]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0047456

2-methylisocitrate dehydratase activity

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q8ZP52

F

Seeded From UniProt

complete

enables

GO:0003994

aconitate hydratase activity

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q8ZP52

F

Seeded From UniProt

complete

involved_in

GO:0019679

propionate metabolic process, methylcitrate cycle

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q8ZP52

P

Seeded From UniProt

complete

involved_in

GO:0006099

tricarboxylic acid cycle

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q8ZP52

P

Seeded From UniProt

complete

enables

GO:0051539

4 iron, 4 sulfur cluster binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P36683

F

Seeded From UniProt

complete

enables

GO:0003994

aconitate hydratase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:4.2.1.3

F

Seeded From UniProt

complete

enables

GO:0047456

2-methylisocitrate dehydratase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:4.2.1.99

F

Seeded From UniProt

complete

enables

GO:0016829

lyase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0456

F

Seeded From UniProt

complete

involved_in

GO:0006099

tricarboxylic acid cycle

GO_REF:0000037
GO_REF:0000041

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0816
UniPathway:UPA00223

P

Seeded From UniProt

complete

enables

GO:0003723

RNA binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0694

F

Seeded From UniProt

complete

enables

GO:0051536

iron-sulfur cluster binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0411

F

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

enables

GO:0051539

4 iron, 4 sulfur cluster binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0004

F

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.00 1.01 1.02 1.03 1.04 1.05 1.06 1.07 1.08 1.09 1.10 1.11 Mengaud, JM & Horwitz, MA (1993) The major iron-containing protein of Legionella pneumophila is an aconitase homologous with the human iron-responsive element-binding protein. J. Bacteriol. 175 5666-76 PubMed GONUTS page