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HUMAN:WASL

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) WASL
Protein Name(s) Neural Wiskott-Aldrich syndrome protein

N-WASP

External Links
UniProt O00401
EMBL D88460
AM295156
AC006333
BC052955
CCDS CCDS34743.1
RefSeq NP_003932.3
UniGene Hs.143728
Hs.731519
Hs.83916
PDB 2FF3
2LNH
2VCP
4CC2
4CC7
PDBsum 2FF3
2LNH
2VCP
4CC2
4CC7
ProteinModelPortal O00401
SMR O00401
BioGrid 114466
DIP DIP-29042N
IntAct O00401
MINT MINT-157215
STRING 9606.ENSP00000223023
PhosphoSite O00401
MaxQB O00401
PaxDb O00401
PRIDE O00401
Ensembl ENST00000223023
GeneID 8976
KEGG hsa:8976
UCSC uc003vkz.3
CTD 8976
GeneCards GC07M123321
HGNC HGNC:12735
HPA CAB005399
HPA005750
MIM 605056
neXtProt NX_O00401
PharmGKB PA37346
eggNOG NOG270974
GeneTree ENSGT00730000110895
HOGENOM HOG000143378
HOVERGEN HBG000222
InParanoid O00401
KO K05747
OMA DAPNGPN
OrthoDB EOG7FJH20
PhylomeDB O00401
TreeFam TF316736
Reactome REACT_12541
REACT_160086
REACT_22351
REACT_228085
REACT_23832
SignaLink O00401
ChiTaRS WASL
EvolutionaryTrace O00401
GeneWiki WASL_(gene)
GenomeRNAi 8976
NextBio 33689
PRO PR:O00401
Proteomes UP000005640
Bgee O00401
CleanEx HS_WASL
Genevestigator O00401
GO GO:0030478
GO:0015629
GO:0016023
GO:0005829
GO:0030666
GO:0070062
GO:0030027
GO:0005634
GO:0005886
GO:0005083
GO:0008154
GO:0007411
GO:0006928
GO:0034629
GO:0038096
GO:0045087
GO:0006900
GO:0007067
GO:1903526
GO:0046209
GO:2000370
GO:0051491
GO:0006461
GO:0050999
GO:0032880
GO:0006355
GO:0009617
GO:0044281
GO:0051653
GO:0006351
GO:0016050
GO:0030050
Gene3D 2.30.29.30
3.90.810.10
InterPro IPR000095
IPR030214
IPR011993
IPR011026
IPR000697
IPR003124
PANTHER PTHR12779:SF3
Pfam PF00786
PF00568
PF02205
SMART SM00285
SM00461
SM00246
SUPFAM SSF47912
PROSITE PS50108
PS50229
PS51082

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:2000402

negative regulation of lymphocyte migration

PMID:22585739[1]

ECO:0000315

P

Fig 5A shows that the presence of N-WASp successfully lowers the percentage of NK cells whose migration was inhibited by NKG2D.

complete
CACAO 5744

involved_in

GO:0030041

actin filament polymerization

PMID:16767080[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:16767080[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:16767080[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0060997

dendritic spine morphogenesis

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q91YD9

P

Seeded From UniProt

complete

involved_in

GO:2000402

negative regulation of lymphocyte migration

PMID:22585739[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:1903526

negative regulation of membrane tubulation

PMID:18388313[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

PMID:18388313[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0070062

extracellular exosome

PMID:19056867[4]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(UBERON:0001088)

Seeded From UniProt

complete

involved_in

GO:2000370

positive regulation of clathrin-dependent endocytosis

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:O08816

P

Seeded From UniProt

complete

involved_in

GO:0051491

positive regulation of filopodium assembly

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:O08816

P

Seeded From UniProt

complete

involved_in

GO:0030050

vesicle transport along actin filament

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:O08816

P

Seeded From UniProt

complete

involved_in

GO:0016050

vesicle organization

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:O08816

P

Seeded From UniProt

complete

part_of

GO:0031410

cytoplasmic vesicle

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:O08816

C

Seeded From UniProt

complete

involved_in

GO:0006900

vesicle budding from membrane

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:O08816

P

Seeded From UniProt

complete

involved_in

GO:0051666

actin cortical patch localization

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001506182
SGD:S000004329
SGD:S000005707

P

Seeded From UniProt

complete

involved_in

GO:0051127

positive regulation of actin nucleation

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001506182
PomBase:SPBC13E7.09

P

Seeded From UniProt

complete

enables

GO:0051015

actin filament binding

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0243516
PANTHER:PTN001506182

F

Seeded From UniProt

complete

part_of

GO:0030479

actin cortical patch

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001506182
PomBase:SPAC4F10.15c
PomBase:SPBC13E7.09
SGD:S000004329
SGD:S000005707
UniProtKB:A0A1D8PU03

C

Seeded From UniProt

complete

involved_in

GO:0030048

actin filament-based movement

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:105059
MGI:MGI:2178801
PANTHER:PTN001506182

P

Seeded From UniProt

complete

involved_in

GO:0006897

endocytosis

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001506182
PomBase:SPAC4F10.15c
SGD:S000004329
UniProtKB:A0A1D8PU03

P

Seeded From UniProt

complete

part_of

GO:0005884

actin filament

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:2178801
PANTHER:PTN001506182
RGD:620887
UniProtKB:P42768

C

Seeded From UniProt

complete

involved_in

GO:0000147

actin cortical patch assembly

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001506182
PomBase:SPAC4F10.15c
PomBase:SPBC13E7.09

P

Seeded From UniProt

complete

involved_in

GO:0060997

dendritic spine morphogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q91YD9
ensembl:ENSMUSP00000031695

P

Seeded From UniProt

complete

involved_in

GO:0051653

spindle localization

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q91YD9
ensembl:ENSMUSP00000031695

P

Seeded From UniProt

complete

involved_in

GO:0034629

cellular protein-containing complex localization

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q91YD9
ensembl:ENSMUSP00000031695

P

Seeded From UniProt

complete

involved_in

GO:0032880

regulation of protein localization

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q91YD9
ensembl:ENSMUSP00000031695

P

Seeded From UniProt

complete

part_of

GO:0030478

actin cap

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q91YD9
ensembl:ENSMUSP00000031695

C

Seeded From UniProt

complete

involved_in

GO:0030036

actin cytoskeleton organization

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q91YD9
ensembl:ENSMUSP00000031695

P

Seeded From UniProt

complete

part_of

GO:0030027

lamellipodium

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q91YD9
ensembl:ENSMUSP00000031695

C

Seeded From UniProt

complete

involved_in

GO:0009617

response to bacterium

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q91YD9
ensembl:ENSMUSP00000031695

P

Seeded From UniProt

complete

enables

GO:0003779

actin binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR003124
InterPro:IPR030214

F

Seeded From UniProt

complete

involved_in

GO:0007015

actin filament organization

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR011026
InterPro:IPR030214

P

Seeded From UniProt

complete

involved_in

GO:2000601

positive regulation of Arp2/3 complex-mediated actin nucleation

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR030214

P

Seeded From UniProt

complete

part_of

GO:0015629

actin cytoskeleton

PMID:9422512[6]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0008154

actin polymerization or depolymerization

PMID:9422512[6]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0065003

protein-containing complex assembly

PMID:9422512[6]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0030695

GTPase regulator activity

PMID:9422512[6]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0061024

membrane organization

Reactome:R-HSA-199991

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0050999

regulation of nitric-oxide synthase activity

Reactome:R-HSA-203641

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0048013

ephrin receptor signaling pathway

Reactome:R-HSA-2682334

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0038096

Fc-gamma receptor signaling pathway involved in phagocytosis

Reactome:R-HSA-2029480

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0030666

endocytic vesicle membrane

Reactome:R-HSA-203625

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

Reactome:R-HSA-418874
Reactome:R-HSA-203625
Reactome:R-HSA-203565

ECO:0000304

author statement supported by traceable reference used in manual assertion



C

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

Reactome:R-HSA-8871194
Reactome:R-HSA-8871193
Reactome:R-HSA-8869438
Reactome:R-HSA-8868661
Reactome:R-HSA-8868660
Reactome:R-HSA-8868659
Reactome:R-HSA-8868658
Reactome:R-HSA-8868651
Reactome:R-HSA-8868648
Reactome:R-HSA-8868236
Reactome:R-HSA-8868230
Reactome:R-HSA-532603
Reactome:R-HSA-418874
Reactome:R-HSA-3928601
Reactome:R-HSA-3928595
Reactome:R-HSA-2197698
Reactome:R-HSA-2197691
Reactome:R-HSA-2197690
Reactome:R-HSA-203565
Reactome:R-HSA-2029466

ECO:0000304

author statement supported by traceable reference used in manual assertion




















C

Seeded From UniProt

complete

involved_in

GO:0051301

cell division

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0132

P

Seeded From UniProt

complete

part_of

GO:0005856

cytoskeleton

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0206
UniProtKB-SubCell:SL-0090

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

involved_in

GO:0007049

cell cycle

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0131

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

enables

GO:0003779

actin binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0009

F

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 Serrano-Pertierra, E et al. (2012) Wiskott-Aldrich syndrome protein (WASp) and N-WASp are involved in the regulation of NK-cell migration upon NKG2D activation. Eur. J. Immunol. 42 2142-51 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 Wu, X et al. (2006) Regulation of RNA-polymerase-II-dependent transcription by N-WASP and its nuclear-binding partners. Nat. Cell Biol. 8 756-63 PubMed GONUTS page
  3. ↑ 3.0 3.1 Shin, N et al. (2008) SNX9 regulates tubular invagination of the plasma membrane through interaction with actin cytoskeleton and dynamin 2. J. Cell. Sci. 121 1252-63 PubMed GONUTS page
  4. ↑ Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page
  5. ↑ 5.0 5.1 5.2 5.3 5.4 5.5 5.6 5.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  6. ↑ 6.0 6.1 6.2 6.3 Miki, H et al. (1998) Induction of filopodium formation by a WASP-related actin-depolymerizing protein N-WASP. Nature 391 93-6 PubMed GONUTS page
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