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HUMAN:UCP1

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) UCP1 (synonyms: SLC25A7, UCP)
Protein Name(s) Mitochondrial brown fat uncoupling protein 1

UCP 1 Solute carrier family 25 member 7 Thermogenin

External Links
UniProt P25874
EMBL X51952
X51953
X51954
X51955
U28480
AC108019
BC069556
BC098168
BC098258
CCDS CCDS3753.1
PIR G01858
RefSeq NP_068605.1
UniGene Hs.249211
ProteinModelPortal P25874
SMR P25874
BioGrid 113197
STRING 9606.ENSP00000262999
TCDB 2.A.29.3.2
PhosphoSite P25874
DMDM 71153184
PaxDb P25874
PRIDE P25874
Ensembl ENST00000262999
GeneID 7350
KEGG hsa:7350
UCSC uc011chj.2
CTD 7350
GeneCards GC04M141480
HGNC HGNC:12517
HPA CAB037199
MIM 113730
neXtProt NX_P25874
PharmGKB PA37164
eggNOG NOG277477
GeneTree ENSGT00760000119170
HOGENOM HOG000165140
HOVERGEN HBG009528
InParanoid P25874
KO K08769
OMA GSWNIIM
OrthoDB EOG793B7Z
PhylomeDB P25874
TreeFam TF323211
Reactome REACT_6196
REACT_6258
GeneWiki Thermogenin
GenomeRNAi 7350
NextBio 28774
PRO PR:P25874
Proteomes UP000005640
Bgee P25874
CleanEx HS_UCP1
ExpressionAtlas P25874
Genevestigator P25874
GO GO:0016021
GO:0005743
GO:0005739
GO:0017077
GO:0050873
GO:0044237
GO:0006839
GO:0015992
GO:0006357
GO:0022904
GO:0044281
Gene3D 1.50.40.10
InterPro IPR002030
IPR018108
IPR023395
Pfam PF00153
PRINTS PR00784
SUPFAM SSF103506
PROSITE PS50920

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0017077

oxidative phosphorylation uncoupler activity

PMID:24196960[1]

ECO:0000314

F

Figure 2: Measures the expression of UCP1 and NADH activity in the bacterial membranes and supernatant.

complete
CACAO 9190

involved_in

GO:0120162

positive regulation of cold-induced thermogenesis

PMID:28630339[2]

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P12242

P

Seeded From UniProt

complete

part_of

GO:0005743

mitochondrial inner membrane

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:W5PSH7

C

Seeded From UniProt

complete

enables

GO:1901612

cardiolipin binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:W5PSH7

F

Seeded From UniProt

complete

enables

GO:0036041

long-chain fatty acid binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P12242

F

Seeded From UniProt

complete

enables

GO:0032555

purine ribonucleotide binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P12242

F

Seeded From UniProt

complete

enables

GO:0017077

oxidative phosphorylation uncoupler activity

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P12242

F

Seeded From UniProt

complete

involved_in

GO:1990845

adaptive thermogenesis

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P12242

P

Seeded From UniProt

complete

involved_in

GO:1990542

mitochondrial transmembrane transport

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P12242

P

Seeded From UniProt

complete

involved_in

GO:1903426

regulation of reactive oxygen species biosynthetic process

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P12242

P

Seeded From UniProt

complete

involved_in

GO:0071398

cellular response to fatty acid

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P12242

P

Seeded From UniProt

complete

involved_in

GO:0034614

cellular response to reactive oxygen species

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P12242

P

Seeded From UniProt

complete

involved_in

GO:0032870

cellular response to hormone stimulus

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P12242

P

Seeded From UniProt

complete

involved_in

GO:0031667

response to nutrient levels

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P12242

P

Seeded From UniProt

complete

involved_in

GO:0009266

response to temperature stimulus

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P12242

P

Seeded From UniProt

complete

involved_in

GO:1902600

proton transmembrane transport

PMID:24196960[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0022857

transmembrane transporter activity

PMID:24196960[1]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0050873

brown fat cell differentiation

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P12242

P

Seeded From UniProt

complete

involved_in

GO:1990845

adaptive thermogenesis

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:98894
PANTHER:PTN002378102

P

Seeded From UniProt

complete

involved_in

GO:1990542

mitochondrial transmembrane transport

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:98894
PANTHER:PTN000642156
RGD:3931

P

Seeded From UniProt

complete

enables

GO:0017077

oxidative phosphorylation uncoupler activity

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1099787
MGI:MGI:98894
PANTHER:PTN000642156
RGD:3931
TAIR:locus:2080300

F

Seeded From UniProt

complete

involved_in

GO:0009409

response to cold

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002378102
RGD:3933

P

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

PMID:9054939[4]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:1990845

adaptive thermogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P12242
ensembl:ENSMUSP00000034146

P

Seeded From UniProt

complete

involved_in

GO:1990542

mitochondrial transmembrane transport

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P12242
ensembl:ENSMUSP00000034146

P

Seeded From UniProt

complete

involved_in

GO:1903426

regulation of reactive oxygen species biosynthetic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P12242
ensembl:ENSMUSP00000034146

P

Seeded From UniProt

complete

involved_in

GO:1902600

proton transmembrane transport

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P12242
ensembl:ENSMUSP00000034146

P

Seeded From UniProt

complete

involved_in

GO:0120162

positive regulation of cold-induced thermogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P12242
ensembl:ENSMUSP00000034146

P

Seeded From UniProt

complete

involved_in

GO:0071398

cellular response to fatty acid

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P12242
ensembl:ENSMUSP00000034146

P

Seeded From UniProt

complete

involved_in

GO:0050873

brown fat cell differentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P12242
ensembl:ENSMUSP00000034146

P

Seeded From UniProt

complete

enables

GO:0036041

long-chain fatty acid binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P12242
ensembl:ENSMUSP00000034146

F

Seeded From UniProt

complete

involved_in

GO:0034614

cellular response to reactive oxygen species

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P12242
ensembl:ENSMUSP00000034146

P

Seeded From UniProt

complete

involved_in

GO:0032870

cellular response to hormone stimulus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P12242
ensembl:ENSMUSP00000034146

P

Seeded From UniProt

complete

enables

GO:0032555

purine ribonucleotide binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P12242
ensembl:ENSMUSP00000034146

F

Seeded From UniProt

complete

involved_in

GO:0031667

response to nutrient levels

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P12242
ensembl:ENSMUSP00000034146

P

Seeded From UniProt

complete

enables

GO:0017077

oxidative phosphorylation uncoupler activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P12242
ensembl:ENSMUSP00000034146

F

Seeded From UniProt

complete

involved_in

GO:0009266

response to temperature stimulus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P12242
ensembl:ENSMUSP00000034146

P

Seeded From UniProt

complete

involved_in

GO:0006357

regulation of transcription by RNA polymerase II

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P12242
ensembl:ENSMUSP00000034146

P

Seeded From UniProt

complete

part_of

GO:0005743

mitochondrial inner membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P12242
ensembl:ENSMUSP00000034146

C

Seeded From UniProt

complete

part_of

GO:0005740

mitochondrial envelope

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P12242
ensembl:ENSMUSP00000034146

C

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P12242
ensembl:ENSMUSP00000034146

C

Seeded From UniProt

complete

involved_in

GO:0002024

diet induced thermogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P12242
ensembl:ENSMUSP00000034146

P

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR040011

C

Seeded From UniProt

complete

involved_in

GO:0006839

mitochondrial transport

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002030

P

Seeded From UniProt

complete

enables

GO:0017077

oxidative phosphorylation uncoupler activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR040011

F

Seeded From UniProt

complete

enables

GO:0022857

transmembrane transporter activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR040062

F

Seeded From UniProt

complete

part_of

GO:0031966

mitochondrial membrane

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002030

C

Seeded From UniProt

complete

involved_in

GO:0071398

cellular response to fatty acid

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR040011

P

Seeded From UniProt

complete

involved_in

GO:1990542

mitochondrial transmembrane transport

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR040011

P

Seeded From UniProt

complete

involved_in

GO:1902600

proton transmembrane transport

Reactome:R-HSA-167827
Reactome:R-HSA-166187

ECO:0000304

author statement supported by traceable reference used in manual assertion


P

Seeded From UniProt

complete

part_of

GO:0005743

mitochondrial inner membrane

Reactome:R-HSA-170026
Reactome:R-HSA-166387
Reactome:R-HSA-166220
Reactome:R-HSA-166214

ECO:0000304

author statement supported by traceable reference used in manual assertion




C

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0496

C

Seeded From UniProt

complete

involved_in

GO:0006811

ion transport

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0406

P

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

part_of

GO:0005743

mitochondrial inner membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0999
UniProtKB-SubCell:SL-0168

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 1.2 Hoang, T et al. (2013) Expression, folding, and proton transport activity of human uncoupling protein-1 (UCP1) in lipid membranes: evidence for associated functional forms. J. Biol. Chem. 288 36244-58 PubMed GONUTS page
  2. ↑ Kazak, L et al. (2017) UCP1 deficiency causes brown fat respiratory chain depletion and sensitizes mitochondria to calcium overload-induced dysfunction. Proc. Natl. Acad. Sci. U.S.A. 114 7981-7986 PubMed GONUTS page
  3. ↑ 3.0 3.1 3.2 3.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  4. ↑ Fleury, C et al. (1997) Uncoupling protein-2: a novel gene linked to obesity and hyperinsulinemia. Nat. Genet. 15 269-72 PubMed GONUTS page
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