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HUMAN:UBP33

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) USP33 (synonyms: KIAA1097, VDU1)
Protein Name(s) Ubiquitin carboxyl-terminal hydrolase 33

Deubiquitinating enzyme 33 Ubiquitin thioesterase 33 Ubiquitin-specific-processing protease 33 VHL-interacting deubiquitinating enzyme 1 hVDU1

External Links
UniProt Q8TEY7
EMBL AF383172
AF383173
AB029020
AK022864
AC114487
BC016663
CCDS CCDS678.1
CCDS679.1
CCDS680.1
RefSeq NP_055832.3
NP_963918.1
NP_963920.1
UniGene Hs.480597
PDB 2UZG
PDBsum 2UZG
ProteinModelPortal Q8TEY7
SMR Q8TEY7
BioGrid 116671
DIP DIP-48942N
IntAct Q8TEY7
MINT MINT-1370210
STRING 9606.ENSP00000350009
MEROPS C19.037
PhosphoSite Q8TEY7
DMDM 116242838
MaxQB Q8TEY7
PaxDb Q8TEY7
PRIDE Q8TEY7
DNASU 23032
Ensembl ENST00000357428
ENST00000370792
ENST00000370793
ENST00000370794
GeneID 23032
KEGG hsa:23032
UCSC uc001dhs.3
uc001dhw.4
CTD 23032
GeneCards GC01M078161
H-InvDB HIX0159957
HGNC HGNC:20059
HPA HPA005719
MIM 615146
neXtProt NX_Q8TEY7
PharmGKB PA134955343
eggNOG COG5560
GeneTree ENSGT00760000119208
HOGENOM HOG000286031
HOVERGEN HBG054196
InParanoid Q8TEY7
KO K11848
OMA TMEEDKS
OrthoDB EOG7CRTP2
PhylomeDB Q8TEY7
TreeFam TF352179
ChiTaRS USP33
EvolutionaryTrace Q8TEY7
GeneWiki USP33
GenomeRNAi 23032
NextBio 44018
PRO PR:Q8TEY7
Proteomes UP000005640
Bgee Q8TEY7
CleanEx HS_USP33
ExpressionAtlas Q8TEY7
Genevestigator Q8TEY7
GO GO:0044297
GO:0005813
GO:0005737
GO:0005794
GO:0048471
GO:0030891
GO:0004197
GO:0001664
GO:0004221
GO:0004843
GO:0008270
GO:0007411
GO:0016477
GO:0051298
GO:0006897
GO:0016579
GO:0071108
GO:0070536
GO:0008277
GO:0006511
Gene3D 3.30.2230.10
3.30.40.10
InterPro IPR006615
IPR001394
IPR018200
IPR028889
IPR013083
IPR001607
Pfam PF06337
PF00443
PF02148
SMART SM00695
SUPFAM SSF143791
PROSITE PS51283
PS00972
PS00973
PS50235
PS50271

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0005813

centrosome

PMID:23486064[1]

ECO:0000314

C

Figure 2

complete
CACAO 6988

GO:0050821

protein stabilization

PMID:23486064[1]

ECO:0000315

P

Supplementary Figure 4e and 4f

complete
CACAO 6989

involved_in

GO:0010506

regulation of autophagy

PMID:24056301[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0009267

cellular response to starvation

PMID:24056301[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0048471

perinuclear region of cytoplasm

PMID:24056301[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0032092

positive regulation of protein binding

PMID:24056301[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0032091

negative regulation of protein binding

PMID:24056301[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0016579

protein deubiquitination

PMID:24056301[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

has_direct_input:(UniProtKB:P11234)

Seeded From UniProt

complete

enables

GO:0004843

thiol-dependent ubiquitin-specific protease activity

PMID:24056301[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

has_direct_input:(UniProtKB:P11234)

Seeded From UniProt

complete

enables

GO:0017160

Ral GTPase binding

PMID:24056301[2]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P11234

F

Seeded From UniProt

complete

enables

GO:0017160

Ral GTPase binding

PMID:24056301[2]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P11233

F

Seeded From UniProt

complete

involved_in

GO:0050821

protein stabilization

PMID:23486064[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005813

centrosome

PMID:23486064[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0071108

protein K48-linked deubiquitination

PMID:19363159[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0070536

protein K63-linked deubiquitination

PMID:19363159[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0051298

centrosome duplication

PMID:23486064[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

NOT|enables

GO:0043130

ubiquitin binding

PMID:17766394[4]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0016579

protein deubiquitination

PMID:23486064[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0016579

protein deubiquitination

PMID:19363159[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0016579

protein deubiquitination

PMID:19424180[5]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0016579

protein deubiquitination

PMID:11739384[6]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0016477

cell migration

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q8R5K2

P

Seeded From UniProt

complete

involved_in

GO:0008277

regulation of G protein-coupled receptor signaling pathway

PMID:19363159[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0008277

regulation of G protein-coupled receptor signaling pathway

PMID:19424180[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0008270

zinc ion binding

PMID:17766394[4]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0007411

axon guidance

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q8R5K2

P

Seeded From UniProt

complete

part_of

GO:0005813

centrosome

PMID:23486064[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0004843

thiol-dependent ubiquitin-specific protease activity

PMID:23486064[1]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0036459

thiol-dependent ubiquitinyl hydrolase activity

PMID:23486064[1]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0036459

thiol-dependent ubiquitinyl hydrolase activity

PMID:19424180[5]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0036459

thiol-dependent ubiquitinyl hydrolase activity

PMID:19363159[3]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0004197

cysteine-type endopeptidase activity

PMID:23486064[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0004197

cysteine-type endopeptidase activity

PMID:19424180[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0004197

cysteine-type endopeptidase activity

PMID:19363159[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0001664

G protein-coupled receptor binding

PMID:19424180[5]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P07550

F

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1858178
PANTHER:PTN001163306

C

Seeded From UniProt

complete

part_of

GO:0005925

focal adhesion

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005794

Golgi apparatus

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0044297

cell body

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8R5K2
ensembl:ENSMUSP00000142708

C

Seeded From UniProt

complete

involved_in

GO:0016477

cell migration

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8R5K2
ensembl:ENSMUSP00000142708

P

Seeded From UniProt

complete

involved_in

GO:0007411

axon guidance

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8R5K2
ensembl:ENSMUSP00000142708

P

Seeded From UniProt

complete

enables

GO:0004843

thiol-dependent ubiquitin-specific protease activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR006615

F

Seeded From UniProt

complete

involved_in

GO:0006511

ubiquitin-dependent protein catabolic process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR018200

P

Seeded From UniProt

complete

enables

GO:0008270

zinc ion binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001607

F

Seeded From UniProt

complete

involved_in

GO:0016579

protein deubiquitination

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001394

P

Seeded From UniProt

complete

enables

GO:0036459

thiol-dependent ubiquitinyl hydrolase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001394
InterPro:IPR018200

F

Seeded From UniProt

complete

enables

GO:0036459

thiol-dependent ubiquitinyl hydrolase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:3.4.19.12

F

Seeded From UniProt

complete

part_of

GO:0005794

Golgi apparatus

PMID:21801292[8]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0030891

VCB complex

PMID:11739384[6]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0006511

ubiquitin-dependent protein catabolic process

PMID:11739384[6]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:11739384[6]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0004843

thiol-dependent ubiquitin-specific protease activity

PMID:11739384[6]
Reactome:R-HSA-8986083

ECO:0000304

author statement supported by traceable reference used in manual assertion


F

Seeded From UniProt

complete

enables

GO:0036459

thiol-dependent ubiquitinyl hydrolase activity

Reactome:R-HSA-5696968
Reactome:R-HSA-5696945

ECO:0000304

author statement supported by traceable reference used in manual assertion


F

Seeded From UniProt

complete

involved_in

GO:0016579

protein deubiquitination

Reactome:R-HSA-5688426

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

Reactome:R-HSA-8986083
Reactome:R-HSA-5696968
Reactome:R-HSA-5696945

ECO:0000304

author statement supported by traceable reference used in manual assertion



C

Seeded From UniProt

complete

part_of

GO:0005794

Golgi apparatus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0333
UniProtKB-SubCell:SL-0132

C

Seeded From UniProt

complete

involved_in

GO:0006897

endocytosis

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0254

P

Seeded From UniProt

complete

involved_in

GO:0006508

proteolysis

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0645

P

Seeded From UniProt

complete

part_of

GO:0005856

cytoskeleton

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0206

C

Seeded From UniProt

complete

enables

GO:0008234

cysteine-type peptidase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0788

F

Seeded From UniProt

complete

enables

GO:0016787

hydrolase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0378

F

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963

C

Seeded From UniProt

complete

enables

GO:0008233

peptidase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0645

F

Seeded From UniProt

complete

part_of

GO:0048471

perinuclear region of cytoplasm

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0198

C

Seeded From UniProt

complete

part_of

GO:0005815

microtubule organizing center

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0048

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 1.9 Li, J et al. (2013) USP33 regulates centrosome biogenesis via deubiquitination of the centriolar protein CP110. Nature 495 255-9 PubMed GONUTS page
  2. 2.0 2.1 2.2 2.3 2.4 2.5 2.6 2.7 2.8 Simicek, M et al. (2013) The deubiquitylase USP33 discriminates between RALB functions in autophagy and innate immune response. Nat. Cell Biol. 15 1220-30 PubMed GONUTS page
  3. 3.0 3.1 3.2 3.3 3.4 3.5 Shenoy, SK et al. (2009) Beta-arrestin-dependent signaling and trafficking of 7-transmembrane receptors is reciprocally regulated by the deubiquitinase USP33 and the E3 ligase Mdm2. Proc. Natl. Acad. Sci. U.S.A. 106 6650-5 PubMed GONUTS page
  4. 4.0 4.1 Allen, MD & Bycroft, M (2007) The solution structure of the ZnF UBP domain of USP33/VDU1. Protein Sci. 16 2072-5 PubMed GONUTS page
  5. 5.0 5.1 5.2 5.3 5.4 Berthouze, M et al. (2009) The deubiquitinases USP33 and USP20 coordinate beta2 adrenergic receptor recycling and resensitization. EMBO J. 28 1684-96 PubMed GONUTS page
  6. 6.0 6.1 6.2 6.3 6.4 Li, Z et al. (2002) Ubiquitination of a novel deubiquitinating enzyme requires direct binding to von Hippel-Lindau tumor suppressor protein. J. Biol. Chem. 277 4656-62 PubMed GONUTS page
  7. Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  8. Thorne, C et al. (2011) Isoform-specific localization of the deubiquitinase USP33 to the Golgi apparatus. Traffic 12 1563-74 PubMed GONUTS page