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HUMAN:TX1B3

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) TAX1BP3 (ECO:0000312 with HGNC:HGNC:30684) (synonyms: TIP1 (ECO:0000312 with EMBL:AAF43104.1))
Protein Name(s) Tax1-binding protein 3

Glutaminase-interacting protein 3 Tax interaction protein 1 TIP-1 Tax-interacting protein 1

External Links
UniProt O14907
EMBL AF028823
AF168787
AF234997
AF277318
AK315408
CH471108
CH471108
BC023980
CCDS CCDS11032.1
RefSeq NP_001191627.1
NP_055419.1
UniGene Hs.12956
Hs.731607
PDB 2KG2
2L4S
2L4T
2VZ5
3GJ9
3SFJ
4E3B
PDBsum 2KG2
2L4S
2L4T
2VZ5
3GJ9
3SFJ
4E3B
ProteinModelPortal O14907
SMR O14907
BioGrid 119061
IntAct O14907
MINT MINT-142501
STRING 9606.ENSP00000225525
PhosphoSite O14907
UCD-2DPAGE O14907
MaxQB O14907
PaxDb O14907
PRIDE O14907
DNASU 30851
Ensembl ENST00000225525
GeneID 30851
KEGG hsa:30851
UCSC uc002fwc.3
CTD 30851
GeneCards GC17M003566
HGNC HGNC:30684
neXtProt NX_O14907
PharmGKB PA134950693
eggNOG NOG236405
GeneTree ENSGT00390000002877
HOGENOM HOG000015753
HOVERGEN HBG052814
InParanoid O14907
OMA DPTQNPF
OrthoDB EOG7S4X7S
PhylomeDB O14907
TreeFam TF318964
BRENDA 3.5.1.2
ChiTaRS TAX1BP3
EvolutionaryTrace O14907
GeneWiki TAX1BP3
GenomeRNAi 30851
NextBio 52992
PRO PR:O14907
Proteomes UP000005640
Bgee O14907
CleanEx HS_TAX1BP3
Genevestigator O14907
GO GO:0005737
GO:0070062
GO:0005634
GO:0005886
GO:0008022
GO:0032864
GO:0008285
GO:2000009
GO:0030178
GO:0007266
GO:0016055
Gene3D 2.30.42.10
InterPro IPR001478
IPR017268
Pfam PF00595
PIRSF PIRSF037712
SMART SM00228
SUPFAM SSF50156
PROSITE PS50106

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0030165

PDZ domain binding

21139582

ECO:0000021

UniProtKB:O14907 UniProtKB:Q5VV41


F

Figure 1 Interactions, regulation and stability of GEF16. (A) Yeast mating assay confirming that Tip-1 binds to short carboxyl terminal GEF16 fragments isolated from the primary Tip-1 yeast two-hybrid screen. (B) Glutathione transferase pull-down of Tip-1 with IVTT full-length wildtype and mutant GEF16 (wtGEF16/mutGEF16). The wtGEF16 contains the PDZ-binding domain ETDV, whereas mutGEF16 has the TDV residues deleted. Tip-1-GST fusion protein and GST control protein were bound to glutathione-sepharose beads. These were mixed with equal amounts of the IVTT wtGEF16 or mutGEF16 proteins, and then washed with binding buffer. Bound proteins were separated by SDS–PAGE and visualised by western immunoblotting with anti-GEF16. The GST-Tip-1 protein bound to the wtGEF16, but did not bind to the mutant form, whereas the GST control did not bind either product

Missing: reference

GO:0043088

regulation of Cdc42 GTPase activity

PMID:21139582[1]

ECO:0000314

P

Fluorescent kinetic analysis of Cdc42 activation by GEF16 in the presence of high-risk HPV16 E6 and Tip-1. Different combinations of 2 mM concentrations of the recombinant proteins GEF16, Tip-1 and HPV16 E6 were added after 4 min of initial readings being taken with Cdc42 and assay buffers alone. Each combination was carried out in triplicate. It can be seen that Cdc42 activation by GEF16 is enhanced in the presence of Tip-1 and E6. HPV16 E6, Tip-1, ARHGEF16 and Cdc42 activation.

complete

part_of

GO:0070062

extracellular exosome

PMID:19056867[2]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(UBERON:0001088)

Seeded From UniProt

complete

involved_in

GO:0090630

activation of GTPase activity

PMID:21139582[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:2000009

negative regulation of protein localization to cell surface

PMID:16855024[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0030178

negative regulation of Wnt signaling pathway

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q9DBG9

P

Seeded From UniProt

complete

enables

GO:0008022

protein C-terminus binding

PMID:16855024[3]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P48050

F

Seeded From UniProt

complete

involved_in

GO:0007266

Rho protein signal transduction

PMID:10940294[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:10940294[4]

ECO:0000303

author statement without traceable support used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0043231

intracellular membrane-bounded organelle

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0015629

actin cytoskeleton

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0001650

fibrillar center

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0030178

negative regulation of Wnt signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9DBG9
ensembl:ENSMUSP00000047410

P

Seeded From UniProt

complete

involved_in

GO:0008285

negative regulation of cell population proliferation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9DBG9
ensembl:ENSMUSP00000047410

P

Seeded From UniProt

complete

enables

GO:0008013

beta-catenin binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9DBG9
ensembl:ENSMUSP00000047410

F

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9DBG9
ensembl:ENSMUSP00000047410

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9DBG9
ensembl:ENSMUSP00000047410

C

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

Reactome:R-HSA-5666216

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1003
UniProtKB-SubCell:SL-0039

C

Seeded From UniProt

complete

involved_in

GO:0016055

Wnt signaling pathway

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0879

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 Oliver, AW et al. (2011) The HPV16 E6 binding protein Tip-1 interacts with ARHGEF16, which activates Cdc42. Br. J. Cancer 104 324-31 PubMed GONUTS page
  2. Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page
  3. 3.0 3.1 Alewine, C et al. (2006) TIP-1 has PDZ scaffold antagonist activity. Mol. Biol. Cell 17 4200-11 PubMed GONUTS page
  4. 4.0 4.1 Reynaud, C et al. (2000) The PDZ protein TIP-1 interacts with the Rho effector rhotekin and is involved in Rho signaling to the serum response element. J. Biol. Chem. 275 33962-8 PubMed GONUTS page