GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.

Have any questions? Please email us at ecoliwiki@gmail.com

HUMAN:TRFE

From GONUTS
Jump to: navigation, search
Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) TF
Protein Name(s) Serotransferrin

Transferrin Beta-1 metal-binding globulin Siderophilin

External Links
UniProt P02787
EMBL M12530
M17611
M17610
M17614
M17612
M17613
S95936
AF288144
AF294270
AF294271
AF288139
AF288140
AF288141
AF288142
AF288143
AY308797
DQ525716
AC080128
AC083905
CH471052
BC059367
M21569
M15673
M21570
X04600
AJ252279
M11372
M11361
M11362
M11363
M11364
M11365
M11366
M11367
M11368
M11369
M11370
M11371
AF118063
M12525
U88581
AF058327
M26641
CCDS CCDS3080.1
PIR A20981
RefSeq NP_001054.1
UniGene Hs.518267
PDB 1A8E
1A8F
1B3E
1BP5
1BTJ
1D3K
1D4N
1DTG
1FQE
1FQF
1JQF
1N7W
1N7X
1N84
1OQG
1OQH
1RYO
1SUV
2HAU
2HAV
2O7U
2O84
3FGS
3QYT
3S9L
3S9M
3S9N
3SKP
3V83
3V89
3V8X
3VE1
4H0W
PDBsum 1A8E
1A8F
1B3E
1BP5
1BTJ
1D3K
1D4N
1DTG
1FQE
1FQF
1JQF
1N7W
1N7X
1N84
1OQG
1OQH
1RYO
1SUV
2HAU
2HAV
2O7U
2O84
3FGS
3QYT
3S9L
3S9M
3S9N
3SKP
3V83
3V89
3V8X
3VE1
4H0W
ProteinModelPortal P02787
SMR P02787
BioGrid 112876
DIP DIP-2738N
IntAct P02787
MINT MINT-1400694
STRING 9606.ENSP00000264998
ChEMBL CHEMBL4865
DrugBank DB01370
DB01294
DB05260
DB00893
MEROPS S60.972
PhosphoSite P02787
UniCarbKB P02787
DMDM 313104271
DOSAC-COBS-2DPAGE P02787
REPRODUCTION-2DPAGE IPI00022463
P02787
SWISS-2DPAGE P02787
UCD-2DPAGE P02787
MaxQB P02787
PaxDb P02787
PRIDE P02787
Ensembl ENST00000402696
GeneID 7018
KEGG hsa:7018
UCSC uc003epu.2
CTD 7018
GeneCards GC03P133464
HGNC HGNC:11740
HPA CAB009538
HPA001527
HPA005692
MIM 190000
209300
neXtProt NX_P02787
Orphanet 1195
PharmGKB PA36457
eggNOG NOG87503
GeneTree ENSGT00390000001619
HOGENOM HOG000252723
HOVERGEN HBG000055
InParanoid P02787
KO K14736
OMA IGLLYCD
OrthoDB EOG7D59N7
PhylomeDB P02787
TreeFam TF324013
Reactome REACT_25060
REACT_25283
ChiTaRS TF
EvolutionaryTrace P02787
GeneWiki Transferrin
GenomeRNAi 7018
NextBio 27415
PMAP-CutDB P02787
PRO PR:P02787
Proteomes UP000005640
Bgee P02787
CleanEx HS_TF
ExpressionAtlas P02787
Genevestigator P02787
GO GO:0016324
GO:0045178
GO:0009925
GO:0072562
GO:0009986
GO:0005905
GO:0016023
GO:0005769
GO:0030139
GO:0010008
GO:0005576
GO:0005615
GO:0070062
GO:0005770
GO:0048471
GO:0055037
GO:0034774
GO:0031982
GO:0008199
GO:0007596
GO:0006879
GO:0030168
GO:0002576
GO:0001895
GO:0033572
GO:0055085
InterPro IPR016357
IPR001156
IPR018195
Pfam PF00405
PIRSF PIRSF002549
PRINTS PR00422
SMART SM00094
PROSITE PS00205
PS00206
PS00207
PS51408

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0048471

perinuclear region of cytoplasm

PMID:20202662[1]

ECO:0000314

C

Fig. 2B

complete
CACAO 2404

enables

GO:0034986

iron chaperone activity

PMID:18353247[2]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0048260

positive regulation of receptor-mediated endocytosis

PMID:18353247[2]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:Q07891,UniProtKB:Q9UP52

P

Seeded From UniProt

complete

enables

GO:1990459

transferrin receptor binding

PMID:18353247[2]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P02786

F

Seeded From UniProt

complete

enables

GO:1990459

transferrin receptor binding

PMID:18353247[2]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q9UP52

F

Seeded From UniProt

complete

involved_in

GO:0034756

regulation of iron ion transport

PMID:18353247[2]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:Q9UP52

P

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

PMID:9990067[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0048260

positive regulation of receptor-mediated endocytosis

PMID:12704209[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0008198

ferrous iron binding

PMID:18353247[2]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0031232

extrinsic component of external side of plasma membrane

PMID:18353247[2]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:Q9UP52

C

Seeded From UniProt

complete

involved_in

GO:0055072

iron ion homeostasis

PMID:18353247[2]

ECO:0000305

curator inference used in manual assertion

GO:1990459

P

part_of:(GO:0071281)

Seeded From UniProt

complete

involved_in

GO:0071281

cellular response to iron ion

PMID:18353247[2]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:Q07891,UniProtKB:Q9UP52

P

Seeded From UniProt

complete

part_of

GO:0048471

perinuclear region of cytoplasm

PMID:20202662[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0070062

extracellular exosome

PMID:23533145[5]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0031982

vesicle

PMID:18353773[6]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0072562

blood microparticle

PMID:22516433[7]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0070062

extracellular exosome

PMID:19056867[8]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(UBERON:0001088)

Seeded From UniProt

complete

part_of

GO:0009986

cell surface

PMID:16195351[9]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

PMID:16502470[10]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(UBERON:0001914)

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

PMID:23580065[11]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(UBERON:0001827)

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

PMID:22664934[12]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(UBERON:0001827)

Seeded From UniProt

complete

involved_in

GO:0001895

retina homeostasis

PMID:23580065[11]

ECO:0007007

high throughput expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:1990712

HFE-transferrin receptor complex

PMID:9546397[13]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:1990459

transferrin receptor binding

PMID:9546397[13]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P02786

F

Seeded From UniProt

complete

part_of

GO:0055037

recycling endosome

PMID:15880641[14]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0048471

perinuclear region of cytoplasm

PMID:15880641[14]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0045178

basal part of cell

PMID:15880641[14]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0016324

apical plasma membrane

PMID:11208127[15]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0031410

cytoplasmic vesicle

PMID:12857860[16]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0009925

basal plasma membrane

PMID:15880641[14]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005905

clathrin-coated pit

PMID:12857860[16]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005770

late endosome

PMID:15880641[14]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005769

early endosome

PMID:15880641[14]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

PMID:14718574[17]

ECO:0000303

author statement without traceable support used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0030139

endocytic vesicle

PMID:15292400[18]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0030139

endocytic vesicle

PMID:15229288[19]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0034755

iron ion transmembrane transport

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0015091

P

Seeded From UniProt

complete

involved_in

GO:0072512

trivalent inorganic cation transport

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0015091

P

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR018195

C

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR016357
InterPro:IPR030685

C

Seeded From UniProt

complete

involved_in

GO:0006826

iron ion transport

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR030685

P

Seeded From UniProt

complete

involved_in

GO:0006879

cellular iron ion homeostasis

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR030685

P

Seeded From UniProt

complete

enables

GO:0008199

ferric iron binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR030685

F

Seeded From UniProt

complete

enables

GO:0015091

ferric iron transmembrane transporter activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR030685

F

Seeded From UniProt

complete

involved_in

GO:0031647

regulation of protein stability

PMID:25635054[20]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

has_regulation_target:(UniProtKB:Q9UP52)

Seeded From UniProt

complete

enables

GO:1990459

transferrin receptor binding

PMID:9465039[21]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0061024

membrane organization

Reactome:R-HSA-199991

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0044267

cellular protein metabolic process

Reactome:R-HSA-392499

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0043687

post-translational protein modification

Reactome:R-HSA-597592

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0034774

secretory granule lumen

Reactome:R-HSA-482770

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0033572

transferrin transport

Reactome:R-HSA-917977

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0030665

clathrin-coated vesicle membrane

Reactome:R-HSA-8871194
Reactome:R-HSA-8871193
Reactome:R-HSA-8869438
Reactome:R-HSA-8868661
Reactome:R-HSA-8868660
Reactome:R-HSA-8868659
Reactome:R-HSA-8868658

ECO:0000304

author statement supported by traceable reference used in manual assertion







C

Seeded From UniProt

complete

part_of

GO:0010008

endosome membrane

Reactome:R-HSA-917835
Reactome:R-HSA-917814
Reactome:R-HSA-917807

ECO:0000304

author statement supported by traceable reference used in manual assertion



C

Seeded From UniProt

complete

involved_in

GO:0006879

cellular iron ion homeostasis

Reactome:R-HSA-917937

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005788

endoplasmic reticulum lumen

Reactome:R-HSA-8952289

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

Reactome:R-HSA-917987
Reactome:R-HSA-917888
Reactome:R-HSA-917839
Reactome:R-HSA-917814
Reactome:R-HSA-917807
Reactome:R-HSA-8868661
Reactome:R-HSA-8868651
Reactome:R-HSA-8868648
Reactome:R-HSA-8868236
Reactome:R-HSA-8868230
Reactome:R-HSA-8868072
Reactome:R-HSA-8868071
Reactome:R-HSA-8867756
Reactome:R-HSA-8867754
Reactome:R-HSA-8866277
Reactome:R-HSA-5691150
Reactome:R-HSA-482770

ECO:0000304

author statement supported by traceable reference used in manual assertion

















C

Seeded From UniProt

complete

involved_in

GO:0002576

platelet degranulation

Reactome:R-HSA-114608

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0055072

iron ion homeostasis

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0410

P

Seeded From UniProt

complete

involved_in

GO:0006811

ion transport

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0406

P

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0964
UniProtKB-SubCell:SL-0243

C

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 Bhattacharyya, S et al. (2010) Ebola virus uses clathrin-mediated endocytosis as an entry pathway. Virology 401 18-28 PubMed GONUTS page
  2. 2.0 2.1 2.2 2.3 2.4 2.5 2.6 2.7 2.8 Waheed, A et al. (2008) HFE association with transferrin receptor 2 increases cellular uptake of transferrin-bound iron. Arch. Biochem. Biophys. 474 193-7 PubMed GONUTS page
  3. Waheed, A et al. (1999) Association of HFE protein with transferrin receptor in crypt enterocytes of human duodenum. Proc. Natl. Acad. Sci. U.S.A. 96 1579-84 PubMed GONUTS page
  4. Griffiths, WJ & Cox, TM (2003) Co-localization of the mammalian hemochromatosis gene product (HFE) and a newly identified transferrin receptor (TfR2) in intestinal tissue and cells. J. Histochem. Cytochem. 51 613-24 PubMed GONUTS page
  5. Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page
  6. Schöbel, S et al. (2008) A novel sorting nexin modulates endocytic trafficking and alpha-secretase cleavage of the amyloid precursor protein. J. Biol. Chem. 283 14257-68 PubMed GONUTS page
  7. Bastos-Amador, P et al. (2012) Proteomic analysis of microvesicles from plasma of healthy donors reveals high individual variability. J Proteomics 75 3574-84 PubMed GONUTS page
  8. Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page
  9. Strick, DJ & Elferink, LA (2005) Rab15 effector protein: a novel protein for receptor recycling from the endocytic recycling compartment. Mol. Biol. Cell 16 5699-709 PubMed GONUTS page
  10. Palmer, DJ et al. (2006) Human colostrum: identification of minor proteins in the aqueous phase by proteomics. Proteomics 6 2208-16 PubMed GONUTS page
  11. 11.0 11.1 Pieragostino, D et al. (2013) Shotgun proteomics reveals specific modulated protein patterns in tears of patients with primary open angle glaucoma naïve to therapy. Mol Biosyst 9 1108-16 PubMed GONUTS page
  12. Böhm, D et al. (2012) Comparison of tear protein levels in breast cancer patients and healthy controls using a de novo proteomic approach. Oncol. Rep. 28 429-38 PubMed GONUTS page
  13. 13.0 13.1 Lebrón, JA et al. (1998) Crystal structure of the hemochromatosis protein HFE and characterization of its interaction with transferrin receptor. Cell 93 111-23 PubMed GONUTS page
  14. 14.0 14.1 14.2 14.3 14.4 14.5 Gruper, Y et al. (2005) Transferrin receptor co-localizes and interacts with the hemochromatosis factor (HFE) and the divalent metal transporter-1 (DMT1) in trophoblast cells. J. Cell. Physiol. 204 901-12 PubMed GONUTS page
  15. Durrbach, A et al. (2000) Truncated brush border myosin I affects membrane traffic in polarized epithelial cells. Traffic 1 411-24 PubMed GONUTS page
  16. 16.0 16.1 Aschenbrenner, L et al. (2003) Myo6 facilitates the translocation of endocytic vesicles from cell peripheries. Mol. Biol. Cell 14 2728-43 PubMed GONUTS page
  17. Anderson, NL et al. (2004) The human plasma proteome: a nonredundant list developed by combination of four separate sources. Mol. Cell Proteomics 3 311-26 PubMed GONUTS page
  18. Simonsen, A et al. (2004) Alfy, a novel FYVE-domain-containing protein associated with protein granules and autophagic membranes. J. Cell. Sci. 117 4239-51 PubMed GONUTS page
  19. Coumailleau, F et al. (2004) Over-expression of Rififylin, a new RING finger and FYVE-like domain-containing protein, inhibits recycling from the endocytic recycling compartment. Mol. Biol. Cell 15 4444-56 PubMed GONUTS page
  20. Chen, J & Enns, CA (2015) CD81 promotes both the degradation of transferrin receptor 2 (TfR2) and the Tfr2-mediated maintenance of hepcidin expression. J. Biol. Chem. 290 7841-50 PubMed GONUTS page
  21. Feder, JN et al. (1998) The hemochromatosis gene product complexes with the transferrin receptor and lowers its affinity for ligand binding. Proc. Natl. Acad. Sci. U.S.A. 95 1472-7 PubMed GONUTS page