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HUMAN:TRFE
Contents
Species (Taxon ID) | Homo sapiens (Human). (9606) | |
Gene Name(s) | TF | |
Protein Name(s) | Serotransferrin
Transferrin Beta-1 metal-binding globulin Siderophilin | |
External Links | ||
UniProt | P02787 | |
EMBL | M12530 M17611 M17610 M17614 M17612 M17613 S95936 AF288144 AF294270 AF294271 AF288139 AF288140 AF288141 AF288142 AF288143 AY308797 DQ525716 AC080128 AC083905 CH471052 BC059367 M21569 M15673 M21570 X04600 AJ252279 M11372 M11361 M11362 M11363 M11364 M11365 M11366 M11367 M11368 M11369 M11370 M11371 AF118063 M12525 U88581 AF058327 M26641 | |
CCDS | CCDS3080.1 | |
PIR | A20981 | |
RefSeq | NP_001054.1 | |
UniGene | Hs.518267 | |
PDB | 1A8E 1A8F 1B3E 1BP5 1BTJ 1D3K 1D4N 1DTG 1FQE 1FQF 1JQF 1N7W 1N7X 1N84 1OQG 1OQH 1RYO 1SUV 2HAU 2HAV 2O7U 2O84 3FGS 3QYT 3S9L 3S9M 3S9N 3SKP 3V83 3V89 3V8X 3VE1 4H0W | |
PDBsum | 1A8E 1A8F 1B3E 1BP5 1BTJ 1D3K 1D4N 1DTG 1FQE 1FQF 1JQF 1N7W 1N7X 1N84 1OQG 1OQH 1RYO 1SUV 2HAU 2HAV 2O7U 2O84 3FGS 3QYT 3S9L 3S9M 3S9N 3SKP 3V83 3V89 3V8X 3VE1 4H0W | |
ProteinModelPortal | P02787 | |
SMR | P02787 | |
BioGrid | 112876 | |
DIP | DIP-2738N | |
IntAct | P02787 | |
MINT | MINT-1400694 | |
STRING | 9606.ENSP00000264998 | |
ChEMBL | CHEMBL4865 | |
DrugBank | DB01370 DB01294 DB05260 DB00893 | |
MEROPS | S60.972 | |
PhosphoSite | P02787 | |
UniCarbKB | P02787 | |
DMDM | 313104271 | |
DOSAC-COBS-2DPAGE | P02787 | |
REPRODUCTION-2DPAGE | IPI00022463 P02787 | |
SWISS-2DPAGE | P02787 | |
UCD-2DPAGE | P02787 | |
MaxQB | P02787 | |
PaxDb | P02787 | |
PRIDE | P02787 | |
Ensembl | ENST00000402696 | |
GeneID | 7018 | |
KEGG | hsa:7018 | |
UCSC | uc003epu.2 | |
CTD | 7018 | |
GeneCards | GC03P133464 | |
HGNC | HGNC:11740 | |
HPA | CAB009538 HPA001527 HPA005692 | |
MIM | 190000 209300 | |
neXtProt | NX_P02787 | |
Orphanet | 1195 | |
PharmGKB | PA36457 | |
eggNOG | NOG87503 | |
GeneTree | ENSGT00390000001619 | |
HOGENOM | HOG000252723 | |
HOVERGEN | HBG000055 | |
InParanoid | P02787 | |
KO | K14736 | |
OMA | IGLLYCD | |
OrthoDB | EOG7D59N7 | |
PhylomeDB | P02787 | |
TreeFam | TF324013 | |
Reactome | REACT_25060 REACT_25283 | |
ChiTaRS | TF | |
EvolutionaryTrace | P02787 | |
GeneWiki | Transferrin | |
GenomeRNAi | 7018 | |
NextBio | 27415 | |
PMAP-CutDB | P02787 | |
PRO | PR:P02787 | |
Proteomes | UP000005640 | |
Bgee | P02787 | |
CleanEx | HS_TF | |
ExpressionAtlas | P02787 | |
Genevestigator | P02787 | |
GO | GO:0016324 GO:0045178 GO:0009925 GO:0072562 GO:0009986 GO:0005905 GO:0016023 GO:0005769 GO:0030139 GO:0010008 GO:0005576 GO:0005615 GO:0070062 GO:0005770 GO:0048471 GO:0055037 GO:0034774 GO:0031982 GO:0008199 GO:0007596 GO:0006879 GO:0030168 GO:0002576 GO:0001895 GO:0033572 GO:0055085 | |
InterPro | IPR016357 IPR001156 IPR018195 | |
Pfam | PF00405 | |
PIRSF | PIRSF002549 | |
PRINTS | PR00422 | |
SMART | SM00094 | |
PROSITE | PS00205 PS00206 PS00207 PS51408 |
Annotations
Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
---|---|---|---|---|---|---|---|---|---|---|
GO:0048471 |
perinuclear region of cytoplasm |
ECO:0000314 |
C |
Fig. 2B |
complete | |||||
enables |
GO:0034986 |
iron chaperone activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0048260 |
positive regulation of receptor-mediated endocytosis |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:1990459 |
transferrin receptor binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:1990459 |
transferrin receptor binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0034756 |
regulation of iron ion transport |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0005576 |
extracellular region |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0048260 |
positive regulation of receptor-mediated endocytosis |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0008198 |
ferrous iron binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0031232 |
extrinsic component of external side of plasma membrane |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0055072 |
iron ion homeostasis |
ECO:0000305 |
curator inference used in manual assertion |
GO:1990459 |
P |
part_of:(GO:0071281) |
Seeded From UniProt |
complete | |
involved_in |
GO:0071281 |
cellular response to iron ion |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0048471 |
perinuclear region of cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0070062 |
extracellular exosome |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0031982 |
vesicle |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0072562 |
blood microparticle |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0070062 |
extracellular exosome |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
part_of:(UBERON:0001088) |
Seeded From UniProt |
complete | ||
part_of |
GO:0009986 |
cell surface |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005615 |
extracellular space |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
part_of:(UBERON:0001914) |
Seeded From UniProt |
complete | ||
part_of |
GO:0005615 |
extracellular space |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
part_of:(UBERON:0001827) |
Seeded From UniProt |
complete | ||
part_of |
GO:0005615 |
extracellular space |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
part_of:(UBERON:0001827) |
Seeded From UniProt |
complete | ||
involved_in |
GO:0001895 |
retina homeostasis |
ECO:0007007 |
high throughput expression pattern evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:1990712 |
HFE-transferrin receptor complex |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:1990459 |
transferrin receptor binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0055037 |
recycling endosome |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0048471 |
perinuclear region of cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0045178 |
basal part of cell |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0016324 |
apical plasma membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0031410 |
cytoplasmic vesicle |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0009925 |
basal plasma membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005905 |
clathrin-coated pit |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005770 |
late endosome |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005769 |
early endosome |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005576 |
extracellular region |
ECO:0000303 |
author statement without traceable support used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0030139 |
endocytic vesicle |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0030139 |
endocytic vesicle |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0034755 |
iron ion transmembrane transport |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0015091 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0072512 |
trivalent inorganic cation transport |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0015091 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0005576 |
extracellular region |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005615 |
extracellular space |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006826 |
iron ion transport |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006879 |
cellular iron ion homeostasis |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0008199 |
ferric iron binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0015091 |
ferric iron transmembrane transporter activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0031647 |
regulation of protein stability |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
has_regulation_target:(UniProtKB:Q9UP52) |
Seeded From UniProt |
complete | ||
enables |
GO:1990459 |
transferrin receptor binding |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0061024 |
membrane organization |
Reactome:R-HSA-199991 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0044267 |
cellular protein metabolic process |
Reactome:R-HSA-392499 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0043687 |
post-translational protein modification |
Reactome:R-HSA-597592 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0034774 |
secretory granule lumen |
Reactome:R-HSA-482770 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | ||
involved_in |
GO:0033572 |
transferrin transport |
Reactome:R-HSA-917977 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0030665 |
clathrin-coated vesicle membrane |
Reactome:R-HSA-8871194 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
part_of |
GO:0010008 |
endosome membrane |
Reactome:R-HSA-917835 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
involved_in |
GO:0006879 |
cellular iron ion homeostasis |
Reactome:R-HSA-917937 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0005788 |
endoplasmic reticulum lumen |
Reactome:R-HSA-8952289 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0005576 |
extracellular region |
Reactome:R-HSA-917987 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
involved_in |
GO:0002576 |
platelet degranulation |
Reactome:R-HSA-114608 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0055072 |
iron ion homeostasis |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006811 |
ion transport |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0005576 |
extracellular region |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0046872 |
metal ion binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Bhattacharyya, S et al. (2010) Ebola virus uses clathrin-mediated endocytosis as an entry pathway. Virology 401 18-28 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 2.7 2.8 Waheed, A et al. (2008) HFE association with transferrin receptor 2 increases cellular uptake of transferrin-bound iron. Arch. Biochem. Biophys. 474 193-7 PubMed GONUTS page
- ↑ Waheed, A et al. (1999) Association of HFE protein with transferrin receptor in crypt enterocytes of human duodenum. Proc. Natl. Acad. Sci. U.S.A. 96 1579-84 PubMed GONUTS page
- ↑ Griffiths, WJ & Cox, TM (2003) Co-localization of the mammalian hemochromatosis gene product (HFE) and a newly identified transferrin receptor (TfR2) in intestinal tissue and cells. J. Histochem. Cytochem. 51 613-24 PubMed GONUTS page
- ↑ Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page
- ↑ Schöbel, S et al. (2008) A novel sorting nexin modulates endocytic trafficking and alpha-secretase cleavage of the amyloid precursor protein. J. Biol. Chem. 283 14257-68 PubMed GONUTS page
- ↑ Bastos-Amador, P et al. (2012) Proteomic analysis of microvesicles from plasma of healthy donors reveals high individual variability. J Proteomics 75 3574-84 PubMed GONUTS page
- ↑ Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page
- ↑ Strick, DJ & Elferink, LA (2005) Rab15 effector protein: a novel protein for receptor recycling from the endocytic recycling compartment. Mol. Biol. Cell 16 5699-709 PubMed GONUTS page
- ↑ Palmer, DJ et al. (2006) Human colostrum: identification of minor proteins in the aqueous phase by proteomics. Proteomics 6 2208-16 PubMed GONUTS page
- ↑ 11.0 11.1 Pieragostino, D et al. (2013) Shotgun proteomics reveals specific modulated protein patterns in tears of patients with primary open angle glaucoma naïve to therapy. Mol Biosyst 9 1108-16 PubMed GONUTS page
- ↑ Böhm, D et al. (2012) Comparison of tear protein levels in breast cancer patients and healthy controls using a de novo proteomic approach. Oncol. Rep. 28 429-38 PubMed GONUTS page
- ↑ 13.0 13.1 Lebrón, JA et al. (1998) Crystal structure of the hemochromatosis protein HFE and characterization of its interaction with transferrin receptor. Cell 93 111-23 PubMed GONUTS page
- ↑ 14.0 14.1 14.2 14.3 14.4 14.5 Gruper, Y et al. (2005) Transferrin receptor co-localizes and interacts with the hemochromatosis factor (HFE) and the divalent metal transporter-1 (DMT1) in trophoblast cells. J. Cell. Physiol. 204 901-12 PubMed GONUTS page
- ↑ Durrbach, A et al. (2000) Truncated brush border myosin I affects membrane traffic in polarized epithelial cells. Traffic 1 411-24 PubMed GONUTS page
- ↑ 16.0 16.1 Aschenbrenner, L et al. (2003) Myo6 facilitates the translocation of endocytic vesicles from cell peripheries. Mol. Biol. Cell 14 2728-43 PubMed GONUTS page
- ↑ Anderson, NL et al. (2004) The human plasma proteome: a nonredundant list developed by combination of four separate sources. Mol. Cell Proteomics 3 311-26 PubMed GONUTS page
- ↑ Simonsen, A et al. (2004) Alfy, a novel FYVE-domain-containing protein associated with protein granules and autophagic membranes. J. Cell. Sci. 117 4239-51 PubMed GONUTS page
- ↑ Coumailleau, F et al. (2004) Over-expression of Rififylin, a new RING finger and FYVE-like domain-containing protein, inhibits recycling from the endocytic recycling compartment. Mol. Biol. Cell 15 4444-56 PubMed GONUTS page
- ↑ Chen, J & Enns, CA (2015) CD81 promotes both the degradation of transferrin receptor 2 (TfR2) and the Tfr2-mediated maintenance of hepcidin expression. J. Biol. Chem. 290 7841-50 PubMed GONUTS page
- ↑ Feder, JN et al. (1998) The hemochromatosis gene product complexes with the transferrin receptor and lowers its affinity for ligand binding. Proc. Natl. Acad. Sci. U.S.A. 95 1472-7 PubMed GONUTS page
b
c
e
- GO:0005769 ! early endosome
- GO:0030139 ! endocytic vesicle
- GO:0005788 ! endoplasmic reticulum lumen
- GO:0010008 ! endosome membrane
- Euarchontoglires
- Eukaryota
- Euteleostomi
- Eutheria
- GO:0005615 ! extracellular space
- GO:0070062 ! extracellular exosome
- GO:0005576 ! extracellular region
- GO:0031232 ! extrinsic component of external side of plasma membrane
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