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HUMAN:TPX2

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) TPX2 (synonyms: C20orf1, C20orf2, DIL2, HCA519)
Protein Name(s) Targeting protein for Xklp2

Differentially expressed in cancerous and non-cancerous lung cells 2 DIL-2 Hepatocellular carcinoma-associated antigen 519 Hepatocellular carcinoma-associated antigen 90 Protein fls353 Restricted expression proliferation-associated protein 100 p100

External Links
UniProt Q9ULW0
EMBL AB027467
AF098158
AB024704
AF146731
AF287265
AL160175
CH471077
CH471077
BC004136
BC020207
AL117534
AF244547
CCDS CCDS13190.1
PIR T17292
RefSeq NP_036244.2
XP_011526999.1
XP_011527000.1
XP_011527001.1
UniGene Hs.244580
PDB 1OL5
3E5A
3HA6
4C3P
PDBsum 1OL5
3E5A
3HA6
4C3P
ProteinModelPortal Q9ULW0
SMR Q9ULW0
BioGrid 116624
DIP DIP-36727N
DIP-46212N
IntAct Q9ULW0
MINT MINT-4720346
STRING 9606.ENSP00000300403
ChEMBL CHEMBL5389
PhosphoSite Q9ULW0
BioMuta TPX2
DMDM 13124096
MaxQB Q9ULW0
PaxDb Q9ULW0
PRIDE Q9ULW0
Ensembl ENST00000300403
ENST00000340513
GeneID 22974
KEGG hsa:22974
UCSC uc002wwp.1
uc010gdv.1
CTD 22974
GeneCards GC20P031739
HGNC HGNC:1249
HPA HPA005487
MIM 605917
neXtProt NX_Q9ULW0
PharmGKB PA25638
eggNOG NOG82198
GeneTree ENSGT00390000009842
HOGENOM HOG000231739
HOVERGEN HBG057334
InParanoid Q9ULW0
KO K16812
OMA RARPVTC
OrthoDB EOG7W9RTQ
PhylomeDB Q9ULW0
TreeFam TF328997
ChiTaRS TPX2
EvolutionaryTrace Q9ULW0
GeneWiki TPX2
GenomeRNAi 22974
NextBio 43781
PRO PR:Q9ULW0
Proteomes UP000005640
Bgee Q9ULW0
CleanEx HS_TPX2
ExpressionAtlas Q9ULW0
Genevisible Q9ULW0
GO GO:0043203
GO:0005737
GO:0005874
GO:0015630
GO:0005654
GO:0005634
GO:0005819
GO:0000922
GO:0005524
GO:0005525
GO:0019901
GO:0032147
GO:0006915
GO:0051301
GO:0008283
GO:0007067
GO:0060236
InterPro IPR015128
IPR027329
IPR027330
IPR009675
PANTHER PTHR14326
Pfam PF09041
PF06886
PF12214

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0007020

microtubule nucleation

PMID:26414402[1]

ECO:0000314

P

Fig 6.b, and Fig 6.c shows microtuble nucleation by TPX2

complete
CACAO 10992

GO:0007026

negative regulation of microtubule depolymerization

PMID:26414402[1]

ECO:0000314

P

Fig 3f shows reduced depolymerization activity with TPX2.

complete
CACAO 11112

enables

GO:0061676

importin-alpha family protein binding

PMID:26165940[2]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0090307

mitotic spindle assembly

PMID:26165940[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0015630

microtubule cytoskeleton

GO_REF:0000054

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0032147

activation of protein kinase activity

PMID:19801554[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0019901

protein kinase binding

PMID:19801554[3]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:O14965

F

Seeded From UniProt

complete

colocalizes_with

GO:0000922

spindle pole

PMID:14718566[4]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0060236

regulation of mitotic spindle organization

PMID:18663142[5]

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:A2APB8

P

Seeded From UniProt

complete

involved_in

GO:0032147

activation of protein kinase activity

PMID:14580337[6]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0019901

protein kinase binding

PMID:18662907[7]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:O14965

F

Seeded From UniProt

complete

enables

GO:0019901

protein kinase binding

PMID:14580337[6]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:O14965

F

Seeded From UniProt

complete

part_of

GO:0005819

spindle

PMID:18663142[5]

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:A2APB8

C

Seeded From UniProt

complete

part_of

GO:0072686

mitotic spindle

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0045171

intercellular bridge

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005815

microtubule organizing center

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0090307

mitotic spindle assembly

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:A2APB8
ensembl:ENSMUSP00000128888

P

Seeded From UniProt

complete

enables

GO:0061676

importin-alpha family protein binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:A2APB8
ensembl:ENSMUSP00000128888

F

Seeded From UniProt

complete

involved_in

GO:0060236

regulation of mitotic spindle organization

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:A2APB8
ensembl:ENSMUSP00000128888

P

Seeded From UniProt

complete

part_of

GO:0043203

axon hillock

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:A2APB8
ensembl:ENSMUSP00000128888

C

Seeded From UniProt

complete

enables

GO:0019901

protein kinase binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:A2APB8
ensembl:ENSMUSP00000128888

F

Seeded From UniProt

complete

part_of

GO:0005819

spindle

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:A2APB8
ensembl:ENSMUSP00000128888

C

Seeded From UniProt

complete

part_of

GO:0005819

spindle

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR009675

C

Seeded From UniProt

complete

part_of

GO:0005874

microtubule

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR009675

C

Seeded From UniProt

complete

involved_in

GO:0032147

activation of protein kinase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR009675

P

Seeded From UniProt

complete

involved_in

GO:0060236

regulation of mitotic spindle organization

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR009675

P

Seeded From UniProt

complete

involved_in

GO:0000278

mitotic cell cycle

PMID:9207457[8]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005819

spindle

PMID:9207457[8]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:9207457[8]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:1901796

regulation of signal transduction by p53 class mediator

Reactome:R-HSA-5633007

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0010389

regulation of G2/M transition of mitotic cell cycle

Reactome:R-HSA-8854518

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

Reactome:R-HSA-8853419
Reactome:R-HSA-8853405

ECO:0000304

author statement supported by traceable reference used in manual assertion


C

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

Reactome:R-HSA-6805103

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963

C

Seeded From UniProt

complete

involved_in

GO:0006915

apoptotic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0053

P

Seeded From UniProt

complete

part_of

GO:0005856

cytoskeleton

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0206

C

Seeded From UniProt

complete

involved_in

GO:0051301

cell division

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0132

P

Seeded From UniProt

complete

involved_in

GO:0007049

cell cycle

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0131

P

Seeded From UniProt

complete

part_of

GO:0005874

microtubule

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0493

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

part_of

GO:0000922

spindle pole

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0448

C

Seeded From UniProt

complete

part_of

GO:0005819

spindle

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0251

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 Roostalu, J et al. (2015) Complementary activities of TPX2 and chTOG constitute an efficient importin-regulated microtubule nucleation module. Nat. Cell Biol. 17 1422-34 PubMed GONUTS page
  2. ↑ 2.0 2.1 Wei, JH et al. (2015) GM130 Regulates Golgi-Derived Spindle Assembly by Activating TPX2 and Capturing Microtubules. Cell 162 287-299 PubMed GONUTS page
  3. ↑ 3.0 3.1 Bibby, RA et al. (2009) A cancer-associated aurora A mutant is mislocalized and misregulated due to loss of interaction with TPX2. J. Biol. Chem. 284 33177-84 PubMed GONUTS page
  4. ↑ Cassimeris, L & Morabito, J (2004) TOGp, the human homolog of XMAP215/Dis1, is required for centrosome integrity, spindle pole organization, and bipolar spindle assembly. Mol. Biol. Cell 15 1580-90 PubMed GONUTS page
  5. ↑ 5.0 5.1 Bird, AW & Hyman, AA (2008) Building a spindle of the correct length in human cells requires the interaction between TPX2 and Aurora A. J. Cell Biol. 182 289-300 PubMed GONUTS page
  6. ↑ 6.0 6.1 Bayliss, R et al. (2003) Structural basis of Aurora-A activation by TPX2 at the mitotic spindle. Mol. Cell 12 851-62 PubMed GONUTS page
  7. ↑ Zhao, B et al. (2008) Modulation of kinase-inhibitor interactions by auxiliary protein binding: crystallography studies on Aurora A interactions with VX-680 and with TPX2. Protein Sci. 17 1791-7 PubMed GONUTS page
  8. ↑ 8.0 8.1 8.2 Heidebrecht, HJ et al. (1997) p100: a novel proliferation-associated nuclear protein specifically restricted to cell cycle phases S, G2, and M. Blood 90 226-33 PubMed GONUTS page
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