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HUMAN:TCO2
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | TCN2 (synonyms: TC2) | |
| Protein Name(s) | Transcobalamin-2
TC-2 Transcobalamin II TC II TCII | |
| External Links | ||
| UniProt | P20062 | |
| EMBL | M60396 L02647 L02648 AF047576 CR456591 AC005006 BC001176 BC011239 | |
| CCDS | CCDS13881.1 CCDS54519.1 | |
| PIR | A39744 | |
| RefSeq | NP_000346.2 NP_001171655.1 | |
| UniGene | Hs.417948 | |
| PDB | 2BB5 | |
| PDBsum | 2BB5 | |
| ProteinModelPortal | P20062 | |
| SMR | P20062 | |
| BioGrid | 112808 | |
| IntAct | P20062 | |
| STRING | 9606.ENSP00000215838 | |
| DrugBank | DB00115 DB00200 | |
| PhosphoSite | P20062 | |
| DMDM | 224471876 | |
| PaxDb | P20062 | |
| PRIDE | P20062 | |
| DNASU | 6948 | |
| Ensembl | ENST00000215838 ENST00000407817 | |
| GeneID | 6948 | |
| KEGG | hsa:6948 | |
| UCSC | uc003aip.2 uc003air.2 | |
| CTD | 6948 | |
| GeneCards | GC22P031002 | |
| HGNC | HGNC:11653 | |
| HPA | HPA000837 | |
| MIM | 275350 613441 | |
| neXtProt | NX_P20062 | |
| Orphanet | 859 | |
| PharmGKB | PA36404 | |
| eggNOG | NOG47054 | |
| GeneTree | ENSGT00530000063370 | |
| HOGENOM | HOG000074060 | |
| HOVERGEN | HBG001328 | |
| InParanoid | P20062 | |
| KO | K14619 | |
| OMA | GEREFWQ | |
| OrthoDB | EOG79GT6F | |
| PhylomeDB | P20062 | |
| TreeFam | TF333092 | |
| Reactome | REACT_163862 REACT_169120 REACT_169178 | |
| EvolutionaryTrace | P20062 | |
| GenomeRNAi | 6948 | |
| NextBio | 27203 | |
| PRO | PR:P20062 | |
| Proteomes | UP000005640 | |
| Bgee | P20062 | |
| CleanEx | HS_TCN2 | |
| ExpressionAtlas | P20062 | |
| Genevestigator | P20062 | |
| GO | GO:0005768 GO:0005576 GO:0005615 GO:0070062 GO:0043202 GO:0031419 GO:0046872 GO:0009235 GO:0015889 GO:0006824 GO:0044281 GO:0006766 GO:0006767 | |
| InterPro | IPR002157 IPR027954 IPR008930 | |
| PANTHER | PTHR10559 | |
| Pfam | PF01122 PF14478 | |
| SUPFAM | SSF48239 | |
| PROSITE | PS00468 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0031419 |
cobalamin binding |
ECO:0000315 |
F |
Figure 1b v shows the effect of the addition of immunostated rabbit, anti-human TCII H-260 to Rhodamine-labelled goat, anti-rabbit IgG secondary antibody on TCII protein expression |
complete | |||||
|
involved_in |
GO:0015889 |
cobalamin transport |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0031419 |
cobalamin binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005615 |
extracellular space |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0031419 |
cobalamin binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0031419 |
cobalamin binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0015889 |
cobalamin transport |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0031419 |
cobalamin binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0015889 |
cobalamin transport |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005615 |
extracellular space |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0043202 |
lysosomal lumen |
Reactome:R-HSA-3000263 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
|
involved_in |
GO:0009235 |
cobalamin metabolic process |
Reactome:R-HSA-196741 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005768 |
endosome |
Reactome:R-HSA-3000122 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
|
part_of |
GO:0005576 |
extracellular region |
Reactome:R-HSA-3325546 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
|
part_of |
GO:0005576 |
extracellular region |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006824 |
cobalt ion transport |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006811 |
ion transport |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0046872 |
metal ion binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Fowler, R et al. (2013) Uptake and transport of B12-conjugated nanoparticles in airway epithelium. J Control Release 172 374-81 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 Quadros, EV et al. (1993) Functional human transcobalamin II isoproteins are secreted by insect cells using the baculovirus expression system. Blood 81 1239-45 PubMed GONUTS page
- ↑ Alam, A et al. (2016) Structural basis of transcobalamin recognition by human CD320 receptor. Nat Commun 7 12100 PubMed GONUTS page
- ↑ Wuerges, J et al. (2006) Structural basis for mammalian vitamin B12 transport by transcobalamin. Proc. Natl. Acad. Sci. U.S.A. 103 4386-91 PubMed GONUTS page
- ↑ Quadros, EV et al. (1986) Purification and molecular characterization of human transcobalamin II. J. Biol. Chem. 261 15455-60 PubMed GONUTS page
- ↑ Platica, O et al. (1991) The cDNA sequence and the deduced amino acid sequence of human transcobalamin II show homology with rat intrinsic factor and human transcobalamin I. J. Biol. Chem. 266 7860-3 PubMed GONUTS page
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