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HUMAN:TAAR1
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | TAAR1 (synonyms: TA1, TAR1, TRAR1) | |
| Protein Name(s) | Trace amine-associated receptor 1
TaR-1 Trace amine receptor 1 | |
| External Links | ||
| UniProt | Q96RJ0 | |
| EMBL | AF380185 AF200627 AY180374 AL513524 BC101825 BC112194 | |
| CCDS | CCDS5158.1 | |
| RefSeq | NP_612200.1 | |
| UniGene | Hs.375030 | |
| ProteinModelPortal | Q96RJ0 | |
| SMR | Q96RJ0 | |
| BioGrid | 126416 | |
| STRING | 9606.ENSP00000275216 | |
| BindingDB | Q96RJ0 | |
| ChEMBL | CHEMBL5857 | |
| DrugBank | DB00182 DB01576 DB01577 DB06714 | |
| GuidetoPHARMACOLOGY | 364 | |
| PhosphoSite | Q96RJ0 | |
| DMDM | 38258636 | |
| MaxQB | Q96RJ0 | |
| PaxDb | Q96RJ0 | |
| PRIDE | Q96RJ0 | |
| DNASU | 134864 | |
| Ensembl | ENST00000275216 | |
| GeneID | 134864 | |
| KEGG | hsa:134864 | |
| UCSC | uc003qdm.1 | |
| CTD | 134864 | |
| GeneCards | GC06M132966 | |
| HGNC | HGNC:17734 | |
| HPA | CAB022754 | |
| MIM | 609333 | |
| neXtProt | NX_Q96RJ0 | |
| PharmGKB | PA134921784 | |
| eggNOG | NOG303390 | |
| GeneTree | ENSGT00760000118774 | |
| HOGENOM | HOG000239243 | |
| HOVERGEN | HBG106962 | |
| InParanoid | Q96RJ0 | |
| KO | K05051 | |
| OMA | ISCVKNN | |
| OrthoDB | EOG7HXCR8 | |
| PhylomeDB | Q96RJ0 | |
| TreeFam | TF343107 | |
| Reactome | REACT_16983 REACT_19327 | |
| GeneWiki | TAAR1 | |
| GenomeRNAi | 134864 | |
| NextBio | 83435 | |
| PRO | PR:Q96RJ0 | |
| Proteomes | UP000005640 | |
| Bgee | Q96RJ0 | |
| CleanEx | HS_TAAR1 | |
| Genevestigator | Q96RJ0 | |
| GO | GO:0016021 GO:0005886 GO:0004930 GO:0001594 GO:0007186 | |
| InterPro | IPR000276 IPR017452 IPR009133 IPR009132 | |
| Pfam | PF00001 | |
| PRINTS | PR00237 PR01831 PR01830 | |
| PROSITE | PS00237 PS50262 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
enables |
GO:0004930 |
G protein-coupled receptor activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0001594 |
trace-amine receptor activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:2148258 |
F |
Seeded From UniProt |
complete | ||
| GO:0004930 |
G-protein coupled receptor activity |
ECO:0000314 |
F |
Figure 2B: Gene TAAR1 produces cAMP in the presence of MDMA. Greater Concentrations of MDMA lead to greater level of cAMP produced. HEK293 cells lineage utilized for direct assay testing. |
complete | |||||
|
enables |
GO:0008227 |
G protein-coupled amine receptor activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q923Y8 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0007186 |
G protein-coupled receptor signaling pathway |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q923Y8 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0001594 |
trace-amine receptor activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q923Y8 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0001594 |
trace-amine receptor activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004930 |
G protein-coupled receptor activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007186 |
G protein-coupled receptor signaling pathway |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
InterPro:IPR000276 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0007186 |
G protein-coupled receptor signaling pathway |
PMID:15718104[3] |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
P |
Seeded From UniProt |
complete | |
|
enables |
GO:0004930 |
G protein-coupled receptor activity |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005886 |
plasma membrane |
Reactome:R-HSA-744887 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
|
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007165 |
signal transduction |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007186 |
G protein-coupled receptor signaling pathway |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004930 |
G protein-coupled receptor activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Bunzow, JR et al. (2001) Amphetamine, 3,4-methylenedioxymethamphetamine, lysergic acid diethylamide, and metabolites of the catecholamine neurotransmitters are agonists of a rat trace amine receptor. Mol. Pharmacol. 60 1181-8 PubMed GONUTS page
- ↑ Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ 3.0 3.1 Lindemann, L et al. (2005) Trace amine-associated receptors form structurally and functionally distinct subfamilies of novel G protein-coupled receptors. Genomics 85 372-85 PubMed GONUTS page
