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HUMAN:SMC1A

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) SMC1A (synonyms: DXS423E, KIAA0178, SB1.8, SMC1, SMC1L1)
Protein Name(s) Structural maintenance of chromosomes protein 1A

SMC protein 1A SMC-1-alpha SMC-1A Sb1.8

External Links
UniProt Q14683
EMBL S78271
D80000
AL161779
Z97054
Z97054
AL161779
BC112127
CCDS CCDS14352.1
PIR I54383
RefSeq NP_006297.2
UniGene Hs.211602
ProteinModelPortal Q14683
SMR Q14683
BioGrid 113871
DIP DIP-30911N
IntAct Q14683
MINT MINT-233274
STRING 9606.ENSP00000323421
PhosphoSite Q14683
DMDM 29336622
MaxQB Q14683
PaxDb Q14683
PeptideAtlas Q14683
PRIDE Q14683
Ensembl ENST00000322213
GeneID 8243
KEGG hsa:8243
UCSC uc004dsg.3
CTD 8243
GeneCards GC0XM053401
GeneReviews SMC1A
HGNC HGNC:11111
HPA CAB025404
HPA005499
MIM 300040
300590
neXtProt NX_Q14683
Orphanet 199
PharmGKB PA35961
eggNOG COG1196
GeneTree ENSGT00580000081569
HOGENOM HOG000195481
HOVERGEN HBG039593
InParanoid Q14683
KO K06636
OMA FNFKSYK
PhylomeDB Q14683
TreeFam TF101156
Reactome REACT_150266
REACT_150421
REACT_150425
REACT_150471
REACT_467
REACT_75792
SignaLink Q14683
ChiTaRS SMC1A
GeneWiki SMC1A
GenomeRNAi 8243
NextBio 31006
PRO PR:Q14683
Proteomes UP000005640
Bgee Q14683
CleanEx HS_SMC1A
ExpressionAtlas Q14683
Genevestigator Q14683
GO GO:0005694
GO:0000775
GO:0008280
GO:0000777
GO:0000794
GO:0005737
GO:0005829
GO:0000776
GO:0030893
GO:0005654
GO:0005634
GO:0005524
GO:0003682
GO:0003777
GO:0044822
GO:0046982
GO:0006281
GO:0010467
GO:0007126
GO:0000278
GO:0007093
GO:0007064
GO:0000070
GO:0007052
GO:0000398
GO:0032876
GO:0009314
GO:0008380
GO:0042770
GO:0007062
GO:0019827
Gene3D 3.40.50.300
InterPro IPR027417
IPR003395
IPR024704
IPR029683
IPR010935
PANTHER PTHR18937:SF170
Pfam PF06470
PF02463
PIRSF PIRSF005719
SMART SM00968
SUPFAM SSF52540
SSF75553

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

part_of

GO:0008278

cohesin complex

PMID:22628566[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:1901673

regulation of mitotic spindle assembly

PMID:11590136[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

happens_during:(GO:0033198)

Seeded From UniProt

complete

part_of

GO:0016363

nuclear matrix

PMID:11590136[2]

ECO:0000314

direct assay evidence used in manual assertion

C

exists_during:(GO:0051325)

Seeded From UniProt

complete

part_of

GO:0097431

mitotic spindle pole

PMID:11590136[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0008278

cohesin complex

PMID:11590136[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0032876

negative regulation of DNA endoreduplication

PMID:15917200[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007062

sister chromatid cohesion

PMID:15917200[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0000776

kinetochore

PMID:11682612[4]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0046982

protein heterodimerization activity

PMID:11590136[2]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q9UQE7

F

Seeded From UniProt

complete

enables

GO:0003723

RNA binding

PMID:22681889[5]

ECO:0007005

high throughput direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0030893

meiotic cohesin complex

PMID:21242291[6]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0009314

response to radiation

PMID:11877377[7]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0051321

meiotic cell cycle

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q9Z1M9

P

Seeded From UniProt

complete

involved_in

GO:0072423

response to DNA damage checkpoint signaling

PMID:11877377[7]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:11076961[8]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0003682

chromatin binding

PMID:11076961[8]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0000776

kinetochore

PMID:12199140[9]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

GO:0042127

regulation of cell proliferation

PMID:14608368[10]

ECO:0000314

P

Fig 1 (k) shows that phosphorylation of serine 966 is upregulated in senescent cells compared to proliferating cells.

complete
CACAO 9428

part_of

GO:0005829

cytosol

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0051321

meiotic cell cycle

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9CU62
ensembl:ENSMUSP00000044645

P

Seeded From UniProt

complete

enables

GO:0036033

mediator complex binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9CU62
ensembl:ENSMUSP00000044645

F

Seeded From UniProt

complete

part_of

GO:0030893

meiotic cohesin complex

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9CU62
ensembl:ENSMUSP00000044645

C

Seeded From UniProt

complete

involved_in

GO:0019827

stem cell population maintenance

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9CU62
ensembl:ENSMUSP00000044645

P

Seeded From UniProt

complete

part_of

GO:0008278

cohesin complex

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9CU62
ensembl:ENSMUSP00000044645

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9CU62
ensembl:ENSMUSP00000044645

C

Seeded From UniProt

complete

enables

GO:0003682

chromatin binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9CU62
ensembl:ENSMUSP00000044645

F

Seeded From UniProt

complete

enables

GO:0003682

chromatin binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR029683

F

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR010935
InterPro:IPR036277

F

Seeded From UniProt

complete

part_of

GO:0005694

chromosome

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR010935
InterPro:IPR036277

C

Seeded From UniProt

complete

involved_in

GO:0006281

DNA repair

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR029683

P

Seeded From UniProt

complete

involved_in

GO:0007064

mitotic sister chromatid cohesion

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR029683

P

Seeded From UniProt

complete

part_of

GO:0008278

cohesin complex

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR029683

C

Seeded From UniProt

complete

involved_in

GO:0051276

chromosome organization

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR010935
InterPro:IPR036277

P

Seeded From UniProt

complete

part_of

GO:0000794

condensed nuclear chromosome

PMID:7757074[11]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0008278

cohesin complex

PMID:11076961[8]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0007064

mitotic sister chromatid cohesion

PMID:12199140[9]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006281

DNA repair

PMID:11877377[7]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0000070

mitotic sister chromatid segregation

PMID:7757074[11]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

Reactome:R-HSA-3108212
Reactome:R-HSA-2473152
Reactome:R-HSA-2473151
Reactome:R-HSA-2470935
Reactome:R-HSA-2468041
Reactome:R-HSA-2468040
Reactome:R-HSA-2468039
Reactome:R-HSA-9011997

ECO:0000304

author statement supported by traceable reference used in manual assertion








C

Seeded From UniProt

complete

part_of

GO:0000775

chromosome, centromeric region

Reactome:R-HSA-2484822
Reactome:R-HSA-2473151
Reactome:R-HSA-2468287
Reactome:R-HSA-2467811
Reactome:R-HSA-2467809
Reactome:R-HSA-1638821
Reactome:R-HSA-1638803

ECO:0000304

author statement supported by traceable reference used in manual assertion







C

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

Reactome:R-HSA-2545253
Reactome:R-HSA-2545203
Reactome:R-HSA-2467811
Reactome:R-HSA-2467794

ECO:0000304

author statement supported by traceable reference used in manual assertion




C

Seeded From UniProt

complete

part_of

GO:0005694

chromosome

Reactome:R-HSA-2468293
Reactome:R-HSA-2468041
Reactome:R-HSA-2467794
Reactome:R-HSA-2466068

ECO:0000304

author statement supported by traceable reference used in manual assertion




C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

involved_in

GO:0007049

cell cycle

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0131

P

Seeded From UniProt

complete

involved_in

GO:0006281

DNA repair

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0234

P

Seeded From UniProt

complete

part_of

GO:0000776

kinetochore

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0995

C

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0067

F

Seeded From UniProt

complete

involved_in

GO:0051301

cell division

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0132

P

Seeded From UniProt

complete

enables

GO:0000166

nucleotide binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0547

F

Seeded From UniProt

complete

part_of

GO:0005694

chromosome

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0158
UniProtKB-SubCell:SL-0468

C

Seeded From UniProt

complete

involved_in

GO:0051321

meiotic cell cycle

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0469

P

Seeded From UniProt

complete

part_of

GO:0000775

chromosome, centromeric region

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0137

C

Seeded From UniProt

complete

involved_in

GO:0006974

cellular response to DNA damage stimulus

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0227

P

Seeded From UniProt

complete

part_of

GO:0000777

condensed chromosome kinetochore

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0149

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. Bermudez, VP et al. (2012) In vitro loading of human cohesin on DNA by the human Scc2-Scc4 loader complex. Proc. Natl. Acad. Sci. U.S.A. 109 9366-71 PubMed GONUTS page
  2. 2.0 2.1 2.2 2.3 2.4 Gregson, HC et al. (2001) A potential role for human cohesin in mitotic spindle aster assembly. J. Biol. Chem. 276 47575-82 PubMed GONUTS page
  3. 3.0 3.1 Strachan, T (2005) Cornelia de Lange Syndrome and the link between chromosomal function, DNA repair and developmental gene regulation. Curr. Opin. Genet. Dev. 15 258-64 PubMed GONUTS page
  4. Van Hooser, AA et al. (2001) Specification of kinetochore-forming chromatin by the histone H3 variant CENP-A. J. Cell. Sci. 114 3529-42 PubMed GONUTS page
  5. Baltz, AG et al. (2012) The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Mol. Cell 46 674-90 PubMed GONUTS page
  6. Lee, J & Hirano, T (2011) RAD21L, a novel cohesin subunit implicated in linking homologous chromosomes in mammalian meiosis. J. Cell Biol. 192 263-76 PubMed GONUTS page
  7. 7.0 7.1 7.2 Yazdi, PT et al. (2002) SMC1 is a downstream effector in the ATM/NBS1 branch of the human S-phase checkpoint. Genes Dev. 16 571-82 PubMed GONUTS page
  8. 8.0 8.1 8.2 Sumara, I et al. (2000) Characterization of vertebrate cohesin complexes and their regulation in prophase. J. Cell Biol. 151 749-62 PubMed GONUTS page
  9. 9.0 9.1 Gregson, HC et al. (2002) Localization of human SMC1 protein at kinetochores. Chromosome Res. 10 267-77 PubMed GONUTS page
  10. d'Adda di Fagagna, F et al. (2003) A DNA damage checkpoint response in telomere-initiated senescence. Nature 426 194-8 PubMed GONUTS page
  11. 11.0 11.1 Rocques, PJ et al. (1995) The human SB1.8 gene (DXS423E) encodes a putative chromosome segregation protein conserved in lower eukaryotes and prokaryotes. Hum. Mol. Genet. 4 243-9 PubMed GONUTS page