HUMAN:SCN3B

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	SCN3B (synonyms: KIAA1158)
Protein Name(s)	Sodium channel subunit beta-3
External Links
UniProt	Q9NY72
EMBL	AJ243396 AL136589 AB032984 AK314513 DQ677666 BC117282 BC126265
CCDS	CCDS8442.1
RefSeq	NP_001035241.1 NP_060870.1 XP_006718945.1
UniGene	Hs.4865
PDB	4L1D
PDBsum	4L1D
ProteinModelPortal	Q9NY72
SMR	Q9NY72
BioGrid	120912
MINT	MINT-4724379
STRING	9606.ENSP00000299333
DrugBank	DB00313 DB00909
PhosphoSite	Q9NY72
DMDM	12229762
PRIDE	Q9NY72
DNASU	55800
Ensembl	ENST00000299333 ENST00000392770 ENST00000530277
GeneID	55800
KEGG	hsa:55800
UCSC	uc001pza.1
CTD	55800
GeneCards	GC11M123500
GeneReviews	SCN3B
HGNC	HGNC:20665
HPA	HPA042518
MIM	608214 613120
neXtProt	NX_Q9NY72
Orphanet	130 334
PharmGKB	PA130546912
eggNOG	NOG40812
GeneTree	ENSGT00390000018560
HOGENOM	HOG000276881
HOVERGEN	HBG056582
InParanoid	Q9NY72
KO	K04847
OMA	LLIEMVY
OrthoDB	EOG7M3J19
PhylomeDB	Q9NY72
TreeFam	TF332097
Reactome	REACT_22266
GeneWiki	SCN3B
GenomeRNAi	55800
NextBio	60937
PMAP-CutDB	Q9NY72
PRO	PR:Q9NY72
Proteomes	UP000005640
Bgee	Q9NY72
CleanEx	HS_SCN3B
ExpressionAtlas	Q9NY72
Genevestigator	Q9NY72
GO	GO:0016021 GO:0005886 GO:0001518 GO:0030018 GO:0044325 GO:0017080 GO:0005248 GO:0086006 GO:0086014 GO:0007411 GO:0086002 GO:0060048 GO:0051899 GO:0086010 GO:0086012 GO:0010460 GO:0010765 GO:0072659 GO:0060371 GO:0086091 GO:2000649 GO:0060373 GO:0086070 GO:0019233 GO:0035725 GO:0006814 GO:0086005
Gene3D	2.60.40.10
InterPro	IPR007110 IPR013783 IPR003599 IPR013106 IPR027098 IPR027096
PANTHER	PTHR10546 PTHR10546:SF1
Pfam	PF07686
SMART	SM00409
PROSITE	PS50835

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
part_of	GO:0005886	plasma membrane	GO_REF:0000054	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:2000649	regulation of sodium ion transmembrane transporter activity	PMID:20042427^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_direct_input:(UniProtKB:Q14524)	Seeded From UniProt	complete
involved_in	GO:0086091	regulation of heart rate by cardiac conduction	PMID:20042427^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0086091	regulation of heart rate by cardiac conduction	PMID:21051419^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0086015	SA node cell action potential	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q8BHK2	P		Seeded From UniProt	complete
involved_in	GO:0086014	atrial cardiac muscle cell action potential	PMID:21051419^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0086012	membrane depolarization during cardiac muscle cell action potential	PMID:21051419^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0086010	membrane depolarization during action potential	PMID:21051419^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0086010	membrane depolarization during action potential	PMID:20226894^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0086010	membrane depolarization during action potential	PMID:20042427^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0086006	voltage-gated sodium channel activity involved in cardiac muscle cell action potential	PMID:21051419^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0086006	voltage-gated sodium channel activity involved in cardiac muscle cell action potential	PMID:20042427^[1]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0086005	ventricular cardiac muscle cell action potential	PMID:20042427^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0086002	cardiac muscle cell action potential involved in contraction	PMID:21051419^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0072659	protein localization to plasma membrane	PMID:20042427^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060373	regulation of ventricular cardiac muscle cell membrane depolarization	PMID:20042427^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060371	regulation of atrial cardiac muscle cell membrane depolarization	PMID:21051419^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060048	cardiac muscle contraction	PMID:20042427^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060048	cardiac muscle contraction	PMID:21051419^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051899	membrane depolarization	PMID:21051419^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0044325	ion channel binding	PMID:20042427^[1]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q14524	F		Seeded From UniProt	complete
involved_in	GO:0035725	sodium ion transmembrane transport	PMID:20226894^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0035725	sodium ion transmembrane transport	PMID:20042427^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0030018	Z disc	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q8BHK2	C		Seeded From UniProt	complete
enables	GO:0017080	sodium channel regulator activity	PMID:20042427^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	has_direct_input:(UniProtKB:Q14524)	Seeded From UniProt	complete
enables	GO:0017080	sodium channel regulator activity	PMID:20226894^[3]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0010765	positive regulation of sodium ion transport	PMID:21051419^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010765	positive regulation of sodium ion transport	PMID:20042427^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010460	positive regulation of heart rate	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q8BHK2	P		Seeded From UniProt	complete
part_of	GO:0001518	voltage-gated sodium channel complex	PMID:20042427^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0001518	voltage-gated sodium channel complex	PMID:21051419^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	PMID:10688874^[4]	ECO:0000303	author statement without traceable support used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0006814	sodium ion transport	PMID:10688874^[4]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0005248	voltage-gated sodium channel activity	PMID:10688874^[4]	ECO:0000303	author statement without traceable support used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:2000649	regulation of sodium ion transmembrane transporter activity	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002237886 UniProtKB:Q07699 UniProtKB:Q9NY72	P		Seeded From UniProt	complete
involved_in	GO:0086091	regulation of heart rate by cardiac conduction	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000057590 UniProtKB:Q07699 UniProtKB:Q9NY72	P		Seeded From UniProt	complete
involved_in	GO:0086005	ventricular cardiac muscle cell action potential	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1918882 PANTHER:PTN002576226 UniProtKB:Q9NY72	P		Seeded From UniProt	complete
involved_in	GO:0086002	cardiac muscle cell action potential involved in contraction	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000057590 UniProtKB:Q07699 UniProtKB:Q9NY72	P		Seeded From UniProt	complete
enables	GO:0044325	ion channel binding	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1918882 PANTHER:PTN002237886 UniProtKB:Q9NY72	F		Seeded From UniProt	complete
enables	GO:0019871	sodium channel inhibitor activity	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:98247 PANTHER:PTN002237886	F		Seeded From UniProt	complete
part_of	GO:0001518	voltage-gated sodium channel complex	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002237886 RGD:3631 UniProtKB:Q07699 UniProtKB:Q9NY72	C		Seeded From UniProt	complete
involved_in	GO:0086015	SA node cell action potential	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BHK2 ensembl:ENSMUSP00000051627	P		Seeded From UniProt	complete
enables	GO:0086006	voltage-gated sodium channel activity involved in cardiac muscle cell action potential	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BHK2 ensembl:ENSMUSP00000051627	F		Seeded From UniProt	complete
involved_in	GO:0086005	ventricular cardiac muscle cell action potential	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BHK2 ensembl:ENSMUSP00000051627	P		Seeded From UniProt	complete
involved_in	GO:0061337	cardiac conduction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BHK2 ensembl:ENSMUSP00000051627	P		Seeded From UniProt	complete
involved_in	GO:0060371	regulation of atrial cardiac muscle cell membrane depolarization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BHK2 ensembl:ENSMUSP00000051627	P		Seeded From UniProt	complete
enables	GO:0044325	ion channel binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BHK2 ensembl:ENSMUSP00000051627	F		Seeded From UniProt	complete
part_of	GO:0030018	Z disc	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BHK2 ensembl:ENSMUSP00000051627	C		Seeded From UniProt	complete
involved_in	GO:0010460	positive regulation of heart rate	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BHK2 ensembl:ENSMUSP00000051627	P		Seeded From UniProt	complete
involved_in	GO:0019233	sensory perception of pain	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JK00 ensembl:ENSRNOP00000071448	P		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JK00 ensembl:ENSRNOP00000071448	C		Seeded From UniProt	complete
involved_in	GO:0007399	nervous system development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JK00 ensembl:ENSRNOP00000071448	P		Seeded From UniProt	complete
involved_in	GO:0006814	sodium ion transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JK00 ensembl:ENSRNOP00000071448	P		Seeded From UniProt	complete
part_of	GO:0001518	voltage-gated sodium channel complex	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR027096 InterPro:IPR027098	C		Seeded From UniProt	complete
involved_in	GO:0006814	sodium ion transport	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR027096 InterPro:IPR027098	P		Seeded From UniProt	complete
enables	GO:0017080	sodium channel regulator activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR027096 InterPro:IPR027098	F		Seeded From UniProt	complete
part_of	GO:0001518	voltage-gated sodium channel complex	PMID:21895525^[6]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0005244	voltage-gated ion channel activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0851	F		Seeded From UniProt	complete
enables	GO:0005272	sodium channel activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0894	F		Seeded From UniProt	complete
involved_in	GO:0006811	ion transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0406	P		Seeded From UniProt	complete
involved_in	GO:0034765	regulation of ion transmembrane transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0851	P		Seeded From UniProt	complete
involved_in	GO:0006814	sodium ion transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0739	P		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472 UniProtKB-SubCell:SL-0162	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.00 ^1.01 ^1.02 ^1.03 ^1.04 ^1.05 ^1.06 ^1.07 ^1.08 ^1.09 ^1.10 ^1.11 ^1.12 Valdivia, CR et al. (2010) Loss-of-function mutation of the SCN3B-encoded sodium channel {beta}3 subunit associated with a case of idiopathic ventricular fibrillation. Cardiovasc. Res. 86 392-400 PubMed GONUTS page
↑ ^2.00 ^2.01 ^2.02 ^2.03 ^2.04 ^2.05 ^2.06 ^2.07 ^2.08 ^2.09 ^2.10 Olesen, MS et al. (2011) Mutations in sodium channel β-subunit SCN3B are associated with early-onset lone atrial fibrillation. Cardiovasc. Res. 89 786-93 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Tan, BH et al. (2010) Sudden infant death syndrome-associated mutations in the sodium channel beta subunits. Heart Rhythm 7 771-8 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Morgan, K et al. (2000) beta 3: an additional auxiliary subunit of the voltage-sensitive sodium channel that modulates channel gating with distinct kinetics. Proc. Natl. Acad. Sci. U.S.A. 97 2308-13 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 ^5.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Calloe, K et al. (2011) Multiple arrhythmic syndromes in a newborn, owing to a novel mutation in SCN5A. Can. J. Physiol. Pharmacol. 89 723-36 PubMed GONUTS page

[PMID:20042427-1] 1.00 ^1.01 ^1.02 ^1.03 ^1.04 ^1.05 ^1.06 ^1.07 ^1.08 ^1.09 ^1.10 ^1.11 ^1.12 Valdivia, CR et al. (2010) Loss-of-function mutation of the SCN3B-encoded sodium channel {beta}3 subunit associated with a case of idiopathic ventricular fibrillation. Cardiovasc. Res. 86 392-400 PubMed GONUTS page

[PMID:21051419-2] 2.00 ^2.01 ^2.02 ^2.03 ^2.04 ^2.05 ^2.06 ^2.07 ^2.08 ^2.09 ^2.10 Olesen, MS et al. (2011) Mutations in sodium channel β-subunit SCN3B are associated with early-onset lone atrial fibrillation. Cardiovasc. Res. 89 786-93 PubMed GONUTS page

[PMID:20226894-3] 3.0 ^3.1 ^3.2 Tan, BH et al. (2010) Sudden infant death syndrome-associated mutations in the sodium channel beta subunits. Heart Rhythm 7 771-8 PubMed GONUTS page

[PMID:10688874-4] 4.0 ^4.1 ^4.2 Morgan, K et al. (2000) beta 3: an additional auxiliary subunit of the voltage-sensitive sodium channel that modulates channel gating with distinct kinetics. Proc. Natl. Acad. Sci. U.S.A. 97 2308-13 PubMed GONUTS page

[PMID:21873635-5] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 ^5.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:21895525-6] Calloe, K et al. (2011) Multiple arrhythmic syndromes in a newborn, owing to a novel mutation in SCN5A. Can. J. Physiol. Pharmacol. 89 723-36 PubMed GONUTS page

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HUMAN:SCN3B

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Notes

References

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