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HUMAN:SACA3
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | SPACA3 (synonyms: LYC3, LYZL3, SLLP1, SPRASA) | |
| Protein Name(s) | Sperm acrosome membrane-associated protein 3
Cancer/testis antigen 54 CT54 Lysozyme-like acrosomal sperm-specific secretory protein ALLP-17 Lysozyme-like protein 3 Sperm lysozyme-like protein 1 Sperm protein reactive with antisperm antibodies Sperm protein reactive with ASA Sperm acrosome membrane-associated protein 3, membrane form Sperm acrosome membrane-associated protein 3, processed form | |
| External Links | ||
| UniProt | Q8IXA5 | |
| EMBL | AF216311 AF099029 AY358653 BC100886 BC100887 | |
| CCDS | CCDS11275.1 | |
| RefSeq | NP_776246.1 | |
| UniGene | Hs.434112 | |
| ProteinModelPortal | Q8IXA5 | |
| SMR | Q8IXA5 | |
| BioGrid | 125897 | |
| IntAct | Q8IXA5 | |
| STRING | 9606.ENSP00000269053 | |
| CAZy | GH22 | |
| PhosphoSite | Q8IXA5 | |
| DMDM | 74723659 | |
| PaxDb | Q8IXA5 | |
| PRIDE | Q8IXA5 | |
| DNASU | 124912 | |
| Ensembl | ENST00000269053 ENST00000580599 | |
| GeneID | 124912 | |
| KEGG | hsa:124912 | |
| UCSC | uc002hhs.1 | |
| CTD | 124912 | |
| GeneCards | GC17P031318 | |
| H-InvDB | HIX0039076 | |
| HGNC | HGNC:16260 | |
| HPA | HPA023633 | |
| MIM | 612749 | |
| neXtProt | NX_Q8IXA5 | |
| PharmGKB | PA38101 | |
| eggNOG | NOG68773 | |
| GeneTree | ENSGT00550000074398 | |
| HOGENOM | HOG000037357 | |
| HOVERGEN | HBG052297 | |
| InParanoid | Q8IXA5 | |
| OMA | GYWEAWR | |
| OrthoDB | EOG7BW0M5 | |
| PhylomeDB | Q8IXA5 | |
| TreeFam | TF324882 | |
| ChiTaRS | SPACA3 | |
| GeneWiki | SPACA3 | |
| GenomeRNAi | 124912 | |
| NextBio | 81416 | |
| PRO | PR:Q8IXA5 | |
| Proteomes | UP000005640 | |
| Bgee | Q8IXA5 | |
| CleanEx | HS_SPACA3 | |
| ExpressionAtlas | Q8IXA5 | |
| Genevestigator | Q8IXA5 | |
| GO | GO:0002080 GO:0005576 GO:0016021 GO:0005764 GO:0030141 GO:0003796 GO:0016998 GO:0050830 GO:0042117 GO:0009253 GO:0043032 GO:0050766 GO:0009615 GO:0035036 | |
| InterPro | IPR001916 IPR019799 IPR000974 IPR023346 IPR030058 | |
| PANTHER | PTHR11407:SF25 | |
| Pfam | PF00062 | |
| PRINTS | PR00137 PR00135 | |
| SMART | SM00263 | |
| SUPFAM | SSF53955 | |
| PROSITE | PS00128 PS51348 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
NOT|enables |
GO:0003796 |
lysozyme activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0002080 |
acrosomal membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0043159 |
acrosomal matrix |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007342 |
fusion of sperm to egg plasma membrane involved in single fertilization |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0030141 |
secretory granule |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0050830 |
defense response to Gram-positive bacterium |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:96897 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0050829 |
defense response to Gram-negative bacterium |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:96897 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0035036 |
sperm-egg recognition |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9D9X8 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0007342 |
fusion of sperm to egg plasma membrane involved in single fertilization |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9D9X8 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0001669 |
acrosomal vesicle |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9D9X8 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0009566 |
fertilization |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0050766 |
positive regulation of phagocytosis |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0043032 |
positive regulation of macrophage activation |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0042117 |
monocyte activation |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0031410 |
cytoplasmic vesicle |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005576 |
extracellular region |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0002080 |
acrosomal membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 Mandal, A et al. (2003) SLLP1, a unique, intra-acrosomal, non-bacteriolytic, c lysozyme-like protein of human spermatozoa. Biol. Reprod. 68 1525-37 PubMed GONUTS page
- ↑ Herrero, MB et al. (2005) Mouse SLLP1, a sperm lysozyme-like protein involved in sperm-egg binding and fertilization. Dev. Biol. 284 126-42 PubMed GONUTS page
- ↑ Cramer, EM & Breton-Gorius, J (1987) Ultrastructural localization of lysozyme in human neutrophils by immunogold. J. Leukoc. Biol. 41 242-7 PubMed GONUTS page
- ↑ 4.0 4.1 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 Ibrahim, HR et al. (2001) Genetic evidence that antibacterial activity of lysozyme is independent of its catalytic function. FEBS Lett. 506 27-32 PubMed GONUTS page
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