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HUMAN:PRC1

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) PRC1 (ECO:0000312 with EMBL:AAC02688.1)
Protein Name(s) Protein regulator of cytokinesis 1
External Links
UniProt O43663
EMBL AF044588
AK297117
AC068831
BC003138
BC005140
BX647317
CCDS CCDS32334.1
CCDS45352.1
CCDS45353.2
RefSeq NP_001254509.1
NP_003972.1
UniGene Hs.366401
PDB 3NRX
3NRY
4L3I
4L6Y
PDBsum 3NRX
3NRY
4L3I
4L6Y
ProteinModelPortal O43663
SMR O43663
BioGrid 114517
DIP DIP-34436N
IntAct O43663
MINT MINT-1459735
STRING 9606.ENSP00000377793
PhosphoSite O43663
MaxQB O43663
PaxDb O43663
PRIDE O43663
DNASU 9055
Ensembl ENST00000361188
ENST00000394249
ENST00000442656
GeneID 9055
KEGG hsa:9055
UCSC uc002bqm.4
uc010uqs.3
CTD 9055
GeneCards GC15M091509
HGNC HGNC:9341
HPA HPA034521
MIM 603484
neXtProt NX_O43663
PharmGKB PA33703
eggNOG NOG298643
GeneTree ENSGT00390000009453
HOGENOM HOG000082534
HOVERGEN HBG052963
InParanoid O43663
KO K16732
OMA NEINEPN
OrthoDB EOG7QRQTF
PhylomeDB O43663
TreeFam TF323976
ChiTaRS PRC1
EvolutionaryTrace O43663
GeneWiki PRC1
GenomeRNAi 9055
NextBio 33927
PRO PR:O43663
Proteomes UP000005640
Bgee O43663
CleanEx HS_PRC1
ExpressionAtlas O43663
Genevestigator O43663
GO GO:0005737
GO:0015630
GO:0005634
GO:0005886
GO:0005819
GO:0005876
GO:0000922
GO:0042802
GO:0019901
GO:0000910
GO:0000022
InterPro IPR007145
PANTHER PTHR19321
Pfam PF03999

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0008284

positive regulation of cell population proliferation

PMID:17409436[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0070938

contractile ring

PMID:17409436[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0030496

midbody

PMID:17409436[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:17409436[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0019894

kinesin binding

PMID:16431929[2]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q02241

F

Seeded From UniProt

complete

enables

GO:0019894

kinesin binding

PMID:16431929[2]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:O95235

F

Seeded From UniProt

complete

enables

GO:0019894

kinesin binding

PMID:16431929[2]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:O95239

F

Seeded From UniProt

complete

enables

GO:0019901

protein kinase binding

PMID:17351640[3]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P53350

F

Seeded From UniProt

complete

part_of

GO:0005819

spindle

PMID:17351640[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0032465

regulation of cytokinesis

PMID:17351640[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0000226

microtubule cytoskeleton organization

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR007145

P

Seeded From UniProt

complete

involved_in

GO:0001578

microtubule bundle formation

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR032921

P

Seeded From UniProt

complete

part_of

GO:0005856

cytoskeleton

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR032921

C

Seeded From UniProt

complete

enables

GO:0008017

microtubule binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR007145
InterPro:IPR032921

F

Seeded From UniProt

complete

involved_in

GO:0032465

regulation of cytokinesis

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR032921

P

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

PMID:23870126[4]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:O43663-1

F

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

PMID:20691902[5]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:O43663-1

F

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

PMID:16603632[6]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:O43663-1

F

Seeded From UniProt

complete

part_of

GO:0005876

spindle microtubule

PMID:9885575[7]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:9885575[7]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0000022

mitotic spindle elongation

PMID:9885575[7]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

Reactome:R-HSA-5671970

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005856

cytoskeleton

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0206

C

Seeded From UniProt

complete

involved_in

GO:0007049

cell cycle

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0131

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

part_of

GO:0005874

microtubule

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0493

C

Seeded From UniProt

complete

involved_in

GO:0051301

cell division

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0132

P

Seeded From UniProt

complete

part_of

GO:0030496

midbody

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0469

C

Seeded From UniProt

complete

part_of

GO:0000922

spindle pole

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0448

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 1.2 1.3 Kanehira, M et al. (2007) Oncogenic role of MPHOSPH1, a cancer-testis antigen specific to human bladder cancer. Cancer Res. 67 3276-85 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 Gruneberg, U et al. (2006) KIF14 and citron kinase act together to promote efficient cytokinesis. J. Cell Biol. 172 363-72 PubMed GONUTS page
  3. ↑ 3.0 3.1 3.2 Neef, R et al. (2007) Choice of Plk1 docking partners during mitosis and cytokinesis is controlled by the activation state of Cdk1. Nat. Cell Biol. 9 436-44 PubMed GONUTS page
  4. ↑ Subramanian, R et al. (2013) Marking and measuring single microtubules by PRC1 and kinesin-4. Cell 154 377-90 PubMed GONUTS page
  5. ↑ Subramanian, R et al. (2010) Insights into antiparallel microtubule crosslinking by PRC1, a conserved nonmotor microtubule binding protein. Cell 142 433-43 PubMed GONUTS page
  6. ↑ Zhu, C et al. (2006) Spatiotemporal control of spindle midzone formation by PRC1 in human cells. Proc. Natl. Acad. Sci. U.S.A. 103 6196-201 PubMed GONUTS page
  7. ↑ 7.0 7.1 7.2 Jiang, W et al. (1998) PRC1: a human mitotic spindle-associated CDK substrate protein required for cytokinesis. Mol. Cell 2 877-85 PubMed GONUTS page
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