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HUMAN:PNPH

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) PNP (synonyms: NP)
Protein Name(s) Purine nucleoside phosphorylase

PNP Inosine phosphorylase Inosine-guanosine phosphorylase

External Links
UniProt P00491
EMBL X00737
M13953
J02672
M13951
M13952
AY817667
AK313490
CR407607
CH471078
CH471078
BC104206
BC104207
BC106074
CCDS CCDS9552.1
PIR A00578
RefSeq NP_000261.2
UniGene Hs.75514
PDB 1M73
1PF7
1PWY
1RCT
1RFG
1RR6
1RSZ
1RT9
1ULA
1ULB
1V2H
1V3Q
1V41
1V45
1YRY
2A0W
2A0X
2A0Y
2OC4
2OC9
2ON6
2Q7O
3BGS
3D1V
3GB9
3GGS
3INY
3K8O
3K8Q
3PHB
4EAR
4EB8
4ECE
4GKA
PDBsum 1M73
1PF7
1PWY
1RCT
1RFG
1RR6
1RSZ
1RT9
1ULA
1ULB
1V2H
1V3Q
1V41
1V45
1YRY
2A0W
2A0X
2A0Y
2OC4
2OC9
2ON6
2Q7O
3BGS
3D1V
3GB9
3GGS
3INY
3K8O
3K8Q
3PHB
4EAR
4EB8
4ECE
4GKA
ProteinModelPortal P00491
SMR P00491
BioGrid 110921
DIP DIP-50406N
IntAct P00491
MINT MINT-1375849
STRING 9606.ENSP00000354532
BindingDB P00491
ChEMBL CHEMBL4338
DrugBank DB00242
DB00900
PhosphoSite P00491
DMDM 108935929
OGP P00491
MaxQB P00491
PaxDb P00491
PRIDE P00491
Ensembl ENST00000361505
GeneID 4860
KEGG hsa:4860
UCSC uc001vxo.4
CTD 4860
GeneCards GC14P021021
HGNC HGNC:7892
HPA HPA001625
MIM 164050
613179
neXtProt NX_P00491
Orphanet 760
PharmGKB PA31694
eggNOG COG0005
HOVERGEN HBG002460
InParanoid P00491
KO K03783
OMA ERFFDMT
PhylomeDB P00491
TreeFam TF300049
BioCyc MetaCyc:HS02151-MONOMER
BRENDA 2.4.2.1
Reactome REACT_1923
REACT_2086
SABIO-RK P00491
SignaLink P00491
UniPathway UPA00606
ChiTaRS PNP
EvolutionaryTrace P00491
GeneWiki Purine_nucleoside_phosphorylase
GenomeRNAi 4860
NextBio 18722
PRO PR:P00491
Proteomes UP000005640
Bgee P00491
CleanEx HS_NP
ExpressionAtlas P00491
Genevestigator P00491
GO GO:0005737
GO:0005856
GO:0005829
GO:0070062
GO:0005622
GO:0008144
GO:0001882
GO:0042301
GO:0002060
GO:0004731
GO:0006955
GO:0006148
GO:0070970
GO:0034356
GO:0006738
GO:0006139
GO:0055086
GO:0046638
GO:0042102
GO:0006144
GO:0006195
GO:0043101
GO:0042493
GO:0044281
GO:0034418
Gene3D 3.40.50.1580
InterPro IPR000845
IPR001369
IPR011270
IPR011268
IPR018099
PANTHER PTHR11904
Pfam PF01048
PIRSF PIRSF000477
SUPFAM SSF53167
TIGRFAMs TIGR01700
TIGR01697
PROSITE PS01240

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

part_of

GO:0070062

extracellular exosome

PMID:23533145[1]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0070062

extracellular exosome

PMID:19056867[2]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(UBERON:0001088)

Seeded From UniProt

complete

part_of

GO:0070062

extracellular exosome

PMID:20458337[3]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(CL:0000639)

Seeded From UniProt

complete

involved_in

GO:0070970

interleukin-2 secretion

PMID:16930574[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0042493

response to drug

PMID:15047506[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0042493

response to drug

PMID:18938130[6]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0042301

phosphate ion binding

PMID:18938130[6]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0034356

NAD biosynthesis via nicotinamide riboside salvage pathway

PMID:19001417[7]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:P53915

P

Seeded From UniProt

complete

enables

GO:0008144

drug binding

PMID:18938130[6]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0006955

immune response

PMID:16930574[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006738

nicotinamide riboside catabolic process

PMID:19001417[7]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006139

nucleobase-containing compound metabolic process

PMID:3029074[8]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:16930574[4]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:3029074[8]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0004731

purine-nucleoside phosphorylase activity

PMID:18938130[6]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0004731

purine-nucleoside phosphorylase activity

PMID:16930574[4]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0004731

purine-nucleoside phosphorylase activity

PMID:9305962[9]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0004731

purine-nucleoside phosphorylase activity

PMID:3029074[8]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0002060

purine nucleobase binding

PMID:9305962[9]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0001882

nucleoside binding

PMID:9305962[9]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:21873635[10]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG20250
PANTHER:PTN000224756
RGD:1597189
UniProtKB:P00491

C

Seeded From UniProt

complete

enables

GO:0004731

purine-nucleoside phosphorylase activity

PMID:21873635[10]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG20250
MGI:MGI:97365
PANTHER:PTN000224756
RGD:1597189
SGD:S000004199
UniProtKB:P00491
UniProtKB:P55859
UniProtKB:P9WP01

F

Seeded From UniProt

complete

involved_in

GO:0046638

positive regulation of alpha-beta T cell differentiation

PMID:16964310[11]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0042102

positive regulation of T cell proliferation

PMID:16964310[11]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0034418

urate biosynthetic process

PMID:16964310[11]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006148

inosine catabolic process

PMID:16964310[11]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0004731

purine-nucleoside phosphorylase activity

PMID:16964310[11]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0042278

purine nucleoside metabolic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P85973
ensembl:ENSRNOP00000013582

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P85973
ensembl:ENSRNOP00000013582

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P85973
ensembl:ENSRNOP00000013582

C

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P85973
ensembl:ENSRNOP00000013582

C

Seeded From UniProt

complete

enables

GO:0004731

purine-nucleoside phosphorylase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P85973
ensembl:ENSRNOP00000013582

F

Seeded From UniProt

complete

enables

GO:0003824

catalytic activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000845
InterPro:IPR035994

F

Seeded From UniProt

complete

enables

GO:0004731

purine-nucleoside phosphorylase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR011268
InterPro:IPR011270

F

Seeded From UniProt

complete

involved_in

GO:0006139

nucleobase-containing compound metabolic process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR011268
InterPro:IPR011270

P

Seeded From UniProt

complete

involved_in

GO:0009116

nucleoside metabolic process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000845
InterPro:IPR035994

P

Seeded From UniProt

complete

enables

GO:0016763

transferase activity, transferring pentosyl groups

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR018099

F

Seeded From UniProt

complete

enables

GO:0004731

purine-nucleoside phosphorylase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:2.4.2.1

F

Seeded From UniProt

complete

part_of

GO:1904813

ficolin-1-rich granule lumen

Reactome:R-HSA-6800434

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0043312

neutrophil degranulation

Reactome:R-HSA-6798695

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0043101

purine-containing compound salvage

Reactome:R-HSA-74217

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0034774

secretory granule lumen

Reactome:R-HSA-6798748

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0006195

purine nucleotide catabolic process

Reactome:R-HSA-74259

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

Reactome:R-HSA-74249
Reactome:R-HSA-74242
Reactome:R-HSA-112034
Reactome:R-HSA-112033

ECO:0000304

author statement supported by traceable reference used in manual assertion




C

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

Reactome:R-HSA-6800434
Reactome:R-HSA-6798748

ECO:0000304

author statement supported by traceable reference used in manual assertion


C

Seeded From UniProt

complete

enables

GO:0016757

transferase activity, transferring glycosyl groups

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0328

F

Seeded From UniProt

complete

enables

GO:0016740

transferase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0808

F

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

part_of

GO:0005856

cytoskeleton

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0206
UniProtKB-SubCell:SL-0090

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page
  2. Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page
  3. Buschow, SI et al. () MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis. Immunol. Cell Biol. 88 851-6 PubMed GONUTS page
  4. 4.0 4.1 4.2 4.3 Toro, A et al. (2006) Intracellular delivery of purine nucleoside phosphorylase (PNP) fused to protein transduction domain corrects PNP deficiency in vitro. Cell. Immunol. 240 107-15 PubMed GONUTS page
  5. Ray, AS et al. (2004) Role of purine nucleoside phosphorylase in interactions between 2',3'-dideoxyinosine and allopurinol, ganciclovir, or tenofovir. Antimicrob. Agents Chemother. 48 1089-95 PubMed GONUTS page
  6. 6.0 6.1 6.2 6.3 Todorova, NA & Schwarz, FP (2008) Effect of the phosphate substrate on drug-inhibitor binding to human purine nucleoside phosphorylase. Arch. Biochem. Biophys. 480 122-31 PubMed GONUTS page
  7. 7.0 7.1 Belenky, P et al. (2009) Nicotinamide riboside and nicotinic acid riboside salvage in fungi and mammals. Quantitative basis for Urh1 and purine nucleoside phosphorylase function in NAD+ metabolism. J. Biol. Chem. 284 158-64 PubMed GONUTS page
  8. 8.0 8.1 8.2 Williams, SR et al. (1987) A human purine nucleoside phosphorylase deficiency caused by a single base change. J. Biol. Chem. 262 2332-8 PubMed GONUTS page
  9. 9.0 9.1 9.2 Erion, MD et al. (1997) Purine nucleoside phosphorylase. 1. Structure-function studies. Biochemistry 36 11725-34 PubMed GONUTS page
  10. 10.0 10.1 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  11. 11.0 11.1 11.2 11.3 11.4 Toro, A & Grunebaum, E (2006) TAT-mediated intracellular delivery of purine nucleoside phosphorylase corrects its deficiency in mice. J. Clin. Invest. 116 2717-26 PubMed GONUTS page