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HUMAN:PNPH
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | PNP (synonyms: NP) | |
| Protein Name(s) | Purine nucleoside phosphorylase
PNP Inosine phosphorylase Inosine-guanosine phosphorylase | |
| External Links | ||
| UniProt | P00491 | |
| EMBL | X00737 M13953 J02672 M13951 M13952 AY817667 AK313490 CR407607 CH471078 CH471078 BC104206 BC104207 BC106074 | |
| CCDS | CCDS9552.1 | |
| PIR | A00578 | |
| RefSeq | NP_000261.2 | |
| UniGene | Hs.75514 | |
| PDB | 1M73 1PF7 1PWY 1RCT 1RFG 1RR6 1RSZ 1RT9 1ULA 1ULB 1V2H 1V3Q 1V41 1V45 1YRY 2A0W 2A0X 2A0Y 2OC4 2OC9 2ON6 2Q7O 3BGS 3D1V 3GB9 3GGS 3INY 3K8O 3K8Q 3PHB 4EAR 4EB8 4ECE 4GKA | |
| PDBsum | 1M73 1PF7 1PWY 1RCT 1RFG 1RR6 1RSZ 1RT9 1ULA 1ULB 1V2H 1V3Q 1V41 1V45 1YRY 2A0W 2A0X 2A0Y 2OC4 2OC9 2ON6 2Q7O 3BGS 3D1V 3GB9 3GGS 3INY 3K8O 3K8Q 3PHB 4EAR 4EB8 4ECE 4GKA | |
| ProteinModelPortal | P00491 | |
| SMR | P00491 | |
| BioGrid | 110921 | |
| DIP | DIP-50406N | |
| IntAct | P00491 | |
| MINT | MINT-1375849 | |
| STRING | 9606.ENSP00000354532 | |
| BindingDB | P00491 | |
| ChEMBL | CHEMBL4338 | |
| DrugBank | DB00242 DB00900 | |
| PhosphoSite | P00491 | |
| DMDM | 108935929 | |
| OGP | P00491 | |
| MaxQB | P00491 | |
| PaxDb | P00491 | |
| PRIDE | P00491 | |
| Ensembl | ENST00000361505 | |
| GeneID | 4860 | |
| KEGG | hsa:4860 | |
| UCSC | uc001vxo.4 | |
| CTD | 4860 | |
| GeneCards | GC14P021021 | |
| HGNC | HGNC:7892 | |
| HPA | HPA001625 | |
| MIM | 164050 613179 | |
| neXtProt | NX_P00491 | |
| Orphanet | 760 | |
| PharmGKB | PA31694 | |
| eggNOG | COG0005 | |
| HOVERGEN | HBG002460 | |
| InParanoid | P00491 | |
| KO | K03783 | |
| OMA | ERFFDMT | |
| PhylomeDB | P00491 | |
| TreeFam | TF300049 | |
| BioCyc | MetaCyc:HS02151-MONOMER | |
| BRENDA | 2.4.2.1 | |
| Reactome | REACT_1923 REACT_2086 | |
| SABIO-RK | P00491 | |
| SignaLink | P00491 | |
| UniPathway | UPA00606 | |
| ChiTaRS | PNP | |
| EvolutionaryTrace | P00491 | |
| GeneWiki | Purine_nucleoside_phosphorylase | |
| GenomeRNAi | 4860 | |
| NextBio | 18722 | |
| PRO | PR:P00491 | |
| Proteomes | UP000005640 | |
| Bgee | P00491 | |
| CleanEx | HS_NP | |
| ExpressionAtlas | P00491 | |
| Genevestigator | P00491 | |
| GO | GO:0005737 GO:0005856 GO:0005829 GO:0070062 GO:0005622 GO:0008144 GO:0001882 GO:0042301 GO:0002060 GO:0004731 GO:0006955 GO:0006148 GO:0070970 GO:0034356 GO:0006738 GO:0006139 GO:0055086 GO:0046638 GO:0042102 GO:0006144 GO:0006195 GO:0043101 GO:0042493 GO:0044281 GO:0034418 | |
| Gene3D | 3.40.50.1580 | |
| InterPro | IPR000845 IPR001369 IPR011270 IPR011268 IPR018099 | |
| PANTHER | PTHR11904 | |
| Pfam | PF01048 | |
| PIRSF | PIRSF000477 | |
| SUPFAM | SSF53167 | |
| TIGRFAMs | TIGR01700 TIGR01697 | |
| PROSITE | PS01240 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
part_of |
GO:0070062 |
extracellular exosome |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0070062 |
extracellular exosome |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
part_of:(UBERON:0001088) |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0070062 |
extracellular exosome |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
part_of:(CL:0000639) |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0070970 |
interleukin-2 secretion |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0042493 |
response to drug |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0042493 |
response to drug |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0042301 |
phosphate ion binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0034356 |
NAD biosynthesis via nicotinamide riboside salvage pathway |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008144 |
drug binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006955 |
immune response |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006738 |
nicotinamide riboside catabolic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006139 |
nucleobase-containing compound metabolic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004731 |
purine-nucleoside phosphorylase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004731 |
purine-nucleoside phosphorylase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004731 |
purine-nucleoside phosphorylase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004731 |
purine-nucleoside phosphorylase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0002060 |
purine nucleobase binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0001882 |
nucleoside binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
EcoGene:EG20250 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004731 |
purine-nucleoside phosphorylase activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
EcoGene:EG20250 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0046638 |
positive regulation of alpha-beta T cell differentiation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0042102 |
positive regulation of T cell proliferation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0034418 |
urate biosynthetic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006148 |
inosine catabolic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004731 |
purine-nucleoside phosphorylase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005829 |
cytosol |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0042278 |
purine nucleoside metabolic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P85973 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P85973 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P85973 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005576 |
extracellular region |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P85973 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004731 |
purine-nucleoside phosphorylase activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P85973 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003824 |
catalytic activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004731 |
purine-nucleoside phosphorylase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006139 |
nucleobase-containing compound metabolic process |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0009116 |
nucleoside metabolic process |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016763 |
transferase activity, transferring pentosyl groups |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004731 |
purine-nucleoside phosphorylase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:1904813 |
ficolin-1-rich granule lumen |
Reactome:R-HSA-6800434 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0043312 |
neutrophil degranulation |
Reactome:R-HSA-6798695 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0043101 |
purine-containing compound salvage |
Reactome:R-HSA-74217 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0034774 |
secretory granule lumen |
Reactome:R-HSA-6798748 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006195 |
purine nucleotide catabolic process |
Reactome:R-HSA-74259 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005829 |
cytosol |
Reactome:R-HSA-74249 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
|
part_of |
GO:0005576 |
extracellular region |
Reactome:R-HSA-6800434 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
|
enables |
GO:0016757 |
transferase activity, transferring glycosyl groups |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016740 |
transferase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005856 |
cytoskeleton |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page
- ↑ Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page
- ↑ Buschow, SI et al. () MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis. Immunol. Cell Biol. 88 851-6 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 4.3 Toro, A et al. (2006) Intracellular delivery of purine nucleoside phosphorylase (PNP) fused to protein transduction domain corrects PNP deficiency in vitro. Cell. Immunol. 240 107-15 PubMed GONUTS page
- ↑ Ray, AS et al. (2004) Role of purine nucleoside phosphorylase in interactions between 2',3'-dideoxyinosine and allopurinol, ganciclovir, or tenofovir. Antimicrob. Agents Chemother. 48 1089-95 PubMed GONUTS page
- ↑ 6.0 6.1 6.2 6.3 Todorova, NA & Schwarz, FP (2008) Effect of the phosphate substrate on drug-inhibitor binding to human purine nucleoside phosphorylase. Arch. Biochem. Biophys. 480 122-31 PubMed GONUTS page
- ↑ 7.0 7.1 Belenky, P et al. (2009) Nicotinamide riboside and nicotinic acid riboside salvage in fungi and mammals. Quantitative basis for Urh1 and purine nucleoside phosphorylase function in NAD+ metabolism. J. Biol. Chem. 284 158-64 PubMed GONUTS page
- ↑ 8.0 8.1 8.2 Williams, SR et al. (1987) A human purine nucleoside phosphorylase deficiency caused by a single base change. J. Biol. Chem. 262 2332-8 PubMed GONUTS page
- ↑ 9.0 9.1 9.2 Erion, MD et al. (1997) Purine nucleoside phosphorylase. 1. Structure-function studies. Biochemistry 36 11725-34 PubMed GONUTS page
- ↑ 10.0 10.1 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ 11.0 11.1 11.2 11.3 11.4 Toro, A & Grunebaum, E (2006) TAT-mediated intracellular delivery of purine nucleoside phosphorylase corrects its deficiency in mice. J. Clin. Invest. 116 2717-26 PubMed GONUTS page
c
e
i
n
- GO:0034356 ! NAD biosynthesis via nicotinamide riboside salvage pathway
- GO:0043312 ! neutrophil degranulation
- GO:0006738 ! nicotinamide riboside catabolic process
- GO:0006139 ! nucleobase-containing compound metabolic process
- GO:0001882 ! nucleoside binding
- GO:0009116 ! nucleoside metabolic process
- GO:0005634 ! nucleus
p
- GO:0016763 ! pentosyltransferase activity
- GO:0042301 ! phosphate ion binding
- GO:0042102 ! positive regulation of T cell proliferation
- GO:0046638 ! positive regulation of alpha-beta T cell differentiation
- Primates
- GO:0043101 ! purine-containing compound salvage
- GO:0004731 ! purine-nucleoside phosphorylase activity
- GO:0042278 ! purine nucleoside metabolic process
- GO:0002060 ! purine nucleobase binding
- GO:0006195 ! purine nucleotide catabolic process
