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HUMAN:PLK1

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) PLK1 (synonyms: PLK)
Protein Name(s) Serine/threonine-protein kinase PLK1

Polo-like kinase 1 PLK-1 Serine/threonine-protein kinase 13 STPK13

External Links
UniProt P53350
EMBL U01038
L19559
X73458
X75932
BC002369
BC003002
BC014846
X90725
U78073
CCDS CCDS10616.1
PIR S34130
RefSeq NP_005021.2
UniGene Hs.592049
PDB 1Q4K
1Q4O
1UMW
2OGQ
2OJX
2OU7
2OWB
2RKU
2V5Q
2YAC
3BZI
3C5L
3FC2
3FVH
3HIH
3HIK
3KB7
3P2W
3P2Z
3P34
3P35
3P36
3P37
3Q1I
3RQ7
3THB
4A4L
4A4O
4DFW
4E67
4E9C
4E9D
4H5X
4H71
4HAB
4HCO
4HY2
4J52
4J53
4LKL
4LKM
4MLU
4O9W
4RCP
PDBsum 1Q4K
1Q4O
1UMW
2OGQ
2OJX
2OU7
2OWB
2RKU
2V5Q
2YAC
3BZI
3C5L
3FC2
3FVH
3HIH
3HIK
3KB7
3P2W
3P2Z
3P34
3P35
3P36
3P37
3Q1I
3RQ7
3THB
4A4L
4A4O
4DFW
4E67
4E9C
4E9D
4H5X
4H71
4HAB
4HCO
4HY2
4J52
4J53
4LKL
4LKM
4MLU
4O9W
4RCP
DisProt DP00428
ProteinModelPortal P53350
SMR P53350
BioGrid 111362
DIP DIP-29696N
IntAct P53350
MINT MINT-86316
STRING 9606.ENSP00000300093
BindingDB P53350
ChEMBL CHEMBL3024
GuidetoPHARMACOLOGY 2168
PhosphoSite P53350
DMDM 1709658
MaxQB P53350
PaxDb P53350
PRIDE P53350
DNASU 5347
Ensembl ENST00000300093
GeneID 5347
KEGG hsa:5347
UCSC uc002dlz.1
CTD 5347
GeneCards GC16P023719
HGNC HGNC:9077
HPA HPA051638
HPA053229
MIM 602098
neXtProt NX_P53350
PharmGKB PA33410
eggNOG COG0515
GeneTree ENSGT00530000062954
HOGENOM HOG000248546
HOVERGEN HBG001843
InParanoid P53350
KO K06631
OMA YQKIRYA
OrthoDB EOG78M01K
PhylomeDB P53350
TreeFam TF101089
BRENDA 2.7.11.21
Reactome REACT_1006
REACT_1016
REACT_1100
REACT_150425
REACT_150471
REACT_15296
REACT_15364
REACT_15451
REACT_160122
REACT_160315
REACT_172744
REACT_1857
REACT_1932
REACT_6761
REACT_682
REACT_6875
REACT_6904
SignaLink P53350
ChiTaRS PLK1
EvolutionaryTrace P53350
GeneWiki PLK1
GenomeRNAi 5347
NextBio 20722
PRO PR:P53350
Proteomes UP000005640
Bgee P53350
CleanEx HS_PLK1
ExpressionAtlas P53350
Genevestigator P53350
GO GO:0005813
GO:0000942
GO:0005737
GO:0005829
GO:0000776
GO:0015630
GO:0030496
GO:0005730
GO:0005654
GO:0005634
GO:0005819
GO:0051233
GO:0000922
GO:0010997
GO:0005524
GO:0016301
GO:0008017
GO:0004672
GO:0019901
GO:0004674
GO:0007092
GO:0031145
GO:0008283
GO:0051297
GO:0000910
GO:0045184
GO:0031572
GO:0000086
GO:0007091
GO:0001578
GO:0000278
GO:0000281
GO:0007067
GO:0007077
GO:0000070
GO:0007094
GO:0043066
GO:0045736
GO:0000122
GO:0018105
GO:0040038
GO:0010800
GO:0032436
GO:0045862
GO:0051437
GO:0051443
GO:0031648
GO:0071168
GO:0006468
GO:0016567
GO:0051726
GO:0007346
GO:0030071
GO:0043393
GO:0051439
GO:0046677
InterPro IPR011009
IPR000959
IPR000719
IPR017441
IPR002290
IPR008271
Pfam PF00069
PF00659
SMART SM00220
SUPFAM SSF56112
PROSITE PS50078
PS00107
PS50011
PS00108

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

part_of

GO:0005813

centrosome

PMID:24157919[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

GO:1901673

regulation of spindle assembly involved in mitosis

PMID:22621898[2]

ECO:0000314

P

Figure 1 - "Plk1 activity prevents premature midzone bundles forming in metaphase"

complete
CACAO 7245

part_of

GO:0000776

kinetochore

PMID:24157919[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

GO:0001934

positive regulation of protein phosphorylation

PMID:22621898[2]

ECO:0000315

P

Figure 2 -" Plk1 phosphorylates PRC1"

complete
CACAO 7246

involved_in

GO:0006468

protein phosphorylation

PMID:17461553[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

GO:0006468

protein phosphorylation

PMID:22701722[4]

ECO:0000314

P

Figure 3 shows Plk1 directly phosphorylates NPHP1 in vitro.

complete
CACAO 7977

enables

GO:0004672

protein kinase activity

PMID:17461553[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

GO:0051179

localization

PMID:22701722[4]

ECO:0000314

P

Figure 1 shows Plk1 colocalizes with NPHP1 at the base of the cilium.

complete
CACAO 8010

enables

GO:0005524

ATP binding

PMID:17461553[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0000287

magnesium ion binding

PMID:17461553[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0000776

kinetochore

PMID:25395579[5]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0090435

protein localization to nuclear envelope

PMID:20679239[6]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006468

protein phosphorylation

PMID:20679239[6]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0051081

nuclear envelope disassembly

PMID:20679239[6]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006468

protein phosphorylation

PMID:22701722[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:1901673

regulation of mitotic spindle assembly

PMID:22621898[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005813

centrosome

GO_REF:0000054

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:1904776

regulation of protein localization to cell cortex

PMID:23509069[7]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0000132

establishment of mitotic spindle orientation

PMID:23509069[7]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0030071

regulation of mitotic metaphase/anaphase transition

PMID:23509069[7]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006468

protein phosphorylation

PMID:23509069[7]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0004674

protein serine/threonine kinase activity

PMID:23509069[7]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0051233

spindle midzone

PMID:21041660[8]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0045736

negative regulation of cyclin-dependent protein serine/threonine kinase activity

PMID:21041660[8]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0043393

regulation of protein binding

PMID:21041660[8]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0030071

regulation of mitotic metaphase/anaphase transition

PMID:21041660[8]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0019901

protein kinase binding

PMID:21041660[8]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q99741

F

Seeded From UniProt

complete

part_of

GO:0015630

microtubule cytoskeleton

PMID:21041660[8]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0010800

positive regulation of peptidyl-threonine phosphorylation

PMID:21041660[8]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

colocalizes_with

GO:0005876

spindle microtubule

PMID:21041660[8]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005813

centrosome

PMID:21041660[8]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0004674

protein serine/threonine kinase activity

PMID:21041660[8]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0004672

protein kinase activity

PMID:17146433[9]

ECO:0000314

direct assay evidence used in manual assertion

F

has_input:(UniProtKB:Q9H4X1)

Seeded From UniProt

complete

part_of

GO:0000942

condensed nuclear chromosome outer kinetochore

PMID:18195732[10]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0000922

spindle pole

PMID:21041660[8]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0000776

kinetochore

PMID:21041660[8]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0071168

protein localization to chromatin

PMID:21111234[11]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0051443

positive regulation of ubiquitin-protein transferase activity

PMID:19473992[12]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007098

centrosome cycle

PMID:8991084[13]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007098

centrosome cycle

PMID:18477460[14]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0051233

spindle midzone

PMID:19468302[15]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0045862

positive regulation of proteolysis

PMID:16885022[16]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0043066

negative regulation of apoptotic process

PMID:18174154[17]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0032436

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

PMID:19473992[12]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0031648

protein destabilization

PMID:16885022[16]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0072425

signal transduction involved in G2 DNA damage checkpoint

PMID:18662541[18]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0030496

midbody

PMID:19468300[19]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0019901

protein kinase binding

PMID:12639966[20]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:O94804

F

Seeded From UniProt

complete

enables

GO:0019901

protein kinase binding

PMID:18615013[21]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:O14965

F

Seeded From UniProt

complete

involved_in

GO:0018105

peptidyl-serine phosphorylation

PMID:16885022[16]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0016567

protein ubiquitination

PMID:16885022[16]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0010997

anaphase-promoting complex binding

PMID:18662541[18]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q9UM11

F

Seeded From UniProt

complete

enables

GO:0008017

microtubule binding

PMID:12939256[22]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0007346

regulation of mitotic cell cycle

PMID:17495026[23]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007094

mitotic spindle assembly checkpoint

PMID:23455478[24]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:1904668

positive regulation of ubiquitin protein ligase activity

PMID:15148369[25]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0000278

mitotic cell cycle

PMID:18477460[14]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0000278

mitotic cell cycle

PMID:18615013[21]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006468

protein phosphorylation

PMID:19468300[19]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005819

spindle

PMID:12939256[22]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005819

spindle

PMID:17351640[26]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005813

centrosome

PMID:23455478[24]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005813

centrosome

PMID:8991084[13]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005813

centrosome

PMID:12524548[27]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005813

centrosome

PMID:18477460[14]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005813

centrosome

PMID:21399614[28]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005813

centrosome

PMID:18615013[21]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:18615013[21]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0004674

protein serine/threonine kinase activity

PMID:23455478[24]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0004674

protein serine/threonine kinase activity

PMID:19473992[12]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0004674

protein serine/threonine kinase activity

PMID:19468302[15]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

GO:0005813

centrosome

PMID:27579920[29]

ECO:0000314

C

Fig 3D The protein localization patterns of human PLK foci were observed and presumed to be in centrosomes after forty-eight hours, using confocal laser scanning microscopy.

complete
CACAO 12483

enables

GO:0004674

protein serine/threonine kinase activity

PMID:12939256[22]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0004674

protein serine/threonine kinase activity

PMID:17351640[26]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0004674

protein serine/threonine kinase activity

PMID:19160488[30]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0004674

protein serine/threonine kinase activity

PMID:12524548[27]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0004674

protein serine/threonine kinase activity

PMID:18477460[14]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0004674

protein serine/threonine kinase activity

PMID:15148369[25]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0004674

protein serine/threonine kinase activity

PMID:18174154[17]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0004674

protein serine/threonine kinase activity

PMID:19468300[19]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0004672

protein kinase activity

PMID:19596235[31]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0001578

microtubule bundle formation

PMID:12939256[22]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0032465

regulation of cytokinesis

PMID:12939256[22]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0032465

regulation of cytokinesis

PMID:17351640[26]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0000776

kinetochore

PMID:23455478[24]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0000776

kinetochore

PMID:18477460[14]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0000776

kinetochore

PMID:18615013[21]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0000776

kinetochore

PMID:17617734[32]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0000281

mitotic cytokinesis

PMID:19468302[15]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0000122

negative regulation of transcription by RNA polymerase II

PMID:18174154[17]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0000086

G2/M transition of mitotic cell cycle

PMID:19160488[30]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0000070

mitotic sister chromatid segregation

PMID:23455478[24]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0032465

regulation of cytokinesis

PMID:21873635[33]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000679869
PomBase:SPAC23C11.16
SGD:S000004603
UniProtKB:P53350
UniProtKB:Q9H4B4

P

Seeded From UniProt

complete

part_of

GO:0005813

centrosome

PMID:21873635[33]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0003124
MGI:MGI:97621
PANTHER:PTN000679869
UniProtKB:P53350
UniProtKB:Q9H4B4
UniProtKB:Q9NYY3
WB:WBGene00004042
dictyBase:DDB_G0274503

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:21873635[33]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0003124
MGI:MGI:97621
PANTHER:PTN000679869
RGD:3352
UniProtKB:Q496M5
UniProtKB:Q57YD1
UniProtKB:Q9H4B4
UniProtKB:Q9NYY3
WB:WBGene00004042
WB:WBGene00004043

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:21873635[33]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0003124
MGI:MGI:3026984
MGI:MGI:97621
PANTHER:PTN000679869
PomBase:SPAC23C11.16
RGD:3352
SGD:S000004603
UniProtKB:C8VMZ9
UniProtKB:P53350
UniProtKB:Q5ABG0
UniProtKB:Q9H4B4
WB:WBGene00004042

C

Seeded From UniProt

complete

enables

GO:0004674

protein serine/threonine kinase activity

PMID:21873635[33]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0003124
FB:FBgn0026371
MGI:MGI:101783
MGI:MGI:109604
MGI:MGI:1099790
MGI:MGI:97621
PANTHER:PTN000757484
PomBase:SPAC23C11.16
RGD:620760
UniProtKB:O00444
UniProtKB:P53350
UniProtKB:Q9H4B4
UniProtKB:Q9NYY3

F

Seeded From UniProt

complete

part_of

GO:0000922

spindle pole

PMID:21873635[33]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0003124
PANTHER:PTN000679869
PomBase:SPAC23C11.16
RGD:3352
SGD:S000004603
UniProtKB:P53350
dictyBase:DDB_G0274503

C

Seeded From UniProt

complete

involved_in

GO:0000278

mitotic cell cycle

PMID:21873635[33]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0003124
MGI:MGI:109604
MGI:MGI:1099790
PANTHER:PTN000679869
SGD:S000004603
UniProtKB:C8VMZ9
UniProtKB:P53350
UniProtKB:Q9H4B4
UniProtKB:Q9NYY3
WB:WBGene00004042
ZFIN:ZDB-GENE-021115-7

P

Seeded From UniProt

complete

enables

GO:0004674

protein serine/threonine kinase activity

PMID:20577264[34]

ECO:0000269

experimental evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0004674

protein serine/threonine kinase activity

PMID:18378770[35]

ECO:0000269

experimental evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0045184

establishment of protein localization

PMID:18331714[36]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0004672

protein kinase activity

PMID:22854038[37]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0000922

spindle pole

PMID:18331714[36]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

PMID:26192437[38]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P53350

F

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

PMID:23354166[39]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P53350

F

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

PMID:21041660[8]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P53350

F

Seeded From UniProt

complete

involved_in

GO:0018105

peptidyl-serine phosphorylation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q07832
ensembl:ENSMUSP00000033154

P

Seeded From UniProt

complete

involved_in

GO:0016321

female meiosis chromosome segregation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q07832
ensembl:ENSMUSP00000033154

P

Seeded From UniProt

complete

involved_in

GO:0006468

protein phosphorylation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q07832
ensembl:ENSMUSP00000033154

P

Seeded From UniProt

complete

part_of

GO:0005814

centriole

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q07832
ensembl:ENSMUSP00000033154

C

Seeded From UniProt

complete

enables

GO:0004674

protein serine/threonine kinase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q07832
ensembl:ENSMUSP00000033154

F

Seeded From UniProt

complete

part_of

GO:0000795

synaptonemal complex

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q07832
ensembl:ENSMUSP00000033154

C

Seeded From UniProt

complete

part_of

GO:0000785

chromatin

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q07832
ensembl:ENSMUSP00000033154

C

Seeded From UniProt

complete

part_of

GO:0000780

condensed nuclear chromosome, centromeric region

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q07832
ensembl:ENSMUSP00000033154

C

Seeded From UniProt

complete

part_of

GO:0000776

kinetochore

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q07832
ensembl:ENSMUSP00000033154

C

Seeded From UniProt

complete

involved_in

GO:0070194

synaptonemal complex disassembly

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q07832
ensembl:ENSMUSP00000033154

P

Seeded From UniProt

complete

involved_in

GO:0045143

homologous chromosome segregation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q07832
ensembl:ENSMUSP00000033154

P

Seeded From UniProt

complete

involved_in

GO:0043393

regulation of protein binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q07832
ensembl:ENSMUSP00000033154

P

Seeded From UniProt

complete

part_of

GO:0034451

centriolar satellite

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q07832
ensembl:ENSMUSP00000033154

C

Seeded From UniProt

complete

involved_in

GO:0033365

protein localization to organelle

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q07832
ensembl:ENSMUSP00000033154

P

Seeded From UniProt

complete

enables

GO:0004672

protein kinase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000719
InterPro:IPR008271

F

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000719
InterPro:IPR017441

F

Seeded From UniProt

complete

involved_in

GO:0006468

protein phosphorylation

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000719
InterPro:IPR008271

P

Seeded From UniProt

complete

involved_in

GO:0000278

mitotic cell cycle

PMID:9177283[40]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:1904668

positive regulation of ubiquitin protein ligase activity

Reactome:R-HSA-2214351
Reactome:R-HSA-163010

ECO:0000304

author statement supported by traceable reference used in manual assertion


P

Seeded From UniProt

complete

involved_in

GO:1902749

regulation of cell cycle G2/M phase transition

Reactome:R-HSA-8852276

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:1901990

regulation of mitotic cell cycle phase transition

Reactome:R-HSA-176412

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:1900182

positive regulation of protein localization to nucleus

Reactome:R-HSA-8852317

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0097711

ciliary basal body-plasma membrane docking

Reactome:R-HSA-5620912

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0051726

regulation of cell cycle

Reactome:R-HSA-162657
Reactome:R-HSA-156711
Reactome:R-HSA-156699
Reactome:R-HSA-156678

ECO:0000304

author statement supported by traceable reference used in manual assertion




P

Seeded From UniProt

complete

involved_in

GO:0031145

anaphase-promoting complex-dependent catabolic process

Reactome:R-HSA-174178

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0016301

kinase activity

Reactome:R-HSA-2294580
Reactome:R-HSA-2214351

ECO:0000304

author statement supported by traceable reference used in manual assertion


F

Seeded From UniProt

complete

involved_in

GO:0010389

regulation of G2/M transition of mitotic cell cycle

Reactome:R-HSA-8854518

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007077

mitotic nuclear envelope disassembly

Reactome:R-HSA-2980766

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007062

sister chromatid cohesion

Reactome:R-HSA-2466068
Reactome:R-HSA-1638803

ECO:0000304

author statement supported by traceable reference used in manual assertion


P

Seeded From UniProt

complete

involved_in

GO:0006511

ubiquitin-dependent protein catabolic process

Reactome:R-HSA-174195

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

Reactome:R-NUL-2423781
Reactome:R-HSA-8853419
Reactome:R-HSA-8853405
Reactome:R-HSA-8852324
Reactome:R-HSA-8852317
Reactome:R-HSA-5666169
Reactome:R-HSA-5666160
Reactome:R-HSA-5666129
Reactome:R-HSA-5638009
Reactome:R-HSA-5626699
Reactome:R-HSA-5626681
Reactome:R-HSA-5626228
Reactome:R-HSA-5626227
Reactome:R-HSA-5626223
Reactome:R-HSA-5626220
Reactome:R-HSA-5617816
Reactome:R-HSA-4088305
Reactome:R-HSA-380508
Reactome:R-HSA-380455
Reactome:R-HSA-380316
Reactome:R-HSA-380311
Reactome:R-HSA-380303
Reactome:R-HSA-380294
Reactome:R-HSA-380283
Reactome:R-HSA-380272
Reactome:R-HSA-375302
Reactome:R-HSA-3002798
Reactome:R-HSA-3000327
Reactome:R-HSA-3000319
Reactome:R-HSA-3000310
Reactome:R-HSA-2984226
Reactome:R-HSA-2574845
Reactome:R-HSA-2574840
Reactome:R-HSA-2562526
Reactome:R-HSA-2484822
Reactome:R-HSA-2468287
Reactome:R-HSA-2467811
Reactome:R-HSA-2467809
Reactome:R-HSA-2466068
Reactome:R-HSA-2214351
Reactome:R-HSA-174195
Reactome:R-HSA-174105
Reactome:R-HSA-174088
Reactome:R-HSA-1638821
Reactome:R-HSA-1638803
Reactome:R-HSA-156678
Reactome:R-HSA-141439
Reactome:R-HSA-141431
Reactome:R-HSA-141422
Reactome:R-HSA-141409

ECO:0000304

author statement supported by traceable reference used in manual assertion


















































C

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

Reactome:R-HSA-4088134
Reactome:R-HSA-4088130
Reactome:R-HSA-3002811
Reactome:R-HSA-3002798
Reactome:R-HSA-2294590
Reactome:R-HSA-2294580
Reactome:R-HSA-174174
Reactome:R-HSA-174119
Reactome:R-HSA-163010
Reactome:R-HSA-162657
Reactome:R-HSA-156723
Reactome:R-HSA-156699
Reactome:R-HSA-156682
Reactome:R-HSA-156673

ECO:0000304

author statement supported by traceable reference used in manual assertion














C

Seeded From UniProt

complete

enables

GO:0004674

protein serine/threonine kinase activity

Reactome:R-HSA-380272
Reactome:R-HSA-2984226
Reactome:R-HSA-2562526
Reactome:R-HSA-2466068
Reactome:R-HSA-174174
Reactome:R-HSA-174119
Reactome:R-HSA-1638803
Reactome:R-HSA-163010
Reactome:R-HSA-162657
Reactome:R-HSA-156723
Reactome:R-HSA-156699
Reactome:R-HSA-156682
Reactome:R-HSA-156678
Reactome:R-HSA-156673

ECO:0000304

author statement supported by traceable reference used in manual assertion














F

Seeded From UniProt

complete

involved_in

GO:0000086

G2/M transition of mitotic cell cycle

Reactome:R-HSA-69275

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007049

cell cycle

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0131

P

Seeded From UniProt

complete

enables

GO:0016301

kinase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0418

F

Seeded From UniProt

complete

enables

GO:0000166

nucleotide binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0547

F

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0067

F

Seeded From UniProt

complete

part_of

GO:0000775

chromosome, centromeric region

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0137

C

Seeded From UniProt

complete

part_of

GO:0005694

chromosome

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0158

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

involved_in

GO:0016310

phosphorylation

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0418

P

Seeded From UniProt

complete

part_of

GO:0000776

kinetochore

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0995

C

Seeded From UniProt

complete

involved_in

GO:0051301

cell division

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0132

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963

C

Seeded From UniProt

complete

part_of

GO:0005856

cytoskeleton

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0206

C

Seeded From UniProt

complete

enables

GO:0004674

protein serine/threonine kinase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0723

F

Seeded From UniProt

complete

enables

GO:0016740

transferase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0808

F

Seeded From UniProt

complete

part_of

GO:0005815

microtubule organizing center

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0048

C

Seeded From UniProt

complete

part_of

GO:0005819

spindle

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0251

C

Seeded From UniProt

complete

part_of

GO:0030496

midbody

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0469

C

Seeded From UniProt

complete

part_of

GO:0000777

condensed chromosome kinetochore

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0149

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 Porter, IM et al. (2013) Bod1 regulates protein phosphatase 2A at mitotic kinetochores. Nat Commun 4 2677 PubMed GONUTS page
  2. 2.0 2.1 2.2 Hu, CK et al. (2012) Plk1 negatively regulates PRC1 to prevent premature midzone formation before cytokinesis. Mol. Biol. Cell 23 2702-11 PubMed GONUTS page
  3. 3.0 3.1 3.2 3.3 Kothe, M et al. (2007) Structure of the catalytic domain of human polo-like kinase 1. Biochemistry 46 5960-71 PubMed GONUTS page
  4. 4.0 4.1 4.2 Seeger-Nukpezah, T et al. (2012) The centrosomal kinase Plk1 localizes to the transition zone of primary cilia and induces phosphorylation of nephrocystin-1. PLoS ONE 7 e38838 PubMed GONUTS page
  5. Bancroft, J et al. (2015) Chromosome congression is promoted by CENP-Q- and CENP-E-dependent pathways. J. Cell. Sci. 128 171-84 PubMed GONUTS page
  6. 6.0 6.1 6.2 Li, H et al. (2010) Polo-like kinase 1 phosphorylation of p150Glued facilitates nuclear envelope breakdown during prophase. Proc. Natl. Acad. Sci. U.S.A. 107 14633-8 PubMed GONUTS page
  7. 7.0 7.1 7.2 7.3 7.4 Zhu, M et al. (2013) MISP is a novel Plk1 substrate required for proper spindle orientation and mitotic progression. J. Cell Biol. 200 773-87 PubMed GONUTS page
  8. 8.00 8.01 8.02 8.03 8.04 8.05 8.06 8.07 8.08 8.09 8.10 8.11 8.12 Yim, H & Erikson, RL (2010) Cell division cycle 6, a mitotic substrate of polo-like kinase 1, regulates chromosomal segregation mediated by cyclin-dependent kinase 1 and separase. Proc. Natl. Acad. Sci. U.S.A. 107 19742-7 PubMed GONUTS page
  9. Saigusa, K et al. (2007) RGC32, a novel p53-inducible gene, is located on centrosomes during mitosis and results in G2/M arrest. Oncogene 26 1110-21 PubMed GONUTS page
  10. Chen, Q et al. (2008) Cyclin B1 is localized to unattached kinetochores and contributes to efficient microtubule attachment and proper chromosome alignment during mitosis. Cell Res. 18 268-80 PubMed GONUTS page
  11. Nishiyama, T et al. (2010) Sororin mediates sister chromatid cohesion by antagonizing Wapl. Cell 143 737-49 PubMed GONUTS page
  12. 12.0 12.1 12.2 Yang, X et al. (2009) Plk1-mediated phosphorylation of Topors regulates p53 stability. J. Biol. Chem. 284 18588-92 PubMed GONUTS page
  13. 13.0 13.1 Lane, HA & Nigg, EA (1996) Antibody microinjection reveals an essential role for human polo-like kinase 1 (Plk1) in the functional maturation of mitotic centrosomes. J. Cell Biol. 135 1701-13 PubMed GONUTS page
  14. 14.0 14.1 14.2 14.3 14.4 Yamashiro, S et al. (2008) Myosin phosphatase-targeting subunit 1 regulates mitosis by antagonizing polo-like kinase 1. Dev. Cell 14 787-97 PubMed GONUTS page
  15. 15.0 15.1 15.2 Burkard, ME et al. (2009) Plk1 self-organization and priming phosphorylation of HsCYK-4 at the spindle midzone regulate the onset of division in human cells. PLoS Biol. 7 e1000111 PubMed GONUTS page
  16. 16.0 16.1 16.2 16.3 Peschiaroli, A et al. (2006) SCFbetaTrCP-mediated degradation of Claspin regulates recovery from the DNA replication checkpoint response. Mol. Cell 23 319-29 PubMed GONUTS page
  17. 17.0 17.1 17.2 Koida, N et al. (2008) Inhibitory role of Plk1 in the regulation of p73-dependent apoptosis through physical interaction and phosphorylation. J. Biol. Chem. 283 8555-63 PubMed GONUTS page
  18. 18.0 18.1 Bassermann, F et al. (2008) The Cdc14B-Cdh1-Plk1 axis controls the G2 DNA-damage-response checkpoint. Cell 134 256-67 PubMed GONUTS page
  19. 19.0 19.1 19.2 Wolfe, BA et al. (2009) Polo-like kinase 1 directs assembly of the HsCyk-4 RhoGAP/Ect2 RhoGEF complex to initiate cleavage furrow formation. PLoS Biol. 7 e1000110 PubMed GONUTS page
  20. Walter, SA et al. (2003) Stk10, a new member of the polo-like kinase kinase family highly expressed in hematopoietic tissue. J. Biol. Chem. 278 18221-8 PubMed GONUTS page
  21. 21.0 21.1 21.2 21.3 21.4 Macůrek, L et al. (2008) Polo-like kinase-1 is activated by aurora A to promote checkpoint recovery. Nature 455 119-23 PubMed GONUTS page
  22. 22.0 22.1 22.2 22.3 22.4 Neef, R et al. (2003) Phosphorylation of mitotic kinesin-like protein 2 by polo-like kinase 1 is required for cytokinesis. J. Cell Biol. 162 863-75 PubMed GONUTS page
  23. Stegmeier, F et al. (2007) The tumor suppressor CYLD regulates entry into mitosis. Proc. Natl. Acad. Sci. U.S.A. 104 8869-74 PubMed GONUTS page
  24. 24.0 24.1 24.2 24.3 24.4 Beck, J et al. (2013) Ubiquitylation-dependent localization of PLK1 in mitosis. Nat. Cell Biol. 15 430-9 PubMed GONUTS page
  25. 25.0 25.1 Moshe, Y et al. (2004) Role of Polo-like kinase in the degradation of early mitotic inhibitor 1, a regulator of the anaphase promoting complex/cyclosome. Proc. Natl. Acad. Sci. U.S.A. 101 7937-42 PubMed GONUTS page
  26. 26.0 26.1 26.2 Neef, R et al. (2007) Choice of Plk1 docking partners during mitosis and cytokinesis is controlled by the activation state of Cdk1. Nat. Cell Biol. 9 436-44 PubMed GONUTS page
  27. 27.0 27.1 Jackman, M et al. (2003) Active cyclin B1-Cdk1 first appears on centrosomes in prophase. Nat. Cell Biol. 5 143-8 PubMed GONUTS page
  28. Jakobsen, L et al. (2011) Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methods. EMBO J. 30 1520-35 PubMed GONUTS page
  29. Zurnic, I et al. (2016) Interactions of Prototype Foamy Virus Capsids with Host Cell Polo-Like Kinases Are Important for Efficient Viral DNA Integration. PLoS Pathog. 12 e1005860 PubMed GONUTS page
  30. 30.0 30.1 Fu, Z et al. (2008) Plk1-dependent phosphorylation of FoxM1 regulates a transcriptional programme required for mitotic progression. Nat. Cell Biol. 10 1076-82 PubMed GONUTS page
  31. Svendsen, JM et al. (2009) Mammalian BTBD12/SLX4 assembles a Holliday junction resolvase and is required for DNA repair. Cell 138 63-77 PubMed GONUTS page
  32. Pouwels, J et al. (2007) Shugoshin 1 plays a central role in kinetochore assembly and is required for kinetochore targeting of Plk1. Cell Cycle 6 1579-85 PubMed GONUTS page
  33. 33.0 33.1 33.2 33.3 33.4 33.5 33.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  34. Liu, XS et al. (2010) Polo-like kinase 1 phosphorylation of G2 and S-phase-expressed 1 protein is essential for p53 inactivation during G2 checkpoint recovery. EMBO Rep. 11 626-32 PubMed GONUTS page
  35. Seki, A et al. (2008) Plk1- and beta-TrCP-dependent degradation of Bora controls mitotic progression. J. Cell Biol. 181 65-78 PubMed GONUTS page
  36. 36.0 36.1 Wang, X et al. (2008) sSgo1, a major splice variant of Sgo1, functions in centriole cohesion where it is regulated by Plk1. Dev. Cell 14 331-41 PubMed GONUTS page
  37. Jordan, PW et al. (2012) Polo-like kinase is required for synaptonemal complex disassembly and phosphorylation in mouse spermatocytes. J. Cell. Sci. 125 5061-72 PubMed GONUTS page
  38. Hanafusa, H et al. (2015) PLK1-dependent activation of LRRK1 regulates spindle orientation by phosphorylating CDK5RAP2. Nat. Cell Biol. 17 1024-35 PubMed GONUTS page
  39. Januschke, J et al. (2013) Centrobin controls mother-daughter centriole asymmetry in Drosophila neuroblasts. Nat. Cell Biol. 15 241-8 PubMed GONUTS page
  40. Smith, MR et al. (1997) Malignant transformation of mammalian cells initiated by constitutive expression of the polo-like kinase. Biochem. Biophys. Res. Commun. 234 397-405 PubMed GONUTS page