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HUMAN:PACS2

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) PACS2 (synonyms: KIAA0602, PACS1L)
Protein Name(s) Phosphofurin acidic cluster sorting protein 2

PACS-2 PACS1-like protein

External Links
UniProt Q86VP3
EMBL AY320284
AB011174
AL512355
AL928654
BC010663
BC050351
BC065220
BC131591
CCDS CCDS32168.1
CCDS45178.2
CCDS58339.1
PIR T00262
RefSeq NP_001094383.2
NP_001230056.1
NP_056012.2
UniGene Hs.525626
ProteinModelPortal Q86VP3
BioGrid 116845
IntAct Q86VP3
MINT MINT-2796645
STRING 9606.ENSP00000393559
TCDB 1.A.5.1.1
iPTMnet Q86VP3
PhosphoSitePlus Q86VP3
BioMuta PACS2
DMDM 117949768
MaxQB Q86VP3
PaxDb Q86VP3
PeptideAtlas Q86VP3
PRIDE Q86VP3
Ensembl ENST00000325438
ENST00000430725
ENST00000447393
GeneID 23241
KEGG hsa:23241
UCSC uc001yqs.4
CTD 23241
DisGeNET 23241
GeneCards PACS2
HGNC HGNC:23794
HPA HPA001423
HPA077892
MIM 610423
neXtProt NX_Q86VP3
OpenTargets ENSG00000179364
PharmGKB PA134941470
eggNOG KOG3709
ENOG410XQNV
GeneTree ENSGT00390000003281
HOGENOM HOG000047329
HOVERGEN HBG053488
InParanoid Q86VP3
OMA NERCPDA
OrthoDB EOG090B02NB
PhylomeDB Q86VP3
ChiTaRS PACS2
GenomeRNAi 23241
PRO PR:Q86VP3
Proteomes UP000005640
Bgee ENSG00000179364
CleanEx HS_PACS2
ExpressionAtlas Q86VP3
Genevisible Q86VP3
GO GO:0005783
GO:0005788
GO:0005739
GO:0044325
GO:0006915
GO:0000045
GO:0034497
GO:0072661
GO:0016032
InterPro IPR019381
Pfam PF10254

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:1990456

mitochondrion-ER tethering

PMID:15692567[1]

ECO:0000315

P

Human PACS2//The depletion of PACS‐2, but not PACS‐1, caused extensive mitochondrial fragmentation, and appeared to uncouple the fragmented mitochondria from the ER (Figure 1E)

complete
CACAO 12300

GO:0032469

endoplasmic reticulum calcium ion homeostasis

PMID:15692567[1]

ECO:0000315

P

Human PACS-2 Fig. 3C, histamine elicited a two-fold greater increase in calcium released from the ER into the cytosol of PACS-2-depleted cells compared to PACS-1-depleted or control cells.

complete
CACAO 12400

GO:0006915

apoptotic process

PMID:15692567[1]

ECO:0000315

P

Human PACS-2 depletion conferred a marked resistance to STS, increasing the percentage of viable cells by nearly four-fold. The antiapoptotic effects of the PACS-2 siRNA were corroborated by analyzing the STS-mediated caspase cleavage of poly-ADP-ribose polymerase (PARP) to generate p85.

complete
CACAO 12401

involved_in

GO:0072659

protein localization to plasma membrane

PMID:15692563[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

has_input:(UniProtKB:Q13563)

Seeded From UniProt

complete

part_of

GO:0005783

endoplasmic reticulum

PMID:15692563[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0072659

protein localization to plasma membrane

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000998635
UniProtKB:Q6VY07
UniProtKB:Q86VP3

P

Seeded From UniProt

complete

enables

GO:0044325

ion channel binding

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000749749
UniProtKB:Q6VY07

F

Seeded From UniProt

complete

involved_in

GO:0034497

protein localization to phagophore assembly site

PMID:23455425[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0000045

autophagosome assembly

PMID:23455425[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0496
UniProtKB-SubCell:SL-0173

C

Seeded From UniProt

complete

involved_in

GO:0006915

apoptotic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0053

P

Seeded From UniProt

complete

involved_in

GO:0016032

viral process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0945

P

Seeded From UniProt

complete

part_of

GO:0005783

endoplasmic reticulum

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0256
UniProtKB-SubCell:SL-0095

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 Simmen, T et al. (2005) PACS-2 controls endoplasmic reticulum-mitochondria communication and Bid-mediated apoptosis. EMBO J. 24 717-29 PubMed GONUTS page
  2. 2.0 2.1 Köttgen, M et al. (2005) Trafficking of TRPP2 by PACS proteins represents a novel mechanism of ion channel regulation. EMBO J. 24 705-16 PubMed GONUTS page
  3. 3.0 3.1 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  4. 4.0 4.1 Hamasaki, M et al. (2013) Autophagosomes form at ER-mitochondria contact sites. Nature 495 389-93 PubMed GONUTS page