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HUMAN:NOTC4

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) NOTCH4 (synonyms: INT3)
Protein Name(s) Neurogenic locus notch homolog protein 4

Notch 4 hNotch4 Notch 4 extracellular truncation Notch 4 intracellular domain

External Links
UniProt Q99466
EMBL D63395
D86566
U95299
U89335
AL662884
BX284686
BX284927
BX284927
BX284686
CR812478
CR933878
AB023961
AB024520
AB024578
CCDS CCDS34420.1
RefSeq NP_004548.3
UniGene Hs.436100
ProteinModelPortal Q99466
SMR Q99466
BioGrid 110917
IntAct Q99466
STRING 9606.ENSP00000364163
PhosphoSite Q99466
DMDM 20139103
MaxQB Q99466
PaxDb Q99466
PRIDE Q99466
Ensembl ENST00000375023
ENST00000425600
ENST00000439349
ENST00000457094
GeneID 4855
KEGG hsa:4855
UCSC uc003oba.3
uc003obb.3
CTD 4855
GeneCards GC06M032166
GC06Mi32173
GC06Mm32239
GC06Mo32169
HGNC HGNC:7884
HPA CAB012331
MIM 164951
neXtProt NX_Q99466
PharmGKB PA31686
eggNOG COG0666
GeneTree ENSGT00760000118786
HOVERGEN HBG052650
InParanoid Q99466
KO K02599
OMA DKCQNGG
PhylomeDB Q99466
TreeFam TF351641
Reactome REACT_118568
REACT_118636
REACT_118722
REACT_118798
REACT_14835
SignaLink Q99466
GeneWiki NOTCH4
GenomeRNAi 4855
NextBio 18702
PRO PR:Q99466
Proteomes UP000005640
UP000005640
Bgee Q99466
CleanEx HS_NOTCH4
Genevestigator Q99466
GO GO:0009986
GO:0005829
GO:0005789
GO:0005576
GO:0000139
GO:0005887
GO:0005654
GO:0005634
GO:0005886
GO:0005509
GO:0046982
GO:0004872
GO:0030154
GO:0001709
GO:0009790
GO:0001886
GO:0010467
GO:0030097
GO:0030879
GO:0001763
GO:0045596
GO:0045602
GO:0007220
GO:0007219
GO:0001569
GO:0007221
GO:0045893
GO:0006367
Gene3D 1.25.40.20
InterPro IPR002110
IPR020683
IPR000742
IPR001881
IPR013032
IPR000152
IPR018097
IPR009030
IPR008297
IPR022355
IPR000800
IPR011656
Pfam PF00023
PF12796
PF00008
PF07645
PF12661
PF07684
PF00066
PIRSF PIRSF002279
PRINTS PR01452
PR01987
SMART SM00248
SM00181
SM00179
SM00004
SUPFAM SSF48403
SSF57184
SSF90193
PROSITE PS50297
PS50088
PS00010
PS00022
PS01186
PS50026
PS01187
PS50258

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0045602

negative regulation of endothelial cell differentiation

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P31695

P

Seeded From UniProt

complete

involved_in

GO:0045596

negative regulation of cell differentiation

PMID:11823422[1]

ECO:0000303

author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0030879

mammary gland development

PMID:9576833[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0030154

cell differentiation

PMID:11823422[1]

ECO:0000303

author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0009986

cell surface

PMID:11823422[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0001944

vasculature development

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P31695

P

Seeded From UniProt

complete

involved_in

GO:0001763

morphogenesis of a branching structure

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P31695

P

Seeded From UniProt

complete

involved_in

GO:0001569

branching involved in blood vessel morphogenesis

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P31695

P

Seeded From UniProt

complete

involved_in

GO:0045446

endothelial cell differentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q6MG89
ensembl:ENSRNOP00000000513

P

Seeded From UniProt

complete

involved_in

GO:0042060

wound healing

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q6MG89
ensembl:ENSRNOP00000000513

P

Seeded From UniProt

complete

involved_in

GO:0001886

endothelial cell morphogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q6MG89
ensembl:ENSRNOP00000000513

P

Seeded From UniProt

complete

enables

GO:0005509

calcium ion binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001881
InterPro:IPR018097

F

Seeded From UniProt

complete

involved_in

GO:0006355

regulation of transcription, DNA-templated

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR022355

P

Seeded From UniProt

complete

involved_in

GO:0007219

Notch signaling pathway

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR008297
InterPro:IPR011656
InterPro:IPR022355

P

Seeded From UniProt

complete

involved_in

GO:0007275

multicellular organism development

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR011656

P

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR008297
InterPro:IPR010660
InterPro:IPR011656

C

Seeded From UniProt

complete

involved_in

GO:0030154

cell differentiation

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR008297
InterPro:IPR010660
InterPro:IPR011656

P

Seeded From UniProt

complete

enables

GO:0038023

signaling receptor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR022355

F

Seeded From UniProt

complete

involved_in

GO:0050793

regulation of developmental process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR008297

P

Seeded From UniProt

complete

part_of

GO:0005887

integral component of plasma membrane

PMID:9168133[3]
PMID:11823422[1]

ECO:0000304

author statement supported by traceable reference used in manual assertion


C

Seeded From UniProt

complete

involved_in

GO:0007221

positive regulation of transcription of Notch receptor target

PMID:18663143[4]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0046982

protein heterodimerization activity

PMID:8681805[5]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0045893

positive regulation of transcription, DNA-templated

PMID:11823422[1]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0030097

hemopoiesis

PMID:11532344[6]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:8681805[5]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0005509

calcium ion binding

PMID:11823422[1]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0038023

signaling receptor activity

PMID:11823422[1]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0001709

cell fate determination

PMID:11823422[1]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045747

positive regulation of Notch signaling pathway

Reactome:R-HSA-9604308

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0035278

miRNA mediated inhibition of translation

Reactome:R-HSA-1912410

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006367

transcription initiation from RNA polymerase II promoter

Reactome:R-HSA-350054

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

Reactome:R-HSA-1912382

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

Reactome:R-NUL-9604388
Reactome:R-HSA-9604328
Reactome:R-HSA-9604308

ECO:0000304

author statement supported by traceable reference used in manual assertion



C

Seeded From UniProt

complete

part_of

GO:0005789

endoplasmic reticulum membrane

Reactome:R-HSA-1912410

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

Reactome:R-HSA-9604308
Reactome:R-HSA-212356

ECO:0000304

author statement supported by traceable reference used in manual assertion


C

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

Reactome:R-HSA-1912382

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0000139

Golgi membrane

Reactome:R-HSA-1912382
Reactome:R-HSA-1912369

ECO:0000304

author statement supported by traceable reference used in manual assertion


C

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

involved_in

GO:0007275

multicellular organism development

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0217

P

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

involved_in

GO:0007219

Notch signaling pathway

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0914

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1003
UniProtKB-SubCell:SL-0039

C

Seeded From UniProt

complete

involved_in

GO:0030154

cell differentiation

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0221

P

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 Shimizu, K et al. (2002) Integrity of intracellular domain of Notch ligand is indispensable for cleavage required for release of the Notch2 intracellular domain. EMBO J. 21 294-302 PubMed GONUTS page
  2. ↑ Uyttendaele, H et al. (1998) Notch4 and Wnt-1 proteins function to regulate branching morphogenesis of mammary epithelial cells in an opposing fashion. Dev. Biol. 196 204-17 PubMed GONUTS page
  3. ↑ Sugaya, K et al. (1997) Gene organization of human NOTCH4 and (CTG)n polymorphism in this human counterpart gene of mouse proto-oncogene Int3. Gene 189 235-44 PubMed GONUTS page
  4. ↑ Niessen, K et al. (2008) Slug is a direct Notch target required for initiation of cardiac cushion cellularization. J. Cell Biol. 182 315-25 PubMed GONUTS page
  5. ↑ 5.0 5.1 Uyttendaele, H et al. (1996) Notch4/int-3, a mammary proto-oncogene, is an endothelial cell-specific mammalian Notch gene. Development 122 2251-9 PubMed GONUTS page
  6. ↑ Kojika, S & Griffin, JD (2001) Notch receptors and hematopoiesis. Exp. Hematol. 29 1041-52 PubMed GONUTS page
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