HUMAN:NGBR

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	NUS1 (synonyms: C6orf68, NGBR)
Protein Name(s)	Dehydrodolichyl diphosphate syntase complex subunit NUS1 (ECO:0000305) Di-trans,poly-cis-decaprenylcistransferase (ECO:0000305) Nogo-B receptor (ECO:0000303 with PMID:16835300^[1]) NgBR (ECO:0000303 with PMID:16835300^[1]) Nuclear undecaprenyl pyrophosphate synthase 1 homolog (ECO:0000305)
External Links
UniProt	Q96E22
EMBL	Z98172 AL590303 AL590303 Z98172 CH471051 BC013026 BC063794 BC066910 BC110325 BC150654 BC150655 U82319
CCDS	CCDS5118.1
RefSeq	NP_612468.1
UniGene	Hs.289008 Hs.525826
ProteinModelPortal	Q96E22
BioGrid	125481
IntAct	Q96E22
MINT	MINT-3052208
STRING	9606.ENSP00000357480
DMDM	74762651
MaxQB	Q96E22
PaxDb	Q96E22
PRIDE	Q96E22
Ensembl	ENST00000368494
GeneID	116150
KEGG	hsa:116150
UCSC	uc003pxw.3
CTD	116150
GeneCards	GC06P117997
H-InvDB	HIX0022536
HGNC	HGNC:21042
HPA	HPA027504
MIM	610463
neXtProt	NX_Q96E22
PharmGKB	PA162398248
eggNOG	COG0020
GeneTree	ENSGT00390000003223
HOGENOM	HOG000007321
HOVERGEN	HBG082024
InParanoid	Q96E22
OMA	YVSVYDH
OrthoDB	EOG773XGR
PhylomeDB	Q96E22
TreeFam	TF332448
UniPathway	UPA00378
GenomeRNAi	116150
NextBio	79794
PRO	PR:Q96E22
Proteomes	UP000005640
Bgee	Q96E22
CleanEx	HS_NUS1
Genevestigator	Q96E22
GO	GO:0005789 GO:0016021 GO:0016765 GO:0001525 GO:0030154 GO:0032367 GO:0006486 GO:0055092
Gene3D	3.40.1180.10
InterPro	IPR001441
Pfam	PF01255
SUPFAM	SSF64005

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0005515	protein binding	PMID:19723497^[2]	ECO:0000021		UniProtKB:Q9Z0J0	F		Figure 1A	complete
	GO:0050821	protein stabilization	PMID:19723497^[2]	ECO:0000315			P		figure 1E, F	complete
	GO:0010468	regulation of gene expression	PMID:19723497^[2]	ECO:0000315			P		Fig.1E,F	complete
	GO:0030301	cholesterol transport	PMID:19723497^[2]	ECO:0000315			P		figure 5A,B	complete
	GO:0042632	cholesterol homeostasis	PMID:19723497^[2]	ECO:0000315			P		figure 5,6	complete
	GO:0032935	sterol sensor activity	PMID:19723497^[2]	ECO:0000315			F		figure 6A	complete
	GO:0005783	endoplasmic reticulum	PMID:19723497^[2]	ECO:0000314			C		figure 3A,B	complete
involved_in	GO:0006489	dolichyl diphosphate biosynthetic process	PMID:28842490^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:1904423	dehydrodolichyl diphosphate synthase complex	PMID:28842490^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0045547	dehydrodolichyl diphosphate synthase activity	PMID:28842490^[3]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0043536	positive regulation of blood vessel endothelial cell migration	PMID:28602162^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0002618) part_of:(GO:0038084)	Seeded From UniProt	complete
involved_in	GO:0038084	vascular endothelial growth factor signaling pathway	PMID:28602162^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0002618)	Seeded From UniProt	complete
involved_in	GO:0051000	positive regulation of nitric-oxide synthase activity	PMID:28602162^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0002618) has_regulation_target:(ENSEMBL:ENSG00000164867) part_of:(GO:0038084)	Seeded From UniProt	complete
involved_in	GO:0032383	regulation of intracellular cholesterol transport	PMID:19723497^[2]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P61916	P		Seeded From UniProt	complete
involved_in	GO:0019408	dolichol biosynthetic process	PMID:25066056^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005789	endoplasmic reticulum membrane	PMID:19723497^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
contributes_to	GO:0004659	prenyltransferase activity	PMID:25066056^[5]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0055092	sterol homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99LJ8 ensembl:ENSMUSP00000023830	P		Seeded From UniProt	complete
involved_in	GO:0042632	cholesterol homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99LJ8 ensembl:ENSMUSP00000023830	P		Seeded From UniProt	complete
involved_in	GO:0035268	protein mannosylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99LJ8 ensembl:ENSMUSP00000023830	P		Seeded From UniProt	complete
involved_in	GO:0032383	regulation of intracellular cholesterol transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99LJ8 ensembl:ENSMUSP00000023830	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99LJ8 ensembl:ENSMUSP00000023830	C		Seeded From UniProt	complete
enables	GO:0004659	prenyltransferase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99LJ8 ensembl:ENSMUSP00000023830	F		Seeded From UniProt	complete
involved_in	GO:0001525	angiogenesis	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR038887	P		Seeded From UniProt	complete
enables	GO:0016765	transferase activity, transferring alkyl or aryl (other than methyl) groups	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001441 InterPro:IPR036424	F		Seeded From UniProt	complete
involved_in	GO:0019408	dolichol biosynthetic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR038887	P		Seeded From UniProt	complete
part_of	GO:1904423	dehydrodolichyl diphosphate synthase complex	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR038887	C		Seeded From UniProt	complete
involved_in	GO:0006489	dolichyl diphosphate biosynthetic process	Reactome:R-HSA-446199	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005789	endoplasmic reticulum membrane	Reactome:R-HSA-4419978	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0217	P		Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0221	P		Seeded From UniProt	complete
involved_in	GO:0006629	lipid metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0443	P		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
involved_in	GO:0001525	angiogenesis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0037	P		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0256	C		Seeded From UniProt	complete
part_of	GO:0005789	endoplasmic reticulum membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0097	C		Seeded From UniProt	complete
involved_in	GO:0006486	protein glycosylation	GO_REF:0000041	ECO:0000322	imported manually asserted information used in automatic assertion	UniPathway:UPA00378	P		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Miao, RQ et al. (2006) Identification of a receptor necessary for Nogo-B stimulated chemotaxis and morphogenesis of endothelial cells. Proc. Natl. Acad. Sci. U.S.A. 103 10997-1002 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 ^2.8 Harrison, KD et al. (2009) Nogo-B receptor stabilizes Niemann-Pick type C2 protein and regulates intracellular cholesterol trafficking. Cell Metab. 10 208-18 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Grabińska, KA et al. (2017) A conserved C-terminal RG motif in the NgBR subunit of -prenyltransferase is critical for prenyltransferase activity. J. Biol. Chem. 292 17351-17361 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Jo, HN et al. (2017) Endothelial miR-26a regulates VEGF-Nogo-B receptor-mediated angiogenesis. BMB Rep 50 384-389 PubMed GONUTS page
↑ ^5.0 ^5.1 Park, EJ et al. (2014) Mutation of Nogo-B receptor, a subunit of cis-prenyltransferase, causes a congenital disorder of glycosylation. Cell Metab. 20 448-57 PubMed GONUTS page

[PMID:16835300-1] 1.0 ^1.1 Miao, RQ et al. (2006) Identification of a receptor necessary for Nogo-B stimulated chemotaxis and morphogenesis of endothelial cells. Proc. Natl. Acad. Sci. U.S.A. 103 10997-1002 PubMed GONUTS page

[PMID:19723497-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 ^2.8 Harrison, KD et al. (2009) Nogo-B receptor stabilizes Niemann-Pick type C2 protein and regulates intracellular cholesterol trafficking. Cell Metab. 10 208-18 PubMed GONUTS page

[PMID:28842490-3] 3.0 ^3.1 ^3.2 Grabińska, KA et al. (2017) A conserved C-terminal RG motif in the NgBR subunit of -prenyltransferase is critical for prenyltransferase activity. J. Biol. Chem. 292 17351-17361 PubMed GONUTS page

[PMID:28602162-4] 4.0 ^4.1 ^4.2 Jo, HN et al. (2017) Endothelial miR-26a regulates VEGF-Nogo-B receptor-mediated angiogenesis. BMB Rep 50 384-389 PubMed GONUTS page

[PMID:25066056-5] 5.0 ^5.1 Park, EJ et al. (2014) Mutation of Nogo-B receptor, a subunit of cis-prenyltransferase, causes a congenital disorder of glycosylation. Cell Metab. 20 448-57 PubMed GONUTS page

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HUMAN:NGBR

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