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HUMAN:NBR1
Contents
Species (Taxon ID) | Homo sapiens (Human). (9606) | |
Gene Name(s) | NBR1 (synonyms: 1A13B, KIAA0049, M17S2) | |
Protein Name(s) | Next to BRCA1 gene 1 protein
Cell migration-inducing gene 19 protein Membrane component chromosome 17 surface marker 2 Neighbor of BRCA1 gene 1 protein Protein 1A1-3B | |
External Links | ||
UniProt | Q14596 | |
EMBL | X76952 D30756 AY450308 AC060780 AC109326 CH471152 BC009808 AF227189 U25764 | |
CCDS | CCDS45694.1 | |
RefSeq | NP_001278500.1 NP_001278501.1 NP_005890.2 NP_114068.1 | |
UniGene | Hs.277721 Hs.708158 | |
PDB | 1WJ6 2BKF 2CP8 2G4S 2L8J 2MGW 2MJ5 4OLE | |
PDBsum | 1WJ6 2BKF 2CP8 2G4S 2L8J 2MGW 2MJ5 4OLE | |
ProteinModelPortal | Q14596 | |
SMR | Q14596 | |
BioGrid | 110253 | |
IntAct | Q14596 | |
MINT | MINT-2806845 | |
STRING | 9606.ENSP00000343479 | |
PhosphoSite | Q14596 | |
DMDM | 296439290 | |
MaxQB | Q14596 | |
PaxDb | Q14596 | |
PRIDE | Q14596 | |
DNASU | 4077 | |
Ensembl | ENST00000341165 ENST00000422280 ENST00000586650 ENST00000589872 ENST00000590996 | |
GeneID | 4077 | |
KEGG | hsa:4077 | |
UCSC | uc010czd.3 uc010whu.2 | |
CTD | 4077 | |
GeneCards | GC17P041322 | |
HGNC | HGNC:6746 | |
HPA | HPA022999 HPA023999 | |
MIM | 166945 | |
neXtProt | NX_Q14596 | |
PharmGKB | PA30510 | |
eggNOG | NOG239857 | |
GeneTree | ENSGT00390000016335 | |
HOGENOM | HOG000220861 | |
HOVERGEN | HBG052578 | |
InParanoid | Q14596 | |
KO | K17987 | |
OMA | AHLFEMG | |
OrthoDB | EOG7FNC6V | |
PhylomeDB | Q14596 | |
TreeFam | TF328428 | |
EvolutionaryTrace | Q14596 | |
GeneWiki | NBR1 | |
GenomeRNAi | 4077 | |
NextBio | 15978 | |
PRO | PR:Q14596 | |
Proteomes | UP000005640 | |
Bgee | Q14596 | |
CleanEx | HS_NBR1 | |
ExpressionAtlas | Q14596 | |
Genevestigator | Q14596 | |
GO | GO:0005776 GO:0031410 GO:0005829 GO:0070062 GO:0005770 GO:0005764 GO:0031430 GO:0016020 GO:0000407 GO:0051019 GO:0043130 GO:0008270 GO:0016236 GO:0045668 GO:0051259 GO:0030500 GO:0032872 | |
InterPro | IPR000270 IPR009060 IPR015940 IPR000433 | |
Pfam | PF00564 PF00569 | |
SMART | SM00666 SM00291 | |
SUPFAM | SSF46934 | |
PROSITE | PS50030 PS01357 PS50135 |
Annotations
Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
---|---|---|---|---|---|---|---|---|---|---|
colocalizes_with |
GO:0005739 |
mitochondrion |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0016020 |
membrane |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0051019 |
mitogen-activated protein kinase binding |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0045668 |
negative regulation of osteoblast differentiation |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0032872 |
regulation of stress-activated MAPK cascade |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0030500 |
regulation of bone mineralization |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
colocalizes_with |
GO:0005776 |
autophagosome |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0051259 |
protein complex oligomerization |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0043130 |
ubiquitin binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
GO:0051019 |
mitogen-activated protein kinase binding |
ECO:0000314 |
F |
Fig.1 BRCA1 phosphorylation |
complete | |||||
involved_in |
GO:0016236 |
macroautophagy |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0005829 |
cytosol |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005770 |
late endosome |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0043130 |
ubiquitin binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000468017 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0016236 |
macroautophagy |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000468017 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0005776 |
autophagosome |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:108498 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0000407 |
phagophore assembly site |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:108498 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0043231 |
intracellular membrane-bounded organelle |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0016604 |
nuclear body |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005654 |
nucleoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0051019 |
mitogen-activated protein kinase binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P97432 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0045668 |
negative regulation of osteoblast differentiation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P97432 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0032872 |
regulation of stress-activated MAPK cascade |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P97432 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0030500 |
regulation of bone mineralization |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P97432 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0005776 |
autophagosome |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P97432 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0005770 |
late endosome |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P97432 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0000407 |
phagophore assembly site |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P97432 |
C |
Seeded From UniProt |
complete | ||
enables |
GO:0008270 |
zinc ion binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0016236 |
macroautophagy |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0043130 |
ubiquitin binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0031410 |
cytoplasmic vesicle |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005764 |
lysosome |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0046872 |
metal ion binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0031430 |
M band |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005776 |
autophagosome |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Chan, NC et al. (2011) Broad activation of the ubiquitin-proteasome system by Parkin is critical for mitophagy. Hum. Mol. Genet. 20 1726-37 PubMed GONUTS page
- ↑ Ghosh, D et al. (2010) Defining the membrane proteome of NK cells. J Mass Spectrom 45 1-25 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 Kirkin, V et al. (2009) A role for NBR1 in autophagosomal degradation of ubiquitinated substrates. Mol. Cell 33 505-16 PubMed GONUTS page
- ↑ Waters, S et al. (2009) Interactions with LC3 and polyubiquitin chains link nbr1 to autophagic protein turnover. FEBS Lett. 583 1846-52 PubMed GONUTS page
- ↑ Parameswaran, B et al. (2015) Damage-induced BRCA1 phosphorylation by Chk2 contributes to the timing of end resection. Cell Cycle 14 437-48 PubMed GONUTS page
- ↑ 6.0 6.1 6.2 6.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
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