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HUMAN:NBR1

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) NBR1 (synonyms: 1A13B, KIAA0049, M17S2)
Protein Name(s) Next to BRCA1 gene 1 protein

Cell migration-inducing gene 19 protein Membrane component chromosome 17 surface marker 2 Neighbor of BRCA1 gene 1 protein Protein 1A1-3B

External Links
UniProt Q14596
EMBL X76952
D30756
AY450308
AC060780
AC109326
CH471152
BC009808
AF227189
U25764
CCDS CCDS45694.1
RefSeq NP_001278500.1
NP_001278501.1
NP_005890.2
NP_114068.1
UniGene Hs.277721
Hs.708158
PDB 1WJ6
2BKF
2CP8
2G4S
2L8J
2MGW
2MJ5
4OLE
PDBsum 1WJ6
2BKF
2CP8
2G4S
2L8J
2MGW
2MJ5
4OLE
ProteinModelPortal Q14596
SMR Q14596
BioGrid 110253
IntAct Q14596
MINT MINT-2806845
STRING 9606.ENSP00000343479
PhosphoSite Q14596
DMDM 296439290
MaxQB Q14596
PaxDb Q14596
PRIDE Q14596
DNASU 4077
Ensembl ENST00000341165
ENST00000422280
ENST00000586650
ENST00000589872
ENST00000590996
GeneID 4077
KEGG hsa:4077
UCSC uc010czd.3
uc010whu.2
CTD 4077
GeneCards GC17P041322
HGNC HGNC:6746
HPA HPA022999
HPA023999
MIM 166945
neXtProt NX_Q14596
PharmGKB PA30510
eggNOG NOG239857
GeneTree ENSGT00390000016335
HOGENOM HOG000220861
HOVERGEN HBG052578
InParanoid Q14596
KO K17987
OMA AHLFEMG
OrthoDB EOG7FNC6V
PhylomeDB Q14596
TreeFam TF328428
EvolutionaryTrace Q14596
GeneWiki NBR1
GenomeRNAi 4077
NextBio 15978
PRO PR:Q14596
Proteomes UP000005640
Bgee Q14596
CleanEx HS_NBR1
ExpressionAtlas Q14596
Genevestigator Q14596
GO GO:0005776
GO:0031410
GO:0005829
GO:0070062
GO:0005770
GO:0005764
GO:0031430
GO:0016020
GO:0000407
GO:0051019
GO:0043130
GO:0008270
GO:0016236
GO:0045668
GO:0051259
GO:0030500
GO:0032872
InterPro IPR000270
IPR009060
IPR015940
IPR000433
Pfam PF00564
PF00569
SMART SM00666
SM00291
SUPFAM SSF46934
PROSITE PS50030
PS01357
PS50135

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

colocalizes_with

GO:0005739

mitochondrion

PMID:21296869[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0016020

membrane

PMID:19946888[2]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0051019

mitogen-activated protein kinase binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P97432

F

Seeded From UniProt

complete

involved_in

GO:0045668

negative regulation of osteoblast differentiation

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P97432

P

Seeded From UniProt

complete

involved_in

GO:0032872

regulation of stress-activated MAPK cascade

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P97432

P

Seeded From UniProt

complete

involved_in

GO:0030500

regulation of bone mineralization

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P97432

P

Seeded From UniProt

complete

colocalizes_with

GO:0005776

autophagosome

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P97432

C

Seeded From UniProt

complete

involved_in

GO:0051259

protein complex oligomerization

PMID:19250911[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0043130

ubiquitin binding

PMID:19427866[4]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

GO:0051019

mitogen-activated protein kinase binding

PMID:25659039[5]

ECO:0000314

F

Fig.1 BRCA1 phosphorylation

complete
CACAO 10639

involved_in

GO:0016236

macroautophagy

PMID:19250911[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

PMID:19250911[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005770

late endosome

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P97432

C

Seeded From UniProt

complete

enables

GO:0043130

ubiquitin binding

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000468017
UniProtKB:Q14596

F

Seeded From UniProt

complete

involved_in

GO:0016236

macroautophagy

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000468017
UniProtKB:Q14596

P

Seeded From UniProt

complete

part_of

GO:0005776

autophagosome

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:108498
PANTHER:PTN000468017

C

Seeded From UniProt

complete

part_of

GO:0000407

phagophore assembly site

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:108498
PANTHER:PTN000468017

C

Seeded From UniProt

complete

part_of

GO:0043231

intracellular membrane-bounded organelle

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0016604

nuclear body

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0051019

mitogen-activated protein kinase binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P97432
ensembl:ENSMUSP00000099388

F

Seeded From UniProt

complete

involved_in

GO:0045668

negative regulation of osteoblast differentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P97432
ensembl:ENSMUSP00000099388

P

Seeded From UniProt

complete

involved_in

GO:0032872

regulation of stress-activated MAPK cascade

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P97432
ensembl:ENSMUSP00000099388

P

Seeded From UniProt

complete

involved_in

GO:0030500

regulation of bone mineralization

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P97432
ensembl:ENSMUSP00000099388

P

Seeded From UniProt

complete

part_of

GO:0005776

autophagosome

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P97432
ensembl:ENSMUSP00000099388

C

Seeded From UniProt

complete

part_of

GO:0005770

late endosome

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P97432
ensembl:ENSMUSP00000099388

C

Seeded From UniProt

complete

part_of

GO:0000407

phagophore assembly site

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P97432
ensembl:ENSMUSP00000099388

C

Seeded From UniProt

complete

enables

GO:0008270

zinc ion binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000433

F

Seeded From UniProt

complete

involved_in

GO:0016236

macroautophagy

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR033513

P

Seeded From UniProt

complete

enables

GO:0043130

ubiquitin binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR033513

F

Seeded From UniProt

complete

part_of

GO:0031410

cytoplasmic vesicle

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0968

C

Seeded From UniProt

complete

part_of

GO:0005764

lysosome

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0458
UniProtKB-SubCell:SL-0158

C

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

part_of

GO:0031430

M band

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0315

C

Seeded From UniProt

complete

part_of

GO:0005776

autophagosome

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0023

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. Chan, NC et al. (2011) Broad activation of the ubiquitin-proteasome system by Parkin is critical for mitophagy. Hum. Mol. Genet. 20 1726-37 PubMed GONUTS page
  2. Ghosh, D et al. (2010) Defining the membrane proteome of NK cells. J Mass Spectrom 45 1-25 PubMed GONUTS page
  3. 3.0 3.1 3.2 Kirkin, V et al. (2009) A role for NBR1 in autophagosomal degradation of ubiquitinated substrates. Mol. Cell 33 505-16 PubMed GONUTS page
  4. Waters, S et al. (2009) Interactions with LC3 and polyubiquitin chains link nbr1 to autophagic protein turnover. FEBS Lett. 583 1846-52 PubMed GONUTS page
  5. Parameswaran, B et al. (2015) Damage-induced BRCA1 phosphorylation by Chk2 contributes to the timing of end resection. Cell Cycle 14 437-48 PubMed GONUTS page
  6. 6.0 6.1 6.2 6.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page