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HUMAN:MITF
Contents
Species (Taxon ID) | Homo sapiens (Human). (9606) | |
Gene Name(s) | MITF (synonyms: BHLHE32) | |
Protein Name(s) | Microphthalmia-associated transcription factor
Class E basic helix-loop-helix protein 32 bHLHe32 | |
External Links | ||
UniProt | O75030 | |
EMBL | AB006909 AB006989 Z29678 GU355676 AL110195 AK296129 AC099326 AC104445 AC104449 AC124915 BC026961 BC065243 AF034755 AB032359 AB032358 AB032357 AB009608 | |
CCDS | CCDS2913.1 CCDS43106.1 CCDS43107.1 CCDS46865.1 CCDS46866.2 CCDS54607.1 | |
PIR | I38024 T14752 | |
RefSeq | NP_000239.1 NP_001171896.1 NP_006713.1 NP_937801.1 NP_937802.1 NP_937820.1 NP_937821.2 XP_005264811.1 XP_005264812.1 | |
UniGene | Hs.166017 Hs.618266 | |
PDB | 4C7N | |
PDBsum | 4C7N | |
ProteinModelPortal | O75030 | |
SMR | O75030 | |
BioGrid | 110432 | |
DIP | DIP-59573N | |
IntAct | O75030 | |
MINT | MINT-7997258 | |
STRING | 9606.ENSP00000295600 | |
ChEMBL | CHEMBL1741165 | |
PhosphoSite | O75030 | |
MaxQB | O75030 | |
PaxDb | O75030 | |
PRIDE | O75030 | |
Ensembl | ENST00000314557 ENST00000314589 ENST00000328528 ENST00000352241 ENST00000394351 ENST00000448226 ENST00000472437 ENST00000531774 | |
GeneID | 4286 | |
KEGG | hsa:4286 | |
UCSC | uc003dnz.3 uc003doa.3 uc003dob.3 uc003doe.3 uc003dof.3 uc021xam.1 | |
CTD | 4286 | |
GeneCards | GC03P069788 | |
HGNC | HGNC:7105 | |
HPA | CAB002578 HPA003259 | |
MIM | 103470 103500 156845 193510 614456 | |
neXtProt | NX_O75030 | |
Orphanet | 319276 293822 352740 319298 42665 895 | |
PharmGKB | PA30823 | |
eggNOG | NOG251286 | |
GeneTree | ENSGT00390000004402 | |
HOGENOM | HOG000231368 | |
HOVERGEN | HBG006768 | |
InParanoid | O75030 | |
KO | K09455 | |
OMA | VLENCNQ | |
OrthoDB | EOG72G182 | |
PhylomeDB | O75030 | |
TreeFam | TF317174 | |
SignaLink | O75030 | |
GeneWiki | Microphthalmia-associated_transcription_factor | |
GenomeRNAi | 4286 | |
NextBio | 16861 | |
PMAP-CutDB | O75030 | |
PRO | PR:O75030 | |
Proteomes | UP000005640 | |
Bgee | O75030 | |
CleanEx | HS_MITF | |
ExpressionAtlas | O75030 | |
Genevestigator | O75030 | |
GO | GO:0005634 GO:0043234 GO:0003682 GO:0000978 GO:0001077 GO:0000979 GO:0003705 GO:0001227 GO:0046849 GO:0043010 GO:0044336 GO:0045165 GO:0030318 GO:0000122 GO:0030316 GO:0045944 GO:0045893 GO:0006461 GO:0042127 GO:0045670 GO:0006355 | |
Gene3D | 4.10.280.10 | |
InterPro | IPR011598 IPR021802 | |
Pfam | PF11851 PF00010 | |
SMART | SM00353 | |
SUPFAM | SSF47459 | |
PROSITE | PS50888 |
Annotations
Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
---|---|---|---|---|---|---|---|---|---|---|
GO:2001141 |
regulation of RNA biosynthetic process |
ECO:0000314 |
P |
figure 5b1 and 5b2 show that MITF-M transfection upregulates PKC-beta promoter activity approximately 60-fold over control vector transfection. |
complete | |||||
GO:0010628 |
positive regulation of gene expression |
ECO:0000314 |
P |
The over-expression of the transcription factor MITF in HEMn-LP cells (cells with the C-allele, which have lighter pigmentation)led to increased OCA2 expression, which darkened the pigmentation of the cell (Figure 4-E). |
complete | |||||
GO:0010628 |
positive regulation of gene expression |
ECO:0000315 |
P |
The over-expression of the negative transcription form of MITF in HEMn-LP cells (dnMITF )led to decreased OCA2 expression, which lightened the pigmentation of the cell (Figure 4E). This was an IMP was the conclusion about the role of MITF was drawn from a mutant phenotype. |
complete | |||||
GO:2000144 |
positive regulation of DNA-templated transcription, initiation |
ECO:0000314 |
P |
Figure 2. CATGTG is a DNA sequence conserved in human MC1R genes, which are responsible for melanin synthesis. A PicaGene Luciferase assay was conducted using luciferase as a reporter gene to measure the activity of the MC1R promoter. When transcription factor MITF was introduced into a human cell with CATGTG present, luciferase activity increased, indicating that the MITF bound to CATGTG and increased MC1R promoter activity. A human -447 cell without CATGTG was used as a negative control; luciferase activity was unaffected by the presence of MITF. Human cells with the tryrosinase enzyme and the TRP-1 gene were used as positive controls, because MITF has already been shown to positively regulate their transcription in other experiments. The findings of this control were consistent with the expected results because the presence of MITF increased luciferase activty. Overall, this proves that the presence of MITF initiates transactivation of MC1R by binding with CATGTG. |
complete | |||||
GO:0010628 |
positive regulation of gene expression |
ECO:0000314 |
P |
Figure 2. CATGTG is a DNA sequence conserved in human MC1R genes, which are responsible for melanin synthesis. A PicaGene Luciferase assay was conducted using luciferase as a reporter gene to measure the activity of the MC1R promoter. When transcription factor MITF was introduced into a human cell with CATGTG present, luciferase activity increased, indicating that the MITF bound to CATGTG and increased MC1R promoter activity. A human -447 cell without CATGTG was used as a negative control; luciferase activity was unaffected by the presence of MITF. Human cells with the tryrosinase enzyme and the TRP-1 gene were used as positive controls, because MITF has already been shown to positively regulate their transcription in other experiments. The findings of this control were consistent with the expected results because the presence of MITF increased luciferase activty. Overall, this proves that the presence of MITF correlates with an increase of melanin synthesis and positively regulates the gene expression of MC1R. |
complete | |||||
GO:2000144 |
positive regulation of DNA-templated transcription, initiation |
ECO:0000314 |
P |
Figure 1A/B. Transient cotransfection assays using luciferase as a reporter gene were performed on two types of cells (pigmented and unpigmented) to determine the result of overexpression of MITF. The psV2 gene is derived from luciferase and therefore is used as a control because its luciferase activity will not be affected by MITF. Luciferase activity increased more than the control when MITF was overproduced in both cells containing the TRP-1 gene, indicating that MITF transactivates the TRP-1 gene promoter. |
complete | |||||
GO:0010628 |
positive regulation of gene expression |
ECO:0000315 |
P |
Human fetal cells were transfected with MITF siRNA versus control siRNA. Figure 4B shows that a knockdown (reduction) of MITF causes a down-reguation of the gene TRPM1 when all other factors are held constant. Therefore, MITF is responsible for the upregulation of TRPM1. |
complete | |||||
enables |
GO:0000981 |
DNA-binding transcription factor activity, RNA polymerase II-specific |
ECO:0000303 |
author statement without traceable support used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0000981 |
DNA-binding transcription factor activity, RNA polymerase II-specific |
ECO:0000255 |
match to sequence model evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0000981 |
DNA-binding transcription factor activity, RNA polymerase II-specific |
ECO:0005556 |
multiple sequence alignment evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0030336 |
negative regulation of cell migration |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006355 |
regulation of transcription, DNA-templated |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0070888 |
E-box binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0010628 |
positive regulation of gene expression |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:2000144 |
positive regulation of DNA-templated transcription, initiation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:2000144 |
positive regulation of DNA-templated transcription, initiation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0010628 |
positive regulation of gene expression |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0010628 |
positive regulation of gene expression |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0001227 |
DNA-binding transcription repressor activity, RNA polymerase II-specific |
ECO:0000303 |
author statement without traceable support used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:2001141 |
regulation of RNA biosynthetic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0000122 |
negative regulation of transcription by RNA polymerase II |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
has_regulation_target:(UniProtKB:P37275) |
Seeded From UniProt |
complete | ||
involved_in |
GO:0045944 |
positive regulation of transcription by RNA polymerase II |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
has_regulation_target:(NCBI_Gene:17229) |
Seeded From UniProt |
complete | ||
enables |
GO:0001228 |
DNA-binding transcription activator activity, RNA polymerase II-specific |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
F |
occurs_at:(SO:0001952) |
Seeded From UniProt |
complete | ||
enables |
GO:0001228 |
DNA-binding transcription activator activity, RNA polymerase II-specific |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
occurs_at:(SO:0001952) |
Seeded From UniProt |
complete | ||
enables |
GO:0000978 |
RNA polymerase II proximal promoter sequence-specific DNA binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0045944 |
positive regulation of transcription by RNA polymerase II |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
has_regulation_target:(UniProtKB:Q14956) |
Seeded From UniProt |
complete | ||
involved_in |
GO:0045944 |
positive regulation of transcription by RNA polymerase II |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0045893 |
positive regulation of transcription, DNA-templated |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0045893 |
positive regulation of transcription, DNA-templated |
ECO:0000303 |
author statement without traceable support used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0032991 |
protein-containing complex |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0030318 |
melanocyte differentiation |
ECO:0000303 |
author statement without traceable support used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0065003 |
protein-containing complex assembly |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006355 |
regulation of transcription, DNA-templated |
ECO:0000303 |
author statement without traceable support used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006355 |
regulation of transcription, DNA-templated |
ECO:0000303 |
author statement without traceable support used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0005634 |
nucleus |
ECO:0000303 |
author statement without traceable support used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005634 |
nucleus |
ECO:0000303 |
author statement without traceable support used in manual assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0001228 |
DNA-binding transcription activator activity, RNA polymerase II-specific |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
occurs_at:(SO:0001952) |
Seeded From UniProt |
complete | ||
involved_in |
GO:0030318 |
melanocyte differentiation |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:104554 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0006351 |
transcription, DNA-templated |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O88368 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0070888 |
E-box binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q08874 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0046983 |
protein dimerization activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q08874 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0046849 |
bone remodeling |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q08874 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0045944 |
positive regulation of transcription by RNA polymerase II |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q08874 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0045893 |
positive regulation of transcription, DNA-templated |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q08874 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0045670 |
regulation of osteoclast differentiation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q08874 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0045165 |
cell fate commitment |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q08874 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0044336 |
canonical Wnt signaling pathway involved in negative regulation of apoptotic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q08874 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0043473 |
pigmentation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q08874 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0043066 |
negative regulation of apoptotic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q08874 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0043010 |
camera-type eye development |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q08874 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0042127 |
regulation of cell population proliferation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q08874 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0030318 |
melanocyte differentiation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q08874 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0030316 |
osteoclast differentiation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q08874 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0030154 |
cell differentiation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q08874 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0016055 |
Wnt signaling pathway |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q08874 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0010468 |
regulation of gene expression |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q08874 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0006357 |
regulation of transcription by RNA polymerase II |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q08874 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0006355 |
regulation of transcription, DNA-templated |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q08874 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0005634 |
nucleus |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q08874 |
C |
Seeded From UniProt |
complete | ||
enables |
GO:0003700 |
DNA-binding transcription factor activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q08874 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0003682 |
chromatin binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q08874 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0003677 |
DNA binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q08874 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0001228 |
DNA-binding transcription activator activity, RNA polymerase II-specific |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q08874 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0000981 |
DNA-binding transcription factor activity, RNA polymerase II-specific |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q08874 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0000978 |
RNA polymerase II proximal promoter sequence-specific DNA binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q08874 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0003700 |
DNA-binding transcription factor activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0005634 |
nucleus |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006355 |
regulation of transcription, DNA-templated |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006357 |
regulation of transcription by RNA polymerase II |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0046983 |
protein dimerization activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0005654 |
nucleoplasm |
Reactome:R-HSA-3232162 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | ||
enables |
GO:0003677 |
DNA binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0007275 |
multicellular organism development |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Park, HY et al. (2006) MITF mediates cAMP-induced protein kinase C-beta expression in human melanocytes. Biochem. J. 395 571-8 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 Visser, M et al. (2012) HERC2 rs12913832 modulates human pigmentation by attenuating chromatin-loop formation between a long-range enhancer and the OCA2 promoter. Genome Res. 22 446-55 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 Aoki, H & Moro, O (2002) Involvement of microphthalmia-associated transcription factor (MITF) in expression of human melanocortin-1 receptor (MC1R). Life Sci. 71 2171-9 PubMed GONUTS page
- ↑ 4.0 4.1 Yasumoto, K et al. (1997) Functional analysis of microphthalmia-associated transcription factor in pigment cell-specific transcription of the human tyrosinase family genes. J. Biol. Chem. 272 503-9 PubMed GONUTS page
- ↑ 5.0 5.1 Adijanto, J et al. (2012) Microphthalmia-associated transcription factor (MITF) promotes differentiation of human retinal pigment epithelium (RPE) by regulating microRNAs-204/211 expression. J. Biol. Chem. 287 20491-503 PubMed GONUTS page
- ↑ 6.0 6.1 Vaquerizas, JM et al. (2009) A census of human transcription factors: function, expression and evolution. Nat. Rev. Genet. 10 252-63 PubMed GONUTS page
- ↑ Segura, MF et al. (2009) Aberrant miR-182 expression promotes melanoma metastasis by repressing FOXO3 and microphthalmia-associated transcription factor. Proc. Natl. Acad. Sci. U.S.A. 106 1814-9 PubMed GONUTS page
- ↑ 8.0 8.1 8.2 George, A et al. (2016) Biallelic Mutations in MITF Cause Coloboma, Osteopetrosis, Microphthalmia, Macrocephaly, Albinism, and Deafness. Am. J. Hum. Genet. 99 1388-1394 PubMed GONUTS page
- ↑ 9.0 9.1 Denecker, G et al. (2014) Identification of a ZEB2-MITF-ZEB1 transcriptional network that controls melanogenesis and melanoma progression. Cell Death Differ. 21 1250-61 PubMed GONUTS page
- ↑ 10.0 10.1 10.2 10.3 Joo, A et al. (2004) STAT3 and MITF cooperatively induce cellular transformation through upregulation of c-fos expression. Oncogene 23 726-34 PubMed GONUTS page
- ↑ Hong, SB et al. (2010) Inactivation of the FLCN tumor suppressor gene induces TFE3 transcriptional activity by increasing its nuclear localization. PLoS ONE 5 e15793 PubMed GONUTS page
- ↑ 12.0 12.1 12.2 12.3 Masuda, T & Esumi, N (2010) SOX9, through interaction with microphthalmia-associated transcription factor (MITF) and OTX2, regulates BEST1 expression in the retinal pigment epithelium. J. Biol. Chem. 285 26933-44 PubMed GONUTS page
- ↑ 13.0 13.1 13.2 13.3 Amae, S et al. (1998) Identification of a novel isoform of microphthalmia-associated transcription factor that is enriched in retinal pigment epithelium. Biochem. Biophys. Res. Commun. 247 710-5 PubMed GONUTS page
- ↑ 14.0 14.1 14.2 Fuse, N et al. (1999) Molecular cloning of cDNA encoding a novel microphthalmia-associated transcription factor isoform with a distinct amino-terminus. J. Biochem. 126 1043-51 PubMed GONUTS page
- ↑ Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
c
d
- GO:0001227 ! DNA-binding transcription repressor activity, RNA polymerase II-specific
- GO:0003700 ! DNA-binding transcription factor activity
- GO:0001228 ! DNA-binding transcription activator activity, RNA polymerase II-specific
- GO:0000981 ! DNA-binding transcription factor activity, RNA polymerase II-specific
- GO:0006351 ! DNA-templated transcription
- GO:0003677 ! DNA binding
m
n
p
- GO:0043473 ! pigmentation
- GO:0045944 ! positive regulation of transcription by RNA polymerase II
- GO:0045893 ! positive regulation of DNA-templated transcription
- GO:2000144 ! positive regulation of DNA-templated transcription initiation
- GO:0010628 ! positive regulation of gene expression
- Primates
- GO:0065003 ! protein-containing complex assembly
- GO:0032991 ! protein-containing complex
- GO:0046983 ! protein dimerization activity
r
- GO:2001141 ! regulation of RNA biosynthetic process
- GO:0006357 ! regulation of transcription by RNA polymerase II
- GO:0010468 ! regulation of gene expression
- GO:0045670 ! regulation of osteoclast differentiation
- GO:0006355 ! regulation of DNA-templated transcription
- GO:0042127 ! regulation of cell population proliferation
- GO:0000978 ! RNA polymerase II cis-regulatory region sequence-specific DNA binding