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HUMAN:MICA

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) MICA (ECO:0000312 with EMBL:CAI41907.1) (synonyms: PERB11.1 (ECO:0000303 with PMID:8613147[1]))
Protein Name(s) MHC class I polypeptide-related sequence A

MIC-A

External Links
UniProt Q29983
EMBL L14848
X92841
AL845443
CR847852
BC016929
BG114064
L29406
L29408
L29409
L29411
U56940
U56941
U56942
U56943
U56944
U56945
U56946
U56947
U56948
U56949
U56950
U56951
U56952
U56953
U56954
U56955
Y16801
Y16802
Y16803
Y16804
Y16805
Y16806
Y16807
Y16808
Y16809
Y16810
Y16811
Y18110
Y18111
Y18112
AF097403
AF097404
AF097405
AF097406
AB015600
AJ563426
AH007168
AH007170
AH007171
AH007173
AH007174
AH007186
AH007175
AH007176
AH007177
AH007178
AH007179
AH007180
AH007182
AH007183
AH007184
AH007185
AH008136
AH008137
AH008138
AH008139
AH008140
AH008141
AH008142
AH008143
AH008144
AH008145
AH008146
AH008147
AH008148
AH007169
AH007172
AH007167
AH007181
AH010819
AH011143
AH010820
AH010821
AH010545
AH010526
AH010568
AH010569
AH010532
AH010546
AH010560
AH010561
AH010587
AH010562
AH010571
AH010572
AH010740
AJ250499
AJ250500
AJ250501
AJ250502
AJ250503
AJ250504
AJ250505
AJ250506
AJ250507
AJ250802
AJ250803
AJ250804
AJ250805
AJ250990
AJ250991
AJ271789
AY603357
AJ249394
AJ295250
AJ295251
AJ580805
AJ580806
AH014149
AM899996
EU254723
AM944063
AH006330
AH006331
AH006332
AH006333
AH006334
AH007472
AH007473
AH007474
AH007475
AH007476
AH007477
AF106652
AF106650
AF106651
AH007479
EU267602
AY095537
PIR A55739
RefSeq NP_000238.1
UniGene Hs.130838
PDB 1B3J
1HYR
PDBsum 1B3J
1HYR
DisProt DP00670
ProteinModelPortal Q29983
SMR Q29983
BioGrid 319735
DIP DIP-29681N
IntAct Q29983
MINT MINT-8214461
PhosphoSite Q29983
DMDM 74740024
MaxQB Q29983
PaxDb Q29983
PRIDE Q29983
Ensembl ENST00000400325
ENST00000418465
ENST00000547609
GeneID 100507436
KEGG hsa:100507436
UCSC uc021zpf.1
CTD 100507436
GeneCards GC06P031373
GC06Pl31410
GC06Pn31357
HGNC HGNC:7090
MIM 177900
600169
607507
neXtProt NX_Q29983
PharmGKB PA30811
eggNOG NOG299132
HOVERGEN HBG106364
InParanoid Q29983
KO K07985
OMA ASGFYPW
PhylomeDB Q29983
ChiTaRS MICA
EvolutionaryTrace Q29983
GeneWiki MHC_class_I_polypeptide-related_sequence_A
GenomeRNAi 100507436
NextBio 34054692
PMAP-CutDB Q29983
PRO PR:Q29983
Proteomes UP000005640
Genevestigator Q29983
GO GO:0009986
GO:0005737
GO:0005615
GO:0005887
GO:0046703
GO:0019882
GO:0006974
GO:0019835
GO:0042742
GO:0051607
GO:0046629
GO:0002418
GO:0042267
GO:0009408
GO:0001913
GO:0016032
Gene3D 2.60.40.10
3.30.500.10
InterPro IPR007110
IPR013783
IPR003597
IPR011161
IPR011162
IPR001039
Pfam PF07654
PF00129
SMART SM00407
SUPFAM SSF54452
PROSITE PS50835

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0032815

negative regulation of natural killer cell activation

PMID:20068167[2]

ECO:0000314

P

Fig 6

complete
CACAO 6066

GO:0045953

negative regulation of natural killer cell mediated cytotoxicity

PMID:20068167[2]

ECO:0000315

P

Fig 6 shows that the presence of MICA*008 compromises NK mediated lysis of cells.

complete
CACAO 6067

involved_in

GO:0045953

negative regulation of natural killer cell mediated cytotoxicity

PMID:20068167[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0032815

negative regulation of natural killer cell activation

PMID:20068167[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0009986

cell surface

PMID:18676862[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005887

integral component of plasma membrane

PMID:18676862[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

PMID:18676862[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0051607

defense response to virus

PMID:16750166[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0051607

defense response to virus

PMID:11224526[5]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0046703

natural killer cell lectin-like receptor binding

PMID:10426993[6]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P26718

F

Seeded From UniProt

complete

enables

GO:0046703

natural killer cell lectin-like receptor binding

PMID:11491531[7]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0046629

gamma-delta T cell activation

PMID:9497295[8]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0042742

defense response to bacterium

PMID:11830641[9]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0042742

defense response to bacterium

PMID:11485740[10]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0042267

natural killer cell mediated cytotoxicity

PMID:10426993[6]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

NOT|enables

GO:0030881

beta-2-microglobulin binding

PMID:8901601[11]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0009986

cell surface

PMID:8901601[11]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0009408

response to heat

PMID:8901601[11]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006974

cellular response to DNA damage stimulus

PMID:15995699[12]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0002418

immune response to tumor cell

PMID:10359807[13]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0001913

T cell mediated cytotoxicity

PMID:10426993[6]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0046703

natural killer cell lectin-like receptor binding

PMID:21873635[14]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:109431
MGI:MGI:109432
MGI:MGI:109477
MGI:MGI:1861032
MGI:MGI:1925027
MGI:MGI:2675273
MGI:MGI:3649078
MGI:MGI:3774845
PANTHER:PTN000422395
UniProtKB:Q29980
UniProtKB:Q29983
UniProtKB:Q6H3X3
UniProtKB:Q8TD07
UniProtKB:Q9BZM4
UniProtKB:Q9BZM5
UniProtKB:Q9BZM6

F

Seeded From UniProt

complete

involved_in

GO:0042271

susceptibility to natural killer cell mediated cytotoxicity

PMID:21873635[14]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:109432
MGI:MGI:1925027
PANTHER:PTN000422395

P

Seeded From UniProt

complete

involved_in

GO:0042267

natural killer cell mediated cytotoxicity

PMID:21873635[14]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1861032
MGI:MGI:3649078
MGI:MGI:3774845
PANTHER:PTN000422395
UniProtKB:Q29983
UniProtKB:Q6H3X3
UniProtKB:Q8TD07
UniProtKB:Q9BZM4
UniProtKB:Q9BZM5
UniProtKB:Q9BZM6

P

Seeded From UniProt

complete

involved_in

GO:0030101

natural killer cell activation

PMID:21873635[14]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000422395
UniProtKB:Q9BZM4
UniProtKB:Q9BZM5
UniProtKB:Q9BZM6

P

Seeded From UniProt

complete

part_of

GO:0009897

external side of plasma membrane

PMID:21873635[14]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:107674
MGI:MGI:109431
MGI:MGI:109432
MGI:MGI:1861032
MGI:MGI:1925027
MGI:MGI:2179988
MGI:MGI:2179989
MGI:MGI:95896
MGI:MGI:95904
MGI:MGI:95915
MGI:MGI:95938
PANTHER:PTN002314307
UniProtKB:Q30201

C

Seeded From UniProt

complete

involved_in

GO:0006955

immune response

PMID:21873635[14]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002314307
UniProtKB:P01891
UniProtKB:Q31612

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

PMID:21873635[14]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:95896
PANTHER:PTN002314307
UniProtKB:Q95460
UniProtKB:Q9BZM6

C

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

PMID:21873635[14]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:95929
PANTHER:PTN002314307
UniProtKB:P25311
UniProtKB:Q29983
UniProtKB:Q30201
UniProtKB:Q9BZM5

C

Seeded From UniProt

complete

involved_in

GO:0001913

T cell mediated cytotoxicity

PMID:21873635[14]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:2675273
PANTHER:PTN000422395
UniProtKB:Q29983

P

Seeded From UniProt

complete

involved_in

GO:0050776

regulation of immune response

Reactome:R-HSA-198933

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

Reactome:R-HSA-198983

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

involved_in

GO:0002250

adaptive immune response

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1064

P

Seeded From UniProt

complete

involved_in

GO:0016032

viral process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0945

P

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1003
UniProtKB-SubCell:SL-0039

C

Seeded From UniProt

complete

involved_in

GO:0002376

immune system process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0391

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

involved_in

GO:0019835

cytolysis

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0204

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. Bahram, S et al. (1996) Nucleotide sequence of the human MHC class I MICA gene. Immunogenetics 44 80-1 PubMed GONUTS page
  2. 2.0 2.1 2.2 2.3 Ashiru, O et al. (2010) Natural killer cell cytotoxicity is suppressed by exposure to the human NKG2D ligand MICA*008 that is shed by tumor cells in exosomes. Cancer Res. 70 481-9 PubMed GONUTS page
  3. 3.0 3.1 3.2 Waldhauer, I et al. (2008) Tumor-associated MICA is shed by ADAM proteases. Cancer Res. 68 6368-76 PubMed GONUTS page
  4. Chalupny, NJ et al. (2006) Down-regulation of the NKG2D ligand MICA by the human cytomegalovirus glycoprotein UL142. Biochem. Biophys. Res. Commun. 346 175-81 PubMed GONUTS page
  5. Groh, V et al. (2001) Costimulation of CD8alphabeta T cells by NKG2D via engagement by MIC induced on virus-infected cells. Nat. Immunol. 2 255-60 PubMed GONUTS page
  6. 6.0 6.1 6.2 Bauer, S et al. (1999) Activation of NK cells and T cells by NKG2D, a receptor for stress-inducible MICA. Science 285 727-9 PubMed GONUTS page
  7. Steinle, A et al. () Interactions of human NKG2D with its ligands MICA, MICB, and homologs of the mouse RAE-1 protein family. Immunogenetics 53 279-87 PubMed GONUTS page
  8. Groh, V et al. (1998) Recognition of stress-induced MHC molecules by intestinal epithelial gammadelta T cells. Science 279 1737-40 PubMed GONUTS page
  9. Tieng, V et al. (2002) Binding of Escherichia coli adhesin AfaE to CD55 triggers cell-surface expression of the MHC class I-related molecule MICA. Proc. Natl. Acad. Sci. U.S.A. 99 2977-82 PubMed GONUTS page
  10. Das, H et al. (2001) MICA engagement by human Vgamma2Vdelta2 T cells enhances their antigen-dependent effector function. Immunity 15 83-93 PubMed GONUTS page
  11. 11.0 11.1 11.2 Groh, V et al. (1996) Cell stress-regulated human major histocompatibility complex class I gene expressed in gastrointestinal epithelium. Proc. Natl. Acad. Sci. U.S.A. 93 12445-50 PubMed GONUTS page
  12. Gasser, S et al. (2005) The DNA damage pathway regulates innate immune system ligands of the NKG2D receptor. Nature 436 1186-90 PubMed GONUTS page
  13. Groh, V et al. (1999) Broad tumor-associated expression and recognition by tumor-derived gamma delta T cells of MICA and MICB. Proc. Natl. Acad. Sci. U.S.A. 96 6879-84 PubMed GONUTS page
  14. 14.0 14.1 14.2 14.3 14.4 14.5 14.6 14.7 14.8 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page