HUMAN:MICA

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	MICA (ECO:0000312 with EMBL:CAI41907.1) (synonyms: PERB11.1 (ECO:0000303 with PMID:8613147^[1]))
Protein Name(s)	MHC class I polypeptide-related sequence A MIC-A
External Links
UniProt	Q29983
EMBL	L14848 X92841 AL845443 CR847852 BC016929 BG114064 L29406 L29408 L29409 L29411 U56940 U56941 U56942 U56943 U56944 U56945 U56946 U56947 U56948 U56949 U56950 U56951 U56952 U56953 U56954 U56955 Y16801 Y16802 Y16803 Y16804 Y16805 Y16806 Y16807 Y16808 Y16809 Y16810 Y16811 Y18110 Y18111 Y18112 AF097403 AF097404 AF097405 AF097406 AB015600 AJ563426 AH007168 AH007170 AH007171 AH007173 AH007174 AH007186 AH007175 AH007176 AH007177 AH007178 AH007179 AH007180 AH007182 AH007183 AH007184 AH007185 AH008136 AH008137 AH008138 AH008139 AH008140 AH008141 AH008142 AH008143 AH008144 AH008145 AH008146 AH008147 AH008148 AH007169 AH007172 AH007167 AH007181 AH010819 AH011143 AH010820 AH010821 AH010545 AH010526 AH010568 AH010569 AH010532 AH010546 AH010560 AH010561 AH010587 AH010562 AH010571 AH010572 AH010740 AJ250499 AJ250500 AJ250501 AJ250502 AJ250503 AJ250504 AJ250505 AJ250506 AJ250507 AJ250802 AJ250803 AJ250804 AJ250805 AJ250990 AJ250991 AJ271789 AY603357 AJ249394 AJ295250 AJ295251 AJ580805 AJ580806 AH014149 AM899996 EU254723 AM944063 AH006330 AH006331 AH006332 AH006333 AH006334 AH007472 AH007473 AH007474 AH007475 AH007476 AH007477 AF106652 AF106650 AF106651 AH007479 EU267602 AY095537
PIR	A55739
RefSeq	NP_000238.1
UniGene	Hs.130838
PDB	1B3J 1HYR
PDBsum	1B3J 1HYR
DisProt	DP00670
ProteinModelPortal	Q29983
SMR	Q29983
BioGrid	319735
DIP	DIP-29681N
IntAct	Q29983
MINT	MINT-8214461
PhosphoSite	Q29983
DMDM	74740024
MaxQB	Q29983
PaxDb	Q29983
PRIDE	Q29983
Ensembl	ENST00000400325 ENST00000418465 ENST00000547609
GeneID	100507436
KEGG	hsa:100507436
UCSC	uc021zpf.1
CTD	100507436
GeneCards	GC06P031373 GC06Pl31410 GC06Pn31357
HGNC	HGNC:7090
MIM	177900 600169 607507
neXtProt	NX_Q29983
PharmGKB	PA30811
eggNOG	NOG299132
HOVERGEN	HBG106364
InParanoid	Q29983
KO	K07985
OMA	ASGFYPW
PhylomeDB	Q29983
ChiTaRS	MICA
EvolutionaryTrace	Q29983
GeneWiki	MHC_class_I_polypeptide-related_sequence_A
GenomeRNAi	100507436
NextBio	34054692
PMAP-CutDB	Q29983
PRO	PR:Q29983
Proteomes	UP000005640
Genevestigator	Q29983
GO	GO:0009986 GO:0005737 GO:0005615 GO:0005887 GO:0046703 GO:0019882 GO:0006974 GO:0019835 GO:0042742 GO:0051607 GO:0046629 GO:0002418 GO:0042267 GO:0009408 GO:0001913 GO:0016032
Gene3D	2.60.40.10 3.30.500.10
InterPro	IPR007110 IPR013783 IPR003597 IPR011161 IPR011162 IPR001039
Pfam	PF07654 PF00129
SMART	SM00407
SUPFAM	SSF54452
PROSITE	PS50835

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0032815	negative regulation of natural killer cell activation	PMID:20068167^[2]	ECO:0000314			P	Fig 6	complete CACAO 6066
	GO:0045953	negative regulation of natural killer cell mediated cytotoxicity	PMID:20068167^[2]	ECO:0000315			P	Fig 6 shows that the presence of MICA*008 compromises NK mediated lysis of cells.	complete CACAO 6067
involved_in	GO:0045953	negative regulation of natural killer cell mediated cytotoxicity	PMID:20068167^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0032815	negative regulation of natural killer cell activation	PMID:20068167^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0009986	cell surface	PMID:18676862^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:18676862^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:18676862^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0051607	defense response to virus	PMID:16750166^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0051607	defense response to virus	PMID:11224526^[5]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0046703	natural killer cell lectin-like receptor binding	PMID:10426993^[6]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P26718	F	Seeded From UniProt	complete
enables	GO:0046703	natural killer cell lectin-like receptor binding	PMID:11491531^[7]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0046629	gamma-delta T cell activation	PMID:9497295^[8]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0042742	defense response to bacterium	PMID:11830641^[9]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0042742	defense response to bacterium	PMID:11485740^[10]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0042267	natural killer cell mediated cytotoxicity	PMID:10426993^[6]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
NOT\|enables	GO:0030881	beta-2-microglobulin binding	PMID:8901601^[11]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
part_of	GO:0009986	cell surface	PMID:8901601^[11]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0009408	response to heat	PMID:8901601^[11]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006974	cellular response to DNA damage stimulus	PMID:15995699^[12]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0002418	immune response to tumor cell	PMID:10359807^[13]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0001913	T cell mediated cytotoxicity	PMID:10426993^[6]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0046703	natural killer cell lectin-like receptor binding	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:109431 MGI:MGI:109432 MGI:MGI:109477 MGI:MGI:1861032 MGI:MGI:1925027 MGI:MGI:2675273 MGI:MGI:3649078 MGI:MGI:3774845 PANTHER:PTN000422395 UniProtKB:Q29980 UniProtKB:Q29983 UniProtKB:Q6H3X3 UniProtKB:Q8TD07 UniProtKB:Q9BZM4 UniProtKB:Q9BZM5 UniProtKB:Q9BZM6	F	Seeded From UniProt	complete
involved_in	GO:0042271	susceptibility to natural killer cell mediated cytotoxicity	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:109432 MGI:MGI:1925027 PANTHER:PTN000422395	P	Seeded From UniProt	complete
involved_in	GO:0042267	natural killer cell mediated cytotoxicity	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1861032 MGI:MGI:3649078 MGI:MGI:3774845 PANTHER:PTN000422395 UniProtKB:Q29983 UniProtKB:Q6H3X3 UniProtKB:Q8TD07 UniProtKB:Q9BZM4 UniProtKB:Q9BZM5 UniProtKB:Q9BZM6	P	Seeded From UniProt	complete
involved_in	GO:0030101	natural killer cell activation	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000422395 UniProtKB:Q9BZM4 UniProtKB:Q9BZM5 UniProtKB:Q9BZM6	P	Seeded From UniProt	complete
part_of	GO:0009897	external side of plasma membrane	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:107674 MGI:MGI:109431 MGI:MGI:109432 MGI:MGI:1861032 MGI:MGI:1925027 MGI:MGI:2179988 MGI:MGI:2179989 MGI:MGI:95896 MGI:MGI:95904 MGI:MGI:95915 MGI:MGI:95938 PANTHER:PTN002314307 UniProtKB:Q30201	C	Seeded From UniProt	complete
involved_in	GO:0006955	immune response	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002314307 UniProtKB:P01891 UniProtKB:Q31612	P	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:95896 PANTHER:PTN002314307 UniProtKB:Q95460 UniProtKB:Q9BZM6	C	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:95929 PANTHER:PTN002314307 UniProtKB:P25311 UniProtKB:Q29983 UniProtKB:Q30201 UniProtKB:Q9BZM5	C	Seeded From UniProt	complete
involved_in	GO:0001913	T cell mediated cytotoxicity	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:2675273 PANTHER:PTN000422395 UniProtKB:Q29983	P	Seeded From UniProt	complete
involved_in	GO:0050776	regulation of immune response	Reactome:R-HSA-198933	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	Reactome:R-HSA-198983	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C	Seeded From UniProt	complete
involved_in	GO:0002250	adaptive immune response	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1064	P	Seeded From UniProt	complete
involved_in	GO:0016032	viral process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0945	P	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C	Seeded From UniProt	complete
involved_in	GO:0002376	immune system process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0391	P	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C	Seeded From UniProt	complete
involved_in	GO:0019835	cytolysis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0204	P	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Bahram, S et al. (1996) Nucleotide sequence of the human MHC class I MICA gene. Immunogenetics 44 80-1 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 Ashiru, O et al. (2010) Natural killer cell cytotoxicity is suppressed by exposure to the human NKG2D ligand MICA*008 that is shed by tumor cells in exosomes. Cancer Res. 70 481-9 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Waldhauer, I et al. (2008) Tumor-associated MICA is shed by ADAM proteases. Cancer Res. 68 6368-76 PubMed GONUTS page
↑ Chalupny, NJ et al. (2006) Down-regulation of the NKG2D ligand MICA by the human cytomegalovirus glycoprotein UL142. Biochem. Biophys. Res. Commun. 346 175-81 PubMed GONUTS page
↑ Groh, V et al. (2001) Costimulation of CD8alphabeta T cells by NKG2D via engagement by MIC induced on virus-infected cells. Nat. Immunol. 2 255-60 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 Bauer, S et al. (1999) Activation of NK cells and T cells by NKG2D, a receptor for stress-inducible MICA. Science 285 727-9 PubMed GONUTS page
↑ Steinle, A et al. () Interactions of human NKG2D with its ligands MICA, MICB, and homologs of the mouse RAE-1 protein family. Immunogenetics 53 279-87 PubMed GONUTS page
↑ Groh, V et al. (1998) Recognition of stress-induced MHC molecules by intestinal epithelial gammadelta T cells. Science 279 1737-40 PubMed GONUTS page
↑ Tieng, V et al. (2002) Binding of Escherichia coli adhesin AfaE to CD55 triggers cell-surface expression of the MHC class I-related molecule MICA. Proc. Natl. Acad. Sci. U.S.A. 99 2977-82 PubMed GONUTS page
↑ Das, H et al. (2001) MICA engagement by human Vgamma2Vdelta2 T cells enhances their antigen-dependent effector function. Immunity 15 83-93 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 Groh, V et al. (1996) Cell stress-regulated human major histocompatibility complex class I gene expressed in gastrointestinal epithelium. Proc. Natl. Acad. Sci. U.S.A. 93 12445-50 PubMed GONUTS page
↑ Gasser, S et al. (2005) The DNA damage pathway regulates innate immune system ligands of the NKG2D receptor. Nature 436 1186-90 PubMed GONUTS page
↑ Groh, V et al. (1999) Broad tumor-associated expression and recognition by tumor-derived gamma delta T cells of MICA and MICB. Proc. Natl. Acad. Sci. U.S.A. 96 6879-84 PubMed GONUTS page
↑ ^14.0 ^14.1 ^14.2 ^14.3 ^14.4 ^14.5 ^14.6 ^14.7 ^14.8 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:8613147-1] Bahram, S et al. (1996) Nucleotide sequence of the human MHC class I MICA gene. Immunogenetics 44 80-1 PubMed GONUTS page

[PMID:20068167-2] 2.0 ^2.1 ^2.2 ^2.3 Ashiru, O et al. (2010) Natural killer cell cytotoxicity is suppressed by exposure to the human NKG2D ligand MICA*008 that is shed by tumor cells in exosomes. Cancer Res. 70 481-9 PubMed GONUTS page

[PMID:18676862-3] 3.0 ^3.1 ^3.2 Waldhauer, I et al. (2008) Tumor-associated MICA is shed by ADAM proteases. Cancer Res. 68 6368-76 PubMed GONUTS page

[PMID:16750166-4] Chalupny, NJ et al. (2006) Down-regulation of the NKG2D ligand MICA by the human cytomegalovirus glycoprotein UL142. Biochem. Biophys. Res. Commun. 346 175-81 PubMed GONUTS page

[PMID:11224526-5] Groh, V et al. (2001) Costimulation of CD8alphabeta T cells by NKG2D via engagement by MIC induced on virus-infected cells. Nat. Immunol. 2 255-60 PubMed GONUTS page

[PMID:10426993-6] 6.0 ^6.1 ^6.2 Bauer, S et al. (1999) Activation of NK cells and T cells by NKG2D, a receptor for stress-inducible MICA. Science 285 727-9 PubMed GONUTS page

[PMID:11491531-7] Steinle, A et al. () Interactions of human NKG2D with its ligands MICA, MICB, and homologs of the mouse RAE-1 protein family. Immunogenetics 53 279-87 PubMed GONUTS page

[PMID:9497295-8] Groh, V et al. (1998) Recognition of stress-induced MHC molecules by intestinal epithelial gammadelta T cells. Science 279 1737-40 PubMed GONUTS page

[PMID:11830641-9] Tieng, V et al. (2002) Binding of Escherichia coli adhesin AfaE to CD55 triggers cell-surface expression of the MHC class I-related molecule MICA. Proc. Natl. Acad. Sci. U.S.A. 99 2977-82 PubMed GONUTS page

[PMID:11485740-10] Das, H et al. (2001) MICA engagement by human Vgamma2Vdelta2 T cells enhances their antigen-dependent effector function. Immunity 15 83-93 PubMed GONUTS page

[PMID:8901601-11] 11.0 ^11.1 ^11.2 Groh, V et al. (1996) Cell stress-regulated human major histocompatibility complex class I gene expressed in gastrointestinal epithelium. Proc. Natl. Acad. Sci. U.S.A. 93 12445-50 PubMed GONUTS page

[PMID:15995699-12] Gasser, S et al. (2005) The DNA damage pathway regulates innate immune system ligands of the NKG2D receptor. Nature 436 1186-90 PubMed GONUTS page

[PMID:10359807-13] Groh, V et al. (1999) Broad tumor-associated expression and recognition by tumor-derived gamma delta T cells of MICA and MICB. Proc. Natl. Acad. Sci. U.S.A. 96 6879-84 PubMed GONUTS page

[PMID:21873635-14] 14.0 ^14.1 ^14.2 ^14.3 ^14.4 ^14.5 ^14.6 ^14.7 ^14.8 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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HUMAN:MICA

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Annotations

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References

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