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HUMAN:MFS12

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) MFSD12 (synonyms: C19orf28)
Protein Name(s) Major facilitator superfamily domain-containing protein 12
External Links
UniProt Q6NUT3
EMBL AC005786
AC005787
CH471139
CH471139
BC036706
BC068439
CCDS CCDS42465.1
CCDS74256.1
RefSeq NP_001274458.1
NP_778148.2
XP_006722710.1
XP_011525986.1
UniGene Hs.656901
ProteinModelPortal Q6NUT3
BioGrid 125979
IntAct Q6NUT3
STRING 9606.ENSP00000381566
iPTMnet Q6NUT3
PhosphoSitePlus Q6NUT3
SwissPalm Q6NUT3
BioMuta MFSD12
DMDM 125991816
MaxQB Q6NUT3
PaxDb Q6NUT3
PeptideAtlas Q6NUT3
PRIDE Q6NUT3
Ensembl ENST00000355415
ENST00000389395
ENST00000588918
GeneID 126321
KEGG hsa:126321
UCSC uc002lxz.5
CTD 126321
DisGeNET 126321
EuPathDB HostDB:ENSG00000161091.12
GeneCards MFSD12
HGNC HGNC:28299
HPA HPA042149
HPA043088
MIM 617745
neXtProt NX_Q6NUT3
OpenTargets ENSG00000161091
PharmGKB PA134955537
eggNOG ENOG410IMQF
ENOG4111I58
GeneTree ENSGT00390000016464
HOGENOM HOG000006540
HOVERGEN HBG056517
InParanoid Q6NUT3
OMA VTNDHEK
OrthoDB EOG091G0GHZ
PhylomeDB Q6NUT3
TreeFam TF314080
ChiTaRS MFSD12
GenomeRNAi 126321
PRO PR:Q6NUT3
Proteomes UP000005640
Bgee ENSG00000161091
CleanEx HS_C19orf28
ExpressionAtlas Q6NUT3
Genevisible Q6NUT3
GO GO:0016021
GO:0005765
CDD cd06174
InterPro IPR020846
IPR036259
SUPFAM SSF103473

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0005770

late endosome

PMID:29025994[1]

ECO:0000314

C

MFSD12 in Homo Sapiens co-localizes with LAMP2 in the late endosome as shown in fig 6E and 6H

complete
CACAO 13089

part_of

GO:0005765

lysosomal membrane

PMID:17897319[2]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0071702

organic substance transport

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG10578
MGI:MGI:1923824
MGI:MGI:3583946
PANTHER:PTN000140373
UniProtKB:A6NFX1
UniProtKB:Q8NA29
ZFIN:ZDB-GENE-040801-89
ZFIN:ZDB-GENE-041114-166

P

Seeded From UniProt

complete

part_of

GO:0005887

integral component of plasma membrane

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG10578
MGI:MGI:1923824
MGI:MGI:3583946
PANTHER:PTN000140373
UniProtKB:A6NFX1

C

Seeded From UniProt

complete

enables

GO:0005215

transporter activity

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG10578
EcoGene:EG11658
EcoGene:EG11841
MGI:MGI:1923824
MGI:MGI:3583946
PANTHER:PTN000140373
UniProtKB:A6NFX1
UniProtKB:Q8NA29

F

Seeded From UniProt

complete

involved_in

GO:0055085

transmembrane transport

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0015293

P

Seeded From UniProt

complete

involved_in

GO:0008643

carbohydrate transport

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR039672

P

Seeded From UniProt

complete

enables

GO:0015293

symporter activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR039672

F

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR039672

C

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472
UniProtKB-SubCell:SL-0162

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. Crawford, NG et al. (2017) Loci associated with skin pigmentation identified in African populations. Science 358 PubMed GONUTS page
  2. Schröder, B et al. (2007) Integral and associated lysosomal membrane proteins. Traffic 8 1676-86 PubMed GONUTS page
  3. 3.0 3.1 3.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page