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HUMAN:MDR1
Contents
Species (Taxon ID) | Homo sapiens (Human). (9606) | |
Gene Name(s) | ABCB1 (synonyms: MDR1, PGY1) | |
Protein Name(s) | Multidrug resistance protein 1
ATP-binding cassette sub-family B member 1 P-glycoprotein 1 | |
External Links | ||
UniProt | P08183 | |
EMBL | M14758 M29447 M29424 M29425 M29426 M29427 M29428 M29429 M29430 M29431 M29432 M29433 M29434 M29435 M29436 M29437 M29438 M29439 M29440 M29441 M29442 M29443 M29444 M29445 M29446 AF016535 EU854148 AY910577 AK290159 AC002457 AC005068 M37724 M37725 X58723 | |
CCDS | CCDS5608.1 | |
PIR | A34914 | |
RefSeq | NP_000918.2 | |
UniGene | Hs.489033 Hs.737655 | |
ProteinModelPortal | P08183 | |
SMR | P08183 | |
BioGrid | 111262 | |
IntAct | P08183 | |
MINT | MINT-5000901 | |
STRING | 9606.ENSP00000265724 | |
BindingDB | P08183 | |
ChEMBL | CHEMBL4302 | |
DrugBank | DB01193 DB00316 DB00945 DB00171 DB05773 DB08916 DB00518 DB00802 DB00523 DB00915 DB00345 DB01118 DB00321 DB00381 DB00701 DB00276 DB06605 DB01169 DB00637 DB01072 DB00335 DB01076 DB06626 DB00972 DB00207 DB01086 DB01244 DB00443 DB00810 DB08873 DB06616 DB08870 DB01200 DB00921 DB00490 DB06772 DB00201 DB08907 DB00796 DB01197 DB00564 DB08889 DB01136 DB00520 DB00608 DB00477 DB00672 DB01239 DB01340 DB00501 DB00537 DB00515 DB00215 DB01211 DB00349 DB00845 DB00882 DB01242 DB00575 DB00758 DB00257 DB00363 DB01394 DB00286 DB08865 DB00531 DB00091 DB06695 DB08912 DB00970 DB06292 DB01254 DB00694 DB04840 DB01151 DB00967 DB01234 DB00514 DB00829 DB00586 DB00255 DB01396 DB00390 DB00320 DB00343 DB00975 DB01248 DB01184 DB00590 DB01142 DB00997 DB00470 DB04855 DB00216 DB00584 DB08899 DB00751 DB01253 DB00696 DB00530 DB00199 DB00783 DB01196 DB04573 DB00655 DB00977 DB00773 DB06414 DB00973 DB01023 DB00813 DB06702 DB00950 DB08874 DB00196 DB00472 DB00875 DB00623 DB00690 DB08906 DB00176 DB00317 DB00441 DB01016 DB00027 DB00502 DB00741 DB01050 DB00619 DB00458 DB05039 DB00224 DB00328 DB00762 DB01167 DB08820 DB00602 DB01221 DB01587 DB01026 DB00709 DB00555 DB00448 DB01259 DB00480 DB01202 DB01137 DB08918 DB00451 DB00281 DB08882 DB00279 DB01583 DB00722 DB08827 DB00836 DB01601 DB00455 DB00678 DB00227 DB00742 DB00934 DB00643 DB00358 DB00351 DB00371 DB00333 DB00563 DB00959 DB00264 DB01110 DB00683 DB00834 DB08893 DB00305 DB01204 DB00295 DB00688 DB01203 DB01183 DB00704 DB01149 DB00220 DB01400 DB00622 DB01115 DB04868 DB00401 DB01595 DB01054 DB00585 DB00717 DB00334 DB00338 DB01229 DB00213 DB00715 DB06589 DB00790 DB01174 DB00252 DB01100 DB08860 DB08910 DB08901 DB01263 DB00175 DB00457 DB00860 DB00635 DB01032 DB00396 DB01069 DB01182 DB00571 DB00344 DB01224 DB01103 DB00908 DB00468 DB00863 DB00234 DB08896 DB00206 DB01045 DB08864 DB00734 DB00503 DB06228 DB00778 DB00936 DB01232 DB00747 DB01037 DB01104 DB06207 DB06290 DB00641 DB00877 DB01261 DB08934 DB00398 DB01208 DB00421 DB00428 DB01138 DB00669 DB01268 DB00864 DB00675 DB05521 DB00966 DB06287 DB01162 DB00624 DB08816 DB00373 DB06212 DB01030 DB00539 DB00656 DB00831 DB00508 DB00440 DB00726 DB01361 DB01339 DB00285 DB00661 DB00570 DB00541 DB00361 DB08828 DB04877 DB00495 | |
MoonProt | P08183 | |
TCDB | 3.A.1.201.1 | |
PhosphoSite | P08183 | |
DMDM | 238054374 | |
MaxQB | P08183 | |
PaxDb | P08183 | |
PRIDE | P08183 | |
DNASU | 5243 | |
Ensembl | ENST00000265724 ENST00000543898 ENST00000622132 | |
GeneID | 5243 | |
KEGG | hsa:5243 | |
UCSC | uc003uiz.2 uc011khc.2 | |
CTD | 5243 | |
GeneCards | GC07M087132 | |
H-InvDB | HIX0033521 | |
HGNC | HGNC:40 | |
HPA | CAB001716 HPA002199 | |
MIM | 171050 612244 | |
neXtProt | NX_P08183 | |
Orphanet | 771 | |
PharmGKB | PA267 | |
eggNOG | COG1132 | |
GeneTree | ENSGT00530000062896 | |
HOVERGEN | HBG080809 | |
InParanoid | P08183 | |
KO | K05658 | |
OMA | RTINVRH | |
OrthoDB | EOG7Z3F4H | |
PhylomeDB | P08183 | |
TreeFam | TF105193 | |
Reactome | REACT_120801 REACT_15480 | |
ChiTaRS | ABCB1 | |
GeneWiki | P-glycoprotein | |
GenomeRNAi | 5243 | |
NextBio | 20254 | |
PRO | PR:P08183 | |
Proteomes | UP000005640 | |
Bgee | P08183 | |
CleanEx | HS_ABCB1 | |
ExpressionAtlas | P08183 | |
Genevestigator | P08183 | |
GO | GO:0009986 GO:0070062 GO:0016021 GO:0016020 GO:0005886 GO:0005524 GO:0042626 GO:0005215 GO:0008559 GO:0006855 GO:0000086 GO:0042493 GO:0044281 GO:0072089 GO:0055085 GO:0006810 | |
Gene3D | 3.40.50.300 | |
InterPro | IPR003593 IPR011527 IPR003439 IPR017871 IPR030258 IPR027417 | |
PANTHER | PTHR24221:SF155 | |
Pfam | PF00664 PF00005 | |
SMART | SM00382 | |
SUPFAM | SSF52540 SSF90123 | |
PROSITE | PS50929 PS00211 PS50893 |
Annotations
Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
---|---|---|---|---|---|---|---|---|---|---|
enables |
GO:0090554 |
phosphatidylcholine-translocating ATPase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
part_of:(GO:0045332) |
Seeded From UniProt |
complete | ||
part_of |
GO:0016324 |
apical plasma membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0099040 |
ceramide translocation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0099038 |
ceramide-translocating ATPase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
part_of:(GO:0099040) |
Seeded From UniProt |
complete | ||
involved_in |
GO:0045332 |
phospholipid translocation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
transports_or_maintains_localization_of:(CHEBI:64482)|transports_or_maintains_localization_of:(CHEBI:16038) |
Seeded From UniProt |
complete | ||
enables |
GO:0090555 |
phosphatidylethanolamine-translocating ATPase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
part_of:(GO:0045332) |
Seeded From UniProt |
complete | ||
involved_in |
GO:2001225 |
regulation of chloride transport |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0047484 |
regulation of response to osmotic stress |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:1901529 |
positive regulation of anion channel activity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0070062 |
extracellular exosome |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0070062 |
extracellular exosome |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
part_of:(UBERON:0001088) |
Seeded From UniProt |
complete | ||
involved_in |
GO:0072089 |
stem cell proliferation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0009986 |
cell surface |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0000086 |
G2/M transition of mitotic cell cycle |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0099038 |
ceramide-translocating ATPase activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:97570 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0090555 |
phosphatidylethanolamine-translocating ATPase activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:97570 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0090554 |
phosphatidylcholine-translocating ATPase activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:97570 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0042626 |
ATPase activity, coupled to transmembrane movement of substances |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
EcoGene:EG10613 |
F |
Seeded From UniProt |
complete | ||
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
EcoGene:EG10613 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0005886 |
plasma membrane |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0004513 |
C |
Seeded From UniProt |
complete | ||
enables |
GO:0005524 |
ATP binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
InterPro:IPR003439 |
F |
Seeded From UniProt |
complete | ||
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0016887 |
ATPase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0042626 |
ATPase activity, coupled to transmembrane movement of substances |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0055085 |
transmembrane transport |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0042626 |
ATPase activity, coupled to transmembrane movement of substances |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0042493 |
response to drug |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0016020 |
membrane |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0005524 |
ATP binding |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0005215 |
transporter activity |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0055085 |
transmembrane transport |
Reactome:R-HSA-382556 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0005886 |
plasma membrane |
Reactome:R-HSA-1467457 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | ||
enables |
GO:0000166 |
nucleotide binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005886 |
plasma membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0005524 |
ATP binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 van Helvoort, A et al. (1996) MDR1 P-glycoprotein is a lipid translocase of broad specificity, while MDR3 P-glycoprotein specifically translocates phosphatidylcholine. Cell 87 507-17 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 Hardy, SP et al. (1995) Protein kinase C-mediated phosphorylation of the human multidrug resistance P-glycoprotein regulates cell volume-activated chloride channels. EMBO J. 14 68-75 PubMed GONUTS page
- ↑ Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page
- ↑ Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 Yamamoto, A et al. (2009) ABCB1 is predominantly expressed in human fetal neural stem/progenitor cells at an early development stage. J. Neurosci. Res. 87 2615-23 PubMed GONUTS page
- ↑ 6.0 6.1 6.2 6.3 6.4 6.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ 7.0 7.1 7.2 7.3 Gros, P et al. () Isolation and expression of a complementary DNA that confers multidrug resistance. Nature 323 728-31 PubMed GONUTS page
- ↑ 8.0 8.1 Gros, P et al. (1986) Mammalian multidrug resistance gene: complete cDNA sequence indicates strong homology to bacterial transport proteins. Cell 47 371-80 PubMed GONUTS page
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