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HUMAN:MDR1

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) ABCB1 (synonyms: MDR1, PGY1)
Protein Name(s) Multidrug resistance protein 1

ATP-binding cassette sub-family B member 1 P-glycoprotein 1

External Links
UniProt P08183
EMBL M14758
M29447
M29424
M29425
M29426
M29427
M29428
M29429
M29430
M29431
M29432
M29433
M29434
M29435
M29436
M29437
M29438
M29439
M29440
M29441
M29442
M29443
M29444
M29445
M29446
AF016535
EU854148
AY910577
AK290159
AC002457
AC005068
M37724
M37725
X58723
CCDS CCDS5608.1
PIR A34914
RefSeq NP_000918.2
UniGene Hs.489033
Hs.737655
ProteinModelPortal P08183
SMR P08183
BioGrid 111262
IntAct P08183
MINT MINT-5000901
STRING 9606.ENSP00000265724
BindingDB P08183
ChEMBL CHEMBL4302
DrugBank DB01193
DB00316
DB00945
DB00171
DB05773
DB08916
DB00518
DB00802
DB00523
DB00915
DB00345
DB01118
DB00321
DB00381
DB00701
DB00276
DB06605
DB01169
DB00637
DB01072
DB00335
DB01076
DB06626
DB00972
DB00207
DB01086
DB01244
DB00443
DB00810
DB08873
DB06616
DB08870
DB01200
DB00921
DB00490
DB06772
DB00201
DB08907
DB00796
DB01197
DB00564
DB08889
DB01136
DB00520
DB00608
DB00477
DB00672
DB01239
DB01340
DB00501
DB00537
DB00515
DB00215
DB01211
DB00349
DB00845
DB00882
DB01242
DB00575
DB00758
DB00257
DB00363
DB01394
DB00286
DB08865
DB00531
DB00091
DB06695
DB08912
DB00970
DB06292
DB01254
DB00694
DB04840
DB01151
DB00967
DB01234
DB00514
DB00829
DB00586
DB00255
DB01396
DB00390
DB00320
DB00343
DB00975
DB01248
DB01184
DB00590
DB01142
DB00997
DB00470
DB04855
DB00216
DB00584
DB08899
DB00751
DB01253
DB00696
DB00530
DB00199
DB00783
DB01196
DB04573
DB00655
DB00977
DB00773
DB06414
DB00973
DB01023
DB00813
DB06702
DB00950
DB08874
DB00196
DB00472
DB00875
DB00623
DB00690
DB08906
DB00176
DB00317
DB00441
DB01016
DB00027
DB00502
DB00741
DB01050
DB00619
DB00458
DB05039
DB00224
DB00328
DB00762
DB01167
DB08820
DB00602
DB01221
DB01587
DB01026
DB00709
DB00555
DB00448
DB01259
DB00480
DB01202
DB01137
DB08918
DB00451
DB00281
DB08882
DB00279
DB01583
DB00722
DB08827
DB00836
DB01601
DB00455
DB00678
DB00227
DB00742
DB00934
DB00643
DB00358
DB00351
DB00371
DB00333
DB00563
DB00959
DB00264
DB01110
DB00683
DB00834
DB08893
DB00305
DB01204
DB00295
DB00688
DB01203
DB01183
DB00704
DB01149
DB00220
DB01400
DB00622
DB01115
DB04868
DB00401
DB01595
DB01054
DB00585
DB00717
DB00334
DB00338
DB01229
DB00213
DB00715
DB06589
DB00790
DB01174
DB00252
DB01100
DB08860
DB08910
DB08901
DB01263
DB00175
DB00457
DB00860
DB00635
DB01032
DB00396
DB01069
DB01182
DB00571
DB00344
DB01224
DB01103
DB00908
DB00468
DB00863
DB00234
DB08896
DB00206
DB01045
DB08864
DB00734
DB00503
DB06228
DB00778
DB00936
DB01232
DB00747
DB01037
DB01104
DB06207
DB06290
DB00641
DB00877
DB01261
DB08934
DB00398
DB01208
DB00421
DB00428
DB01138
DB00669
DB01268
DB00864
DB00675
DB05521
DB00966
DB06287
DB01162
DB00624
DB08816
DB00373
DB06212
DB01030
DB00539
DB00656
DB00831
DB00508
DB00440
DB00726
DB01361
DB01339
DB00285
DB00661
DB00570
DB00541
DB00361
DB08828
DB04877
DB00495
MoonProt P08183
TCDB 3.A.1.201.1
PhosphoSite P08183
DMDM 238054374
MaxQB P08183
PaxDb P08183
PRIDE P08183
DNASU 5243
Ensembl ENST00000265724
ENST00000543898
ENST00000622132
GeneID 5243
KEGG hsa:5243
UCSC uc003uiz.2
uc011khc.2
CTD 5243
GeneCards GC07M087132
H-InvDB HIX0033521
HGNC HGNC:40
HPA CAB001716
HPA002199
MIM 171050
612244
neXtProt NX_P08183
Orphanet 771
PharmGKB PA267
eggNOG COG1132
GeneTree ENSGT00530000062896
HOVERGEN HBG080809
InParanoid P08183
KO K05658
OMA RTINVRH
OrthoDB EOG7Z3F4H
PhylomeDB P08183
TreeFam TF105193
Reactome REACT_120801
REACT_15480
ChiTaRS ABCB1
GeneWiki P-glycoprotein
GenomeRNAi 5243
NextBio 20254
PRO PR:P08183
Proteomes UP000005640
Bgee P08183
CleanEx HS_ABCB1
ExpressionAtlas P08183
Genevestigator P08183
GO GO:0009986
GO:0070062
GO:0016021
GO:0016020
GO:0005886
GO:0005524
GO:0042626
GO:0005215
GO:0008559
GO:0006855
GO:0000086
GO:0042493
GO:0044281
GO:0072089
GO:0055085
GO:0006810
Gene3D 3.40.50.300
InterPro IPR003593
IPR011527
IPR003439
IPR017871
IPR030258
IPR027417
PANTHER PTHR24221:SF155
Pfam PF00664
PF00005
SMART SM00382
SUPFAM SSF52540
SSF90123
PROSITE PS50929
PS00211
PS50893

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

enables

GO:0090554

phosphatidylcholine-translocating ATPase activity

PMID:8898203[1]

ECO:0000314

direct assay evidence used in manual assertion

F

part_of:(GO:0045332)

Seeded From UniProt

complete

part_of

GO:0016324

apical plasma membrane

PMID:8898203[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0099040

ceramide translocation

PMID:8898203[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0099038

ceramide-translocating ATPase activity

PMID:8898203[1]

ECO:0000314

direct assay evidence used in manual assertion

F

part_of:(GO:0099040)

Seeded From UniProt

complete

involved_in

GO:0045332

phospholipid translocation

PMID:8898203[1]

ECO:0000314

direct assay evidence used in manual assertion

P

transports_or_maintains_localization_of:(CHEBI:64482)|transports_or_maintains_localization_of:(CHEBI:16038)

Seeded From UniProt

complete

enables

GO:0090555

phosphatidylethanolamine-translocating ATPase activity

PMID:8898203[1]

ECO:0000314

direct assay evidence used in manual assertion

F

part_of:(GO:0045332)

Seeded From UniProt

complete

involved_in

GO:2001225

regulation of chloride transport

PMID:7828597[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0047484

regulation of response to osmotic stress

PMID:7828597[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:1901529

positive regulation of anion channel activity

PMID:7828597[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0070062

extracellular exosome

PMID:23533145[3]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0070062

extracellular exosome

PMID:19056867[4]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(UBERON:0001088)

Seeded From UniProt

complete

involved_in

GO:0072089

stem cell proliferation

PMID:19384922[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0009986

cell surface

PMID:19384922[5]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0000086

G2/M transition of mitotic cell cycle

PMID:19384922[5]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0099038

ceramide-translocating ATPase activity

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:97570
PANTHER:PTN002516971
UniProtKB:P08183

F

Seeded From UniProt

complete

enables

GO:0090555

phosphatidylethanolamine-translocating ATPase activity

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:97570
PANTHER:PTN002516971
UniProtKB:P08183

F

Seeded From UniProt

complete

enables

GO:0090554

phosphatidylcholine-translocating ATPase activity

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:97570
PANTHER:PTN002516971
UniProtKB:P08183

F

Seeded From UniProt

complete

enables

GO:0042626

ATPase activity, coupled to transmembrane movement of substances

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG10613
EcoGene:EG11405
FB:FBgn0004513
MGI:MGI:97570
MGI:MGI:98483
PANTHER:PTN002517083
PomBase:SPBC25B2.02c
PomBase:SPCC737.09c
SGD:S000004916
TAIR:locus:2041434
UniProtKB:A0A1D8PKI5
UniProtKB:P21439
UniProtKB:Q03519
UniProtKB:Q9NP58
UniProtKB:Q9NP78
ZFIN:ZDB-GENE-080204-52

F

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG10613
EcoGene:EG11405
FB:FBgn0004513
MGI:MGI:1924956
PANTHER:PTN002517083
PomBase:SPCC737.09c
RGD:3817
RGD:3818
UniProtKB:Q03518
UniProtKB:Q03519
UniProtKB:Q2M3G0
UniProtKB:Q8IDT6
UniProtKB:Q9NP58
UniProtKB:Q9NP78
UniProtKB:Q9NRK6
WB:WBGene00001815

C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0004513
MGI:MGI:1924956
MGI:MGI:97569
MGI:MGI:97570
PANTHER:PTN002795061
RGD:3318
RGD:619930
RGD:620248
UniProtKB:P08183
UniProtKB:P21439
UniProtKB:Q2M3G0
WB:WBGene00003995

C

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR003439
InterPro:IPR011527
InterPro:IPR017871
InterPro:IPR036640

F

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR011527
InterPro:IPR036640

C

Seeded From UniProt

complete

enables

GO:0016887

ATPase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR003439
InterPro:IPR017871

F

Seeded From UniProt

complete

enables

GO:0042626

ATPase activity, coupled to transmembrane movement of substances

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR011527

F

Seeded From UniProt

complete

involved_in

GO:0055085

transmembrane transport

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR011527

P

Seeded From UniProt

complete

enables

GO:0042626

ATPase activity, coupled to transmembrane movement of substances

PMID:3022150[7]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0042493

response to drug

PMID:3022150[7]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

PMID:3768958[8]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0016020

membrane

PMID:3022150[7]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

PMID:3768958[8]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0005215

transporter activity

PMID:3022150[7]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0055085

transmembrane transport

Reactome:R-HSA-382556

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

Reactome:R-HSA-1467457

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0000166

nucleotide binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0547

F

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1003
UniProtKB-SubCell:SL-0039

C

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0067

F

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 1.4 1.5 van Helvoort, A et al. (1996) MDR1 P-glycoprotein is a lipid translocase of broad specificity, while MDR3 P-glycoprotein specifically translocates phosphatidylcholine. Cell 87 507-17 PubMed GONUTS page
  2. 2.0 2.1 2.2 Hardy, SP et al. (1995) Protein kinase C-mediated phosphorylation of the human multidrug resistance P-glycoprotein regulates cell volume-activated chloride channels. EMBO J. 14 68-75 PubMed GONUTS page
  3. Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page
  4. Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page
  5. 5.0 5.1 5.2 Yamamoto, A et al. (2009) ABCB1 is predominantly expressed in human fetal neural stem/progenitor cells at an early development stage. J. Neurosci. Res. 87 2615-23 PubMed GONUTS page
  6. 6.0 6.1 6.2 6.3 6.4 6.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  7. 7.0 7.1 7.2 7.3 Gros, P et al. () Isolation and expression of a complementary DNA that confers multidrug resistance. Nature 323 728-31 PubMed GONUTS page
  8. 8.0 8.1 Gros, P et al. (1986) Mammalian multidrug resistance gene: complete cDNA sequence indicates strong homology to bacterial transport proteins. Cell 47 371-80 PubMed GONUTS page