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HUMAN:MCU

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) MCU (ECO:0000303 with PMID:21685886[1], ECO:0000312 with HGNC:HGNC:23526)
Protein Name(s) Calcium uniporter protein, mitochondrial (ECO:0000303 with PMID:21685886[1])

HsMCU (ECO:0000303 with PMID:27135929[2]) Coiled-coil domain-containing protein 109A (ECO:0000305)

External Links
UniProt Q8NE86
EMBL AK315519
AK128016
AC016542
AC069548
CH471083
BC010682
BC034235
CCDS CCDS59218.1
CCDS59219.1
CCDS7317.1
RefSeq NP_001257608.1
NP_001257609.1
NP_612366.1
UniGene Hs.591366
PDB 4XSJ
4XTB
5BZ6
5KUE
5KUG
5KUI
5KUJ
PDBsum 4XSJ
4XTB
5BZ6
5KUE
5KUG
5KUI
5KUJ
ProteinModelPortal Q8NE86
SMR Q8NE86
BioGrid 124733
DIP DIP-60468N
IntAct Q8NE86
MINT MINT-8051705
STRING 9606.ENSP00000362144
iPTMnet Q8NE86
PhosphoSitePlus Q8NE86
SwissPalm Q8NE86
DMDM 74730222
EPD Q8NE86
MaxQB Q8NE86
PaxDb Q8NE86
PeptideAtlas Q8NE86
PRIDE Q8NE86
TopDownProteomics Q8NE86-3
DNASU 90550
Ensembl ENST00000357157
ENST00000373053
ENST00000536019
GeneID 90550
KEGG hsa:90550
UCSC uc001jtc.3
CTD 90550
DisGeNET 90550
GeneCards MCU
HGNC HGNC:23526
HPA HPA016480
MIM 614197
neXtProt NX_Q8NE86
OpenTargets ENSG00000156026
PharmGKB PA134888841
eggNOG KOG2966
ENOG410Y3YU
GeneTree ENSGT00390000004496
HOGENOM HOG000008081
HOVERGEN HBG060246
InParanoid Q8NE86
KO K20858
OMA GAVYCST
OrthoDB EOG091G092C
PhylomeDB Q8NE86
TreeFam TF314435
ChiTaRS MCU
GenomeRNAi 90550
PRO PR:Q8NE86
Proteomes UP000005640
Bgee ENSG00000156026
CleanEx HS_CCDC109A
ExpressionAtlas Q8NE86
Genevisible Q8NE86
GO GO:0034704
GO:0031305
GO:0005743
GO:0005739
GO:1990246
GO:0005262
GO:0015292
GO:0019722
GO:0042593
GO:0006851
GO:0036444
GO:0032024
GO:0051561
GO:0035786
InterPro IPR006769
Pfam PF04678

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0090023

positive regulation of neutrophil chemotaxis

PMID:28388446[3]

ECO:0000315

P

Activation of the MCU promotes neutrophil polarization and chemotaxis; additionally, inhibition of the MCU blunted both processes, as seen on Fig. 1. Calcium uniporter protein, mitochondrial Homo sapiens (Human)

complete
CACAO 12720

GO:0090141

positive regulation of mitochondrial fission

PMID:28388446[3]

ECO:0000315

P

Figure 4 shows the effect of MCU on mitochondrial morphology, specifically indicating mitochondrial fission. Calcium uniporter protein, mitochondrial Homo sapiens (Human)

complete
CACAO 12721

GO:0090527

actin filament reorganization

PMID:28388446[3]

ECO:0000315

P

F-actin accumulation (or polymerization) at the uroprod of neutrophils during MCU-dependent chemotaxis. Observable at Fig. 2. Calcium uniporter protein, mitochondrial Homo sapiens (Human)

complete
CACAO 12722

involved_in

GO:0051561

positive regulation of mitochondrial calcium ion concentration

PMID:23755363[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006851

mitochondrial calcium ion transmembrane transport

PMID:23755363[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0036444

calcium import into the mitochondrion

PMID:23755363[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0005262

calcium channel activity

PMID:23755363[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0015292

uniporter activity

PMID:23755363[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0034704

calcium channel complex

PMID:23755363[4]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0031305

integral component of mitochondrial inner membrane

PMID:23755363[4]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0031305

integral component of mitochondrial inner membrane

PMID:27099988[5]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:1990246

uniplex complex

PMID:24560927[6]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:1990246

uniplex complex

PMID:24231807[7]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0051561

positive regulation of mitochondrial calcium ion concentration

PMID:21685886[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0051561

positive regulation of mitochondrial calcium ion concentration

PMID:24560927[6]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0051561

positive regulation of mitochondrial calcium ion concentration

PMID:21685888[8]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0042593

glucose homeostasis

PMID:22829870[9]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0051259

protein complex oligomerization

PMID:21685886[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0034704

calcium channel complex

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q3UMR5

C

Seeded From UniProt

complete

involved_in

GO:0032024

positive regulation of insulin secretion

PMID:22829870[9]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0031305

integral component of mitochondrial inner membrane

PMID:24231807[7]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0019722

calcium-mediated signaling

PMID:21685886[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0019722

calcium-mediated signaling

PMID:21685888[8]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0015292

uniporter activity

PMID:24560927[6]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0015292

uniporter activity

PMID:21685888[8]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0015292

uniporter activity

PMID:21685886[1]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0006851

mitochondrial calcium ion transmembrane transport

PMID:21685886[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006851

mitochondrial calcium ion transmembrane transport

PMID:24560927[6]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006851

mitochondrial calcium ion transmembrane transport

PMID:21685888[8]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005743

mitochondrial inner membrane

PMID:21685886[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005743

mitochondrial inner membrane

PMID:21685888[8]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0005262

calcium channel activity

PMID:24560927[6]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0005262

calcium channel activity

PMID:21685888[8]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:1990246

uniplex complex

PMID:21873635[10]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000335994
UniProtKB:Q8NE86
UniProtKB:Q9NWR8

C

Seeded From UniProt

complete

involved_in

GO:0051560

mitochondrial calcium ion homeostasis

PMID:21873635[10]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0042185
MGI:MGI:1914065
PANTHER:PTN000335994
RGD:1589771
WB:WBGene00019296

P

Seeded From UniProt

complete

involved_in

GO:0036444

calcium import into the mitochondrion

PMID:21873635[10]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0042185
PANTHER:PTN000335994
UniProtKB:Q8NE86
WB:WBGene00019296
dictyBase:DDB_G0286429

P

Seeded From UniProt

complete

part_of

GO:0031305

integral component of mitochondrial inner membrane

PMID:21873635[10]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000335994
UniProtKB:Q8NE86
UniProtKB:Q9NWR8

C

Seeded From UniProt

complete

enables

GO:0015292

uniporter activity

PMID:21873635[10]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000335993
RGD:1589771
UniProtKB:Q8NE86

F

Seeded From UniProt

complete

enables

GO:0005262

calcium channel activity

PMID:21873635[10]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000335994
UniProtKB:Q8NE86

F

Seeded From UniProt

complete

part_of

GO:1990246

uniplex complex

PMID:22925203[11]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0036444

calcium import into the mitochondrion

PMID:22925203[11]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0051561

positive regulation of mitochondrial calcium ion concentration

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:M0RDI5
ensembl:ENSRNOP00000067686

P

Seeded From UniProt

complete

involved_in

GO:0051560

mitochondrial calcium ion homeostasis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:M0RDI5
ensembl:ENSRNOP00000067686

P

Seeded From UniProt

complete

enables

GO:0015292

uniporter activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:M0RDI5
ensembl:ENSRNOP00000067686

F

Seeded From UniProt

complete

involved_in

GO:0006851

mitochondrial calcium ion transmembrane transport

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:M0RDI5
ensembl:ENSRNOP00000067686

P

Seeded From UniProt

complete

part_of

GO:0005743

mitochondrial inner membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:M0RDI5
ensembl:ENSRNOP00000067686

C

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:M0RDI5
ensembl:ENSRNOP00000067686

C

Seeded From UniProt

complete

part_of

GO:1990246

uniplex complex

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q3UMR5
ensembl:ENSMUSP00000020312

C

Seeded From UniProt

complete

involved_in

GO:0051561

positive regulation of mitochondrial calcium ion concentration

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q3UMR5
ensembl:ENSMUSP00000020312

P

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q3UMR5
ensembl:ENSMUSP00000020312

F

Seeded From UniProt

complete

part_of

GO:0034704

calcium channel complex

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q3UMR5
ensembl:ENSMUSP00000020312

C

Seeded From UniProt

complete

involved_in

GO:0006851

mitochondrial calcium ion transmembrane transport

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q3UMR5
ensembl:ENSMUSP00000020312

P

Seeded From UniProt

complete

involved_in

GO:0051560

mitochondrial calcium ion homeostasis

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR039055

P

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

PMID:29995857[12]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q8NE86-1

F

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

PMID:21685886[1]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q8NE86-1

F

Seeded From UniProt

complete

involved_in

GO:0006851

mitochondrial calcium ion transmembrane transport

Reactome:R-HSA-8949215

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005743

mitochondrial inner membrane

Reactome:R-HSA-8953461
Reactome:R-HSA-8949178

ECO:0000304

author statement supported by traceable reference used in manual assertion


C

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0496

C

Seeded From UniProt

complete

enables

GO:0005262

calcium channel activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0107

F

Seeded From UniProt

complete

involved_in

GO:0006811

ion transport

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0406

P

Seeded From UniProt

complete

involved_in

GO:0070588

calcium ion transmembrane transport

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0107

P

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

part_of

GO:0005743

mitochondrial inner membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0999
UniProtKB-SubCell:SL-0168

C

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

involved_in

GO:0006816

calcium ion transport

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0109

P

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 Baughman, JM et al. (2011) Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter. Nature 476 341-5 PubMed GONUTS page
  2. ↑ Oxenoid, K et al. (2016) Architecture of the mitochondrial calcium uniporter. Nature 533 269-73 PubMed GONUTS page
  3. ↑ 3.0 3.1 3.2 Zheng, X et al. (2017) Phosphorylation of dynamin-related protein 1 at Ser616 regulates mitochondrial fission and is involved in mitochondrial calcium uniporter-mediated neutrophil polarization and chemotaxis. Mol. Immunol. 87 23-32 PubMed GONUTS page
  4. ↑ 4.0 4.1 4.2 4.3 4.4 4.5 4.6 Chaudhuri, D et al. (2013) MCU encodes the pore conducting mitochondrial calcium currents. Elife 2 e00704 PubMed GONUTS page
  5. ↑ Tsai, MF et al. (2016) Dual functions of a small regulatory subunit in the mitochondrial calcium uniporter complex. Elife 5 PubMed GONUTS page
  6. ↑ 6.0 6.1 6.2 6.3 6.4 Patron, M et al. (2014) MICU1 and MICU2 finely tune the mitochondrial Ca2+ uniporter by exerting opposite effects on MCU activity. Mol. Cell 53 726-37 PubMed GONUTS page
  7. ↑ 7.0 7.1 Sancak, Y et al. (2013) EMRE is an essential component of the mitochondrial calcium uniporter complex. Science 342 1379-82 PubMed GONUTS page
  8. ↑ 8.0 8.1 8.2 8.3 8.4 8.5 De Stefani, D et al. (2011) A forty-kilodalton protein of the inner membrane is the mitochondrial calcium uniporter. Nature 476 336-40 PubMed GONUTS page
  9. ↑ 9.0 9.1 Tarasov, AI et al. (2012) The mitochondrial Ca2+ uniporter MCU is essential for glucose-induced ATP increases in pancreatic β-cells. PLoS ONE 7 e39722 PubMed GONUTS page
  10. ↑ 10.0 10.1 10.2 10.3 10.4 10.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  11. ↑ 11.0 11.1 Tsai, LC et al. (2012) Inactivation of Pde8b enhances memory, motor performance, and protects against age-induced motor coordination decay. Genes Brain Behav. 11 837-47 PubMed GONUTS page
  12. ↑ Baradaran, R et al. (2018) Cryo-EM structures of fungal and metazoan mitochondrial calcium uniporters. Nature 559 580-584 PubMed GONUTS page
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