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HUMAN:MCHR1
Contents
Species (Taxon ID) | Homo sapiens (Human). (9606) | |
Gene Name(s) | MCHR1 (synonyms: GPR24, SLC1) | |
Protein Name(s) | Melanin-concentrating hormone receptor 1
MCH receptor 1 MCH-R1 MCHR-1 G-protein coupled receptor 24 MCH-1R MCH1R MCHR SLC-1 Somatostatin receptor-like protein | |
External Links | ||
UniProt | Q99705 | |
EMBL | AB063174 AF490537 CR456497 BT006725 AY562945 AK314857 Z86090 CH471095 BC001736 BC021146 U71092 | |
CCDS | CCDS14004.1 | |
PIR | JC7080 | |
RefSeq | NP_005288.3 | |
UniGene | Hs.248122 | |
ProteinModelPortal | Q99705 | |
SMR | Q99705 | |
STRING | 9606.ENSP00000249016 | |
BindingDB | Q99705 | |
ChEMBL | CHEMBL2111437 | |
GuidetoPHARMACOLOGY | 280 | |
TCDB | 9.A.14.13.6 | |
PhosphoSite | Q99705 | |
DMDM | 33860175 | |
PaxDb | Q99705 | |
PRIDE | Q99705 | |
DNASU | 2847 | |
Ensembl | ENST00000249016 | |
GeneID | 2847 | |
KEGG | hsa:2847 | |
UCSC | uc003ayz.3 | |
CTD | 2847 | |
GeneCards | GC22P041074 | |
HGNC | HGNC:4479 | |
HPA | HPA004149 | |
MIM | 601751 | |
neXtProt | NX_Q99705 | |
PharmGKB | PA28867 | |
eggNOG | NOG282817 | |
GeneTree | ENSGT00760000118797 | |
HOGENOM | HOG000000704 | |
HOVERGEN | HBG105726 | |
InParanoid | Q99705 | |
KO | K04320 | |
OMA | ITPVWLY | |
OrthoDB | EOG7BKCVQ | |
PhylomeDB | Q99705 | |
TreeFam | TF315737 | |
Reactome | REACT_14819 REACT_18283 REACT_19231 | |
GeneWiki | Melanin-concentrating_hormone_receptor_1 | |
GenomeRNAi | 2847 | |
NextBio | 11231 | |
PRO | PR:Q99705 | |
Proteomes | UP000005640 | |
Bgee | Q99705 | |
CleanEx | HS_MCHR1 | |
ExpressionAtlas | Q99705 | |
Genevestigator | Q99705 | |
GO | GO:0005887 GO:0031513 GO:0005886 GO:0004930 GO:0042562 GO:0030273 GO:0008188 GO:0007193 GO:0007631 GO:0007186 GO:0006091 GO:0051928 GO:0007204 | |
InterPro | IPR000276 IPR017452 IPR004047 IPR008361 | |
Pfam | PF00001 | |
PRINTS | PR00237 PR01507 PR01783 | |
PROSITE | PS50262 |
Annotations
Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
---|---|---|---|---|---|---|---|---|---|---|
part_of |
GO:0097730 |
non-motile cilium |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0042277 |
peptide binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN001200938 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0030273 |
melanin-concentrating hormone receptor activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN001955515 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0007218 |
neuropeptide signaling pathway |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0036789 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0005887 |
integral component of plasma membrane |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0266429 |
C |
Seeded From UniProt |
complete | ||
enables |
GO:0004930 |
G protein-coupled receptor activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1330275 |
F |
Seeded From UniProt |
complete | ||
part_of |
GO:0005929 |
cilium |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0051928 |
positive regulation of calcium ion transport |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P97639 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0042562 |
hormone binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P97639 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0030273 |
melanin-concentrating hormone receptor activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P97639 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0008022 |
protein C-terminus binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P97639 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0007204 |
positive regulation of cytosolic calcium ion concentration |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P97639 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0007166 |
cell surface receptor signaling pathway |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P97639 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0005886 |
plasma membrane |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P97639 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0097730 |
non-motile cilium |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q8JZL2 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0060170 |
ciliary membrane |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q8JZL2 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0005886 |
plasma membrane |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q8JZL2 |
C |
Seeded From UniProt |
complete | ||
enables |
GO:0005102 |
signaling receptor binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q8JZL2 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0004930 |
G protein-coupled receptor activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0007186 |
G protein-coupled receptor signaling pathway |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0007218 |
neuropeptide signaling pathway |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
InterPro:IPR000276 |
C |
Seeded From UniProt |
complete | ||
enables |
GO:0030273 |
melanin-concentrating hormone receptor activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0008188 |
neuropeptide receptor activity |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0007631 |
feeding behavior |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0007204 |
positive regulation of cytosolic calcium ion concentration |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0007193 |
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0007186 |
G protein-coupled receptor signaling pathway |
PMID:10421368[5] |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
P |
Seeded From UniProt |
complete | |
involved_in |
GO:0006091 |
generation of precursor metabolites and energy |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0005887 |
integral component of plasma membrane |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0004930 |
G protein-coupled receptor activity |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0005886 |
plasma membrane |
Reactome:R-HSA-947673 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
part_of |
GO:0005886 |
plasma membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0004930 |
G protein-coupled receptor activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0007165 |
signal transduction |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0007186 |
G protein-coupled receptor signaling pathway |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ Badgandi, HB et al. (2017) Tubby family proteins are adapters for ciliary trafficking of integral membrane proteins. J. Cell Biol. 216 743-760 PubMed GONUTS page
- ↑ Macdonald, D et al. (2000) Molecular characterization of the melanin-concentrating hormone/receptor complex: identification of critical residues involved in binding and activation. Mol. Pharmacol. 58 217-25 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 4.3 4.4 4.5 Chambers, J et al. (1999) Melanin-concentrating hormone is the cognate ligand for the orphan G-protein-coupled receptor SLC-1. Nature 400 261-5 PubMed GONUTS page
- ↑ Saito, Y et al. (1999) Molecular characterization of the melanin-concentrating-hormone receptor. Nature 400 265-9 PubMed GONUTS page
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