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HUMAN:MCHR1

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) MCHR1 (synonyms: GPR24, SLC1)
Protein Name(s) Melanin-concentrating hormone receptor 1

MCH receptor 1 MCH-R1 MCHR-1 G-protein coupled receptor 24 MCH-1R MCH1R MCHR SLC-1 Somatostatin receptor-like protein

External Links
UniProt Q99705
EMBL AB063174
AF490537
CR456497
BT006725
AY562945
AK314857
Z86090
CH471095
BC001736
BC021146
U71092
CCDS CCDS14004.1
PIR JC7080
RefSeq NP_005288.3
UniGene Hs.248122
ProteinModelPortal Q99705
SMR Q99705
STRING 9606.ENSP00000249016
BindingDB Q99705
ChEMBL CHEMBL2111437
GuidetoPHARMACOLOGY 280
TCDB 9.A.14.13.6
PhosphoSite Q99705
DMDM 33860175
PaxDb Q99705
PRIDE Q99705
DNASU 2847
Ensembl ENST00000249016
GeneID 2847
KEGG hsa:2847
UCSC uc003ayz.3
CTD 2847
GeneCards GC22P041074
HGNC HGNC:4479
HPA HPA004149
MIM 601751
neXtProt NX_Q99705
PharmGKB PA28867
eggNOG NOG282817
GeneTree ENSGT00760000118797
HOGENOM HOG000000704
HOVERGEN HBG105726
InParanoid Q99705
KO K04320
OMA ITPVWLY
OrthoDB EOG7BKCVQ
PhylomeDB Q99705
TreeFam TF315737
Reactome REACT_14819
REACT_18283
REACT_19231
GeneWiki Melanin-concentrating_hormone_receptor_1
GenomeRNAi 2847
NextBio 11231
PRO PR:Q99705
Proteomes UP000005640
Bgee Q99705
CleanEx HS_MCHR1
ExpressionAtlas Q99705
Genevestigator Q99705
GO GO:0005887
GO:0031513
GO:0005886
GO:0004930
GO:0042562
GO:0030273
GO:0008188
GO:0007193
GO:0007631
GO:0007186
GO:0006091
GO:0051928
GO:0007204
InterPro IPR000276
IPR017452
IPR004047
IPR008361
Pfam PF00001
PRINTS PR00237
PR01507
PR01783
PROSITE PS50262

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

part_of

GO:0097730

non-motile cilium

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q8JZL2

C

Seeded From UniProt

complete

enables

GO:0042277

peptide binding

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001200938
ZFIN:ZDB-GENE-030729-1

F

Seeded From UniProt

complete

enables

GO:0030273

melanin-concentrating hormone receptor activity

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001955515
RGD:619841

F

Seeded From UniProt

complete

involved_in

GO:0007218

neuropeptide signaling pathway

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0036789
FB:FBgn0036790
FB:FBgn0266429
MGI:MGI:97438
MGI:MGI:98327
MGI:MGI:98328
PANTHER:PTN000659780

P

Seeded From UniProt

complete

part_of

GO:0005887

integral component of plasma membrane

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0266429
MGI:MGI:97439
PANTHER:PTN001200938
UniProtKB:P41145
UniProtKB:P41146
ZFIN:ZDB-GENE-990415-199

C

Seeded From UniProt

complete

enables

GO:0004930

G protein-coupled receptor activity

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1330275
PANTHER:PTN001200938
RGD:3234
UniProtKB:P41146
UniProtKB:Q9Y5Y4

F

Seeded From UniProt

complete

part_of

GO:0005929

cilium

PMID:28154160[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0051928

positive regulation of calcium ion transport

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P97639
ensembl:ENSRNOP00000025564

P

Seeded From UniProt

complete

enables

GO:0042562

hormone binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P97639
ensembl:ENSRNOP00000025564

F

Seeded From UniProt

complete

enables

GO:0030273

melanin-concentrating hormone receptor activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P97639
ensembl:ENSRNOP00000025564

F

Seeded From UniProt

complete

enables

GO:0008022

protein C-terminus binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P97639
ensembl:ENSRNOP00000025564

F

Seeded From UniProt

complete

involved_in

GO:0007204

positive regulation of cytosolic calcium ion concentration

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P97639
ensembl:ENSRNOP00000025564

P

Seeded From UniProt

complete

involved_in

GO:0007166

cell surface receptor signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P97639
ensembl:ENSRNOP00000025564

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P97639
ensembl:ENSRNOP00000025564

C

Seeded From UniProt

complete

part_of

GO:0097730

non-motile cilium

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8JZL2
ensembl:ENSMUSP00000126191

C

Seeded From UniProt

complete

part_of

GO:0060170

ciliary membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8JZL2
ensembl:ENSMUSP00000126191

C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8JZL2
ensembl:ENSMUSP00000126191

C

Seeded From UniProt

complete

enables

GO:0005102

signaling receptor binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8JZL2
ensembl:ENSMUSP00000126191

F

Seeded From UniProt

complete

enables

GO:0004930

G protein-coupled receptor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000276

F

Seeded From UniProt

complete

involved_in

GO:0007186

G protein-coupled receptor signaling pathway

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000276
InterPro:IPR008361

P

Seeded From UniProt

complete

involved_in

GO:0007218

neuropeptide signaling pathway

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR004047

P

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000276
InterPro:IPR004047
InterPro:IPR008361
InterPro:IPR017452

C

Seeded From UniProt

complete

enables

GO:0030273

melanin-concentrating hormone receptor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR004047

F

Seeded From UniProt

complete

enables

GO:0008188

neuropeptide receptor activity

PMID:10860944[3]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0007631

feeding behavior

PMID:10421367[4]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007204

positive regulation of cytosolic calcium ion concentration

PMID:10421367[4]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007193

adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway

PMID:10421367[4]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007186

G protein-coupled receptor signaling pathway

PMID:10421368[5]
Reactome:R-HSA-388396

ECO:0000304

author statement supported by traceable reference used in manual assertion


P

Seeded From UniProt

complete

involved_in

GO:0006091

generation of precursor metabolites and energy

PMID:10421367[4]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005887

integral component of plasma membrane

PMID:10421367[4]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0004930

G protein-coupled receptor activity

PMID:10421367[4]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

Reactome:R-HSA-947673
Reactome:R-HSA-749456
Reactome:R-HSA-749454
Reactome:R-HSA-749452
Reactome:R-HSA-749448
Reactome:R-HSA-380073
Reactome:R-HSA-379048

ECO:0000304

author statement supported by traceable reference used in manual assertion







C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1003
UniProtKB-SubCell:SL-0039

C

Seeded From UniProt

complete

enables

GO:0004930

G protein-coupled receptor activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0297

F

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

involved_in

GO:0007165

signal transduction

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0807

P

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

involved_in

GO:0007186

G protein-coupled receptor signaling pathway

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0297

P

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 1.2 1.3 1.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  2. ↑ Badgandi, HB et al. (2017) Tubby family proteins are adapters for ciliary trafficking of integral membrane proteins. J. Cell Biol. 216 743-760 PubMed GONUTS page
  3. ↑ Macdonald, D et al. (2000) Molecular characterization of the melanin-concentrating hormone/receptor complex: identification of critical residues involved in binding and activation. Mol. Pharmacol. 58 217-25 PubMed GONUTS page
  4. ↑ 4.0 4.1 4.2 4.3 4.4 4.5 Chambers, J et al. (1999) Melanin-concentrating hormone is the cognate ligand for the orphan G-protein-coupled receptor SLC-1. Nature 400 261-5 PubMed GONUTS page
  5. ↑ Saito, Y et al. (1999) Molecular characterization of the melanin-concentrating-hormone receptor. Nature 400 265-9 PubMed GONUTS page
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