HUMAN:MARK4

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	MARK4 (synonyms: KIAA1860, MARKL1)
Protein Name(s)	MAP/microtubule affinity-regulating kinase 4 MAP/microtubule affinity-regulating kinase-like 1
External Links
UniProt	Q96L34
EMBL	AY057448 AB049127 AB088047 AY120867 AB058763 AK027619 AK075272
CCDS	CCDS12658.1 CCDS56097.1
RefSeq	NP_001186796.1 NP_113605.2
UniGene	Hs.34314
ProteinModelPortal	Q96L34
SMR	Q96L34
BioGrid	121760
IntAct	Q96L34
MINT	MINT-6425023
STRING	9606.ENSP00000300843
BindingDB	Q96L34
ChEMBL	CHEMBL5754
GuidetoPHARMACOLOGY	2100
PhosphoSite	Q96L34
DMDM	29840797
MaxQB	Q96L34
PaxDb	Q96L34
PRIDE	Q96L34
DNASU	57787
Ensembl	ENST00000262891 ENST00000300843
GeneID	57787
KEGG	hsa:57787
UCSC	uc002pba.2 uc002pbb.2
CTD	57787
GeneCards	GC19P045583
HGNC	HGNC:13538
HPA	HPA039186
MIM	606495
neXtProt	NX_Q96L34
PharmGKB	PA30641
eggNOG	COG0515
GeneTree	ENSGT00760000118892
HOGENOM	HOG000233025
HOVERGEN	HBG052453
InParanoid	Q96L34
KO	K08798
OMA	DSMSTPN
OrthoDB	EOG79CXXX
PhylomeDB	Q96L34
TreeFam	TF315213
SignaLink	Q96L34
GeneWiki	MARK4
GenomeRNAi	57787
NextBio	64721
PRO	PR:Q96L34
Proteomes	UP000005640
Bgee	Q96L34
CleanEx	HS_MARK4
ExpressionAtlas	Q96L34
Genevestigator	Q96L34
GO	GO:0005813 GO:0015630 GO:0005815 GO:0043005 GO:0005524 GO:0043015 GO:0008017 GO:0004674 GO:0050321 GO:0043130 GO:0001578 GO:0000226 GO:0007399 GO:0043068 GO:0006468
Gene3D	3.30.310.80
InterPro	IPR028375 IPR001772 IPR011009 IPR000719 IPR017441 IPR002290 IPR008271 IPR015940 IPR000449
Pfam	PF02149 PF00069 PF00627
SMART	SM00220 SM00165
SUPFAM	SSF103243 SSF56112
PROSITE	PS50032 PS00107 PS50011 PS00108 PS50030

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0036064	cilium basal body	PMID:23400999^[1]	ECO:0000315			C		Figure 2	complete CACAO 7151
enables	GO:0004674	protein serine/threonine kinase activity	PMID:28386764^[2]	ECO:0000303	author statement without traceable support used in manual assertion		F	has_input:(UniProtKB:P10636)	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:23666762^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0030425	dendrite	PMID:23666762^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	PMID:23666762^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion	UniProtKB:Q96L34	P		Seeded From UniProt	complete
enables	GO:0050321	tau-protein kinase activity	PMID:23666762^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0048156	tau protein binding	PMID:28386764^[2]	ECO:0000303	author statement without traceable support used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0046605	regulation of centrosome cycle	PMID:25123532^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0000930	gamma-tubulin complex	PMID:25123532^[4]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(GO:0005813)	Seeded From UniProt	complete
part_of	GO:0030496	midbody	PMID:25123532^[4]	ECO:0000314	direct assay evidence used in manual assertion		C	exists_during:(GO:0000910)	Seeded From UniProt	complete
part_of	GO:0005813	centrosome	PMID:25123532^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0050321	tau-protein kinase activity	PMID:27708431^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0050321	tau-protein kinase activity	PMID:28386764^[2]	ECO:0000303	author statement without traceable support used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0036064	ciliary basal body	PMID:23400999^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0044782	cilium organization	PMID:23400999^[1]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q5BJF6	P		Seeded From UniProt	complete
involved_in	GO:1904781	positive regulation of protein localization to centrosome	PMID:23400999^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:Q5BJF6)	Seeded From UniProt	complete
NOT\|involved_in	GO:0000226	microtubule cytoskeleton organization	PMID:23400999^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045724	positive regulation of cilium assembly	PMID:23400999^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0050321	tau-protein kinase activity	PMID:14594945^[6]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0043130	ubiquitin binding	PMID:14594945^[6]	ECO:0000303	author statement without traceable support used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0043068	positive regulation of programmed cell death	PMID:15009667^[7]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0043015	gamma-tubulin binding	PMID:14594945^[6]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	PMID:14594945^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0015630	microtubule cytoskeleton	PMID:14594945^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0008017	microtubule binding	PMID:14594945^[6]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0007399	nervous system development	PMID:14594945^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005815	microtubule organizing center	PMID:14594945^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005813	centrosome	PMID:14594945^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	PMID:15009667^[7]	ECO:0000303	author statement without traceable support used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:15009667^[7]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0001578	microtubule bundle formation	PMID:14594945^[6]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0000226	microtubule cytoskeleton organization	PMID:14594945^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0050321	tau-protein kinase activity	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0260934 PANTHER:PTN000680111 RGD:619882 RGD:708483 UniProtKB:Q96L34	F		Seeded From UniProt	complete
involved_in	GO:0035556	intracellular signal transduction	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002519176 RGD:619882 UniProtKB:Q7KZI7 UniProtKB:Q9P0L2	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0038167 MGI:MGI:2446296 PANTHER:PTN002519176 RGD:619882 SGD:S000000015 UniProtKB:P27448 UniProtKB:Q7KZI7 UniProtKB:Q96L34 UniProtKB:Q96RG2 UniProtKB:Q9P0L2 WB:WBGene00003916	C		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0260934 PANTHER:PTN002519176 RGD:619882 RGD:708483 SGD:S000000015 SGD:S000005405 UniProtKB:A0A1D8PN61 UniProtKB:P27448 UniProtKB:Q7KZI7 UniProtKB:Q93V58 UniProtKB:Q96L34 UniProtKB:Q96RG2 UniProtKB:Q9P0L2 UniProtKB:Q9Y2K2 WB:WBGene00003916	F		Seeded From UniProt	complete
involved_in	GO:0000226	microtubule cytoskeleton organization	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0260934 PANTHER:PTN000680111 RGD:619882 UniProtKB:Q96L34	P		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR008271	F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR033624	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR017441	F		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR008271	P		Seeded From UniProt	complete
involved_in	GO:0030010	establishment of cell polarity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR033624	P		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	PMID:14594945^[6]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0097711	ciliary basal body-plasma membrane docking	Reactome:R-HSA-5620912	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-HSA-5638009 Reactome:R-HSA-5626699 Reactome:R-HSA-5626681 Reactome:R-HSA-5626227 Reactome:R-HSA-5617816	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005856	cytoskeleton	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0206 UniProtKB-SubCell:SL-0090	C		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
involved_in	GO:0030030	cell projection organization	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0970	P		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
involved_in	GO:0051301	cell division	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0132	P		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
part_of	GO:0042995	cell projection	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0966	C		Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0723	F		Seeded From UniProt	complete
involved_in	GO:0007049	cell cycle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0131	P		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
part_of	GO:0005815	microtubule organizing center	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0048	C		Seeded From UniProt	complete
part_of	GO:0030425	dendrite	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0283	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 Kuhns, S et al. (2013) The microtubule affinity regulating kinase MARK4 promotes axoneme extension during early ciliogenesis. J. Cell Biol. 200 505-22 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Guo, T et al. (2017) Roles of tau protein in health and disease. Acta Neuropathol. 133 665-704 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 Gu, GJ et al. (2013) Role of individual MARK isoforms in phosphorylation of tau at Ser²⁶² in Alzheimer's disease. Neuromolecular Med. 15 458-69 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 Rovina, D et al. () Microtubule-associated protein/microtubule affinity-regulating kinase 4 (MARK4) plays a role in cell cycle progression and cytoskeletal dynamics. Eur. J. Cell Biol. 93 355-65 PubMed GONUTS page
↑ Sun, W et al. (2016) Attenuation of synaptic toxicity and MARK4/PAR1-mediated Tau phosphorylation by methylene blue for Alzheimer's disease treatment. Sci Rep 6 34784 PubMed GONUTS page
↑ ^6.00 ^6.01 ^6.02 ^6.03 ^6.04 ^6.05 ^6.06 ^6.07 ^6.08 ^6.09 ^6.10 ^6.11 Trinczek, B et al. (2004) MARK4 is a novel microtubule-associated proteins/microtubule affinity-regulating kinase that binds to the cellular microtubule network and to centrosomes. J. Biol. Chem. 279 5915-23 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 Schneider, A et al. (2004) Identification of regulated genes during permanent focal cerebral ischaemia: characterization of the protein kinase 9b5/MARKL1/MARK4. J. Neurochem. 88 1114-26 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 ^8.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:23400999-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 Kuhns, S et al. (2013) The microtubule affinity regulating kinase MARK4 promotes axoneme extension during early ciliogenesis. J. Cell Biol. 200 505-22 PubMed GONUTS page

[PMID:28386764-2] 2.0 ^2.1 ^2.2 Guo, T et al. (2017) Roles of tau protein in health and disease. Acta Neuropathol. 133 665-704 PubMed GONUTS page

[PMID:23666762-3] 3.0 ^3.1 ^3.2 ^3.3 Gu, GJ et al. (2013) Role of individual MARK isoforms in phosphorylation of tau at Ser²⁶² in Alzheimer's disease. Neuromolecular Med. 15 458-69 PubMed GONUTS page

[PMID:25123532-4] 4.0 ^4.1 ^4.2 ^4.3 Rovina, D et al. () Microtubule-associated protein/microtubule affinity-regulating kinase 4 (MARK4) plays a role in cell cycle progression and cytoskeletal dynamics. Eur. J. Cell Biol. 93 355-65 PubMed GONUTS page

[PMID:27708431-5] Sun, W et al. (2016) Attenuation of synaptic toxicity and MARK4/PAR1-mediated Tau phosphorylation by methylene blue for Alzheimer's disease treatment. Sci Rep 6 34784 PubMed GONUTS page

[PMID:14594945-6] 6.00 ^6.01 ^6.02 ^6.03 ^6.04 ^6.05 ^6.06 ^6.07 ^6.08 ^6.09 ^6.10 ^6.11 Trinczek, B et al. (2004) MARK4 is a novel microtubule-associated proteins/microtubule affinity-regulating kinase that binds to the cellular microtubule network and to centrosomes. J. Biol. Chem. 279 5915-23 PubMed GONUTS page

[PMID:15009667-7] 7.0 ^7.1 ^7.2 Schneider, A et al. (2004) Identification of regulated genes during permanent focal cerebral ischaemia: characterization of the protein kinase 9b5/MARKL1/MARK4. J. Neurochem. 88 1114-26 PubMed GONUTS page

[PMID:21873635-8] 8.0 ^8.1 ^8.2 ^8.3 ^8.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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HUMAN:MARK4

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