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HUMAN:MARH7

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) MARCH7 (synonyms: AXOT, RNF177)
Protein Name(s) E3 ubiquitin-protein ligase MARCH7

Axotrophin Membrane-associated RING finger protein 7 Membrane-associated RING-CH protein VII MARCH-VII RING finger protein 177 RING-type E3 ubiquitin transferase MARCH7 (ECO:0000305)

External Links
UniProt Q9H992
EMBL AK022973
AK292836
AK302347
AK222880
AC009961
CH471058
BC003404
BC065014
CCDS CCDS2210.1
CCDS63039.1
RefSeq NP_001269734.1
NP_001269735.1
NP_001269736.1
NP_073737.1
XP_005246830.1
UniGene Hs.529272
ProteinModelPortal Q9H992
SMR Q9H992
BioGrid 122319
IntAct Q9H992
MINT MINT-2876071
STRING 9606.ENSP00000259050
iPTMnet Q9H992
PhosphoSitePlus Q9H992
BioMuta MARK7
DMDM 74762745
EPD Q9H992
MaxQB Q9H992
PaxDb Q9H992
PeptideAtlas Q9H992
PRIDE Q9H992
Ensembl ENST00000259050
ENST00000409175
ENST00000409591
GeneID 64844
KEGG hsa:64844
UCSC uc002uax.5
CTD 64844
DisGeNET 64844
EuPathDB HostDB:ENSG00000136536.14
GeneCards MARCH7
HGNC HGNC:17393
HPA HPA014275
HPA022152
MIM 613334
neXtProt NX_Q9H992
OpenTargets ENSG00000136536
PharmGKB PA25198
eggNOG KOG1609
COG5183
GeneTree ENSGT00530000063836
HOGENOM HOG000232048
HOVERGEN HBG080528
InParanoid Q9H992
KO K10662
OMA PDNRASE
OrthoDB EOG091G052E
PhylomeDB Q9H992
TreeFam TF330816
BRENDA 6.3.2.19
UniPathway UPA00143
ChiTaRS MARCH7
GeneWiki MARCH7
GenomeRNAi 64844
PRO PR:Q9H992
Proteomes UP000005640
Bgee ENSG00000136536
CleanEx HS_MARCH7
ExpressionAtlas Q9H992
Genevisible Q9H992
GO GO:0016740
GO:0008270
GO:0042130
GO:0016567
GO:0002643
Gene3D 3.30.40.10
InterPro IPR011016
IPR013083
Pfam PF12906
SMART SM00744
PROSITE PS51292

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0006513

protein monoubiquitination

PMID:24905733[1]

ECO:0000314

P

The organism is H. Sapiens and the Protein is March7 but it referred as axotrophin in the journal. Figure 3E shows that MARCH7 (E3 ubiquitin-protein ligase MARCH7) ubiquitinates tau (Microtubule-associated protein tau)

complete
CACAO 13038

involved_in

GO:1902166

negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

PMID:29295817[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0097371

MDM2/MDM4 family protein binding

PMID:29295817[2]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q00987

F

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q9WV66

C

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q9WV66

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q9WV66

C

Seeded From UniProt

complete

enables

GO:0043130

ubiquitin binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q9WV66

F

Seeded From UniProt

complete

involved_in

GO:0051865

protein autoubiquitination

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q9WV66

P

Seeded From UniProt

complete

involved_in

GO:0008284

positive regulation of cell population proliferation

PMID:29295817[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0031624

ubiquitin conjugating enzyme binding

PMID:18410486[3]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P61088

F

Seeded From UniProt

complete

enables

GO:0031624

ubiquitin conjugating enzyme binding

PMID:18410486[3]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P61086

F

Seeded From UniProt

complete

involved_in

GO:1905524

negative regulation of protein autoubiquitination

PMID:29295817[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

has_regulation_target:(UniProtKB:Q00987)

Seeded From UniProt

complete

involved_in

GO:0050821

protein stabilization

PMID:29295817[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

has_direct_input:(UniProtKB:Q00987)

Seeded From UniProt

complete

involved_in

GO:1902916

positive regulation of protein polyubiquitination

PMID:29295817[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

has_regulation_target:(UniProtKB:P04637)|has_direct_input(UniProtKB:Q00987)

Seeded From UniProt

complete

involved_in

GO:0043518

negative regulation of DNA damage response, signal transduction by p53 class mediator

PMID:29295817[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:1901799

negative regulation of proteasomal protein catabolic process

PMID:29295817[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

has_direct_input:(UniProtKB:Q00987)

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:29295817[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0051865

protein autoubiquitination

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1931053
PANTHER:PTN000375252

P

Seeded From UniProt

complete

enables

GO:0043130

ubiquitin binding

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1931053
PANTHER:PTN000375252

F

Seeded From UniProt

complete

enables

GO:0031624

ubiquitin conjugating enzyme binding

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000375252
UniProtKB:Q9H992

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1931053
PANTHER:PTN000375252
UniProtKB:Q9H992

C

Seeded From UniProt

complete

involved_in

GO:0051865

protein autoubiquitination

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9WV66
ensembl:ENSMUSP00000099809

P

Seeded From UniProt

complete

enables

GO:0043130

ubiquitin binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9WV66
ensembl:ENSMUSP00000099809

F

Seeded From UniProt

complete

involved_in

GO:0042130

negative regulation of T cell proliferation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9WV66
ensembl:ENSMUSP00000099809

P

Seeded From UniProt

complete

enables

GO:0019899

enzyme binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9WV66
ensembl:ENSMUSP00000099809

F

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9WV66
ensembl:ENSMUSP00000099809

C

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9WV66
ensembl:ENSMUSP00000099809

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9WV66
ensembl:ENSMUSP00000099809

C

Seeded From UniProt

complete

involved_in

GO:0002643

regulation of tolerance induction

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9WV66
ensembl:ENSMUSP00000099809

P

Seeded From UniProt

complete

enables

GO:0008270

zinc ion binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR011016

F

Seeded From UniProt

complete

enables

GO:0016740

transferase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0808

F

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

involved_in

GO:0016567

protein ubiquitination

GO_REF:0000041

ECO:0000322

imported manually asserted information used in automatic assertion

UniPathway:UPA00143

P

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ Flach, K et al. (2014) Axotrophin/MARCH7 acts as an E3 ubiquitin ligase and ubiquitinates tau protein in vitro impairing microtubule binding. Biochim. Biophys. Acta 1842 1527-38 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 2.7 2.8 Zhao, K et al. (2018) Regulation of the Mdm2-p53 pathway by the ubiquitin E3 ligase MARCH7. EMBO Rep. 19 305-319 PubMed GONUTS page
  3. ↑ 3.0 3.1 Nathan, JA et al. (2008) The ubiquitin E3 ligase MARCH7 is differentially regulated by the deubiquitylating enzymes USP7 and USP9X. Traffic 9 1130-45 PubMed GONUTS page
  4. ↑ 4.0 4.1 4.2 4.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
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