HUMAN:M3K6

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	MAP3K6 (synonyms: ASK2, MAPKKK6, MEKK6)
Protein Name(s)	Mitogen-activated protein kinase kinase kinase 6 Apoptosis signal-regulating kinase 2
External Links
UniProt	O95382
EMBL	AB167411 FO393419 BC015914 BC129950 BC129951 AB208805 AF100318
CCDS	CCDS299.1 CCDS72738.1
RefSeq	NP_001284538.1 NP_004663.3
UniGene	Hs.194694
ProteinModelPortal	O95382
SMR	O95382
BioGrid	114524
IntAct	O95382
MINT	MINT-7997495
STRING	9606.ENSP00000350195
BindingDB	O95382
ChEMBL	CHEMBL1163123
GuidetoPHARMACOLOGY	2081
PhosphoSite	O95382
MaxQB	O95382
PaxDb	O95382
PRIDE	O95382
Ensembl	ENST00000357582 ENST00000374040 ENST00000493901
GeneID	9064
KEGG	hsa:9064
UCSC	uc001bny.1 uc001bnz.1 uc009vsw.1
CTD	9064
GeneCards	GC01M027681
H-InvDB	HIX0000314
HGNC	HGNC:6858
HPA	HPA051192
MIM	604468
neXtProt	NX_O95382
PharmGKB	PA30602
eggNOG	COG0515
GeneTree	ENSGT00760000119077
HOVERGEN	HBG006305
InParanoid	O95382
KO	K04425
OMA	KMQYYWD
PhylomeDB	O95382
TreeFam	TF105115
BRENDA	2.7.11.25
SignaLink	O95382
ChiTaRS	MAP3K6
GenomeRNAi	9064
NextBio	33967
PRO	PR:O95382
Proteomes	UP000005640
Bgee	O95382
CleanEx	HS_MAP3K6
ExpressionAtlas	O95382
Genevestigator	O95382
GO	GO:0005524 GO:0000287 GO:0004709 GO:0007257 GO:0000186 GO:0006468 GO:0007165
InterPro	IPR025136 IPR011009 IPR000719 IPR017441 IPR013761 IPR002290 IPR008271
Pfam	PF13281 PF00069
SMART	SM00220
SUPFAM	SSF47769 SSF56112
PROSITE	PS00107 PS50011 PS00108

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0006468	protein phosphorylation		ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0005524	ATP binding		ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004709	MAP kinase kinase kinase activity		ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0000287	magnesium ion binding		ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004709	MAP kinase kinase kinase activity		ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1346876 PANTHER:PTN000684847 RGD:1306565 UniProtKB:O95382 UniProtKB:Q99683	F		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity		ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000172316 UniProtKB:Q99683	F		Seeded From UniProt	complete
involved_in	GO:0000186	activation of MAPKK activity		ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000684847 UniProtKB:Q99683	P		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR008271	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR017441	F		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR008271	P		Seeded From UniProt	complete
enables	GO:0004709	MAP kinase kinase kinase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.7.11.25	F		Seeded From UniProt	complete
involved_in	GO:0007257	activation of JUN kinase activity		ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction		ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004709	MAP kinase kinase kinase activity		ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0723	F		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
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References

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