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HUMAN:LMNB1

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) LMNB1 (synonyms: LMN2, LMNB)
Protein Name(s) Lamin-B1
External Links
UniProt P20700
EMBL M34458
L37747
L37737
L37738
L37739
L37740
L37741
L37742
L37743
L37744
L37745
L37746
AK312603
CH471086
BC012295
BC103723
CCDS CCDS4140.1
PIR A34707
RefSeq NP_005564.1
UniGene Hs.89497
PDB 2KPW
3JT0
3TYY
3UMN
PDBsum 2KPW
3JT0
3TYY
3UMN
ProteinModelPortal P20700
SMR P20700
BioGrid 110187
DIP DIP-34897N
IntAct P20700
MINT MINT-3009331
STRING 9606.ENSP00000261366
PhosphoSite P20700
DMDM 125953
SWISS-2DPAGE P20700
MaxQB P20700
PaxDb P20700
PeptideAtlas P20700
PRIDE P20700
DNASU 4001
Ensembl ENST00000261366
GeneID 4001
KEGG hsa:4001
UCSC uc003kud.2
CTD 4001
GeneCards GC05P126112
HGNC HGNC:6637
HPA CAB005269
HPA050524
MIM 150340
169500
neXtProt NX_P20700
Orphanet 99027
PharmGKB PA30403
eggNOG NOG325506
GeneTree ENSGT00760000118905
HOGENOM HOG000007711
HOVERGEN HBG013015
InParanoid P20700
KO K07611
OMA QKESRAC
OrthoDB EOG7MD4PW
PhylomeDB P20700
TreeFam TF101181
Reactome REACT_13472
REACT_160242
REACT_160251
REACT_169121
REACT_200828
REACT_75792
ChiTaRS LMNB1
EvolutionaryTrace P20700
GeneWiki LMNB1
GenomeRNAi 4001
NextBio 15700
PMAP-CutDB P20700
PRO PR:P20700
Proteomes UP000005640
Bgee P20700
CleanEx HS_LMNB1
ExpressionAtlas P20700
Genevestigator P20700
GO GO:0005638
GO:0016020
GO:0005635
GO:0005637
GO:0031965
GO:0005654
GO:0005198
GO:0006915
GO:0006921
Gene3D 2.60.40.1260
InterPro IPR001664
IPR018039
IPR027696
IPR001322
PANTHER PTHR23239
PTHR23239:SF157
Pfam PF00038
PF00932
SUPFAM SSF74853
PROSITE PS00226

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0005634

nucleus

PMID:28334682[1]

ECO:0000314

C

Organism: Homo sapiens. Protein Name: Lamin B1. Notes: Figure 4G is used. MCF-7 cells (which are human) have their nuclei stained blue and are also immunostained so that Lamin B1 will appear green. As can be seen in the micrograph control groups, there is significant overlap of these colors. There thus appears to be a non-transient link between Lamin B1 and the nucleus.

complete
CACAO 12750

colocalizes_with

GO:0005635

nuclear envelope

PMID:21610090[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:10791971[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0031965

nuclear membrane

PMID:16791210[4]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0016020

membrane

PMID:19946888[5]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0031965

nuclear membrane

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:1990837

sequence-specific double-stranded DNA binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P14733
ensembl:ENSMUSP00000025486

F

Seeded From UniProt

complete

enables

GO:0043274

phospholipase binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P14733
ensembl:ENSMUSP00000025486

F

Seeded From UniProt

complete

part_of

GO:0016363

nuclear matrix

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P14733
ensembl:ENSMUSP00000025486

C

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P14733
ensembl:ENSMUSP00000025486

C

Seeded From UniProt

complete

part_of

GO:0005638

lamin filament

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P14733
ensembl:ENSMUSP00000025486

C

Seeded From UniProt

complete

part_of

GO:0005637

nuclear inner membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P14733
ensembl:ENSMUSP00000025486

C

Seeded From UniProt

complete

part_of

GO:0005635

nuclear envelope

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P14733
ensembl:ENSMUSP00000025486

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P14733
ensembl:ENSMUSP00000025486

C

Seeded From UniProt

complete

enables

GO:0003690

double-stranded DNA binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P14733
ensembl:ENSMUSP00000025486

F

Seeded From UniProt

complete

enables

GO:0005198

structural molecule activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001664

F

Seeded From UniProt

complete

part_of

GO:0005882

intermediate filament

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001664

C

Seeded From UniProt

complete

part_of

GO:0005638

lamin filament

PMID:7557986[6]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0005198

structural molecule activity

PMID:7557986[6]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0035722

interleukin-12-mediated signaling pathway

Reactome:R-HSA-9020591

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

Reactome:R-HSA-8950681
Reactome:R-HSA-264871

ECO:0000304

author statement supported by traceable reference used in manual assertion


C

Seeded From UniProt

complete

part_of

GO:0005635

nuclear envelope

Reactome:R-HSA-264871

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005882

intermediate filament

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0403

C

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539

C

Seeded From UniProt

complete

part_of

GO:0005637

nuclear inner membrane

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0179

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. Lewinska, A et al. (2017) Phytochemical-induced nucleolar stress results in the inhibition of breast cancer cell proliferation. Redox Biol 12 469-482 PubMed GONUTS page
  2. Gudise, S et al. (2011) Samp1 is functionally associated with the LINC complex and A-type lamina networks. J. Cell. Sci. 124 2077-85 PubMed GONUTS page
  3. Ko, YG et al. (2000) Nucleolar localization of human methionyl-tRNA synthetase and its role in ribosomal RNA synthesis. J. Cell Biol. 149 567-74 PubMed GONUTS page
  4. Sigal, A et al. (2006) Dynamic proteomics in individual human cells uncovers widespread cell-cycle dependence of nuclear proteins. Nat. Methods 3 525-31 PubMed GONUTS page
  5. Ghosh, D et al. (2010) Defining the membrane proteome of NK cells. J Mass Spectrom 45 1-25 PubMed GONUTS page
  6. 6.0 6.1 Lin, F & Worman, HJ (1995) Structural organization of the human gene (LMNB1) encoding nuclear lamin B1. Genomics 27 230-6 PubMed GONUTS page