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HUMAN:LIPE
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | LIPG | |
| Protein Name(s) | Endothelial lipase
Endothelial cell-derived lipase EDL EL | |
| External Links | ||
| UniProt | Q9Y5X9 | |
| EMBL | AF118767 AY358928 EU332856 CH471096 BC060825 | |
| CCDS | CCDS11938.1 | |
| RefSeq | NP_001294935.1 NP_006024.1 | |
| UniGene | Hs.465102 | |
| ProteinModelPortal | Q9Y5X9 | |
| SMR | Q9Y5X9 | |
| BioGrid | 114788 | |
| IntAct | Q9Y5X9 | |
| STRING | 9606.ENSP00000261292 | |
| BindingDB | Q9Y5X9 | |
| ChEMBL | CHEMBL5080 | |
| GuidetoPHARMACOLOGY | 2591 | |
| ESTHER | human-LIPG | |
| BioMuta | LIPG | |
| DMDM | 22001808 | |
| MaxQB | Q9Y5X9 | |
| PaxDb | Q9Y5X9 | |
| PRIDE | Q9Y5X9 | |
| DNASU | 9388 | |
| Ensembl | ENST00000261292 ENST00000580036 | |
| GeneID | 9388 | |
| KEGG | hsa:9388 | |
| UCSC | uc002ldu.1 uc002ldv.3 | |
| CTD | 9388 | |
| GeneCards | GC18P047088 | |
| HGNC | HGNC:6623 | |
| HPA | HPA016966 | |
| MIM | 603684 | |
| neXtProt | NX_Q9Y5X9 | |
| PharmGKB | PA30395 | |
| eggNOG | NOG40923 | |
| GeneTree | ENSGT00760000119069 | |
| HOGENOM | HOG000038553 | |
| HOVERGEN | HBG002259 | |
| InParanoid | Q9Y5X9 | |
| KO | K01046 | |
| OMA | QSWYNLW | |
| PhylomeDB | Q9Y5X9 | |
| TreeFam | TF324997 | |
| ChiTaRS | LIPG | |
| GenomeRNAi | 9388 | |
| NextBio | 35175 | |
| PMAP-CutDB | Q9Y5X9 | |
| PRO | PR:Q9Y5X9 | |
| Proteomes | UP000005640 | |
| Bgee | Q9Y5X9 | |
| CleanEx | HS_LIPG | |
| ExpressionAtlas | Q9Y5X9 | |
| Genevisible | Q9Y5X9 | |
| GO | GO:0009986 GO:0005769 GO:0005615 GO:0005794 GO:0008201 GO:0004465 GO:0008970 GO:0004620 GO:0008283 GO:0042632 GO:0034375 GO:0006629 GO:0009395 GO:0055091 GO:0032376 GO:0010983 GO:0050746 GO:0007584 GO:0043691 | |
| Gene3D | 2.60.60.20 3.40.50.1820 | |
| InterPro | IPR029058 IPR016272 IPR008976 IPR013818 IPR002330 IPR001024 IPR000734 | |
| PANTHER | PTHR11610 | |
| Pfam | PF00151 PF01477 | |
| PIRSF | PIRSF000865 | |
| PRINTS | PR00822 PR00821 | |
| SUPFAM | SSF49723 SSF53474 | |
| PROSITE | PS00120 PS50095 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0008970 |
phospholipase A1 activity |
ECO:0000314 |
F |
Source: MGI |
Missing: reference | |||||
|
involved_in |
GO:0055091 |
phospholipid homeostasis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0043691 |
reverse cholesterol transport |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0042632 |
cholesterol homeostasis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0034375 |
high-density lipoprotein particle remodeling |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0032376 |
positive regulation of cholesterol transport |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0010983 |
positive regulation of high-density lipoprotein particle clearance |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0009395 |
phospholipid catabolic process |
ECO:0000303 |
author statement without traceable support used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005615 |
extracellular space |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004620 |
phospholipase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0009986 |
cell surface |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008970 |
phospholipase A1 activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005794 |
Golgi apparatus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005769 |
early endosome |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0008283 |
cell population proliferation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q8VBX1 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0007584 |
response to nutrient |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q8VBX1 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005615 |
extracellular space |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q8VBX1 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0050746 |
regulation of lipoprotein metabolic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9WVG5 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004620 |
phospholipase activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9WVG5 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004465 |
lipoprotein lipase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006629 |
lipid metabolic process |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0052689 |
carboxylic ester hydrolase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004806 |
triglyceride lipase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008970 |
phospholipase A1 activity |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006629 |
lipid metabolic process |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0034375 |
high-density lipoprotein particle remodeling |
Reactome:R-HSA-8964058 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005576 |
extracellular region |
Reactome:R-HSA-8980228 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0016042 |
lipid catabolic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005576 |
extracellular region |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006629 |
lipid metabolic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016787 |
hydrolase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008201 |
heparin binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 Nijstad, N et al. (2009) Scavenger receptor BI-mediated selective uptake is required for the remodeling of high density lipoprotein by endothelial lipase. J. Biol. Chem. 284 6093-100 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 Jaye, M et al. (1999) A novel endothelial-derived lipase that modulates HDL metabolism. Nat. Genet. 21 424-8 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 Essalmani, R et al. (2013) Furin is the primary in vivo convertase of angiopoietin-like 3 and endothelial lipase in hepatocytes. J. Biol. Chem. 288 26410-8 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 Hirata, K et al. (1999) Cloning of a unique lipase from endothelial cells extends the lipase gene family. J. Biol. Chem. 274 14170-5 PubMed GONUTS page
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- GO:0004620 ! phospholipase activity
- GO:0008970 ! phospholipase A1 activity
- GO:0009395 ! phospholipid catabolic process
- GO:0055091 ! phospholipid homeostasis
- GO:0010983 ! positive regulation of high-density lipoprotein particle clearance
- GO:0032376 ! positive regulation of cholesterol transport
- Primates
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