HUMAN:LIMC1

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	LIMCH1 (synonyms: KIAA1102)
Protein Name(s)	LIM and calponin homology domains-containing protein 1
External Links
UniProt	Q9UPQ0
EMBL	AB029025 AL831962 BX537916 CR749205 CR933645 CR936601 CR936610 CR936664 AC095043 AC105389 AC108050 AC121159 AC124009 BC023546 BC029735 BC095394
CCDS	CCDS33977.1 CCDS47047.1 CCDS54763.1 CCDS54764.1 CCDS54765.1 CCDS75119.1 CCDS75121.1 CCDS82919.1
RefSeq	NP_001106188.1 NP_001106189.1 NP_001106190.1 NP_001106191.1 NP_001276051.1 NP_001276053.1 NP_001317601.1 NP_001317603.1 NP_001317713.1 NP_001317715.1 NP_055803.2
UniGene	Hs.335163
ProteinModelPortal	Q9UPQ0
SMR	Q9UPQ0
BioGrid	116645
IntAct	Q9UPQ0
MINT	MINT-4724874
STRING	9606.ENSP00000316891
iPTMnet	Q9UPQ0
PhosphoSitePlus	Q9UPQ0
BioMuta	LIMCH1
DMDM	296439483
EPD	Q9UPQ0
PaxDb	Q9UPQ0
PeptideAtlas	Q9UPQ0
PRIDE	Q9UPQ0
DNASU	22998
Ensembl	ENST00000313860 ENST00000381753 ENST00000396595 ENST00000508501 ENST00000511496 ENST00000512820 ENST00000512946 ENST00000513024
GeneID	22998
KEGG	hsa:22998
UCSC	uc003gvu.6
CTD	22998
DisGeNET	22998
EuPathDB	HostDB:ENSG00000064042.17
GeneCards	LIMCH1
H-InvDB	HIX0004177 HIX0120158
HGNC	HGNC:29191
HPA	HPA004184 HPA063840
neXtProt	NX_Q9UPQ0
OpenTargets	ENSG00000064042
PharmGKB	PA162393957
eggNOG	ENOG410INGA ENOG410XQB9
GeneTree	ENSGT00530000063559
HOVERGEN	HBG108087
InParanoid	Q9UPQ0
PhylomeDB	Q9UPQ0
TreeFam	TF332155
ChiTaRS	LIMCH1
GeneWiki	LIMCH1
GenomeRNAi	22998
PRO	PR:Q9UPQ0
Proteomes	UP000005640
Bgee	ENSG00000064042
CleanEx	HS_LIMCH1
ExpressionAtlas	Q9UPQ0
Genevisible	Q9UPQ0
GO	GO:0003779 GO:0046872 GO:0031032
CDD	cd00014
Gene3D	1.10.418.10
InterPro	IPR001997 IPR001715 IPR031865 IPR029980 IPR003096 IPR001781
PANTHER	PTHR15551:SF5
Pfam	PF00307 PF15949 PF00412
PRINTS	PR00889 PR00888
SMART	SM00033 SM00132
SUPFAM	SSF47576
PROSITE	PS50021 PS00478 PS50023

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0051496	positive regulation of stress fiber assembly	PMID:28228547	ECO:0000315			P		Homo Sapiens; LIM and calponin homology domains-containing protein 1 (LIMCH1) Figure 6a and 6b show that LIMCH1-depleted cells (LIMCH1.2) in humans showed reduced intensity of total stress fibers, particularly near the center of the cell.	complete CACAO 12944
	GO:0001725	stress fiber	PMID:28228547	ECO:0000314			C		Homo Sapiens; LIM and calponin homology domains-containing protein 1 (LIMCH1) Figure 1b shows that LIMCH1 is colocalized with actin stress fibers in human cells, and Figure 1c confirms this. Since “actin stress fiber” doesn’t exist as a GO term, stress fiber is the closest annotation.	complete CACAO 12948
	GO:0030336	negative regulation of cell migration	PMID:28228547	ECO:0000315			P		Homo Sapiens; LIM and calponin homology domains-containing protein 1 (LIMCH1) Figure 8D, 8E, and 8F all show how in LIMCH1 depleted cells (LIMCH1.2) in humans, the cells experience quicker and more frequent cell migration, implying that LIMCH1 would otherwise be negatively regulating cell migration.	complete CACAO 12950
	GO:0060327	cytoplasmic actin-based contraction involved in cell motility	PMID:28228547	ECO:0000315			P		Homo Sapiens; LIM and calponin homology domains-containing protein 1 (LIMCH1) Figure 8B and 8C both show how, compared to the wild type, a human cell depleted in LIMCH1 decreases in cell contraction. LIMCH1 attenuates actin stress fibers, as seen in Figure 6a and 6b, which can decrease cell motility. The paper concludes that LIMCH1 increases cell motility by decreasing the number of actin stress fibers.	complete CACAO 12951
part_of	GO:0001725	stress fiber	PMID:28228547	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0001934	positive regulation of protein phosphorylation	PMID:28228547	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
colocalizes_with	GO:0016460	myosin II complex	PMID:28228547	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0030336	negative regulation of cell migration	PMID:28228547	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051496	positive regulation of stress fiber assembly	PMID:28228547	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0032034	myosin II head/neck binding	PMID:28228547	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P35579	F		Seeded From UniProt	complete
enables	GO:0032034	myosin II head/neck binding	PMID:28228547	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0051893	regulation of focal adhesion assembly	PMID:28228547	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0003779	actin binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001997	F		Seeded From UniProt	complete
involved_in	GO:0031032	actomyosin structure organization	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001997	P		Seeded From UniProt	complete
part_of	GO:0005856	cytoskeleton	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0206 UniProtKB-SubCell:SL-0090	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963	C		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
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References

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