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HUMAN:KCC4
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | CAMK4 (synonyms: CAMK, CAMK-GR, CAMKIV) | |
| Protein Name(s) | Calcium/calmodulin-dependent protein kinase type IV
CaMK IV CaM kinase-GR | |
| External Links | ||
| UniProt | Q16566 | |
| EMBL | D30742 L17000 L24959 CH471086 CH471086 BC016695 BC025687 | |
| CCDS | CCDS4103.1 | |
| PIR | A53036 | |
| RefSeq | NP_001735.1 | |
| UniGene | Hs.591269 | |
| PDB | 2W4O | |
| PDBsum | 2W4O | |
| ProteinModelPortal | Q16566 | |
| SMR | Q16566 | |
| BioGrid | 107264 | |
| DIP | DIP-41997N | |
| IntAct | Q16566 | |
| MINT | MINT-192934 | |
| STRING | 9606.ENSP00000282356 | |
| BindingDB | Q16566 | |
| ChEMBL | CHEMBL2494 | |
| GuidetoPHARMACOLOGY | 1955 | |
| PhosphoSite | Q16566 | |
| DMDM | 2499586 | |
| MaxQB | Q16566 | |
| PaxDb | Q16566 | |
| PeptideAtlas | Q16566 | |
| PRIDE | Q16566 | |
| DNASU | 814 | |
| Ensembl | ENST00000282356 ENST00000512453 | |
| GeneID | 814 | |
| KEGG | hsa:814 | |
| UCSC | uc003kpf.3 | |
| CTD | 814 | |
| GeneCards | GC05P110587 | |
| HGNC | HGNC:1464 | |
| HPA | CAB004347 HPA011753 HPA017206 | |
| MIM | 114080 | |
| neXtProt | NX_Q16566 | |
| PharmGKB | PA26050 | |
| eggNOG | COG0515 | |
| GeneTree | ENSGT00760000118944 | |
| HOGENOM | HOG000233016 | |
| HOVERGEN | HBG108055 | |
| InParanoid | Q16566 | |
| KO | K05869 | |
| OMA | PIQDGNE | |
| PhylomeDB | Q16566 | |
| TreeFam | TF351230 | |
| BRENDA | 2.7.11.17 | |
| Reactome | REACT_15502 REACT_200608 REACT_20652 REACT_20661 | |
| SignaLink | Q16566 | |
| ChiTaRS | CAMK4 | |
| EvolutionaryTrace | Q16566 | |
| GeneWiki | CAMK4 | |
| GenomeRNAi | 814 | |
| NextBio | 3300 | |
| PMAP-CutDB | Q16566 | |
| PRO | PR:Q16566 | |
| Proteomes | UP000005640 | |
| Bgee | Q16566 | |
| CleanEx | HS_CAMK4 | |
| ExpressionAtlas | Q16566 | |
| Genevestigator | Q16566 | |
| GO | GO:0005829 GO:0070062 GO:0005730 GO:0005654 GO:0005634 GO:0005524 GO:0004683 GO:0007202 GO:0007173 GO:0008543 GO:0006954 GO:0045087 GO:0007616 GO:0043011 GO:0007270 GO:0048011 GO:0006913 GO:0046827 GO:0045893 GO:0006468 GO:0045670 GO:0033081 GO:0007165 GO:0007268 | |
| InterPro | IPR011009 IPR000719 IPR017441 IPR002290 IPR008271 | |
| Pfam | PF00069 | |
| SMART | SM00220 | |
| SUPFAM | SSF56112 | |
| PROSITE | PS00107 PS50011 PS00108 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0004683 |
calmodulin-dependent protein kinase activity |
ECO:0000314 |
F |
Fig 3 or 7 |
complete | |||||
|
enables |
GO:0004683 |
calmodulin-dependent protein kinase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0070062 |
extracellular exosome |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
part_of:(UBERON:0001088) |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0045893 |
positive regulation of transcription, DNA-templated |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0043011 |
myeloid dendritic cell differentiation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007616 |
long-term memory |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
P |
Seeded From UniProt |
Missing: with/from | |||
|
NOT|involved_in |
GO:0002372 |
myeloid dendritic cell cytokine production |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0046777 |
protein autophosphorylation |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000681419 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0035556 |
intracellular signal transduction |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:894279 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0018105 |
peptidyl-serine phosphorylation |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000681419 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0009931 |
calcium-dependent protein serine/threonine kinase activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000681419 |
F |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0017581 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:109298 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0005516 |
calmodulin binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000681419 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004683 |
calmodulin-dependent protein kinase activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000681419 |
F |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005654 |
nucleoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0001650 |
fibrillar center |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0098978 |
glutamatergic synapse |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P13234 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0098794 |
postsynapse |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P13234 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006468 |
protein phosphorylation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P13234 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004683 |
calmodulin-dependent protein kinase activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P13234 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004672 |
protein kinase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005524 |
ATP binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006468 |
protein phosphorylation |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004683 |
calmodulin-dependent protein kinase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007165 |
signal transduction |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006468 |
protein phosphorylation |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0045670 |
regulation of osteoclast differentiation |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0033081 |
regulation of T cell differentiation in thymus |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005654 |
nucleoplasm |
Reactome:R-NUL-9619177 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
|
enables |
GO:0000166 |
nucleotide binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0016310 |
phosphorylation |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0002250 |
adaptive immune response |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006954 |
inflammatory response |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004674 |
protein serine/threonine kinase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005524 |
ATP binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005516 |
calmodulin binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016301 |
kinase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016740 |
transferase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0002376 |
immune system process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Mosialos, G et al. (1994) A Ca2+/calmodulin-dependent protein kinase, CaM kinase-Gr, expressed after transformation of primary human B lymphocytes by Epstein-Barr virus (EBV) is induced by the EBV oncogene LMP1. J. Virol. 68 1697-705 PubMed GONUTS page
- ↑ Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page
- ↑ Enslen, H et al. (1996) Regulation of mitogen-activated protein kinases by a calcium/calmodulin-dependent protein kinase cascade. Proc. Natl. Acad. Sci. U.S.A. 93 10803-8 PubMed GONUTS page
- ↑ 4.0 4.1 Illario, M et al. (2008) Calmodulin-dependent kinase IV links Toll-like receptor 4 signaling with survival pathway of activated dendritic cells. Blood 111 723-31 PubMed GONUTS page
- ↑ Fukushima, H et al. (2008) Upregulation of calcium/calmodulin-dependent protein kinase IV improves memory formation and rescues memory loss with aging. J. Neurosci. 28 9910-9 PubMed GONUTS page
- ↑ 6.0 6.1 6.2 6.3 6.4 6.5 6.6 6.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ 7.0 7.1 Kitani, T et al. (1994) cDNA cloning and expression of human calmodulin-dependent protein kinase IV. J. Biochem. 115 637-40 PubMed GONUTS page
- ↑ 8.0 8.1 Racioppi, L & Means, AR (2008) Calcium/calmodulin-dependent kinase IV in immune and inflammatory responses: novel routes for an ancient traveller. Trends Immunol. 29 600-7 PubMed GONUTS page
c
i
m
p
- GO:0018105 ! peptidyl-serine phosphorylation
- GO:0016310 ! phosphorylation
- GO:0045893 ! positive regulation of DNA-templated transcription
- GO:0098794 ! postsynapse
- Primates
- GO:0046777 ! protein autophosphorylation
- GO:0004672 ! protein kinase activity
- GO:0006468 ! protein phosphorylation
- GO:0004674 ! protein serine/threonine kinase activity
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