HUMAN:KCC2B

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	CAMK2B (synonyms: CAM2, CAMK2, CAMKB)
Protein Name(s)	Calcium/calmodulin-dependent protein kinase type II subunit beta CaM kinase II subunit beta CaMK-II subunit beta
External Links
UniProt	Q13554
EMBL	AF078803 AF081572 AF081924 AF083419 AF140350 U23460 AF112472 AF112471 AJ252236 AJ252237 AJ252238 AK290148 AK315663 CH236960 CH236960 CH236960 CH236960 CH236960 CH236960 CH236960 BC019070 U50358
CCDS	CCDS43573.1 CCDS5483.1 CCDS5484.1 CCDS5485.1 CCDS5486.1 CCDS5487.1 CCDS5488.1 CCDS5489.1
RefSeq	NP_001211.3 NP_001280099.1 NP_742075.1 NP_742076.1 NP_742077.1 NP_742078.1 NP_742079.1 NP_742080.1 NP_742081.1 XP_006715839.1
UniGene	Hs.351887
PDB	3BHH
PDBsum	3BHH
ProteinModelPortal	Q13554
SMR	Q13554
BioGrid	107266
DIP	DIP-39770N
IntAct	Q13554
BindingDB	Q13554
ChEMBL	CHEMBL4121
GuidetoPHARMACOLOGY	1556
PhosphoSite	Q13554
DMDM	334302890
MaxQB	Q13554
PaxDb	Q13554
PRIDE	Q13554
DNASU	816
Ensembl	ENST00000258682 ENST00000346990 ENST00000347193 ENST00000350811 ENST00000353625 ENST00000358707 ENST00000395747 ENST00000395749 ENST00000440254 ENST00000457475
GeneID	816
KEGG	hsa:816
UCSC	uc003tkp.2 uc003tkq.2 uc003tkr.2 uc003tks.2 uc003tkt.2 uc003tku.2 uc003tkv.2 uc003tkw.2
CTD	816
GeneCards	GC07M044225
HGNC	HGNC:1461
HPA	CAB006849 HPA026307 HPA051783 HPA051785 HPA053973
MIM	607707
neXtProt	NX_Q13554
PharmGKB	PA91
eggNOG	COG0515
GeneTree	ENSGT00760000118944
HOVERGEN	HBG108055
InParanoid	Q13554
KO	K04515
OMA	QGPPPCL
OrthoDB	EOG7ZD1VM
PhylomeDB	Q13554
TreeFam	TF315229
BRENDA	2.7.11.17
Reactome	REACT_18307 REACT_200775 REACT_20546 REACT_20568 REACT_20594 REACT_20642 REACT_25078
SignaLink	Q13554
EvolutionaryTrace	Q13554
GeneWiki	CAMK2B
GenomeRNAi	816
NextBio	3310
PRO	PR:Q13554
Proteomes	UP000005640
Bgee	Q13554
ExpressionAtlas	Q13554
Genevestigator	Q13554
GO	GO:0005829 GO:0030666 GO:0005815 GO:0005654 GO:0005886 GO:0033017 GO:0051233 GO:0005524 GO:0004683 GO:0042803 GO:0060466 GO:0006816 GO:0019221 GO:0000082 GO:0002030 GO:0060333 GO:0050885 GO:0018105 GO:2001235 GO:0061003 GO:0010976 GO:0090129 GO:0046777 GO:0006468 GO:0051924 GO:0060998 GO:0048169 GO:0014733 GO:0051823 GO:0032222 GO:0046686 GO:0007165 GO:0007268
InterPro	IPR020636 IPR013543 IPR011009 IPR000719 IPR017441 IPR002290 IPR008271
PANTHER	PTHR24347
Pfam	PF08332 PF00069
SMART	SM00220
SUPFAM	SSF56112
PROSITE	PS00107 PS50011 PS00108

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
involved_in	GO:2001222	regulation of neuron migration	PMID:29100089^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	PMID:20668654^[2]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q13554	F	Seeded From UniProt	complete
involved_in	GO:0090129	positive regulation of synapse maturation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P08413	P	Seeded From UniProt	complete
involved_in	GO:0061003	positive regulation of dendritic spine morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P08413	P	Seeded From UniProt	complete
involved_in	GO:0046777	protein autophosphorylation	PMID:18817731^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0010976	positive regulation of neuron projection development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P08413	P	Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002389359 WB:WBGene00006779	C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1341265 PANTHER:PTN002389359 RGD:2263	C	Seeded From UniProt	complete
enables	GO:0005516	calmodulin binding	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88256 PANTHER:PTN002389359 UniProtKB:Q13557 UniProtKB:Q9UQM7	F	Seeded From UniProt	complete
enables	GO:0004683	calmodulin-dependent protein kinase activity	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0264607 MGI:MGI:88256 MGI:MGI:88257 PANTHER:PTN002389359 RGD:2261 RGD:2262 RGD:2263 RGD:621802 UniProtKB:Q13557 UniProtKB:Q9UQM7 WB:WBGene00006779	F	Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:25416956^[5]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q13554	F	Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:20668654^[2]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q13554	F	Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR008271	F	Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR039071	F	Seeded From UniProt	complete
enables	GO:0004683	calmodulin-dependent protein kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR013543 InterPro:IPR039071	F	Seeded From UniProt	complete
enables	GO:0005516	calmodulin binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR013543	F	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR017441	F	Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR008271 InterPro:IPR013543	P	Seeded From UniProt	complete
enables	GO:0004683	calmodulin-dependent protein kinase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.7.11.17	F	Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	PMID:9060999^[6]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	PMID:9060999^[6]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0060998	regulation of dendritic spine development	PMID:18817731^[3]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0051924	regulation of calcium ion transport	PMID:15294044^[7]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0051823	regulation of synapse structural plasticity	PMID:18817731^[3]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0048169	regulation of long-term neuronal synaptic plasticity	PMID:18817731^[3]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0014733	regulation of skeletal muscle adaptation	PMID:15294044^[7]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:1900034	regulation of cellular response to heat	Reactome:R-HSA-3371571	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0060333	interferon-gamma-mediated signaling pathway	Reactome:R-HSA-877300	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0030666	endocytic vesicle membrane	Reactome:R-HSA-416320	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-HSA-909552	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-HSA-5082387	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0217	P	Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F	Seeded From UniProt	complete
involved_in	GO:0007399	nervous system development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0524	P	Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F	Seeded From UniProt	complete
enables	GO:0005516	calmodulin binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0112	F	Seeded From UniProt	complete
enables	GO:0003779	actin binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0009	F	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963	C	Seeded From UniProt	complete
part_of	GO:0045202	synapse	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0770 UniProtKB-SubCell:SL-0258	C	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C	Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0723	F	Seeded From UniProt	complete
part_of	GO:0005856	cytoskeleton	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0206 UniProtKB-SubCell:SL-0090	C	Seeded From UniProt	complete
part_of	GO:0030054	cell junction	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0965	C	Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P	Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0221	P	Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F	Seeded From UniProt	complete
part_of	GO:0016529	sarcoplasmic reticulum	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0703	C	Seeded From UniProt	complete
part_of	GO:0005815	microtubule organizing center	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0048	C	Seeded From UniProt	complete
part_of	GO:0033017	sarcoplasmic reticulum membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0241	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Küry, S et al. (2017) De Novo Mutations in Protein Kinase Genes CAMK2A and CAMK2B Cause Intellectual Disability. Am. J. Hum. Genet. 101 768-788 PubMed GONUTS page
↑ ^2.0 ^2.1 Rellos, P et al. (2010) Structure of the CaMKIIdelta/calmodulin complex reveals the molecular mechanism of CaMKII kinase activation. PLoS Biol. 8 e1000426 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 Wayman, GA et al. (2008) Calmodulin-kinases: modulators of neuronal development and plasticity. Neuron 59 914-31 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Rolland, T et al. (2014) A proteome-scale map of the human interactome network. Cell 159 1212-26 PubMed GONUTS page
↑ ^6.0 ^6.1 Tombes, RM & Krystal, GW (1997) Identification of novel human tumor cell-specific CaMK-II variants. Biochim. Biophys. Acta 1355 281-92 PubMed GONUTS page
↑ ^7.0 ^7.1 Chin, ER (2004) The role of calcium and calcium/calmodulin-dependent kinases in skeletal muscle plasticity and mitochondrial biogenesis. Proc Nutr Soc 63 279-86 PubMed GONUTS page

[PMID:29100089-1] Küry, S et al. (2017) De Novo Mutations in Protein Kinase Genes CAMK2A and CAMK2B Cause Intellectual Disability. Am. J. Hum. Genet. 101 768-788 PubMed GONUTS page

[PMID:20668654-2] 2.0 ^2.1 Rellos, P et al. (2010) Structure of the CaMKIIdelta/calmodulin complex reveals the molecular mechanism of CaMKII kinase activation. PLoS Biol. 8 e1000426 PubMed GONUTS page

[PMID:18817731-3] 3.0 ^3.1 ^3.2 ^3.3 Wayman, GA et al. (2008) Calmodulin-kinases: modulators of neuronal development and plasticity. Neuron 59 914-31 PubMed GONUTS page

[PMID:21873635-4] 4.0 ^4.1 ^4.2 ^4.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:25416956-5] Rolland, T et al. (2014) A proteome-scale map of the human interactome network. Cell 159 1212-26 PubMed GONUTS page

[PMID:9060999-6] 6.0 ^6.1 Tombes, RM & Krystal, GW (1997) Identification of novel human tumor cell-specific CaMK-II variants. Biochim. Biophys. Acta 1355 281-92 PubMed GONUTS page

[PMID:15294044-7] 7.0 ^7.1 Chin, ER (2004) The role of calcium and calcium/calmodulin-dependent kinases in skeletal muscle plasticity and mitochondrial biogenesis. Proc Nutr Soc 63 279-86 PubMed GONUTS page

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HUMAN:KCC2B

Contents

Annotations

Notes

References

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