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HUMAN:IRF6

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) IRF6
Protein Name(s) Interferon regulatory factor 6

IRF-6

External Links
UniProt O14896
EMBL AF027292
JF346417
AK296960
AL022398
CH471100
CH471100
BC014852
CCDS CCDS1492.1
CCDS55681.1
RefSeq NP_001193625.1
NP_006138.1
UniGene Hs.591415
ProteinModelPortal O14896
SMR O14896
BioGrid 109872
IntAct O14896
STRING 9606.ENSP00000355988
PhosphoSite O14896
MaxQB O14896
PaxDb O14896
PeptideAtlas O14896
PRIDE O14896
Ensembl ENST00000367021
ENST00000542854
GeneID 3664
KEGG hsa:3664
UCSC uc001hhq.2
CTD 3664
GeneCards GC01M209959
GeneReviews IRF6
HGNC HGNC:6121
MIM 119300
119500
607199
608864
neXtProt NX_O14896
Orphanet 1300
1991
2227
99798
888
PharmGKB PA29920
eggNOG NOG45968
GeneTree ENSGT00760000119093
HOGENOM HOG000037433
HOVERGEN HBG105715
InParanoid O14896
KO K10154
OMA HEEENTI
OrthoDB EOG7CCBR1
PhylomeDB O14896
TreeFam TF328512
Reactome REACT_25078
REACT_25162
ChiTaRS IRF6
GeneWiki IRF6
GenomeRNAi 3664
NextBio 14343
PRO PR:O14896
Proteomes UP000005640
Bgee O14896
CleanEx HS_IRF6
ExpressionAtlas O14896
Genevestigator O14896
GO GO:0005737
GO:0005829
GO:0070062
GO:0005634
GO:0003677
GO:0000975
GO:0003700
GO:0007050
GO:0048468
GO:0019221
GO:0060333
GO:0030216
GO:0043616
GO:0060644
GO:0008285
GO:0045893
GO:0006351
GO:0060337
Gene3D 1.10.10.10
2.60.200.10
InterPro IPR019817
IPR001346
IPR019471
IPR017855
IPR008984
IPR011991
Pfam PF00605
PF10401
PRINTS PR00267
SMART SM00348
SUPFAM SSF49879
PROSITE PS00601
PS51507

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

enables

GO:0000981

DNA-binding transcription factor activity, RNA polymerase II-specific

PMID:19274049[1]

ECO:0000303

author statement without traceable support used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0000981

DNA-binding transcription factor activity, RNA polymerase II-specific

PMID:19274049[1]

ECO:0000255

match to sequence model evidence used in manual assertion

InterPro:IPR001346

F

Seeded From UniProt

complete

enables

GO:0000981

DNA-binding transcription factor activity, RNA polymerase II-specific

GO_REF:0000113

ECO:0005556

multiple sequence alignment evidence used in manual assertion

UniProtKB:P15314

F

Seeded From UniProt

complete

enables

GO:0001228

DNA-binding transcription activator activity, RNA polymerase II-specific

GO_REF:0000036

ECO:0000305

curator inference used in manual assertion

GO:0043565,GO:0045944

F

Seeded From UniProt

complete

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:21807998[2]

ECO:0000314

direct assay evidence used in manual assertion

P

has_regulation_target:(NCBI_Gene:5017)

Seeded From UniProt

complete

enables

GO:0043565

sequence-specific DNA binding

PMID:28473536[3]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0070062

extracellular exosome

PMID:19056867[4]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(UBERON:0001088)

Seeded From UniProt

complete

involved_in

GO:0060644

mammary gland epithelial cell differentiation

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P97431

P

Seeded From UniProt

complete

involved_in

GO:0045893

positive regulation of transcription, DNA-templated

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P97431

P

Seeded From UniProt

complete

involved_in

GO:0008285

negative regulation of cell population proliferation

PMID:18212048[5]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007050

cell cycle arrest

PMID:18212048[5]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:18212048[5]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:16049006[6]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0003700

DNA-binding transcription factor activity

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P97431

F

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P97431

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1096873
MGI:MGI:1859179
MGI:MGI:96395
MGI:MGI:96590
PANTHER:PTN000942746
RGD:2920
UniProtKB:O14896
UniProtKB:P10914
UniProtKB:P14316
UniProtKB:Q02556
UniProtKB:Q13568
UniProtKB:Q14653
UniProtKB:Q15306
UniProtKB:Q92985
ZFIN:ZDB-GENE-041114-13
ZFIN:ZDB-GENE-070912-330

C

Seeded From UniProt

complete

involved_in

GO:0002376

immune system process

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1096873
MGI:MGI:1350924
MGI:MGI:1859179
MGI:MGI:1859212
MGI:MGI:96395
MGI:MGI:96590
PANTHER:PTN000942747
UniProtKB:P10914
UniProtKB:P14316
UniProtKB:Q02556
UniProtKB:Q92985
ZFIN:ZDB-GENE-040718-367
ZFIN:ZDB-GENE-070912-330

P

Seeded From UniProt

complete

enables

GO:0000981

DNA-binding transcription factor activity, RNA polymerase II-specific

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1859212
PANTHER:PTN000942746
UniProtKB:P10914
UniProtKB:P14316
UniProtKB:Q02556
UniProtKB:Q14653
UniProtKB:Q15306
UniProtKB:Q92985
ZFIN:ZDB-GENE-070912-330

F

Seeded From UniProt

complete

part_of

GO:0030054

cell junction

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0060644

mammary gland epithelial cell differentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P97431
ensembl:ENSMUSP00000075839

P

Seeded From UniProt

complete

involved_in

GO:0048468

cell development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P97431
ensembl:ENSMUSP00000075839

P

Seeded From UniProt

complete

involved_in

GO:0045893

positive regulation of transcription, DNA-templated

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P97431
ensembl:ENSMUSP00000075839

P

Seeded From UniProt

complete

involved_in

GO:0043616

keratinocyte proliferation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P97431
ensembl:ENSMUSP00000075839

P

Seeded From UniProt

complete

involved_in

GO:0043588

skin development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P97431
ensembl:ENSMUSP00000075839

P

Seeded From UniProt

complete

involved_in

GO:0030216

keratinocyte differentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P97431
ensembl:ENSMUSP00000075839

P

Seeded From UniProt

complete

involved_in

GO:0008285

negative regulation of cell population proliferation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P97431
ensembl:ENSMUSP00000075839

P

Seeded From UniProt

complete

enables

GO:0003700

DNA-binding transcription factor activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P97431
ensembl:ENSMUSP00000075839

F

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P97431
ensembl:ENSMUSP00000075839

F

Seeded From UniProt

complete

enables

GO:0003700

DNA-binding transcription factor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR019471
InterPro:IPR019817

F

Seeded From UniProt

complete

involved_in

GO:0006355

regulation of transcription, DNA-templated

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR019471
InterPro:IPR019817

P

Seeded From UniProt

complete

enables

GO:0044212

transcription regulatory region DNA binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001346

F

Seeded From UniProt

complete

involved_in

GO:0060337

type I interferon signaling pathway

Reactome:R-HSA-909733

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0060333

interferon-gamma-mediated signaling pathway

Reactome:R-HSA-877300

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

Reactome:R-HSA-1031716
Reactome:R-HSA-1015702

ECO:0000304

author statement supported by traceable reference used in manual assertion


C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0238

F

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

involved_in

GO:0030154

cell differentiation

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0221

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 Vaquerizas, JM et al. (2009) A census of human transcription factors: function, expression and evolution. Nat. Rev. Genet. 10 252-63 PubMed GONUTS page
  2. Botti, E et al. (2011) Developmental factor IRF6 exhibits tumor suppressor activity in squamous cell carcinomas. Proc. Natl. Acad. Sci. U.S.A. 108 13710-5 PubMed GONUTS page
  3. Yin, Y et al. (2017) Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science 356 PubMed GONUTS page
  4. Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page
  5. 5.0 5.1 5.2 Bailey, CM et al. (2008) Interferon regulatory factor 6 promotes cell cycle arrest and is regulated by the proteasome in a cell cycle-dependent manner. Mol. Cell. Biol. 28 2235-43 PubMed GONUTS page
  6. Bailey, CM et al. (2005) Mammary serine protease inhibitor (Maspin) binds directly to interferon regulatory factor 6: identification of a novel serpin partnership. J. Biol. Chem. 280 34210-7 PubMed GONUTS page
  7. 7.0 7.1 7.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page