GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
HUMAN:IBP4
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | IGFBP4 (synonyms: IBP4) | |
| Protein Name(s) | Insulin-like growth factor-binding protein 4
IBP-4 IGF-binding protein 4 IGFBP-4 | |
| External Links | ||
| UniProt | P22692 | |
| EMBL | M38177 M62403 U20982 Y12508 AK304572 BT019891 BT019892 AY442346 AC018629 CH471152 BC016041 | |
| CCDS | CCDS11367.1 | |
| PIR | G01662 | |
| RefSeq | NP_001543.2 | |
| UniGene | Hs.462998 | |
| PDB | 1WQJ 2DSP 2DSQ 2DSR | |
| PDBsum | 1WQJ 2DSP 2DSQ 2DSR | |
| ProteinModelPortal | P22692 | |
| SMR | P22692 | |
| BioGrid | 109708 | |
| DIP | DIP-48432N | |
| IntAct | P22692 | |
| MINT | MINT-6630380 | |
| STRING | 9606.ENSP00000269593 | |
| BindingDB | P22692 | |
| ChEMBL | CHEMBL2310 | |
| MEROPS | I31.952 | |
| PhosphoSite | P22692 | |
| DMDM | 124065 | |
| MaxQB | P22692 | |
| PaxDb | P22692 | |
| PeptideAtlas | P22692 | |
| PRIDE | P22692 | |
| DNASU | 3487 | |
| Ensembl | ENST00000269593 | |
| GeneID | 3487 | |
| KEGG | hsa:3487 | |
| UCSC | uc002hus.3 | |
| CTD | 3487 | |
| GeneCards | GC17P038599 | |
| HGNC | HGNC:5473 | |
| MIM | 146733 | |
| neXtProt | NX_P22692 | |
| PharmGKB | PA29706 | |
| eggNOG | NOG46496 | |
| GeneTree | ENSGT00550000074457 | |
| HOGENOM | HOG000253012 | |
| HOVERGEN | HBG002631 | |
| InParanoid | P22692 | |
| OMA | QGRTHED | |
| OrthoDB | EOG74N5HG | |
| PhylomeDB | P22692 | |
| TreeFam | TF331211 | |
| BioCyc | MetaCyc:ENSG00000141753-MONOMER | |
| Reactome | REACT_15428 | |
| ChiTaRS | IGFBP4 | |
| EvolutionaryTrace | P22692 | |
| GeneWiki | IGFBP4 | |
| GenomeRNAi | 3487 | |
| NextBio | 13714 | |
| PMAP-CutDB | P22692 | |
| PRO | PR:P22692 | |
| Proteomes | UP000005640 | |
| Bgee | P22692 | |
| CleanEx | HS_IGFBP4 | |
| ExpressionAtlas | P22692 | |
| Genevestigator | P22692 | |
| GO | GO:0005576 GO:0005615 GO:0008283 GO:0044267 GO:0006259 GO:0006954 GO:0043568 GO:0043410 GO:0001558 GO:0010906 GO:0007165 GO:0001501 GO:0044342 | |
| Gene3D | 4.10.40.20 4.10.800.10 | |
| InterPro | IPR009030 IPR022327 IPR000867 IPR009168 IPR022321 IPR017891 IPR000716 | |
| PANTHER | PTHR11551 | |
| Pfam | PF00219 PF00086 | |
| PRINTS | PR01976 PR01980 | |
| SMART | SM00121 SM00211 | |
| SUPFAM | SSF57184 SSF57610 | |
| PROSITE | PS00222 PS51323 PS00484 PS51162 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
involved_in |
GO:0043567 |
regulation of insulin-like growth factor receptor signaling pathway |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000167605 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0031995 |
insulin-like growth factor II binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000167605 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0031994 |
insulin-like growth factor I binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000167605 |
F |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005615 |
extracellular space |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:96436 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006954 |
inflammatory response |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P21744 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0044342 |
type B pancreatic cell proliferation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P47879 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0043568 |
positive regulation of insulin-like growth factor receptor signaling pathway |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P47879 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0043410 |
positive regulation of MAPK cascade |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P47879 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0040008 |
regulation of growth |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P47879 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0010906 |
regulation of glucose metabolic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P47879 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005615 |
extracellular space |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P47879 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0005520 |
insulin-like growth factor binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P47879 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0001558 |
regulation of cell growth |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P47879 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0005520 |
insulin-like growth factor binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
InterPro:IPR000867 |
F |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005576 |
extracellular region |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
InterPro:IPR000867 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0090090 |
negative regulation of canonical Wnt signaling pathway |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005102 |
signaling receptor binding |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
part_of:(GO:0090090) |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0007165 |
signal transduction |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0044267 |
cellular protein metabolic process |
Reactome:R-HSA-392499 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0043687 |
post-translational protein modification |
Reactome:R-HSA-597592 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005788 |
endoplasmic reticulum lumen |
Reactome:R-HSA-8952289 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005576 |
extracellular region |
Reactome:R-HSA-381543 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
|
part_of |
GO:0005576 |
extracellular region |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0019838 |
growth factor binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ 2.0 2.1 Arenas, E (2014) Wnt signaling in midbrain dopaminergic neuron development and regenerative medicine for Parkinson's disease. J Mol Cell Biol 6 42-53 PubMed GONUTS page
- ↑ Kiefer, MC et al. (1992) Characterization of recombinant human insulin-like growth factor binding proteins 4, 5, and 6 produced in yeast. J. Biol. Chem. 267 12692-9 PubMed GONUTS page
e
i
p
r
