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HUMAN:HCST
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | HCST (synonyms: DAP10, KAP10, PIK3AP) | |
| Protein Name(s) | Hematopoietic cell signal transducer
DNAX-activation protein 10 Membrane protein DAP10 Transmembrane adapter protein KAP10 | |
| External Links | ||
| UniProt | Q9UBK5 | |
| EMBL | AF172929 AF072844 AF072845 AF122904 AF285447 AY359058 AL050163 BC035931 BC046348 BC065224 | |
| CCDS | CCDS32998.1 CCDS46057.1 | |
| PIR | T08788 | |
| RefSeq | NP_001007470.1 NP_055081.1 | |
| UniGene | Hs.117339 | |
| ProteinModelPortal | Q9UBK5 | |
| BioGrid | 116079 | |
| IntAct | Q9UBK5 | |
| STRING | 9606.ENSP00000246551 | |
| DMDM | 74734930 | |
| PaxDb | Q9UBK5 | |
| PRIDE | Q9UBK5 | |
| Ensembl | ENST00000246551 ENST00000437550 | |
| GeneID | 10870 | |
| KEGG | hsa:10870 | |
| UCSC | uc002ock.1 uc002ocl.1 | |
| CTD | 10870 | |
| GeneCards | GC19P036393 | |
| HGNC | HGNC:16977 | |
| HPA | CAB034435 | |
| MIM | 604089 | |
| neXtProt | NX_Q9UBK5 | |
| PharmGKB | PA134956649 | |
| eggNOG | NOG42800 | |
| GeneTree | ENSGT00390000012777 | |
| HOGENOM | HOG000112856 | |
| HOVERGEN | HBG106666 | |
| InParanoid | Q9UBK5 | |
| KO | K07988 | |
| OMA | HPGHILF | |
| OrthoDB | EOG7PP5B3 | |
| PhylomeDB | Q9UBK5 | |
| TreeFam | TF338335 | |
| Reactome | REACT_11152 | |
| ChiTaRS | HCST | |
| GeneWiki | HCST_(gene) | |
| GenomeRNAi | 10870 | |
| NextBio | 41275 | |
| PRO | PR:Q9UBK5 | |
| Proteomes | UP000005640 | |
| Bgee | Q9UBK5 | |
| CleanEx | HS_HCST | |
| Genevestigator | Q9UBK5 | |
| GO | GO:0009986 GO:0016021 GO:0005886 GO:0043548 GO:0005102 GO:0014068 GO:0050776 | |
| InterPro | IPR009861 | |
| PANTHER | PTHR21409 | |
| Pfam | PF07213 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0006468 |
protein phosphorylation |
ECO:0000316 |
UniProtKB:P31749 UniProtKB:P27986
|
P |
Fig 5A Shows that KAP10 cross-linking leads to Akt (PKB/RAC) phosphrylation Fig 5B shows that KAP10 is dependant upon PI-3 Kinase for phosphorylation activity to occur. |
complete | ||||
| GO:0035591 |
signaling adaptor activity |
ECO:0000314 |
F |
FIGURE 5A |
complete | |||||
| GO:0035591 |
signaling adaptor activity |
ECO:0000314 |
F |
Figure 6. |
complete | |||||
|
involved_in |
GO:0006468 |
protein phosphorylation |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0043548 |
phosphatidylinositol 3-kinase binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0014068 |
positive regulation of phosphatidylinositol 3-kinase signaling |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0009986 |
cell surface |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0009986 |
cell surface |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005102 |
signaling receptor binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005102 |
signaling receptor binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005102 |
signaling receptor binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0043548 |
phosphatidylinositol 3-kinase binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000484054 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0014068 |
positive regulation of phosphatidylinositol 3-kinase signaling |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000484054 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0005102 |
signaling receptor binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000484054 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0005102 |
signaling receptor binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0014068 |
positive regulation of phosphatidylinositol 3-kinase signaling |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0043548 |
phosphatidylinositol 3-kinase binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0050776 |
regulation of immune response |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0050776 |
regulation of immune response |
Reactome:R-HSA-198933 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005886 |
plasma membrane |
Reactome:R-HSA-198983 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Chang, C et al. (1999) Cutting edge: KAP10, a novel transmembrane adapter protein genetically linked to DAP12 but with unique signaling properties. J. Immunol. 163 4651-4 PubMed GONUTS page
- ↑ 2.0 2.1 Chauveau, A et al. (2010) Membrane nanotubes facilitate long-distance interactions between natural killer cells and target cells. Proc. Natl. Acad. Sci. U.S.A. 107 5545-50 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 Wu, J et al. (1999) An activating immunoreceptor complex formed by NKG2D and DAP10. Science 285 730-2 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 4.3 Rosen, DB et al. (2004) A Structural basis for the association of DAP12 with mouse, but not human, NKG2D. J. Immunol. 173 2470-8 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
