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HUMAN:HAUS8

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) HAUS8 (synonyms: HICE1)
Protein Name(s) HAUS augmin-like complex subunit 8

HEC1/NDC80-interacting centrosome-associated protein 1 Sarcoma antigen NY-SAR-48

External Links
UniProt Q9BT25
EMBL AK295994
AC020908
CH471106
CH471106
AY211919
BC004398
BC010176
CCDS CCDS32948.1
CCDS46009.1
RefSeq NP_001011699.1
NP_219485.1
UniGene Hs.404088
ProteinModelPortal Q9BT25
BioGrid 125017
DIP DIP-48834N
IntAct Q9BT25
STRING 9606.ENSP00000253669
iPTMnet Q9BT25
PhosphoSite Q9BT25
BioMuta HAUS8
DMDM 229462967
EPD Q9BT25
MaxQB Q9BT25
PaxDb Q9BT25
PRIDE Q9BT25
DNASU 93323
Ensembl ENST00000253669
ENST00000448593
ENST00000593360
GeneID 93323
KEGG hsa:93323
UCSC uc002nfe.4
CTD 93323
GeneCards HAUS8
H-InvDB HIX0014879
HGNC HGNC:30532
HPA HPA039406
MIM 613434
neXtProt NX_Q9BT25
PharmGKB PA165393466
eggNOG ENOG410IEK2
ENOG4112BWM
GeneTree ENSGT00390000010974
HOGENOM HOG000112854
InParanoid Q9BT25
KO K16591
OMA ESRYLQY
OrthoDB EOG7JHM6B
PhylomeDB Q9BT25
TreeFam TF332998
ChiTaRS HAUS8
GenomeRNAi 93323
NextBio 78044
PRO PR:Q9BT25
Proteomes UP000005640
Bgee Q9BT25
ExpressionAtlas Q9BT25
Genevisible Q9BT25
GO GO:0005813
GO:0005737
GO:0070652
GO:0005874
GO:0000922
GO:0051301
GO:0051297
GO:0007067
GO:0051225

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

part_of

GO:0070652

HAUS complex

PMID:19369198[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0070652

HAUS complex

PMID:19427217[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0007098

centrosome cycle

PMID:19427217[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0051225

spindle assembly

PMID:19427217[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0051225

spindle assembly

PMID:19369198[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005813

centrosome

PMID:21399614[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0003674

molecular_function

GO_REF:0000015

ECO:0000307

no biological data found used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0051225

spindle assembly

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001274055
UniProtKB:Q9BT25

P

Seeded From UniProt

complete

involved_in

GO:0007098

centrosome cycle

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001274055
UniProtKB:Q9BT25

P

Seeded From UniProt

complete

part_of

GO:0005880

nuclear microtubule

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001274055
TAIR:locus:2051869

C

Seeded From UniProt

complete

part_of

GO:0005813

centrosome

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001274055
UniProtKB:Q9BT25

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001274055
TAIR:locus:2051869

C

Seeded From UniProt

complete

involved_in

GO:0097711

ciliary basal body-plasma membrane docking

Reactome:R-HSA-5620912

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0010389

regulation of G2/M transition of mitotic cell cycle

Reactome:R-HSA-8854518

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

Reactome:R-HSA-8853419
Reactome:R-HSA-8853405
Reactome:R-HSA-5638009
Reactome:R-HSA-5626699
Reactome:R-HSA-5626681
Reactome:R-HSA-5626228
Reactome:R-HSA-5626227
Reactome:R-HSA-5626223
Reactome:R-HSA-5626220
Reactome:R-HSA-5617816
Reactome:R-HSA-380508
Reactome:R-HSA-380455
Reactome:R-HSA-380316
Reactome:R-HSA-380311
Reactome:R-HSA-380303
Reactome:R-HSA-380294
Reactome:R-HSA-380283
Reactome:R-HSA-380272
Reactome:R-HSA-3000319
Reactome:R-HSA-3000310
Reactome:R-HSA-2574845
Reactome:R-HSA-2574840

ECO:0000304

author statement supported by traceable reference used in manual assertion






















C

Seeded From UniProt

complete

involved_in

GO:0000086

G2/M transition of mitotic cell cycle

Reactome:R-HSA-69275

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007049

cell cycle

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0131

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

involved_in

GO:0051301

cell division

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0132

P

Seeded From UniProt

complete

part_of

GO:0005856

cytoskeleton

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0206

C

Seeded From UniProt

complete

part_of

GO:0005874

microtubule

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0493

C

Seeded From UniProt

complete

part_of

GO:0005819

spindle

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0251

C

Seeded From UniProt

complete

part_of

GO:0005815

microtubule organizing center

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0048

C

Seeded From UniProt

complete

part_of

GO:0000922

spindle pole

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0448

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 Uehara, R et al. (2009) The augmin complex plays a critical role in spindle microtubule generation for mitotic progression and cytokinesis in human cells. Proc. Natl. Acad. Sci. U.S.A. 106 6998-7003 PubMed GONUTS page
  2. 2.0 2.1 2.2 Lawo, S et al. (2009) HAUS, the 8-subunit human Augmin complex, regulates centrosome and spindle integrity. Curr. Biol. 19 816-26 PubMed GONUTS page
  3. Jakobsen, L et al. (2011) Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methods. EMBO J. 30 1520-35 PubMed GONUTS page
  4. 4.0 4.1 4.2 4.3 4.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page