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HUMAN:GPR64

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) GPR64 (synonyms: HE6, TM7LN2)
Protein Name(s) G-protein coupled receptor 64

Human epididymis-specific protein 6 He6

External Links
UniProt Q8IZP9
EMBL X81892
AF538954
AF539455
AF539456
AY143364
AY143365
AY143366
AY143367
AY148343
AL732578
AL732509
AL732578
AL732509
AL732578
AL732509
AL732578
AL732509
AL732509
AL732578
AL732509
AL732578
AL732509
AL732578
AL732509
AL732578
BC113979
CCDS CCDS14191.1
CCDS43921.1
CCDS43922.1
CCDS43923.1
CCDS55376.1
CCDS55377.1
CCDS55378.1
CCDS55379.1
RefSeq NP_001073327.1
NP_001073328.1
NP_001073329.1
NP_001171762.1
NP_001171763.1
NP_001171764.1
NP_001171765.1
NP_001171766.1
NP_005747.2
XP_006724518.1
UniGene Hs.146978
ProteinModelPortal Q8IZP9
SMR Q8IZP9
BioGrid 115451
MEROPS S63.010
PhosphoSite Q8IZP9
DMDM 229462874
MaxQB Q8IZP9
PaxDb Q8IZP9
PRIDE Q8IZP9
Ensembl ENST00000340581
ENST00000354791
ENST00000356606
ENST00000357544
ENST00000357991
ENST00000360279
ENST00000379869
ENST00000379873
ENST00000379876
ENST00000379878
GeneID 10149
KEGG hsa:10149
UCSC uc004cyx.3
uc004cyy.3
uc004cyz.3
uc004cza.3
uc004czb.3
uc004czc.3
uc004czd.3
uc004cze.3
uc004czf.3
uc010nfj.3
CTD 10149
GeneCards GC0XM019007
H-InvDB HIX0016685
HGNC HGNC:4516
HPA HPA001478
MIM 300572
neXtProt NX_Q8IZP9
PharmGKB PA28908
eggNOG NOG12793
GeneTree ENSGT00760000118787
HOVERGEN HBG051817
InParanoid Q8IZP9
KO K08451
OMA LSETYFI
OrthoDB EOG7ZGX28
PhylomeDB Q8IZP9
TreeFam TF321769
GeneWiki GPR64
GenomeRNAi 10149
NextBio 38407
PRO PR:Q8IZP9
Proteomes UP000005640
Bgee Q8IZP9
ExpressionAtlas Q8IZP9
Genevestigator Q8IZP9
GO GO:0016324
GO:0009986
GO:0070062
GO:0016021
GO:0005887
GO:0004930
GO:0007186
GO:0007218
GO:0007283
InterPro IPR017981
IPR000832
IPR017983
IPR000203
Pfam PF00002
PF01825
PRINTS PR00249
SMART SM00303
PROSITE PS00650
PS50261
PS50221

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

part_of

GO:0016324

apical plasma membrane

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q8CJ11

C

Seeded From UniProt

complete

part_of

GO:0009986

cell surface

PMID:19581412[1]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0070062

extracellular exosome

PMID:19199708[2]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(UBERON:0001831)

Seeded From UniProt

complete

involved_in

GO:0007189

adenylate cyclase-activating G protein-coupled receptor signaling pathway

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1916151
PANTHER:PTN000244280
UniProtKB:Q6QNK2

P

Seeded From UniProt

complete

part_of

GO:0005887

integral component of plasma membrane

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:2441950
PANTHER:PTN000244280
UniProtKB:Q9HAR2
WB:WBGene00002251

C

Seeded From UniProt

complete

enables

GO:0004930

G protein-coupled receptor activity

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1340051
PANTHER:PTN000244280
RGD:620768
UniProtKB:O14514
UniProtKB:O60241
UniProtKB:Q6QNK2
UniProtKB:Q86SQ4
ZFIN:ZDB-GENE-041014-357

F

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0016324

apical plasma membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8CJ11
ensembl:ENSRNOP00000039239

C

Seeded From UniProt

complete

enables

GO:0004888

transmembrane signaling receptor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR017981

F

Seeded From UniProt

complete

enables

GO:0004930

G protein-coupled receptor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000832
InterPro:IPR017983

F

Seeded From UniProt

complete

involved_in

GO:0007166

cell surface receptor signaling pathway

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR017981

P

Seeded From UniProt

complete

involved_in

GO:0007186

G protein-coupled receptor signaling pathway

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000832
InterPro:IPR017983

P

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000832
InterPro:IPR017981

C

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

PMID:12420295[4]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0007283

spermatogenesis

PMID:9150425[5]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007186

G protein-coupled receptor signaling pathway

PMID:9150425[5]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005887

integral component of plasma membrane

PMID:9150425[5]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0004930

G protein-coupled receptor activity

PMID:9150425[5]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

enables

GO:0004930

G protein-coupled receptor activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0297

F

Seeded From UniProt

complete

involved_in

GO:0007186

G protein-coupled receptor signaling pathway

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0297

P

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

involved_in

GO:0007165

signal transduction

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0807

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1003

C

Seeded From UniProt

complete

part_of

GO:0016324

apical plasma membrane

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0015

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. Teckchandani, A et al. (2009) Quantitative proteomics identifies a Dab2/integrin module regulating cell migration. J. Cell Biol. 186 99-111 PubMed GONUTS page
  2. Gonzalez-Begne, M et al. (2009) Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). J. Proteome Res. 8 1304-14 PubMed GONUTS page
  3. 3.0 3.1 3.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  4. Obermann, H et al. (2003) HE6, a two-subunit heptahelical receptor associated with apical membranes of efferent and epididymal duct epithelia. Mol. Reprod. Dev. 64 13-26 PubMed GONUTS page
  5. 5.0 5.1 5.2 5.3 Osterhoff, C et al. (1997) Cloning of a human epididymis-specific mRNA, HE6, encoding a novel member of the seven transmembrane-domain receptor superfamily. DNA Cell Biol. 16 379-89 PubMed GONUTS page