GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.

Have any questions? Please email us at ecoliwiki@gmail.com

HUMAN:GLUC

From GONUTS
Jump to: navigation, search
Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) GCG
Protein Name(s) Glucagon

Glicentin Glicentin-related polypeptide GRPP Oxyntomodulin OXM OXY Glucagon Glucagon-like peptide 1 GLP-1 Incretin hormone Glucagon-like peptide 1(7-37) GLP-1(7-37) Glucagon-like peptide 1(7-36) GLP-1(7-36) Glucagon-like peptide 2 GLP-2

External Links
UniProt P01275
EMBL J04040
X03991
V01515
BT006813
AC007750
BC005278
CCDS CCDS46439.1
PIR A24377
RefSeq NP_002045.1
UniGene Hs.516494
Hs.741174
PDB 1BH0
1D0R
1NAU
2G49
2L63
2L64
2M5P
2M5Q
3IOL
4APD
PDBsum 1BH0
1D0R
1NAU
2G49
2L63
2L64
2M5P
2M5Q
3IOL
4APD
ProteinModelPortal P01275
SMR P01275
BioGrid 108911
DIP DIP-46470N
IntAct P01275
MINT MINT-8090511
STRING 9606.ENSP00000387662
BindingDB P01275
ChEMBL CHEMBL5736
PhosphoSite P01275
DMDM 125987831
PaxDb P01275
PRIDE P01275
DNASU 2641
Ensembl ENST00000375497
ENST00000418842
GeneID 2641
KEGG hsa:2641
UCSC uc002ucc.4
CTD 2641
GeneCards GC02M162963
HGNC HGNC:4191
HPA CAB000040
MIM 138030
neXtProt NX_P01275
PharmGKB PA28606
eggNOG NOG42743
GeneTree ENSGT00390000005372
HOGENOM HOG000231876
HOVERGEN HBG003010
InParanoid P01275
KO K05259
OMA KMKSIYF
OrthoDB EOG7WMCM1
PhylomeDB P01275
TreeFam TF332333
Reactome REACT_1665
REACT_18274
REACT_18283
REACT_18377
REACT_19189
REACT_19327
REACT_24019
ChiTaRS GCG
EvolutionaryTrace P01275
GeneWiki Glucagon
GenomeRNAi 2641
NextBio 10412
PMAP-CutDB P01275
PRO PR:P01275
Proteomes UP000005640
Bgee P01275
CleanEx HS_GCG
Genevestigator P01275
GO GO:0005788
GO:0005576
GO:0005615
GO:0005886
GO:0034774
GO:0031769
GO:0005179
GO:0042802
GO:0005102
GO:0007188
GO:0008283
GO:0044267
GO:0071377
GO:0006112
GO:0007631
GO:0007186
GO:0043066
GO:1900118
GO:2001243
GO:0090280
GO:0030819
GO:0070374
GO:0045722
GO:0051571
GO:0035774
GO:0033138
GO:0010800
GO:0032092
GO:0045860
GO:0010737
GO:0050796
GO:0042594
GO:0007165
GO:0044281
InterPro IPR015550
IPR000532
PANTHER PTHR11418
Pfam PF00123
PRINTS PR00275
SMART SM00070
PROSITE PS00260

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0043066

negative regulation of apoptotic process

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:95674
PANTHER:PTN000152008

P

Seeded From UniProt

complete

involved_in

GO:0035774

positive regulation of insulin secretion involved in cellular response to glucose stimulus

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:95674
PANTHER:PTN000152008

P

Seeded From UniProt

complete

enables

GO:0031769

glucagon receptor binding

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000152008
RGD:2668

F

Seeded From UniProt

complete

involved_in

GO:0010737

protein kinase A signaling

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:95674
PANTHER:PTN000152008

P

Seeded From UniProt

complete

involved_in

GO:0007188

adenylate cyclase-modulating G protein-coupled receptor signaling pathway

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000152008
RGD:2668

P

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:95674
PANTHER:PTN000152008
RGD:2668

C

Seeded From UniProt

complete

enables

GO:0005179

hormone activity

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000152008
RGD:2668
UniProtKB:P01272

F

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

PMID:22212535[2]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P01275

F

Seeded From UniProt

complete

involved_in

GO:0010469

regulation of signaling receptor activity

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0005179

P

Seeded From UniProt

complete

involved_in

GO:0010469

regulation of signaling receptor activity

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0005179

P

Seeded From UniProt

complete

involved_in

GO:0010469

regulation of signaling receptor activity

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0005179

P

Seeded From UniProt

complete

involved_in

GO:1900118

negative regulation of execution phase of apoptosis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P55095
ensembl:ENSMUSP00000099794

P

Seeded From UniProt

complete

involved_in

GO:0090280

positive regulation of calcium ion import

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P55095
ensembl:ENSMUSP00000099794

P

Seeded From UniProt

complete

involved_in

GO:0070374

positive regulation of ERK1 and ERK2 cascade

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P55095
ensembl:ENSMUSP00000099794

P

Seeded From UniProt

complete

involved_in

GO:0051571

positive regulation of histone H3-K4 methylation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P55095
ensembl:ENSMUSP00000099794

P

Seeded From UniProt

complete

involved_in

GO:0050796

regulation of insulin secretion

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P55095
ensembl:ENSMUSP00000099794

P

Seeded From UniProt

complete

involved_in

GO:0045860

positive regulation of protein kinase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P55095
ensembl:ENSMUSP00000099794

P

Seeded From UniProt

complete

involved_in

GO:0043066

negative regulation of apoptotic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P55095
ensembl:ENSMUSP00000099794

P

Seeded From UniProt

complete

involved_in

GO:0035948

positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P55095
ensembl:ENSMUSP00000099794

P

Seeded From UniProt

complete

involved_in

GO:0035774

positive regulation of insulin secretion involved in cellular response to glucose stimulus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P55095
ensembl:ENSMUSP00000099794

P

Seeded From UniProt

complete

involved_in

GO:0033138

positive regulation of peptidyl-serine phosphorylation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P55095
ensembl:ENSMUSP00000099794

P

Seeded From UniProt

complete

involved_in

GO:0032092

positive regulation of protein binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P55095
ensembl:ENSMUSP00000099794

P

Seeded From UniProt

complete

involved_in

GO:0010800

positive regulation of peptidyl-threonine phosphorylation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P55095
ensembl:ENSMUSP00000099794

P

Seeded From UniProt

complete

involved_in

GO:0010737

protein kinase A signaling

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P55095
ensembl:ENSMUSP00000099794

P

Seeded From UniProt

complete

involved_in

GO:0007189

adenylate cyclase-activating G protein-coupled receptor signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P55095
ensembl:ENSMUSP00000099794

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P55095
ensembl:ENSMUSP00000099794

C

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P55095
ensembl:ENSMUSP00000099794

C

Seeded From UniProt

complete

enables

GO:0005179

hormone activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000532
InterPro:IPR015550

F

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000532

C

Seeded From UniProt

complete

involved_in

GO:0007631

feeding behavior

PMID:8538742[3]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007186

G protein-coupled receptor signaling pathway

PMID:9990065[4]
PMID:7929237[5]
Reactome:R-HSA-388396

ECO:0000304

author statement supported by traceable reference used in manual assertion



P

Seeded From UniProt

complete

enables

GO:0005102

signaling receptor binding

PMID:9990065[4]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0071377

cellular response to glucagon stimulus

Reactome:R-HSA-163359

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0050796

regulation of insulin secretion

Reactome:R-HSA-422356
Reactome:R-HSA-400508

ECO:0000304

author statement supported by traceable reference used in manual assertion


P

Seeded From UniProt

complete

part_of

GO:0034774

secretory granule lumen

Reactome:R-HSA-421416
Reactome:R-HSA-383313

ECO:0000304

author statement supported by traceable reference used in manual assertion


C

Seeded From UniProt

complete

part_of

GO:0005788

endoplasmic reticulum lumen

Reactome:R-HSA-421416
Reactome:R-HSA-381799

ECO:0000304

author statement supported by traceable reference used in manual assertion


C

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

Reactome:R-HSA-9023633
Reactome:R-HSA-9023632
Reactome:R-HSA-825631
Reactome:R-HSA-749452
Reactome:R-HSA-749448
Reactome:R-HSA-744887
Reactome:R-HSA-744886
Reactome:R-HSA-420123
Reactome:R-HSA-383313
Reactome:R-HSA-381612
Reactome:R-HSA-379048
Reactome:R-HSA-379044
Reactome:R-HSA-163625

ECO:0000304

author statement supported by traceable reference used in manual assertion













C

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0964
UniProtKB-SubCell:SL-0243

C

Seeded From UniProt

complete

enables

GO:0005179

hormone activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0372

F

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  2. ↑ Ghodke, S et al. (2012) Mapping out the multistage fibrillation of glucagon. FEBS J. 279 752-65 PubMed GONUTS page
  3. ↑ Turton, MD et al. (1996) A role for glucagon-like peptide-1 in the central regulation of feeding. Nature 379 69-72 PubMed GONUTS page
  4. ↑ 4.0 4.1 Munroe, DG et al. (1999) Prototypic G protein-coupled receptor for the intestinotrophic factor glucagon-like peptide 2. Proc. Natl. Acad. Sci. U.S.A. 96 1569-73 PubMed GONUTS page
  5. ↑ Wayman, GA et al. (1994) Synergistic activation of the type I adenylyl cyclase by Ca2+ and Gs-coupled receptors in vivo. J. Biol. Chem. 269 25400-5 PubMed GONUTS page
Retrieved from "https://gowiki.tamu.edu/wiki/index.php?title=HUMAN:GLUC&oldid=5955450"