HUMAN:GALC

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	GALC
Protein Name(s)	Galactocerebrosidase GALCERase Galactocerebroside beta-galactosidase Galactosylceramidase Galactosylceramide beta-galactosidase
External Links
UniProt	P54803
EMBL	L38559 L38544 L38545 L38546 L38547 L38548 L38549 L38550 L38551 L38552 L38553 L38555 L38556 L38557 L38558 D86181 AK296530 AK302519 AK302683 AK302956 AL136501 AL157955 L23116 D25283 D25284 BC036518
CCDS	CCDS55936.1 CCDS55937.1 CCDS9878.2
PIR	I54205
RefSeq	NP_000144.2 NP_001188330.1 NP_001188331.1
UniGene	Hs.513439
ProteinModelPortal	P54803
SMR	P54803
BioGrid	108854
STRING	9606.ENSP00000261304
CAZy	GH59
PhosphoSite	P54803
DMDM	229462868
MaxQB	P54803
PaxDb	P54803
PRIDE	P54803
DNASU	2581
Ensembl	ENST00000544807
GeneID	2581
KEGG	hsa:2581
UCSC	uc001xvt.3 uc001xvu.2 uc010tvx.2 uc010tvz.1
CTD	2581
GeneCards	GC14M088399
GeneReviews	GALC
H-InvDB	HIX0026669
HGNC	HGNC:4115
HPA	CAB022196
MIM	245200 606890
neXtProt	NX_P54803
Orphanet	206448 206436 206443
PharmGKB	PA28530
eggNOG	NOG76999
GeneTree	ENSGT00390000003303
HOGENOM	HOG000068033
HOVERGEN	HBG005800
InParanoid	P54803
KO	K01202
PhylomeDB	P54803
TreeFam	TF312985
Reactome	REACT_116105
ChiTaRS	GALC
GeneWiki	Galactosylceramidase
GenomeRNAi	2581
NextBio	10207
PRO	PR:P54803
Proteomes	UP000005640
Bgee	P54803
CleanEx	HS_GALC
ExpressionAtlas	P54803
Genevestigator	P54803
GO	GO:0070062 GO:0043202 GO:0005764 GO:0004336 GO:0005975 GO:0006683 GO:0006687 GO:0044281 GO:0006665
Gene3D	3.20.20.80
InterPro	IPR001286 IPR013781 IPR017853
PANTHER	PTHR15172
Pfam	PF02057
PRINTS	PR00850
SUPFAM	SSF51445

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0006683	galactosylceramide catabolic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P54818	P		Seeded From UniProt	complete
enables	GO:0004336	galactosylceramidase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P54818	F		Seeded From UniProt	complete
involved_in	GO:0042552	myelination	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P54818 ensembl:ENSMUSP00000021390	P		Seeded From UniProt	complete
involved_in	GO:0006683	galactosylceramide catabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P54818 ensembl:ENSMUSP00000021390	P		Seeded From UniProt	complete
enables	GO:0004336	galactosylceramidase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P54818 ensembl:ENSMUSP00000021390	F		Seeded From UniProt	complete
enables	GO:0003824	catalytic activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR013785	F		Seeded From UniProt	complete
enables	GO:0004336	galactosylceramidase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001286	F		Seeded From UniProt	complete
involved_in	GO:0006683	galactosylceramide catabolic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001286	P		Seeded From UniProt	complete
enables	GO:0004336	galactosylceramidase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:3.2.1.46	F		Seeded From UniProt	complete
part_of	GO:0005764	lysosome	PMID:7601472	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0043202	lysosomal lumen	Reactome:R-HSA-1606564	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0006687	glycosphingolipid metabolic process	Reactome:R-HSA-1660662	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004336	galactosylceramidase activity	Reactome:R-HSA-1606564	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005764	lysosome	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0458 UniProtKB-SubCell:SL-0158	C		Seeded From UniProt	complete
involved_in	GO:0008152	metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0326	P		Seeded From UniProt	complete
involved_in	GO:0016042	lipid catabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0442	P		Seeded From UniProt	complete
enables	GO:0016798	hydrolase activity, acting on glycosyl bonds	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0326	F		Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F		Seeded From UniProt	complete
involved_in	GO:0006629	lipid metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0443	P		Seeded From UniProt	complete
involved_in	GO:0006665	sphingolipid metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0746	P		Seeded From UniProt	complete
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